Ligand ID: RIM


Drugbank ID:
DB00478
(Rimantadine)


Indication:
For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults.

Get human targets for RIM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RIM' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.38A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLY A  29
SER A 121
ALA A 116
SER A 123
SER A 144
1.56A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLY A  29
SER A 121
ALA A 116
SER A 123
SER A 144
1.57A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL B 934
ALA B 938
SER B1156
ALA A 938
VAL A 934
1.26A28.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU B1184
LEU B1181
ASP B1180
ILE A 905
1.40A27.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.31A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL E  34
ALA E  38
SER D   8
ALA C  38
VAL C  34
1.26A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 10
ALA G  19
SER G  16
ALA G  23
SER G  46
SER G  52
1.45A8.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 6
LEU G 100
LEU G 103
ILE G 112
ARG G 101
1.64A9.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2ajf ACE2
(Homo
sapiens)		4 / 6
ILE B 223
ARG B 219
LEU B 222
ASP B 201
1.41A7.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL B 934
VAL C 934
ALA C 938
ALA F1156
VAL A 934
1.33A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU E1179
LEU F1182
ASP F1181
ILE B 916
1.61A25.93
None
None
ACE  B 913 ( 3.7A)
ACE  B 913 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		4 / 6
SER A 144
SER A 121
ALA A 116
SER A 123
1.43A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 6
ILE F 305
LEU F 354
LEU F 292
ASP F 289
1.42A15.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 9
ALA H 314
SER H 313
GLY H 317
SER H 311
ALA G 306
1.39A10.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLY B  11
ALA A   7
ALA B   7
VAL B 114
SER B 113
1.56A6.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.41A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ILE S 345
ARG S 342
LEU S 499
ASP S 385
1.42A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
SER T  15
SER W  15
ALA N  18
ALA T  18
1.27A11.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
LEU A  66
ASP A  64
ILE A  91
1.44A23.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 6
ILE B 207
ARG B 193
LEU B 210
LEU B 179
1.35A11.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 9
SER D 184
GLY D 196
ALA D 187
ALA D 166
ALA D 183
1.51A7.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 6
LEU B 210
LEU B 145
ILE B 207
ARG B 150
1.47A11.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 6
ILE B 305
LEU B 354
LEU B 292
ASP B 289
1.37A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 6
LEU A 297
LEU A 298
ASP A 301
ILE A 322
1.31A11.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		2hob
REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV;
synthetic
construct)		5 / 10
ALA A 193
ALA A 194
ALA A 173
VAL A 186
ALA B   2
1.45A6.60
None
None
None
None
02J  B   1 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.37A9.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
LEU B 297
LEU B 298
ASP B 301
ILE B 322
1.32A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.38A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 9
SER A 139
GLY A 138
SER B   1
GLY A 170
SER A 144
1.49A6.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.37A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.41A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
LEU B 297
LEU B 298
ASP B 301
ILE B 322
1.38A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.40A7.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		2wct NSP3
(SARSr-CoV)		5 / 9
SER B 461
GLY B 466
ALA B 493
ALA C 464
ALA B 464
1.31A6.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		2wct NSP3
(SARSr-CoV)		5 / 9
ALA B 493
ALA C 464
GLY C 466
ALA B 464
SER B 461
1.40A6.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		2wct NSP3
(SARSr-CoV)		5 / 10
VAL A 589
ALA A 590
SER A 591
ALA A 493
ALA D 464
1.44A9.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
GLY A  73
ALA A 107
VAL A 104
ALA A  79
SER A 105
1.74A6.41
SAH  A1293 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		3avz 3C-LIKE PROTEINASE
PEPTIDE
ACE-SER-ALA-VAL-ALC-
HIS-H
(SARSr-CoV)		5 / 9
GLY A 183
ALA A 193
ALA B   3
