Ligand ID: MZM


Drugbank ID:
DB00703
(Methazolamide)


Indication:
For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma

Get human targets for MZM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'MZM' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.58A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.65A23.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.71A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
VAL B 261
LEU B 253
VAL B 247
LEU B 202
THR B 201
1.56A23.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.58A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.52A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.45A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.43A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.40A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.44A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.42A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		4 / 8
PHE B  30
HIS B  31
LEU B  54
THR A  10
1.61A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.45A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.53A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.51A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.49A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.54A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.49A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
VAL B 261
THR B 225
THR B 226
1.61A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.61A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
GLN G  61
LEU D  40
LEU H 127
THR H 128
PRO H 126
1.51A22.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2ajf ACE2
(Homo
sapiens)		4 / 8
PHE B 308
HIS B 373
HIS B 417
TRP B 302
1.58A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
ASP F 385
VAL F 498
VAL F 420
LEU F 412
ALA F 406
1.39A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.57A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.67A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.64A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.56A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.61A23.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.60A23.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.55A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.66A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.55A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.62A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2amq 3C-LIKE
PROTEINASE

(SARSr-CoV;
synthetic
construct)		4 / 8
PHE B 181
HIS B 163
HIS B 172
LEU D   4
1.16A22.01
None
PJE  D   5 (-3.7A)
PJE  D   5 (-4.3A)
PJE  D   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.48A23.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP S 385
VAL S 498
VAL S 420
LEU S 412
ALA S 406
1.46A23.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN L 186
VAL L 156
LEU L 133
THR L 132
PRO L 121
1.36A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN L 186
VAL L 156
LEU L 133
THR L 132
PRO L 121
1.33A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L  47
VAL L  48
LEU L  73
THR L  74
ALA L  19
1.52A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
HIS B 172
GLU B 166
HIS B 163
VAL B 114
LEU B 141
1.30A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
HIS B 172
GLU B 166
HIS B 163
VAL B 114
LEU B 141
1.40A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
PHE B 148
HIS B 172
LEU B 174
THR B 171
1.54A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ASP C  41
HIS C  90
LEU C  88
THR C  91
ALA C 150
1.75A22.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
HIS A  70
HIS A  70
VAL A  74
LEU A  93
THR A  68
1.35A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 10
HIS A   2
VAL A  74
LEU A  66
THR A  68
THR A  68
1.47A24.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
HIS A  70
HIS A  70
VAL A  74
LEU A  66
THR A  68
1.44A24.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 10
ASN A  69
HIS A  70
HIS A  70
LEU A  66
THR A  68
1.50A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
HIS A   2
LEU A  93
LEU A  66
THR A  68
THR A  68
1.25A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP C 385
VAL C 498
VAL C 420
LEU C 412
ALA C 406
1.39A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.52A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 246
VAL A 247
LEU A 262
LEU A 205
THR A 201
1.50A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2kaf NSP3
(SARSr-CoV)		4 / 8
HIS A  51
LEU A  44
THR A  43
HIS A  42
1.44A16.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		2kqv NSP3
(SARSr-CoV)		5 / 12
ASN A  75
LEU A  81
THR A  83
ALA A 109
PRO A  80
1.75A18.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 246
VAL A 247
LEU A 262
LEU A 205
THR A 201
1.46A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 8
PHE A 111
HIS A 146
LEU A 114
THR A 142
1.55A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.60A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.53A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.66A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL A 261
LEU A 253
VAL A 247
LEU A 202
THR A 201
1.54A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.66A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.53A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
VAL D  96
LEU D  49
THR D  47
THR D  48
PRO D  50
1.51A22.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.65A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.57A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.56A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.58A24.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.52A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.58A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
PHE B 181
HIS B 163
HIS B 172
LEU D   5
