Ligand ID: PX9


Drugbank ID:
DB09345
(Pramocaine)


Indication:
It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.

Get human targets for PX9 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'PX9' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		1wnc E2 GLYCOPROTEIN
(SARSr)		3 / 3
LYS E 929
ILE F1160
ILE F1164
1.09A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		6 / 12
VAL H  22
LEU K  20
LEU J  26
ILE I  16
LEU I  20
ILE I  13
1.77A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS A  29
ILE B  12
ILE B  16
0.97A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		6 / 12
LEU A  20
LEU F  26
ILE E  16
LEU E  20
GLU D  21
ILE E  13
1.77A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B  19
LEU A  27
ILE C  23
LEU C  20
VAL B  30
1.21A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
VAL D 326
LEU D 192
ILE D 200
ILE D 335
VAL D 346
1.17A24.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		6 / 12
LEU C 291
ILE C 335
LEU C 308
VAL C 329
LEU C 304
PHE C 298
1.54A24.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
LEU C  18
LEU G  96
ILE C  73
VAL C  71
LEU C  22
1.16A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2ajf ACE2
(Homo
sapiens)		6 / 12
VAL B 487
LEU B 278
LEU B 281
GLU B 489
ILE B 256
LEU B 444
1.74A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2ajf ACE2
(Homo
sapiens)		6 / 12
LEU B 570
VAL B 573
LEU B 410
ILE B 407
LEU B 554
LEU B 539
1.36A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2beq SPIKE GLYCOPROTEIN
(SARSr)		3 / 3
LYS C 929
ILE F1161
ILE F1165
1.21A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2beq SPIKE GLYCOPROTEIN
(SARSr)		3 / 3
LYS A 914
ILE A 916
ILE C 916
1.24A14.57
None
None
ACE  C 913 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2beq SPIKE GLYCOPROTEIN
(SARSr)		3 / 3
LYS A 929
ILE D1161
ILE D1165
1.22A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2beq SPIKE GLYCOPROTEIN
(SARSr)		3 / 3
LYS B 929
ILE E1161
ILE E1165
1.27A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2bez SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS C 929
ILE F1161
ILE F1165
1.24A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU A  13
LEU A  88
ILE A  46
LEU A  47
ILE A  45
1.31A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		6 / 12
VAL A  93
LEU B  53
GLU A  91
ILE B  20
VAL B  95
LEU A  53
1.74A20.00
None
D10  B1099 (-4.4A)
None
None
D10  B1099 ( 4.9A)
D10  B1099 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		3 / 3
LYS B  41
ILE B  24
ILE A  20
1.44A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		6 / 12
LEU B 110
ILE B 154
LEU B 127
VAL B 148
LEU B 123
PHE B 117
1.53A26.13
None
None
APR  B 477 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
LEU B 119
LEU B 133
ILE B 152
LEU B 114
VAL B 126
LEU B 174
1.77A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2fxp SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS C  25
ILE C  23
ILE B  23
1.68A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
VAL A  78
LEU A  35
LEU A   7
GLU A  80
VAL A 110
1.41A28.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
LEU A 112
VAL A 110
LEU A   7
VAL A  58
LEU A  45
1.21A28.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
VAL A  58
LEU A   7
LEU A   5
GLU A  80
LYS A  61
1.43A28.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2gri NSP3
(SARSr)		5 / 12
LEU A  28
LEU A  36
LEU A  80
VAL A  58
PHE A  88
1.41A22.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2jze REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LYS A 563
ILE A 560
ILE A 549
0.96A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LYS A 563
ILE A 560
ILE A 549
0.89A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		3 / 3
LYS A  83
ILE A  85
ILE A  65
0.99A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2kqv NSP3
(SARSr-CoV)		3 / 3
LYS A  41
ILE A  38
ILE A  27
0.76A24.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		6 / 12
ILE D 235
GLU D 210
ILE D 306
VAL D 317
LEU B 245
PHE D 329
1.77A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
