Ligand ID: RBT


Drugbank ID:
DB00615
(Rifabutin)


Indication:
For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

Get human targets for RBT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RBT' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 11
GLN B 299
ASP B 295
ARG B 298
SER A 123
ASN B 151
1.48A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		4 / 7
LEU B  54
GLY B  29
TYR B  63
SER B  57
1.44A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		1x7q HLA, A-11
(Homo
sapiens)		4 / 7
LEU A 172
ARG A 169
GLY A   1
SER A   2
1.32A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B1107
GLN B1110
PHE B1112
ASP B1295
ILE B1249
1.65A15.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 11
GLN A 299
ASP A 295
ARG A 298
SER B 123
ASN A 151
1.73A14.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 7
ASN D  74
ARG D  75
LEU D  76
GLY D  69
1.38A24.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
GLN A 107
GLN A 110
PHE A 112
ASP A 295
ILE A 249
1.62A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 107
GLN B 110
PHE B 112
ASP B 295
ILE B 249
1.49A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		5 / 12
VAL A  20
GLU A 178
PHE A 103
VAL A 114
ILE A 136
1.62A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 7
ARG B 100
GLY A 488
TYR B  32
SER B  31
1.02A19.07
 CL  A 246 (-4.2A)
CL  A  88 (-3.3A)
CL  A  88 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG C 444
ARG C 441
GLY C 464
SER C 461
1.30A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
LEU A 108
ARG A  48
GLY A  60
SER A  51
1.20A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		2kys NSP7
(SARSr-CoV)		4 / 7
ASN A  71
ARG A  72
LEU A  73
GLY A  66
1.44A25.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
GLN A 299
ASP A 295
ARG A 298
SER B 123
ASN A 151
1.56A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
VAL A 317
PHE C 194
VAL C  66
GLN C 159
PHE C 176
1.62A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
GLN B 107
GLN B 110
PHE B 112
ASP B 295
ILE B 249
1.61A15.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 11
GLN B 299
ASP B 295
ARG B 298
SER A 123
ASN B 151
1.44A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
PRO D  50
VAL B  40
PHE A  43
PRO A  93
ILE B  38
1.47A22.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 7
ASN B  84
ARG B  40
LEU B  86
GLY B 174
1.40A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ARG A 444
ARG A 441
GLY A 464
SER A 461
1.40A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
VAL B 171
PRO C 113
PHE C 139
ILE C 117
PHE C 135
1.60A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
ARG H 100
GLY H  26
TYR H  27
SER H  25
1.35A20.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 299
ASP A 295
ARG A 298
SER B 123
ASN A 151
1.49A15.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 299
ASP A 295
ARG A 298
SER B 123
ASN A 151
1.56A16.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		5 / 12
VAL F   8
PHE E  56
PHE E  62
GLN D  87
ILE D 124
1.62A2.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		3i6k BETA-2-MICROGLOBULIN
HLA, A-2
MEMBRANE
GLYCOPROTEIN PEPTIDE
(Homo
sapiens;
SARS-COV
TJF)		5 / 12
VAL C   9
PHE B  56
PHE B  62
GLN A  87
ILE A 124
1.58A3.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		3i6k HLA, A-2
(Homo
sapiens)		4 / 7
LEU A 172
ARG A 169
GLY A   1
SER A   2
1.20A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU D 282
ARG B   4
GLY A 170
SER B   1
1.43A18.66
None
None
None
PJE  H   5 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 299
ASP B 295
ARG B 298
SER A 123
ASN B 151
1.55A15.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		3snd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 299
ASP B 295
ARG B 298
SER A 123
ASN B 151
1.60A15.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		3to2 BETA-2-MICROGLOBULIN
(Homo
sapiens)		4 / 7
LEU B  54
GLY B  29
TYR B  63
SER B  57
1.32A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 299
ASP A 295
ARG A 298
SER B 123
ASN A 151
1.64A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 299
ASP B 295
ARG B 298
SER A 123
ASN B 151
1.67A15.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
ASN B 410
LEU B 409
GLY B 505
SER B 503
1.37A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 305
VAL D 290
PHE D 506
PHE D 286
PHE D 426
1.16A21.69
None
None
G3A  D 606 (-4.2A)
None
G3A  D 606 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 305
VAL D 290
PHE D 506
PHE D 286
PHE D 426
1.03A21.85
None
None
None
None
