Ligand ID: RBV


Drugbank ID:
DB00811
(Ribavirin)


Indication:
Indicated for the treatment of chronic Hepatitis C virus (HCV) infection in combination with other antiviral agents with the intent to cure or achieve a sustained virologic response (SVR). Typically added to improve SVR and reduce relapse rates [A19644].

Get human targets for RBV in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RBV' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
GLY A  94
ALA A  97
ASN A  53
SER A  56
ILE A 124
1.66A14.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 174
ALA B 173
ASN B 142
GLU B 166
SER B 144
1.47A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
THR A 224
HIS A 246
LEU A 205
1.04A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		1x7q HLA, A-11
(Homo
sapiens)		3 / 3
THR A 190
HIS A 263
LEU A 215
1.10A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
THR B1224
HIS B1246
LEU B1205
1.14A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN G  47
ALA G  40
LEU I  41
SER H   3
ILE H   2
1.65A9.09
ACT  H 202 ( 4.2A)
None
None
ACT  H 202 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
GLY D 241
GLN D 244
ALA D 242
LEU D 270
GLU D 246
1.57A18.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ARG A 279
LEU A 271
LEU A 282
ASN A 214
GLY A 215
1.40A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG A 279
LEU A 271
LEU A 282
ASN A 214
GLY A 215
1.36A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		3 / 3
THR H 108
HIS H 164
LEU H 178
1.33A19.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU B  87
LEU B  67
THR B  26
THR B  25
GLY B  23
1.65A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
GLY B 134
ASN C  41
GLU B 105
ASN C 100
ILE C 132
1.64A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS B 273
THR B 275
THR C 199
GLY B 288
HIS B 290
1.76A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
THR C 171
HIS B 273
LEU C 200
1.24A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU B  88
LEU B 114
THR B 159
GLY B 161
ASP B 109
1.36A18.81
None
None
BR  B 319 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR R  47
GLU R  66
THR R 101
LEU K  45
HIS L  48
1.73A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
THR J 101
HIS M  48
LEU I  45
1.06A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		3 / 3
THR A  92
HIS A  99
LEU A   7
1.30A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		3 / 3
THR A  92
HIS A  34
LEU A  35
1.11A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
SER B  52
THR A 486
THR A 487
TYR A 491
GLY A 488
1.66A18.61
None
None
None
CL  A  88 ( 4.2A)
CL  A  88 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
THR A 224
HIS A 246
LEU A 205
1.24A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 9
ASP A 183
THR A 120
ASN A 139
GLY A 140
LEU A 189
1.74A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
SER B 328
THR B 326
THR B 330
ASP A 342
ASP A 341
1.54A13.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 12
GLN A  84
ALA A 135
TYR A  88
ASN A  76
SER A  79
1.57A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASP D 282
ASP D 239
LEU D 254
GLY D 253
HIS D 249
1.75A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP A 183
THR A 120
ASN A 139
GLY A 140
LEU A 189
1.69A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
GLY B 174
ALA B 173
LEU D   5
PHE B 181
ASN B  84
1.66A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2qc2 3C-LIKE PROTEINASE
(-)		3 / 3
THR A  35
HIS A 163
LEU A  27
1.38A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A 287
LEU A 282
ASN A 214
GLY A 215
ASP A 216
1.68A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP D 183
THR D 120
ASN D 139
GLY D 140
LEU D 189
1.67A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		2rnk REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
THR A 642
THR A 643
ASN A 645
TYR A 647
GLY A 646
1.80A14.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 174
ALA B 173
ASN B 142
GLU B 166
SER B 144
1.41A21.30
None
None
None
XP1  B1304 (-1.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		2wct NSP3
(SARSr-CoV)		5 / 12
GLU B 403
THR B 400
ASP A 447
GLY D 614
MET A 444
1.73A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A 111
ASP A 108
LEU A  95
THR A  82
GLY B  94
1.55A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
THR A 257
HIS A  69
LEU A  89
1.17A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
GLY A  81
ALA A  79
LEU A  95
SER A 129
ILE A 128
1.40A21.76
SAH  A1293 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
GLY A  81
ALA A  79
LEU A  95
SER A 129
ILE A 128
1.38A21.03
SFG  A1298 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A 111
ASP A 108
LEU A  95
THR A  82
GLY B  94
1.54A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
THR A 257
HIS A  69
LEU A  89
1.16A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 9
SER S 358
THR H  30
TYR H  52
GLY H  53
ASP H  56
1.56A14.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
THR A 445
HIS A 417
LEU A 370
