Ligand ID: MYT


Drugbank ID:
DB01011
(Metyrapone)


Indication:
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome.

Get human targets for MYT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'MYT' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		1ssk NUCLEOCAPSID PROTEIN
(SARSr)		4 / 6
SER A  29
ARG A  85
ALA A  33
THR A  35
1.48A15.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		1uk4 3C-LIKE PROTEINASE
5-MER PEPTIDE OF
INHIBITOR
(SARSr-CoV)		4 / 6
SER G   2
ALA A 173
THR A 135
ALA A 193
1.55A2.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
VAL A 945
LEU B 944
THR C 943
ALA C 940
1.15A12.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG A   4
SER B 139
ALA B 116
ALA B   7
1.49A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG B1004
SER A 139
ALA A 116
ALA A   7
1.53A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
ARG A   4
SER B 139
ALA B 116
ALA B   7
1.43A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
LEU B 322
ILE B 200
ALA B 199
THR B 195
1.00A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 11
PHE H  97
LEU D  18
VAL D  21
ILE D  73
VAL D  71
1.37A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 6
VAL F 135
ILE F 161
ALA F 193
ALA F 157
1.02A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 6
LEU E 292
ILE E 305
ALA E 306
ALA F 314
1.14A13.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 6
ARG C 277
ALA B 265
THR B 264
ALA B 253
1.42A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		4 / 6
VAL L 104
ILE L  75
ALA L  19
ALA L  14
1.04A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		6 / 11
TYR L 179
THR H 165
VAL H 181
GLY H 139
VAL H 198
VAL H 152
1.52A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
LEU A 141
ILE A  19
ALA A  18
THR A  14
1.00A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ARG L 113
ILE L  99
ALA L 104
THR R 101
1.40A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		6 / 11
TYR P  76
LEU P 112
VAL P 108
GLY P 109
ASP P  91
VAL P  97
1.66A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
VAL P 116
LEU P  92
ALA P  54
THR P  56
1.12A16.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 11
LEU A  42
VAL A  95
GLY A  94
THR A  92
VAL A  78
1.45A13.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE E 325
LEU E 421
VAL E 497
VAL E 382
ILE E 345
1.29A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 11
PHE D  68
LEU D  18
VAL D 113
GLY D   9
THR D 111
1.36A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
SER D 184
ILE D 180
THR D 152
ALA C 471
1.45A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
SER A 461
ALA A 471
THR B 204
ALA B 183
1.40A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 6
LEU A 292
ILE A 305
ALA A 306
ALA B 314
1.09A10.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 6
SER A  52
ALA A  56
THR A  58
ALA A  91
1.32A14.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 6
LEU A 119
ILE A  79
ALA A  81
THR A 112
ALA A 137
1.68A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
PHE E 279
LEU E 245
GLY E 243
VAL F 162
ILE F  63
1.24A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 6
LEU B 119
ILE B  79
ALA B  81
THR B 112
ALA B 137
1.63A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		2wct NSP3
(SARSr-CoV)		4 / 6
ILE B 390
ALA B 392
THR B 399
ALA D 558
1.30A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr)		4 / 6
ILE A  36
ALA A  45
THR A  48
ALA A  83
1.28A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 6
ILE A  36
ALA A  45
THR A  48
ALA A  83
1.25A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 11
PHE S 325
LEU S 421
VAL S 497
VAL S 382
ILE S 345
1.35A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
SER C  72
ARG C  66
ALA C  51
ALA C  25
1.48A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LEU B 554
ILE B 407
ALA B 403
ALA B 396
1.09A23.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		3e9s NSP3
(SARSr-CoV)		4 / 6
VAL A 301
LEU A 283
ILE A 277
ALA A 262
1.16A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG B   4
SER A 139
ALA A 116
ALA A   7
1.43A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.78A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 6
