Ligand ID: MIL


Drugbank ID:
DB00235
(Milrinone)


Indication:
Indicated for the treatment of congestive heart failure.

Get human targets for MIL in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'MIL' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU E1167
LEU E 920
SER E 919
0.89A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU B1167
LEU B 920
SER B 919
0.80A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU D  19
LEU E  20
SER E  19
0.83A14.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU E1168
LEU C 920
SER C 919
0.86A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		3 / 3
LEU B 170
LEU B 174
SER B 178
1.05A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
LEU A 745
LEU A 986
SER A 985
1.15A7.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
LEU C 344
LEU C 347
SER C 350
0.98A6.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU A 636
LEU A 597
SER A 582
0.78A7.29
LEU  A 636 ( 0.6A)
LEU  A 597 ( 0.6A)
SER  A 582 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		3 / 3
LEU a  25
LEU A 920
SER A 919
0.77A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU B 636
LEU B 597
SER B 582
0.53A7.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LEU B 636
LEU B 597
SER B 582
0.74A7.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LEU B 636
LEU B 597
SER B 582
0.69A7.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6jyt HELICASE
(SARSr-CoV)		3 / 3
LEU A  25
LEU A   7
SER A 100
1.13A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU A 636
LEU A 597
SER A 582
0.70A7.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6nur NSP7
(SARSr-CoV)		3 / 3
LEU C  17
LEU C  14
SER C  10
1.11A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
LEU L 179
LEU L 181
SER L 182
1.78A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
LEU L 181
LEU L 179
SER L 159
1.45A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
LEU L 179
LEU L 181
SER L 182
1.74A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
LEU L 181
LEU L 179
SER L 159
1.45A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU C 187
LEU C 185
SER C 165
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 185
LEU L 187
SER L 188
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU C 185
LEU C 187
SER C 188
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU C 185
LEU C 187
SER C 188
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 187
LEU L 185
SER L 165
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 187
LEU L 185
SER L 165
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU C 187
LEU C 185
SER C 165
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 185
LEU L 187
SER L 188
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 187
LEU L 185
SER L 165
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU H 128
LEU H 145
SER L 137
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 185
LEU L 187
SER L 188
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 185
LEU L 187
SER L 188
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU L 187
LEU L 185
SER L 165
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU L 185
LEU L 187
SER L 188
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU C 185
LEU C 187
SER C 188
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU L 187
LEU L 185
SER L 165
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU C 185
LEU C 187
SER C 188
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU C 187
LEU C 185
SER C 165
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU L 185
LEU L 187
SER L 188
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU C 187
LEU C 185
SER C 165
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_B_MILB128_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
LEU L 187
LEU L 185
SER L 165
1.42A
None