1.32A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.45A23.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.48A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.45A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.42A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.53A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.59A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.40A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.37A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 246
VAL A 247
LEU A 262
LEU A 205
THR A 201
1.55A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.62A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.65A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.72A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.62A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.53A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 8
PHE B 181
HIS B 163
HIS B 172
LEU B 167
1.57A21.90
None
XP1  B1304 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.55A23.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.49A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.57A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.49A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2w2g NSP3
(SARSr-CoV)		5 / 12
GLN A 490
PHE A 414
VAL A 513
LEU A 504
THR A 502
1.50A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
VAL A  84
PHE A 250
VAL A  44
THR A 195
PRO A   7
1.58A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
VAL A  84
PHE A 250
VAL A  44
THR A 195
PRO A   7
1.56A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.44A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.44A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.47A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.54A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.57A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 246
VAL A 247
LEU A 262
LEU A 205
THR A 201
1.46A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3aw0 3C-LIKE PROTEINASE
PEPTIDE
ACE-SER-ALA-VAL-LEU-
HIS-H
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU B   5
1.32A22.33
None
HSV  B   6 (-4.1A)
None
HSV  B   6 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
VAL B 199
VAL B 121
LEU B 179
THR B 178
ALA B 170
1.65A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 10
VAL B 199
VAL B 121
LEU B 179
THR B 178
ALA B 170
1.57A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
VAL B 199
LEU B 179
THR B 178
ALA B 170
PRO B 169
1.63A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 12
ASP S 385
VAL S 498
VAL S 420
LEU S 412
ALA S 406
1.35A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
VAL B 121
VAL B 144
LEU B 154
THR B 153
THR B 155
1.65A26.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP E 385
VAL E 498
VAL E 420
LEU E 412
ALA E 406
1.38A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP E 385
VAL E 498
VAL E 420
LEU E 412
ALA E 406
1.41A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
PHE B 525
HIS B 378
HIS B 374
HIS B 401
1.59A19.23
None
ZN  B 901 (-3.8A)
ZN  B 901 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP F 385
VAL F 498
VAL F 420
LEU F 412
ALA F 406
1.40A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.61A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.56A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.45A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.48A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.45A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.53A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.55A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.58A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3e9s NSP3
(SARSr-CoV)		4 / 8
PHE A 148
HIS A 172
LEU A 174
THR A 171
1.55A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		3e9s NSP3
(SARSr-CoV)		5 / 10
ASP A  41
HIS A  90
LEU A  88
THR A  91
ALA A 150
1.78A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.54A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.54A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.59A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.47A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.56A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.59A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.47A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS D 246
VAL D 247
LEU D 262
LEU B 205
THR B 201
1.51A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
GLU C 240
HIS C 246
VAL C 247
LEU A 205
THR A 201
1.60A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.47A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.63A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.52A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.62A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
HIS A 172
GLU A 166
HIS A 163
VAL A 114
ALA A 139
1.39A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
HIS A 172
GLU A 166
HIS A 163
VAL A 114
ALA A 139
1.54A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.47A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.47A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.53A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.59A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.56A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.67A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.61A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.57A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.57A24.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.54A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.63A23.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.66A23.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.54A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
HIS A 172
GLU A 166
HIS A 163
LEU A 141
ALA A 140
1.72A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE B 181
HIS B 163