LEU C 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.77A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		4 / 6
ARG A  97
SER C   5
ALA A  69
ALA A  24
1.44A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 6
LEU C 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG A   4
SER B 139
ALA B 116
ALA B   7
1.42A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		3r24 NSP10 AND NSP11
(SARSr-CoV)		6 / 11
TYR B  76
LEU B 112
VAL B 108
GLY B 109
ASP B  91
VAL B  97
1.65A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 6
ILE A  36
ALA A  45
THR A  48
ALA A  83
1.27A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		3sci ACE2
(Homo
sapiens)		4 / 6
LEU B 554
ILE B 407
ALA B 403
ALA B 396
1.14A24.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A 554
ILE A 407
ALA A 403
ALA A 396
1.13A24.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A 181
ALA A 211
THR A 233
ALA A 236
1.39A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG B   4
SER A 139
ALA A 116
ALA A   7
1.47A22.11
None
None
None
EDO  A 401 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG A   4
SER B 139
ALA B 116
ALA B   7
1.52A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG B   4
SER A 139
ALA A 116
ALA A   7
1.50A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		4ud1 N PROTEIN
(MERS-CoV)		4 / 6
ARG C 114
ILE A 120
THR A  56
ALA B 131
1.49A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
ARG B   4
SER A 139
ALA A 116
ALA A   7
1.53A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5c8u NSP10
(SARSr-CoV)		4 / 6
VAL A 116
LEU A  92
ALA A  54
THR A  56
1.16A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5f22 NSP8
(SARSr-CoV)		4 / 6
VAL B 135
ILE B 161
ALA B 193
ALA B 157
1.11A15.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 6
VAL A  11
LEU A  60
ILE A  44
ALA A  53
ALA B 107
1.49A11.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
SER D  79
ALA D  40
THR D 159
ALA D 150
1.50A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
VAL D 301
LEU D 283
ILE D 277
ALA D 262
1.14A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ARG A 996
ARG B1001
ALA B 997
ALA A 998
1.40A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ARG A 996
ILE B 752
ALA B 997
ALA A 998
1.23A17.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
PHE A 112
THR A 257
GLY A 262
THR A 283
ILE A 256
1.42A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ARG A  99
ALA A 250
THR A  71
ALA A 237
1.53A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		5x59 S PROTEIN
(MERS-CoV)		4 / 6
SER C1125
ALA C1109
THR C 961
ALA C 956
1.51A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
PHE C 112
THR C 257
GLY C 262
THR C 283
ILE C 256
1.42A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
ARG A 996
ILE B 752
ALA B 997
ALA A 998
1.35A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
ARG C  99
ALA C 250
THR C  71
ALA C 237
1.27A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		5x5f S PROTEIN
(MERS-CoV)		4 / 6
ILE B1054
ALA B1049
THR B1043
ALA B1046
1.03A16.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE C 325
LEU C 421
VAL C 497
VAL C 382
ILE C 345
1.42A15.00
PHE  C 325 ( 1.3A)
LEU  C 421 ( 0.5A)
VAL  C 497 ( 0.6A)
VAL  C 382 ( 0.6A)
ILE  C 345 ( 0.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
VAL A 301
LEU A 283
ILE A 277
ALA A 262
1.16A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		5yvd NSP15
(MERS-CoV)		4 / 6
ILE B 135
ALA B 134
THR B 131
ALA B 112
1.47A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		5yvd NSP15
(MERS-CoV)		4 / 6
ILE A 135
ALA A 134
THR A 131
ALA A 112
1.37A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE C 325
LEU C 421
VAL C 497
VAL C 382
ILE C 345
1.35A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER B 582
ALA B 633
THR B 631
ALA B 676
1.40A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ARG A 996
ILE C 752
ALA C 997
ALA A 998
1.07A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU B 847
ALA B 854
THR B 856
ALA B1037
1.09A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU C 847
ALA C 854
THR C 856
ALA C1037
