Ligand ID: MN9


Drugbank ID:
DB00141
(N-Acetyl-D-glucosamine)


Indication:
For the treatment and prevention of osteoarthritis, by itself or in combination with chondroitin sulfate.

Get human targets for MN9 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'MN9' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B1205
TYR B1239
LEU B1268
THR B1199
1.44A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER B  81
LEU B  87
TYR B  54
LEU B  58
1.20A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  30
TYR B 101
LEU B 177
THR B  98
1.61A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A  59
TYR A  36
LEU A  81
THR A  43
1.62A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
SER A  63
LEU A  66
ASP A  64
LEU A  66
1.17A18.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		2gt7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  30
TYR B 101
LEU B 177
THR B  98
1.63A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.25A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
LEU A  36
ASP A  35
LEU A  25
THR A 102
1.46A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		4 / 6
THR A 102
LEU A  36
ASP A  35
LEU A  25
1.40A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 10
ILE A 147
THR A 116
GLY A 117
SER A  52
PHE A  54
1.45A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
SER B  81
LEU B  87
TYR B  54
LEU B  58
1.21A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.27A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 5
LEU B  30
TYR B 101
LEU B 177
THR B  98
1.62A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.25A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
ILE E 280
LEU E 263
GLY E 246
GLY E 243
SER F 171
1.64A26.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.24A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		2z3e REPLICASE
POLYPROTEIN 1AB
(PP1AB)
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.22A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER B  81
LEU B  87
TYR B  54
LEU B  58
1.24A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 240
TYR A 243
LEU A 595
THR A 282
1.44A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  30
TYR B 101
LEU B 177
THR B  98
1.62A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.23A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
LEU D  51
ASP D  50
LEU D  69
THR D  19
1.58A15.44
None
GOL  D 127 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.30A22.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.23A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.26A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  30
TYR A 101
LEU A 177
THR A  98
1.62A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.24A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3i6l HLA, A-24
(Homo
sapiens)		4 / 5
LEU D  95
ASP D  74
TYR D  84
THR D 143
1.44A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3i6l HLA, A-24
(Homo
sapiens)		4 / 6
THR D 143
LEU D  95
ASP D  74
TYR D  84
1.41A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.25A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  30
TYR B 101
LEU B 177
THR B  98
1.62A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
THR B 169
SER B 115
LEU B 114
LEU B 118
1.39A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
LEU A  59
TYR A  36
LEU A  81
THR A  43
1.54A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 240
TYR A 243
LEU A 595
THR A 282
1.45A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.25A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
LEU A  59
TYR A  36
LEU A  81
THR A  43
1.46A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER A  81
LEU A  87
TYR A  54
LEU A  58
1.27A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER B  81
LEU B  87
TYR B  54
LEU B  58
1.21A22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  30
TYR A 101
LEU A 177
THR A  98
1.61A22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
THR D 113
SER D 171
LEU D 170
LEU D 174
1.27A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 10
LEU B 174
THR B 113
GLY B 114
GLY B 110
PHE B 183
1.42A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
THR D 113
SER D 171
LEU D 170
LEU D 174
1.27A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		4 / 6
THR A   5
SER A  11
LEU B   7
LEU A  14
1.44A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU D  59
TYR D  36
LEU D  81
THR D  43
1.54A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
THR B 113
SER B 171
LEU B 170
LEU B 174
1.23A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
LEU C 174
THR C 113
GLY C 114
GLY C 110
PHE C 183
1.45A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		5x4r S PROTEIN
(MERS-CoV)		5 / 10
ILE A 333
LEU A 325
GLY A 276
GLY A  55
PHE A  75
1.61A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE A 272
LEU A 264
THR A 215
GLY A 212
PHE A  62
1.56A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
ASP C 719
TYR C 989
LEU C 986
THR C 716
1.20A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
ILE A 272
LEU A 264
THR A 215
GLY A 212
PHE A  62
1.46A13.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
THR C 716
ASP C 719
TYR C 989
LEU C 986
1.17A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		5x5c S PROTEIN
(MERS-CoV)		5 / 10
ILE B 333
LEU B 325
ASP B  49
SER B  51
PHE B 354
1.59A14.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
THR A 672
SER A 345
LEU A 344
LEU A 347
1.36A12.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
LEU A  59
TYR A  36
LEU A  81
THR A  43
1.57A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE C 272
LEU C 264
THR C 215
GLY C 212
PHE C  62
1.35A13.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6acj ACE2
(Homo
sapiens)		5 / 10
ILE D 407
GLY D 551
GLY D 319
SER D 317
PHE D 314
1.61A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ack ACE2
(Homo
sapiens)		4 / 6
THR D  52
SER D  44
LEU D 351
LEU D  45
1.36A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ILE C 272
LEU C 264
THR C 215
GLY C 212
PHE C  62
1.52A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
THR A 716
ASP A 719
TYR A 989
LEU A 986
1.15A14.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
ASP A 719
TYR A 989
LEU A 986
THR A 716
1.19A14.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ILE C 272
LEU C 264
THR C 215
GLY C 212
PHE C  62
1.44A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6cs2 ACE2
(Homo
sapiens)		4 / 6
THR D  92
LEU D  29
ASP D  30
LEU D  97
1.39A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6cs2 ACE2
(Homo
sapiens)		4 / 5
LEU D  29
ASP D  30
LEU D  97
THR D  92
1.35A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6jyt HELICASE
(SARSr-CoV)		4 / 6
THR A 566
SER A 453
LEU A 461
ASP A 450
1.42A19.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6lzg ACE2
(Homo
sapiens)		4 / 5
LEU A 240
TYR A 243
LEU A 595
THR A 282
1.44A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6m0j ACE2
(Homo
sapiens)		4 / 5
LEU A 240
TYR A 243
LEU A 595
THR A 282
1.47A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
LEU C 101
ASP C 445
TYR C 600
LEU C 116
1.57A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6m18 ACE2
(Homo
sapiens)		4 / 5
LEU D  29
ASP D  30
LEU D  97
THR D  92
1.37A15.71
None
NAG  D 904 ( 4.5A)
None
NAG  D 903 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6m1d ACE2
(Homo
sapiens)		4 / 6
THR D  52
SER D  44
LEU D  45
ASP D 355
1.32A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6m1d ACE2
(Homo
sapiens)		5 / 10
ILE B 223
LEU B 222
ASP B 198
GLU B 197
GLY B 200
1.52A16.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		6nur NSP12
(SARSr-CoV)		5 / 10
ILE A 562
TYR A 516
ASP A 517
SER A 518
PHE A 368
1.64A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		6nur NSP12
(SARSr-CoV)		4 / 5
ASP A 211
TYR A 237
LEU A 207
THR A 189
1.51A15.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6nur NSP12
(SARSr-CoV)		4 / 6
THR A 189
SER A 239
LEU A 241
LEU A 207
1.41A15.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
THR L 180
SER H 120
ASP H 144
LEU H 141
1.56A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
THR L 186
SER H 124
ASP H 148
LEU H 145
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
THR C 186
SER B 124
ASP B 148
LEU B 145
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
THR L 186
SER H 124
ASP H 148
LEU H 145
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
THR L 186
SER H 124
ASP H 148
LEU H 145
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
THR C 186
SER B 124
ASP B 148
LEU B 145
1.55A
None