HIS B 172
LEU B 167
1.59A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.70A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.60A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.64A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.52A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		5 / 12
ASN B  21
HIS B  13
THR A 240
ALA A 236
PRO A 235
1.72A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3i6k HLA, A-2
(Homo
sapiens)		4 / 8
PHE E  36
HIS E  70
THR E  73
HIS E  74
1.49A24.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.50A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.48A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.62A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.50A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.65A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.56A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.65A23.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 246
VAL A 247
LEU A 262
LEU A 205
THR A 201
1.46A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.71A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.60A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.54A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.51A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.58A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.55A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.51A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.50A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
GLN A 238
LEU A 217
LEU A 200
THR A 201
THR A 199
1.53A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
VAL A  84
PHE A 250
VAL A  44
THR A 195
PRO A   7
1.55A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP F 385
VAL F 498
VAL F 420
LEU F 412
ALA F 406
1.37A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP F 385
VAL F 498
VAL F 420
LEU F 412
ALA F 406
1.38A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3scj ACE2
(Homo
sapiens)		4 / 8
PHE B 308
HIS B 373
HIS B 417
TRP B 302
1.58A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP E 385
VAL E 498
VAL E 420
LEU E 412
ALA E 406
1.44A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
PHE B 308
HIS B 373
HIS B 417
TRP B 302
1.57A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL E 498
VAL E 420
LEU E 412
ALA E 406
PRO E 450
1.53A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP F 385
VAL F 498
VAL F 420
LEU F 412
ALA F 406
1.42A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL F 498
VAL F 420
LEU F 412
ALA F 406
PRO F 450
1.55A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.57A21.66
None
ECC  H   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		3snd 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-ESTLQ-H
(SARSr-CoV)		4 / 8
PHE A 181
HIS A 163
HIS A 172
LEU C   4
1.07A22.01
None
ECC  C   5 ( 4.0A)
ECC  C   5 ( 4.8A)
ECC  C   5 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 246
VAL A 247
LEU A 262
LEU A 205
THR A 201
1.48A23.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.61A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE B 181
HIS B 163
HIS B 172
LEU B 167
1.61A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.59A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.53A23.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
PHE A  80
LEU A 173
THR A 169
HIS A 172
1.41A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.66A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 303
ASN B 263
HIS B 276
LEU B 260
ALA B 279
1.63A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 10
HIS A 172
HIS B 172
PHE B 128
LEU B 174
THR B 171
1.58A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 10
HIS A 172
HIS B 172
PHE B 128
LEU B 174
THR B 171
1.57A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		4 / 8
HIS B 172
HIS A 172
LEU A 174
THR A 171
1.47A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.62A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 261
LEU B 253
VAL B 247
LEU B 202
THR B 201
1.55A24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
VAL B  29
LYS B  34
LEU B  27
THR A   5
ALA A   4
1.75A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 10
ASP B 331
HIS B 314
VAL B 341
LEU B 321
ALA B 320
1.49A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ASP B 331
HIS B 314
VAL B 341
LEU B 321
ALA B 320
1.60A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 10
ASP B 234
VAL B 167
THR B 215
ALA B 214
TRP B 227
1.71A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
VAL B  29
LYS B  34
LEU B  27
THR A   5
ALA A   4
1.72A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ASP D 331
HIS D 314
VAL D 341
LEU D 321
ALA D 320
1.45A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 10
ASP D 331
HIS D 314
VAL D 341
LEU D 321
ALA D 320
1.34A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
PHE A  80
LEU A 173
THR A 169
HIS A 172
1.44A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
ASP B 234
VAL B 167
THR B 215
ALA B 214
TRP B 227
1.70A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ASP A 331
HIS A 314
VAL A 341
LEU A 321
ALA A 320
1.56A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
ASP B 331
HIS B 314
VAL B 341
LEU B 321
ALA B 320
1.43A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ASP D 303
ASN D 263
HIS D 276
LEU D 260
ALA D 279
1.61A22.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
PHE D  80
LEU D 173
THR D 169
HIS D 172
1.40A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
ASN C1104
VAL C1103
LEU C 849
THR C 797
ALA C1096
1.79A10.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 10
ASN C1104
VAL C1103
LEU C 849
THR C 797
ALA C1096
1.78A10.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
ASP A 643
HIS A 661
VAL A 642
VAL A 675
THR A 662
1.48A10.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASP A 643
HIS A 661
VAL A 642
VAL A 675