VAL B 318
LEU B 297
LEU B 250
ILE B 306
ILE B 235
1.30A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		6 / 12
ILE D 235
LEU D 250
GLU D 210
VAL D 317
LEU B 245
PHE D 329
1.66A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		3 / 3
LYS A 307
ILE A 306
ILE A 235
0.98A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
VAL A 125
LEU A  30
LEU A  32
LEU A 115
VAL A 157
1.33A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
LEU A 202
LEU A 250
ILE A 249
VAL A 296
PHE A 294
1.17A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 202
LEU A 250
ILE A 249
VAL A 296
PHE A 294
1.16A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A  30
LEU A  32
LEU A 115
VAL A 157
1.27A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU B 263
LEU B 265
ILE B 280
LEU B 245
VAL B 294
1.26A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		3 / 3
LYS A 307
ILE A 306
ILE A 235
0.85A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		2w2g NSP3
(SARSr-CoV)		3 / 3
LYS A 563
ILE A 560
ILE A 549
0.96A24.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		2wct NSP3
(SARSr-CoV)		6 / 12
VAL D 574
LEU D 537
LEU D 533
ILE D 560
LYS D 568
VAL D 604
1.58A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3bgf F26G19 FAB
(Mus
musculus)		6 / 12
LEU L  78
VAL L  19
LEU L  21
VAL L  58
LEU L  54
PHE L  62
1.62A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
VAL B 487
LEU B 278
LEU B 281
GLU B 489
ILE B 256
LEU B 444
1.77A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
LEU A 570
VAL A 573
LEU A 410
ILE A 407
LEU A 554
LEU A 539
1.30A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3e9s NSP3
(SARSr-CoV)		6 / 12
LEU A 119
LEU A 133
ILE A 152
LEU A 114
VAL A 126
LEU A 174
1.78A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU C 202
LEU A 250
ILE A 249
VAL A 296
PHE A 294
1.11A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A  30
LEU A  32
LEU A 115
VAL A 157
1.26A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 202
LEU A 250
ILE A 249
VAL A 296
PHE A 294
1.13A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A  30
LEU A  32
LEU A 115
VAL A 157
1.30A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		3 / 3
LYS B  43
ILE A  40
ILE A  36
1.30A16.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3scj ACE2
(Homo
sapiens)		6 / 12
LEU A 570
VAL A 573
LEU A 410
ILE A 407
LEU A 554
LEU A 539
1.26A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
LEU A 570
VAL A 573
LEU A 410
ILE A 407
LEU A 554
LEU A 539
1.38A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		4m0w UBIQUITIN
(Bos
taurus)		3 / 3
LYS B  11
ILE B  13
ILE B  30
1.43A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		6 / 12
LEU A 119
LEU A 133
ILE A 152
LEU A 114
VAL A 126
LEU A 174
1.76A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		6 / 12
LEU B 119
LEU B 133
ILE B 152
LEU B 114
VAL B 126
LEU B 174
1.71A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
LYS B 423
ILE B 298
ILE B 299
1.10A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr)		3 / 3
LYS B 423
ILE B 298
ILE B 299
1.00A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
LEU B  15
VAL B  17
ILE B  61
LEU B  56
VAL A 226
1.18A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
LEU D 119
LEU D 133
ILE D 152
LEU D 114
VAL D 126
LEU D 174
1.68A21.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5f22 NON-STRUCTURAL
PROTEIN
NSP7
(SARSr)		5 / 12
LEU A  18
LEU B  96
ILE B 112
ILE A  73
VAL A  71
0.92A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		3 / 3
LYS C 440
ILE C 510
ILE C 397
1.63A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		6 / 12
LEU C 114
LEU C 142
ILE C  84
LEU C  85
VAL C 104
LEU C 131
1.68A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
LEU D 119
LEU D 133
ILE D 152
LEU D 114
VAL D 126
LEU D 174
1.69A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL B 860
LEU B 804
LEU B 920
ILE B 800
ILE B 913
1.18A9.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL B 860
LEU B 804
LEU B 920
ILE B 800
ILE B 913
1.12A8.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