SAM  D 605 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
ASN D 147
LEU D 151
GLY D  39
SER D  86
1.40A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
VAL A 305
VAL A 290
PHE A 506
PHE A 286
PHE A 426
1.21A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
VAL A 102
VAL A 118
PHE A 254
ILE A 120
PHE A 313
1.04A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A  25
VAL A 102
PHE A  76
PHE A  22
ILE A 117
1.48A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
ARG C 761
LEU C 847
GLY B 682
SER B 680
0.83A7.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
VAL B 102
VAL B 118
PHE B 254
ILE B 120
PHE B 313
1.03A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL A 196
PRO A 136
PHE A 185
PHE A 187
PHE A 138
1.58A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
ARG B 747
GLN A 993
GLN A 936
PRO A 710
ILE A1000
1.58A22.14
15.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		5x5c S PROTEIN
(MERS-CoV)		4 / 7
ASN B 839
LEU B 840
ARG B 841
SER B 845
1.41A7.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 369
PRO C 223
GLN A 549
PRO A 413
PHE A 416
1.37A20.24
VAL  A 369 ( 0.6A)
PRO  C 223 ( 1.1A)
GLN  A 549 ( 0.6A)
PRO  A 413 ( 1.1A)
PHE  A 416 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG C 444
LEU C 443
ARG C 441
GLY C 464
1.41A7.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 185
VAL C  66
PHE C 179
PRO C 210
PHE C 253
1.40A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ARG B 761
LEU B 847
GLY A 682
SER A 680
1.20A7.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
PHE B 185
VAL B 114
PHE B 168
PHE B 103
ILE B 115
1.59A19.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ARG A 761
LEU A 847
GLY C 682
SER C 680
0.95A7.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
PHE C 185
VAL C 114
PHE C 168
PHE C 103
ILE C 115
1.34A19.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ARG C 747
GLN B 993
GLN B 936
PRO B 710
ILE B1000
1.45A22.43
15.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ARG C 747
GLN B 993
GLN B 936
PRO B 710
ILE B1000
1.58A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A 169
LEU A 168
GLY A   1
SER A   2
1.32A18.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6jyt HELICASE
(SARSr-CoV)		4 / 7
ASN A  95
GLY A  91
TYR A  93
SER A  13
0.96A13.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6m17 ACE2
(Homo
sapiens)		5 / 12
PRO D 492
VAL D 685
PHE D 715
PHE D 684
ILE D 618
1.59A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL C 275
PRO C 526
VAL C 505
PHE C 279
ILE C  92
1.61A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG A 761
LEU A 847
GLY B 682
SER B 680
1.02A7.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PRO B1072
VAL A 893
PHE A 782
PHE A 880
PHE A 888
1.51A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L  13
VAL L  63
GLN L  47
ILE L  53
PHE L  67
1.44A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL H  37
VAL L  58
PHE L  98
GLN H   1
ILE L  48
1.55A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ASN L  31
LEU L  33
TYR L  91
SER H  99
1.80A16.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H   4
GLY H  95
TYR H  32
SER H  96
1.74A16.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
ARG C  60
LEU C  53
GLY H  28
TYR H  27
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL C  13
VAL C  64
GLN C  48
ILE C  54
PHE C  68
1.53A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L  13
VAL L  64
GLN L  48
ILE L  54
PHE L  68
1.57A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
ARG L  60
LEU L  53
GLY B  28
TYR B  27
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU B  81
ARG B  38
GLY B 112
TYR B  94
1.73A
None
None
MLI  B 304 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
ASN L  37
LEU L  39
TYR L  97
SER H 103
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
ASN C  37
LEU C  39
TYR C  97
SER B 103
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L  13
VAL L  64
GLN L  48
ILE L  54
PHE L  68
1.55A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H  81
ARG H  38
GLY H 112
TYR H  94
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
ASN L  37
LEU L  39
TYR L  97
SER H 103
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL C  13
VAL C  64
GLN C  48
ILE C  54
PHE C  68
1.56A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
ASN C  37
LEU C  39
TYR C  97
SER B 103
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
ASN L  37
LEU L  39
TYR L  97
SER H 103
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL L  13
VAL L  64
GLN L  48
ILE L  54
PHE L  68
1.56A18.38
None