Ligand ID: NFZ


Drugbank ID:
DB00336
(Nitrofural)


Indication:
For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.

Get human targets for NFZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'NFZ' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2ajf SPIKE PROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.41A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 10
PHE D 315
PHE D 316
PHE C 287
GLY D 322
ASN C 355
1.53A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 8
TYR A 361
PHE A 287
GLY A 279
THR A 283
1.46A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
TYR B 118
ASN B 142
LYS A   1
GLY B 143
1.44A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
TYR Q  96
PHE Q  68
GLU Q  60
THR Q  49
1.35A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
PHE E 361
PHE E 416
VAL E 382
PHE E 501
PHE E 379
1.44A24.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
PHE E 416
VAL E 382
PHE E 501
PHE E 379
PHE E 361
1.41A24.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 10
PHE A 315
PHE A 316
PHE B 287
GLY A 322
ASN B 355
1.58A19.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 10
GLY A 253
PHE A 221
VAL A 303
PHE A 232
PHE A 302
1.74A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
PHE A 580
GLU A 571
GLY A 572
THR A 584
1.49A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2kqv NSP3
(SARSr-CoV)		4 / 8
PHE A  58
GLU A  49
GLY A  50
THR A  62
1.42A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
GLY C 253
PHE C 221
VAL C 303
PHE C 232
PHE C 302
1.69A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
TYR C   7
ASN C   4
LYS C   0
GLY C  20
0.87A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
PHE C 221
VAL C 303
PHE C 232
PHE C 302
GLY C 253
1.73A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2wct NSP3
(SARSr-CoV)		4 / 8
PHE C 580
GLU C 571
GLY C 572
THR C 584
1.20A22.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.40A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.39A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.39A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.41A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.36A22.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.33A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
PHE F 501
VAL F 497
PHE F 329
PHE F 361
ASN F 357
1.60A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR F 436
ASN F 435
GLY F 482
THR F 486
1.33A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5e6j POLYUBIQUITIN-B
REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		4 / 8
PHE E  45
LYS E  49
GLY F  75
THR D 201
1.44A17.43
None
5MW  E  48 ( 3.0A)
5MW  E  48 ( 2.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
TYR P  96
PHE P  68
GLU P  60
THR P  49
1.42A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR B 738
ASN A 951
GLY B 739
THR A 943
1.40A10.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5x4r S PROTEIN
(MERS-CoV)		5 / 10
PHE A  75
TYR A  64
PHE A 327
ASN A 277
GLY A  61
1.64A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5x4r S PROTEIN
(MERS-CoV)		5 / 10
ASN A 277
PHE A 279
GLY A  61
PHE A 327
TYR A  64
1.79A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
TYR C 436
ASN C 435
GLY C 482
THR C 486
1.07A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
PHE A 837
PHE C 527
PHE C 529
GLY C 552
PHE C 545
1.70A10.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
GLY C 552
PHE C 545
PHE A 837
PHE C 527
PHE C 529
1.67A10.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 8
TYR B 609
ASN B 582
GLY B 610
THR C  63
1.41A10.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5x5f S PROTEIN
(MERS-CoV)		5 / 10
ASN A 277
PHE A 279
GLY A  61
PHE A 327
TYR A  64
1.54A10.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5xjk SPIKE PROTEIN S2
(SARSr-CoV)		4 / 8
TYR A  63
PHE A  59
GLU A  65
GLY A  64
1.47A15.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLY C 512
PHE C 316
PHE C 325
VAL C 382
PHE C 379
1.59A10.77
GLY  C 512 ( 0.0A)
PHE  C 316 ( 1.3A)
PHE  C 325 ( 1.3A)
VAL  C 382 ( 0.6A)
PHE  C 379 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 10
PHE C 325
VAL C 382
PHE C 501
PHE C 379
GLY C 512
PHE C 316
1.79A10.77
PHE  C 325 ( 1.3A)
VAL  C 382 ( 0.6A)
PHE  C 501 ( 1.3A)
PHE  C 379 ( 1.3A)
GLY  C 512 ( 0.0A)
PHE  C 316 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PHE A 888
ASN A 889
GLY B1075
THR B1102
1.10A10.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL B 196
PHE B 185
PHE B 187
PHE B 103
GLY B 100
1.41A10.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLY A 512
PHE A 325
VAL A 382
PHE A 501
PHE A 379
1.58A10.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
VAL A 196
PHE A 185
PHE A 187
PHE A 103
GLY A 100
1.44A10.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
PHE B 329
PHE B 361
VAL B 382
TYR B 352
PHE B 325
1.53A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
TYR C 886
PHE C 888
ASN C 889
THR B1102
1.13A10.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
VAL C 196
PHE C 185
PHE C 187
PHE C 103
GLY C 100
1.49A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
VAL A 275
PHE A 276
GLY A 284
PHE A  48
ASN A 435
1.64A16.10
None
None
None
LEU  A 707 (-4.7A)
LEU  A 707 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
TYR C 139
PHE C 141
ASN C 142
GLU C 179
1.14A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6nur NSP12
NSP7
(SARSr-CoV)		5 / 10
PHE A 440
VAL C  11
PHE A 415
TYR A 420
PHE A 843
1.59A12.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6nur NSP12
NSP7
(SARSr-CoV)		5 / 10
VAL C  11
PHE A 415
TYR A 420
PHE A 843
PHE A 440
1.67A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLY E 431
PHE E 429
PHE E 338
VAL E 341
PHE E 342
1.69A22.41
None
None
None
None
NAG  E 601 (-4.6A)