VAL A 171
ALA A 173
1.58A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.37A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
SER L  72
SER L  63
ALA L  51
SER L  52
1.22A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
LEU L  33
LEU L  89
ILE L  48
ARG L  46
1.58A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 6
ILE A 345
ARG A 342
LEU A 499
ASP A 385
1.36A13.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		3bgf F26G19 FAB
(Mus
musculus)		5 / 9
GLY H 104
ALA H  78
SER H  21
ALA H  24
SER H  77
1.58A8.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
SER A 545
SER A 411
ALA A 533
VAL A 318
SER A 547
1.46A4.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
ALA B 550
SER B 547
GLY B 551
SER B 411
SER B 545
1.52A4.24
None
None
None
None
NDG  B 619 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
SER B 411
SER B 545
ALA B 550
SER B 547
1.40A4.24
None
NDG  B 619 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.39A9.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.41A9.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.35A9.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.38A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLY B  29
SER B 121
ALA B 116
SER B 123
SER B 144
1.65A6.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.41A9.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.36A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B  87
LEU B  86
ILE B  43
ARG B  40
1.59A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		3i6l HLA, A-24
NUCLEOPROTEIN
PEPTIDE
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU F   9
LEU D  95
ASP D  74
ILE F   7
1.57A23.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.40A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.41A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.36A9.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B  87
LEU B  86
ILE B  43
ARG B  40
1.54A9.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		6 / 10
VAL B 206
ALA B 205
VAL B 203
SER A  79
ALA B 182
SER B 181
1.77A10.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		6 / 10
VAL A 104
ALA A  79
ALA A  72
SER A  98
ALA A 107
SER A 109
1.76A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
GLY A  73
SER A  98
GLY A  71
ALA A 107
SER A 105
1.55A5.81
SAM  A 302 (-4.1A)
None
SAM  A 302 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
GLY A  73
ALA A 107
VAL A 104
ALA A  79
SER A 105
1.68A5.81
SAM  A 302 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 6
SER A  98
ALA A 107
ALA A  79
SER A 105
1.42A5.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		3sci ACE2
(Homo
sapiens)		4 / 6
SER A  43
ALA A  71
SER A  70
ALA A  65
1.23A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		3scj ACE2
(Homo
sapiens)		5 / 9
SER B 545
SER B 411
ALA B 533
VAL B 318
SER B 547
1.50A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
SER B 545
SER B 411
ALA B 533
VAL B 318
SER B 547
1.52A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ILE B 446
ARG B 518
LEU B 450
LEU B 410
1.32A6.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
SER A 411
SER A 545
ALA A 550
SER A 547
1.37A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.43A9.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.29A6.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.39A8.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.40A7.00
None
DMS  A 403 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.37A8.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
GLY B  88
ALA B  85
ALA B  79
VAL B 282
ALA B 281
1.50A3.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
LEU D 117
LEU D 157
ILE D 166
ARG D 163
1.28A7.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
GLY D  88
ALA D  85
ALA D  79
VAL D 282
ALA D 281
1.49A3.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
LEU B 117
LEU B 157
ILE B 166
ARG B 163
1.20A7.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 9
ALA C   1
GLY C  -1
ALA D 100
GLY C   2
ALA D  96
1.57A10.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		5f22 NSP8
(SARSr-CoV)		4 / 6
LEU B 100
LEU B 103
ILE B 112
ARG B 101
1.77A15.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
LEU D 117
LEU D 157
ILE D 166
ARG D 163
1.14A6.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		5 / 10
VAL A  86