1.28A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
ARG A 169
LEU A 503
LEU A 176
SER A 507
GLY A 130
1.61A21.01
 CL  A 902 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		3e9s NSP3
(SARSr-CoV)		5 / 11
LEU A  88
LEU A 114
THR A 159
GLY A 161
ASP A 109
1.31A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3e9s NSP3
(SARSr-CoV)		3 / 3
THR A  75
HIS A  90
LEU A 153
1.35A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 282
LEU A 253
THR A 257
THR A 304
GLY A 302
1.67A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 242
THR A 198
THR A 196
ASN A 133
GLY A 195
1.26A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 174
ALA A 173
ASN A 142
GLU A 166
SER A 144
1.63A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3i6l HLA, A-24
(Homo
sapiens)		3 / 3
THR D 190
HIS D 263
LEU D 215
1.14A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
THR A  35
HIS A 163
LEU A  27
1.38A21.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 11
LEU A 111
ASP A 108
LEU A  95
THR A  82
GLY B  94
1.56A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
THR A 257
HIS A  69
LEU A  89
1.14A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
GLY A  81
ALA A  79
LEU A  95
SER A 129
ILE A 128
1.40A21.86
SAM  A 302 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
THR F 486
THR F 487
TYR F 491
GLY F 490
ASP F 392
1.77A17.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
THR A 445
HIS A 417
LEU A 370
1.26A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
THR A 257
HIS A 246
LEU A 205
1.29A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		3snc 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-NSTSQ-H
(SARSr-CoV)		5 / 12
THR A 135
GLU A 166
THR H   3
GLY A 174
HIS A 163
1.64A21.28
None
ECC  H   5 ( 3.9A)
ECC  H   5 ( 4.7A)
None
ECC  H   5 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A 190
HIS A 263
LEU A 215
1.05A21.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
THR A 224
HIS A 246
LEU A 205
1.30A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 287
SER A 284
THR B 285
THR B 280
GLY B 283
1.49A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A  88
LEU A 114
THR A 159
GLY A 161
ASP A 109
1.35A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		3 / 3
THR B 171
HIS A  90
LEU A 153
1.30A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 11
LEU B  88
LEU B 114
THR B 159
GLY B 161
ASP B 109
1.28A18.77
None
None
GOL  A 904 ( 4.2A)
GOL  A 904 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		3 / 3
THR A  61
HIS A  52
LEU A  54
1.22A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 287
SER B 284
THR A 285
THR A 280
GLY A 283
1.49A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
THR B 224
HIS B 246
LEU B 205
1.31A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
THR B  97
HIS B 268
LEU B 149
1.15A22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ASN D 334
TYR D 351
GLY D 333
ASP D 352
LEU D 366
1.72A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU D  88
LEU D 114
THR D 159
GLY D 161
ASP D 109
1.32A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 172
HIS A  81
LEU A  86
1.15A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLY D 110
ALA D 270
LEU D 149
ASN D 104
SER D 194
1.69A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		3 / 3
THR D  97
HIS D 268
LEU D 149
1.05A21.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU D  88
LEU D 114
THR D 159
GLY D 161
ASP D 109
1.34A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		5 / 12
GLY A 138
LEU A 131
GLU A 127
SER A 146
ILE A  84
1.35A13.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
GLY A 931
ALA A 930
ASN C 637
ASN A1042
SER A1041
1.50A15.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
LEU B 347
LEU B 324
THR B  70
THR B 322
ASP B 338
1.70A16.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA A 881
ASN A 907
PHE A 782
ASN A 910
ILE A 702
1.49A16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
THR A1009
GLU A1013
GLU A 707
LYS A1027
LEU A1006
1.77A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
ASP B 296
THR B 925
GLY B 928
ASP B 932
ARG C 758
1.78A17.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5x5c S PROTEIN
(MERS-CoV)		3 / 3
THR A 803
HIS C 670
LEU C 347
0.68A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
THR B 302
HIS B 611
LEU B 615
1.29A16.14
THR  B 302 ( 0.8A)
HIS  B 611 ( 1.0A)
LEU  B 615 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 898
ASN C 907
PHE C 782
ASN C 910
ILE C 702
1.68A16.64
LEU  C 898 ( 0.5A)
ASN  C 907 ( 0.6A)
PHE  C 782 ( 1.3A)
ASN  C 910 ( 0.6A)
ILE  C 702 ( 0.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU B 986
LEU B 941
THR B 716
THR B 841
GLY B 820
1.47A17.28
LEU  B 986 ( 0.6A)
LEU  B 941 ( 0.6A)
THR  B 716 ( 0.8A)
THR  B 841 ( 0.8A)
GLY  B 820 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A  88
LEU A 114
THR A 159
GLY A 161
ASP A 109
1.34A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5yvd NSP15
(MERS-CoV)		3 / 3
THR B 280