THR A 662
1.50A10.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
HIS A  70
VAL A  66
LEU A  60
LEU A 209
THR A  92
1.55A11.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
PHE C 179
HIS C  70
LEU C 209
HIS C  33
1.58A12.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ASP C 385
VAL C 498
VAL C 420
LEU C 412
ALA C 406
1.40A11.33
ASP  C 385 ( 0.5A)
VAL  C 498 ( 0.6A)
VAL  C 420 ( 0.6A)
LEU  C 412 ( 0.5A)
ALA  C 406 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.70A11.33
HIS  A1040 ( 1.0A)
VAL  A 933 ( 0.6A)
VAL  A 934 ( 0.6A)
LEU  A 930 ( 0.6A)
ALA  A1038 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.69A11.33
HIS  A1040 ( 1.0A)
VAL  A 933 ( 0.6A)
VAL  A 934 ( 0.6A)
LEU  A 930 ( 0.6A)
ALA  A1038 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP C 385
VAL C 498
VAL C 420
LEU C 412
ALA C 406
1.28A11.33
ASP  C 385 ( 0.5A)
VAL  C 498 ( 0.6A)
VAL  C 420 ( 0.6A)
LEU  C 412 ( 0.5A)
ALA  C 406 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
PHE A  80
LEU A 173
THR A 169
HIS A 172
1.47A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP A 385
VAL A 498
VAL A 420
LEU A 412
ALA A 406
1.37A11.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS B  70
HIS B  33
VAL B  66
LEU B  60
LEU B 209
1.31A12.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 596
VAL B 581
LEU B 615
THR B 616
ALA B 618
1.50A11.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL B 596
VAL B 581
LEU B 615
THR B 616
ALA B 618
1.42A11.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS C1040
VAL C 933
VAL C 934
LEU C 930
ALA C1038
1.64A11.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PHE B 179
HIS B  70
LEU B 209
HIS B  33
1.58A12.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.64A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS C1040
VAL C 933
VAL C 934
LEU C 930
ALA C1038
1.68A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.70A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ASP C 643
HIS C 661
VAL C 642
VAL C 675
THR C 662
1.30A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.55A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP B 385
VAL B 498
VAL B 420
LEU B 412
ALA B 406
1.32A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
PHE A 179
HIS A  70
LEU A 209
HIS A  33
1.51A12.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS B  70
VAL B  66
LEU B  60
LEU B 209
THR B  92
1.39A12.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B 498
VAL B 420
LEU B 412
ALA B 406
PRO B 450
1.46A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
HIS A 192
VAL A 189
LEU A 201
THR A 200
ALA A 246
1.79A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
HIS A 311
VAL A 314
LEU A 363
ALA A 362
PRO A 364
1.66A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		6jyt HELICASE
(SARSr-CoV)		5 / 11
LYS B 347
VAL B 356
LEU B 363
THR B 359
ALA B 362
1.55A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		6jyt HELICASE
(SARSr-CoV)		5 / 10
ASP A 374
VAL A 372
VAL A 397
LEU A 295
ALA A 296
1.48A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ASP A 374
VAL A 372
VAL A 397
LEU A 295
ALA A 296
1.44A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL A 317
VAL A 320
LEU A 234
THR A 235
PRO A 230
1.51A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		6m18 ACE2
(Homo
sapiens)		5 / 11
ASN B 394
HIS B 401
HIS B 378
GLU B 375
ALA B 348
1.79A14.20
None
None
ZN  B 914 ( 4.6A)
ZN  B 914 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
ASP C 512
ASN C 515
VAL C 511
VAL C 506
ALA C  91
1.66A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m18 ACE2
(Homo
sapiens)		5 / 10
ASN B 394
HIS B 401
HIS B 378
GLU B 375
ALA B 348
1.73A14.20
None
None
ZN  B 914 ( 4.6A)
ZN  B 914 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m1d ACE2
(Homo
sapiens)		5 / 11
ASP D 350
ASN D 394
HIS D 401
HIS D 378
LEU D 558
1.75A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LYS A 516
HIS A 296
VAL A 295
LEU A  21
ALA A  19
1.69A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		6m1d ACE2
(Homo
sapiens)		4 / 8
PHE D 315
HIS D 378
HIS D 401
LEU D 558
1.58A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LYS A 516
HIS A 296
VAL A 295
LEU A  21
ALA A  19
1.64A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m1d ACE2
(Homo
sapiens)		5 / 10
ASP D 350
ASN D 394
HIS D 401
HIS D 378
LEU D 558
1.74A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
HIS D 378
HIS D 401
VAL D 404
LEU D 558
PRO D 321
1.77A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.68A11.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.67A11.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
HIS C1030
LEU C1045
THR C 705
HIS C1046
1.60A12.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS A1040
VAL A 933
VAL A 934
LEU A 930
ALA A1038
1.60A11.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		6nur NSP12
(SARSr-CoV)		4 / 8
PHE A 428
HIS A 882
LEU A 869
THR A 870
1.31A14.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		6nur NSP12
(SARSr-CoV)		5 / 12
HIS A 882
LEU A 838
LEU A 869
THR A 870
PRO A 832
1.42A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6nur NSP12
(SARSr-CoV)		5 / 12
LYS A 641
ASP A 477
HIS A 572
VAL A 637
THR A 686
1.46A13.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		6nus NSP12
(SARSr-CoV)		5 / 11
GLU A 658
HIS A 572
LEU A 576
THR A 686
ALA A 685
1.59A13.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP F 398
VAL F 512
VAL F 433
LEU F 425
ALA F 419
1.43A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 184
VAL H 182
LEU H 159
ALA H 158
TRP H 154
1.76A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL B 188
VAL B 186
LEU B 163
ALA B 162
TRP B 158
1.79A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 10
GLN C   6
VAL C 110
LEU C  79
THR C  20
THR C  78
1.79A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 188
VAL H 186
LEU H 163
ALA H 162
TRP H 158
1.78A19.22
None