SER A  93
SER A  83
VAL A 148
SER A 146
1.43A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		5x4r S PROTEIN
(MERS-CoV)		5 / 9
ALA A 138
SER A 137
GLY A 128
SER A 133
SER A 135
1.37A6.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
ALA A 875
GLY A 867
GLY A 871
ALA A 858
SER A 861
1.33A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
LEU C 538
LEU C 519
ASP C 312
ILE C 573
1.68A2.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
SER C  95
SER C 173
ALA C 250
SER C 248
1.36A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		5x5c S PROTEIN
(MERS-CoV)		5 / 9
ALA A 138
SER A 137
GLY A 128
SER A 133
SER A 135
1.37A2.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
SER A 133
SER A 135
ALA A 138
SER A 137
1.45A2.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		5x5c S PROTEIN
(MERS-CoV)		5 / 10
VAL C 846
ALA C1092
SER C1089
ALA C1096
SER C1095
1.13A2.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
LEU C 506
LEU C 507
ASP C 509
ARG C 511
1.67A2.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		5x5f S PROTEIN
(MERS-CoV)		5 / 9
SER C1091
ALA C1096
SER C1095
SER C 845
SER C1089
1.54A2.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		5x5f S PROTEIN
(MERS-CoV)		4 / 6
ILE C1067
ARG C1069
LEU C1070
LEU C1058
1.38A2.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL A  97
SER A  95
VAL A  98
ALA A  91
ALA A 249
1.34A2.90
VAL  A  97 ( 0.6A)
SER  A  95 ( 0.0A)
VAL  A  98 ( 0.6A)
ALA  A  91 ( 0.0A)
ALA  A 249 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU B 264
LEU B  58
ILE B 272
ARG B  38
1.56A2.61
LEU  B 264 ( 0.6A)
LEU  B  58 ( 0.6A)
ILE  B 272 ( 0.7A)
ARG  B  38 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU C 194
LEU C 222
ILE C 226
ARG A 342
1.63A2.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA C 590
SER C 591
GLY C 587
ALA C 658
SER C 659
1.59A1.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
GLY A  77
ALA A 250
SER A 248
ALA A  91
VAL A  97
1.48A1.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER C 964
ALA C 954
SER C 956
ALA C 971
1.37A1.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6acg ACE2
(Homo
sapiens)		5 / 9
SER D 545
ALA D 550
SER D 547
GLY D 319
SER D 411
1.46A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL A 711
ALA A1007
SER A1003
VAL A 763
ALA A1008
1.42A2.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ALA A 875
GLY A 867
GLY A 871
ALA A 858
SER A 861
1.27A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU A 571
LEU A 519
ASP A 564
ILE A 570
1.66A2.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
GLY A 246
ALA A 250
SER A 248
VAL A 140
ALA A 237
1.46A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ILE B 962
ARG B 977
LEU B 978
LEU B 966
1.40A2.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
SER B 686
ALA C 858
ALA C 864
SER C 861
1.37A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
VAL B 990
ALA B 997
ALA B 753
ALA B 748
SER B 750
1.43A2.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ALA A 875
GLY A 867
GLY A 871
ALA A 858
SER A 861
1.29A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A 147
LEU C   9
ILE A 124
ARG A  97
1.54A9.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6lzg ACE2
(Homo
sapiens)		5 / 9
SER A 545
SER A 411
ALA A 533
VAL A 318
SER A 547
1.53A4.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6lzg ACE2
(Homo
sapiens)		4 / 6
LEU A 116
LEU A 108
ILE A 119
ARG A 115
1.11A7.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6m0j ACE2
(Homo
sapiens)		4 / 6
LEU A 116
LEU A 108
ILE A 119
ARG A 115
1.15A6.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
ALA C 247
SER C 323
GLY C 326
GLY C 246
ALA C 406
1.04A3.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
LEU A 482
LEU A 485
ILE A 132
ARG A  57
1.21A7.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
ILE C 132
LEU C  52
LEU C 482
ASP C 486
1.27A7.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m18 ACE2
(Homo
sapiens)		4 / 6
SER D 411
SER D 545
ALA D 550
SER D 547
1.39A2.75
None
NAG  D 910 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6m1d ACE2
(Homo
sapiens)		4 / 6
LEU B 359
TRP B 349
ILE B 358
ARG B 357
1.60A6.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
GLY A 638
SER A 673
ALA A 658
SER A 659
ALA A 595
1.71A1.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER B 659