1.14A17.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
PHE C 329
GLY C 418
VAL C 510
ILE C 345
VAL C 382
1.33A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ARG C  99
ALA C 250
THR C  71
ALA C 237
1.29A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
SER B 685
ILE B 687
ALA C 875
THR C 869
1.19A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6jyt HELICASE
(SARSr-CoV)		5 / 11
GLY A 294
VAL A 372
ASP A 374
ILE A 399
VAL A 397
1.33A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6jyt HELICASE
(SARSr)		4 / 6
ILE B 525
ALA B 522
THR B 530
ALA B 509
1.33A25.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6jyt HELICASE
(SARSr)		4 / 6
ILE B 493
ALA B 522
THR B 530
ALA B 509
1.43A25.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6jyt HELICASE
(SARSr)		4 / 6
ILE A 525
ALA A 522
THR A 530
ALA A 509
1.11A25.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 6
LEU C 495
ILE C 492
ALA C 590
THR C 121
ALA C 117
1.77A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
ILE A 597
ALA A 117
THR A 121
ALA A 590
1.37A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ARG A 758
ILE A 752
ALA A 997
ALA A1004
1.31A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 847
ALA A 854
THR A 856
ALA A1037
1.16A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 11
THR H 179
VAL H 195
GLY H 153
VAL H 212
VAL H 166
1.30A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6nur NSP8
(SARSr-CoV)		4 / 6
VAL D 130
ILE D 156
ALA D 188
ALA D 152
1.02A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6nur NSP8
(SARSr-CoV)		4 / 6
ARG B 190
ALA B 125
THR B 123
ALA B 150
1.52A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6nur NSP12
(SARSr)		4 / 6
SER A 561
ILE A 562
THR A 531
ALA A 660
1.42A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6vw1 ACE2
(Homo
sapiens)		4 / 6
LEU B 554
ILE B 407
ALA B 403
ALA B 396
1.11A23.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
VAL L 191
ILE L 117
ALA L 193
THR L 206
1.30A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
VAL H 181
LEU H 159
THR H 135
ALA H 136
1.73A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
VAL L  27
LEU L   4
ILE L   2
ALA L  34
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L  15
ILE L 106
ALA L  12
ALA L  19
1.77A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LEU H 170
ALA H  84
THR H  87
ALA H  88
1.75A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		6 / 11
THR H 165
LEU H 124
VAL H 181
GLY H 139
VAL H 198
VAL H 152
1.53A16.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yla HEAVY CHAIN
(Homo
sapiens)		6 / 11
THR B 169
LEU B 128
VAL B 185
GLY B 143
VAL B 202
VAL B 156
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
PHE B 126
GLY B 122
THR B 209
VAL B 202
VAL B 211
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
VAL L 197
ILE L 123
ALA L 199
THR L 212
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
PHE H 150
TYR H 180
THR H  91
THR H 114
VAL H  11
1.74A
MLI  H 301 ( 4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
VAL C 197
ILE C 123
ALA C 199
THR C 212
1.36A
None
None
MLI  C 304 ( 3.9A)
MLI  C 304 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yla HEAVY CHAIN
(Homo
sapiens)		6 / 11
THR H 169
LEU H 128
VAL H 185
GLY H 143
VAL H 202
VAL H 156
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
VAL L 197
ILE L 123
ALA L 199
THR L 212
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
PHE H 150
TYR H 180
THR H  91
THR H 114
VAL H  11
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ym0 HEAVY CHAIN
(Homo
sapiens)		6 / 11
THR H 169
LEU H 128
VAL H 185
GLY H 143
VAL H 202
VAL H 156
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
VAL C 197
ILE C 123
ALA C 199
THR C 212
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
VAL L 197
ILE L 123
ALA L 199
THR L 212
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yor IGG H CHAIN
(Homo
sapiens)		6 / 11
THR H 169
LEU H 128
VAL H 185
GLY H 143
VAL H 202
VAL H 156
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yor IGG H CHAIN
(Homo
sapiens)		6 / 11
THR B 169
LEU B 128
VAL B 185
GLY B 143
VAL B 202
VAL B 156
1.50A
None