HIS B 273
LEU B 251
0.82A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5yvd NSP15
(MERS-CoV)		3 / 3
THR A 280
HIS A 273
LEU A 251
0.83A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
THR B 302
HIS B 611
LEU B 615
1.21A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA C 881
ASN C 907
PHE C 782
ASN C 910
ILE C 702
1.48A16.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR C 678
LYS B 796
ASP B 850
GLY C 655
MET B 851
1.68A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
THR A 533
ASN A 528
ASP A 376
LEU C 966
ARG C 965
1.65A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
SER A 432
THR A 485
TYR A 438
GLY A 482
ASP A 480
1.39A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 11
LEU A 966
ASP B 376
LEU B 377
SER A 964
THR B 533
ASN B 528
1.48A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6ack ACE2
(Homo
sapiens)		5 / 11
ARG D 559
LEU D 560
LEU D 392
SER D 563
THR D  92
1.53A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
THR B 302
HIS B 611
LEU B 615
1.20A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU B 986
LEU B 941
THR B 716
THR B 841
GLY B 820
1.18A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA C 881
ASN C 907
PHE C 782
ASN C 910
ILE C 702
1.52A16.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
THR C 485
THR C 431
TYR C 436
GLY C 482
ASP C 480
1.71A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
THR C 150
HIS C 181
LEU C 170
0.99A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU C 986
LEU C 941
THR C 716
THR C 841
GLY C 820
1.14A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA A 881
ASN A 907
PHE A 782
ASN A 910
ILE A 702
1.51A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
THR A  92
GLU A  93
ASP A 208
THR A  31
HIS A  70
1.80A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASP C 727
TYR C 723
GLY C 839
ASP C 719
LEU C 986
1.59A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6cs2 ACE2
(Homo
sapiens)		3 / 3
THR D 445
HIS D 417
LEU D 370
1.31A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A 190
HIS A 263
LEU A 215
1.11A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLY B 150
GLU B 168
ASN A 107
SER A  36
ILE A  35
1.56A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6lzg ACE2
(Homo
sapiens)		3 / 3
THR A 445
HIS A 417
LEU A 370
1.28A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6m0j ACE2
(Homo
sapiens)		3 / 3
THR A 445
HIS A 417
LEU A 370
1.29A21.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6m17 ACE2
(Homo
sapiens)		5 / 12
GLN D 442
ALA D 443
LEU D 591
ASN D 437
ASN D 290
1.60A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY A 272
GLU A  81
ALA A 273
LEU A 495
ILE A 544
1.43A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6m1d ACE2
(Homo
sapiens)		3 / 3
THR D 365
HIS D 417
LEU D 423
1.24A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
THR A 260
GLU A 261
ASP A 266
GLY A  66
HIS A  65
1.79A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 898
ASN A 907
PHE A 782
ASN A 910
ILE A 702
1.68A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C 986
LEU C 941
THR C 716
THR C 841
GLY C 820
1.37A17.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6nus NSP12
(SARSr-CoV)		5 / 12
GLY A 503
ALA A 502
TYR A 516
LEU A 372
ASN A 568
1.26A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		6nus NSP12
(SARSr-CoV)		5 / 12
HIS A 347
THR A 276
LEU A 329
GLY A 345
HIS A 355
1.65A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN C  48
ALA C  90
LEU C  53
GLU C  87
ASN H  77
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY C  72
ALA C  57
LEU C  30
PHE C  77
SER C  25
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN L  48
ALA L  90
LEU L  53
GLU L  87
ASN B  77
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY L  72
ALA L  57
TYR L  97
LEU L  30
SER L  25
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 11
ARG L  60
LEU L  53
LEU L  39
THR L  78
GLY L  72
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY C  72
ALA C  57
TYR C  97
LEU C  30
SER C  25
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
THR L 186
HIS H 204
LEU H 182
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
THR L 186
HIS H 204
LEU H 179
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY L  72
ALA L  57
LEU L  30
PHE L  77
SER L  25
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
THR L 186
HIS H 204
LEU H 182
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
THR L 186
HIS H 204
LEU H 179
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY L  72
ALA L  57
TYR L  97
LEU L  30
PHE L  77
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY C  72
ALA C  57
TYR C  97
LEU C  30
SER C  25
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 11
ARG C  60
LEU C  53
LEU C  39
THR C  78
GLY C  72
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 11
ARG L  60
LEU L  53
LEU L  39
THR L  78
GLY L  72
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY L  72
ALA L  57
TYR L  97
LEU L  30
SER L  25
1.79A
None