Ligand ID: LQQ


Drugbank ID:
DB09073
(Palbociclib)


Indication:
Palbociclib is indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. This indication is approved under accelerated approval based on progression-free survival (PFS). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

Get human targets for LQQ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LQQ' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
LYS A 269
VAL A 247
ASN A 228
LEU A 227
ASP A 229
1.40A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LYS A  97
VAL A  18
VAL A  91
LEU A  75
ALA A  70
1.08A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ILE E1160
VAL E1158
VAL F 934
THR E 923
LEU E 930
ASP E 932
1.66A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		1x7q HLA, A-11
(Homo
sapiens)		5 / 12
ILE A  52
TYR A   7
VAL A  34
ALA A  49
LEU A 179
1.30A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LYS B1097
VAL B1018
VAL B1036
LEU B1075
ALA B1070
1.43A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ILE D 335
VAL D 333
ALA D 306
VAL D 277
LEU D 309
1.16A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ILE E1161
VAL E1159
VAL A 934
THR C 923
LEU C 930
ASP C 932
1.71A9.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 200
VAL B 296
PHE B 291
THR B 243
ALA B 206
1.43A21.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ILE C 154
VAL C 152
ALA C 125
VAL C  96
LEU C 128
1.13A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LYS A  97
VAL A  18
VAL A  36
ASP A  92
ALA A  70
1.28A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ILE A 608
GLY A 609
TYR A 644
THR A 594
LEU A 603
ALA A 631
1.79A15.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2kqv NSP3
(SARSr-CoV)		5 / 12
ILE A  86
GLY A  87
TYR A 122
LEU A  74
ALA A 109
1.39A23.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE A  85
VAL A  66
VAL A 141
THR A  98
ASP A 124
1.36A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.44A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE B  85
VAL B  66
VAL B 141
THR B  98
ASP B 124
1.37A23.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.39A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_2
(CYCLIN-DEPENDENT
KINASE 6)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
LYS B  11
HIS B  80
VAL A 104
ASN B  40
1.74A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.38A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 157
VAL A 148
PHE A 150
THR A  35
LEU A  30
1.41A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LYS B 269
VAL B 247
ASN B 228
LEU B 227
ASP B 229
1.43A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.43A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LYS B 269
VAL B 247
ASN B 228
LEU B 227
ASP B 229
1.30A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE B 200
VAL D 296
PHE D 291
THR D 243
ALA B 206
1.40A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.42A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 157
VAL A 148
PHE A 150
THR A  35
LEU A  30
1.41A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 200
VAL B 296
PHE B 291
THR B 243
ALA B 206
1.39A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3i6k HLA, A-2
(Homo
sapiens)		5 / 12
ILE A  52
TYR A   7
VAL A  34
ALA A  49
LEU A 179
1.24A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL D 157
VAL D 148
PHE D 150
THR D  35
LEU D  30
1.30A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.42A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.44A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
GLY A 148
PHE A  70
ASP A 133
THR A 136
ASP A 114
1.32A21.33
None
None
None
None
SAM  A 302 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_2
(CYCLIN-DEPENDENT
KINASE 6)		3sci ACE2
(Homo
sapiens)		4 / 4
LYS B 247
HIS B 241
VAL B 604
ASN B 601
1.64A19.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_2
(CYCLIN-DEPENDENT
KINASE 6)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
LYS B 247
HIS B 241
VAL B 604
ASN B 601
1.74A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 157
VAL A 148
PHE A 150
THR A  35
LEU A  30
1.40A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LYS A 269
VAL A 247
ASN A 228
LEU A 227
ASP A 229
1.39A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
GLY A  29
THR A  10
LEU A  37
ALA A  40
ASP A  41
1.33A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		6 / 12
VAL D 101
ALA D 100
VAL D 136
THR D 193
LEU D 105
ALA D 138
1.74A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		6 / 12
GLY C  -1
ALA D 100
VAL D 136
THR D 193
LEU D 105
ALA D 138
1.49A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		6 / 12
VAL D 101
ALA D 100
VAL D 136
THR D 193
LEU D 105
ALA D 138
1.70A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY B  29
THR B  10
LEU B  37
ALA B  40
ASP B  41
1.31A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ILE A 228
GLY A 104
VAL A 196
PHE A 187
THR A 160
LEU A 222
1.70A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL B 337
PHE B 387
ASP B 392
ALA B 406
ASP B 407
1.31A13.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL C  98
ALA C  91
VAL C 254
ASP C  77
THR C  75
1.31A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
VAL C1022
THR C 872
ASN C1129
LEU C 894
ALA C1130
1.31A13.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 842
ALA C 714
ASP C 812
THR C 809
ALA C 938
1.33A12.59
VAL  C 842 ( 0.6A)
ALA  C 714 ( 0.0A)
ASP  C 812 ( 0.5A)
THR  C 809 ( 0.8A)
ALA  C 938 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 299
LYS A 297
VAL A 675
ALA A 658
ASP A 649
1.41A13.03
ILE  A 299 ( 0.7A)
LYS  A 297 ( 0.0A)
VAL  A 675 ( 0.6A)
ALA  A 658 ( 0.0A)
ASP  A 649 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE C 228
GLY C 104
VAL C 196
PHE C 187
LEU C 194
1.14A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 328
VAL A 510
VAL A 382
ALA A 350
ASP A 351
1.39A13.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ack ACE2
(Homo
sapiens)		5 / 12
ILE D 307
VAL D 364
LEU D 423
ALA D 296
ASP D 295
1.17A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE B 228
GLY B 104
VAL B 196
PHE B 187
THR B 160
1.32A13.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C 510
ALA C 350
PHE C 325
LEU C 499
ALA C 384
1.14A12.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE B 226
VAL B 196
PHE B 187
THR B 160
LEU B 222
1.41A12.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6jyt HELICASE
(SARSr-CoV)		5 / 12
TYR B 306
VAL B 371
ALA B 393
LEU B 252
ALA B 302
1.35A22.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m18 ACE2
(Homo
sapiens)		5 / 12
ILE B 307
VAL B 364
LEU B 423
ALA B 296
ASP B 295
1.26A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL H 211
ALA H 125
PHE L 118
LEU H 189
ALA H 136
1.70A18.60
None