SER B 673
ALA B 639
ALA B 658
1.40A1.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA C 875
GLY C 867
GLY C 871
ALA C 858
SER C 861
1.52A1.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6nur NSP12
(SARSr-CoV)		4 / 6
ILE A 171
ARG A 173
LEU A 172
LEU A 146
1.31A3.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6nur NSP12
(SARSr-CoV)		4 / 6
LEU A 302
ASP A 303
ILE A 307
ARG A 305
1.49A3.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6nur NSP12
(SARSr-CoV)		5 / 9
GLY A 584
ALA A 581
SER A 578
VAL A 587
ALA A 585
1.60A2.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 9
SER H 132
GLY H 133
ALA H 136
SER H 130
SER H 187
1.73A7.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H 187
SER H 132
ALA H 136
SER H 130
1.68A7.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
ILE L  75
ARG L  61
LEU L  78
LEU L  47
1.52A15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10
VAL H 142
SER H 180
VAL H 150
VAL H 198
SER H 153
1.60A14.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10
ALA H 168
SER H 177
VAL H 150
VAL H 142
SER H 180
1.79A14.91
None
GOL  L 301 (-3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10
VAL H 198
SER H 153
VAL H 142
SER H 179
VAL H 150
1.77A14.91
None
None
None
GOL  L 301 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10
ALA H 168
SER H 177
VAL H 150
VAL H 142
SER H 179
1.77A14.91
None
GOL  L 301 (-3.1A)
None
None
GOL  L 301 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 9
SER H 187
SER H 132
GLY H 133
ALA H 136
SER H 130
1.71A7.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 9
SER H 132
GLY H 133
ALA H 136
SER H 130
SER H 187
1.72A7.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10
VAL H 182
ALA H 137
VAL H 184
ALA H 136
SER H 186
1.60A14.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10
SER H 180
VAL H 142
ALA H 168
SER H 177
VAL H 150
1.64A14.91
None
None
None
GOL  L 301 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10
VAL H 198
VAL H 142
ALA H 168
SER H 177
VAL H 150
1.68A14.91
None
None
None
GOL  L 301 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL B 186
ALA B 141
VAL B 188
ALA B 140
SER B 190
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL H 146
SER H 184
VAL H 154
VAL H 202
SER H 157
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL H 186
ALA H 141
VAL H 188
ALA H 140
SER H 190
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL B 202
VAL B 146
ALA B 172
SER B 181
VAL B 154
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
ILE C  81
ARG C  18
LEU C  79
LEU C  84
1.64A9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
SER H 184
VAL H 146
ALA H 172
SER H 181
VAL H 154
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
ILE C  81
ARG C  67
LEU C  84
LEU C  53
1.51A9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL H 202
VAL H 146
ALA H 172
SER H 181
VAL H 154
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
SER B 184
VAL B 146
ALA B 172
SER B 181
VAL B 154
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL B 146
SER B 184
VAL B 154
VAL B 202
SER B 157
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL H 186
ALA H 141
VAL H 188
ALA H 140
SER H 190
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL H 146
SER H 184
VAL H 154
VAL H 202
SER H 157
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 10
VAL H 202
VAL H 146
ALA H 172
SER H 181
VAL H 154
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 10
SER H 184
VAL H 146
ALA H 172
SER H 181
VAL H 154
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
SER H 184
VAL H 146
ALA H 172
SER H 181
VAL H 154
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
VAL B 202
VAL B 146
ALA B 172
SER B 181
VAL B 154
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
VAL B 146
SER B 184
VAL B 154
VAL B 202
SER B 157
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
VAL B 186
ALA B 141
VAL B 188
ALA B 140
SER B 190
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
VAL H 202
VAL H 146
ALA H 172
SER H 181
VAL H 154
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
VAL H 146
SER H 184
VAL H 154
VAL H 202
SER H 157
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
VAL H 186
ALA H 141
VAL H 188
ALA H 140
SER H 190
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
SER B 184
VAL B 146
ALA B 172
SER B 181
VAL B 154
1.58A
None