LYS A 297
ILE A 584
ILE A 652
1.39A8.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
LEU A 402
LEU A 441
ILE A 573
ILE A 480
PHE A 385
1.24A7.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 860
LEU C 804
LEU C 920
ILE C 800
ILE C 913
1.07A8.51
VAL  C 860 ( 0.6A)
LEU  C 804 ( 0.5A)
LEU  C 920 ( 0.6A)
ILE  C 800 ( 0.7A)
ILE  C 913 ( 0.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B1045
ILE B 787
LEU B 788
VAL B1043
LEU B 804
1.12A8.51
LEU  B1045 ( 0.6A)
ILE  B 787 ( 0.7A)
LEU  B 788 ( 0.6A)
VAL  B1043 ( 0.6A)
LEU  B 804 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 860
LEU C 804
LEU C 920
ILE C 800
ILE C 913
1.05A9.55
VAL  C 860 ( 0.6A)
LEU  C 804 ( 0.5A)
LEU  C 920 ( 0.6A)
ILE  C 800 ( 0.7A)
ILE  C 913 ( 0.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS B 777
ILE B 787
ILE B 800
1.49A8.51
LYS  B 777 ( 0.0A)
ILE  B 787 ( 0.7A)
ILE  B 800 ( 0.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		6 / 12
LEU A 119
LEU A 133
ILE A 152
LEU A 114
VAL A 126
LEU A 174
1.64A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5yvd NSP15
(MERS-CoV)		5 / 12
LEU A 303
LEU A 247
ILE A 190
VAL A 317
PHE A 326
1.27A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		5yvd NSP15
(MERS-CoV)		3 / 3
LYS A 286
ILE A 277
ILE A 260
1.24A19.76
GOL  A 401 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		5yvd NSP15
(MERS-CoV)		3 / 3
LYS B 286
ILE B 277
ILE B 260
1.18A19.76
GOL  B 401 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
LEU B 898
LEU C 898
LEU a  39
ILE B 905
ILE C 905
1.21A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 860
LEU A 804
LEU A 920
ILE A 800
ILE A 913
1.01A9.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 860
LEU A 804
LEU A 920
ILE A 800
ILE A 913
1.05A8.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6acg ACE2
(Homo
sapiens)		6 / 12
VAL D 487
LEU D 278
LEU D 281
GLU D 489
ILE D 256
LEU D 444
1.78A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS C 297
ILE C 584
ILE C 652
1.10A8.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
LEU A 499
ILE A 397
LEU A 412
VAL A 496
VAL A 388
PHE A 387
1.41A8.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B 860
LEU B 804
LEU B 920
ILE B 800
ILE B 913
1.03A9.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B 860
LEU B 804
LEU B 920
ILE B 800
ILE B 913
1.05A8.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A1045
ILE A 787
LEU A 788
VAL A1043
LEU A 804
1.02A9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL A 860
LEU A 804
LEU A 920
ILE A 800
ILE A 913
1.01A9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL A 860
LEU A 804
LEU A 920
ILE A 800
ILE A 913
1.00A9.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LYS B  18
ILE B 152
ILE B 117
1.13A9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		6cs2 ACE2
(Homo
sapiens)		3 / 3
LYS D  94
ILE D  88
ILE D  21
1.09A14.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
LEU C 398
VAL C  55
LEU C 140
ILE C 136
LEU C  52
PHE C 420
1.64A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6m18 ACE2
(Homo
sapiens)		6 / 12
LEU B 570
VAL B 573
LEU B 410
ILE B 407
LEU B 554
LEU B 539
1.38A11.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
LYS C 301
ILE C 305
ILE C 309
1.51A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B1045
ILE B 787
LEU B 788
VAL B1043
LEU B 804
0.98A8.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 860
LEU B 804
LEU B 920
ILE B 800
ILE B 913
1.02A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 860
LEU B 804
LEU B 920
ILE B 800
ILE B 913
1.04A8.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6nus NSP12
NSP8
(SARSr-CoV)		6 / 12
VAL A 398
LEU B  98
LEU B 103
ILE B 120
VAL A 330
VAL A 342
1.54A9.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L 191
ILE L 117
LYS L 190
GLU L 213
VAL L 196
1.72A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L 191
ILE L 117
LYS L 190
GLU L 213
VAL L 196
1.78A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L 207
LYS H 137
VAL L 211
VAL L 202
LEU L 142
1.46A
None