Ligand ID: LPR


Drugbank ID:
DB00722
(Lisinopril)


Indication:
For the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.

Get human targets for LPR in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LPR' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 290
HIS B 172
HIS B 163
GLU B 166
LYS A   3
1.77A18.01
None
None
ATO  B2006 ( 4.6A)
ATO  B2006 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B  94
THR B  35
PHE B 159
0.83A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		1x7q HLA, A-11
(Homo
sapiens)		3 / 3
ALA A  69
THR A  73
PHE A  36
1.40A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		1x7q HLA, A-11
(Homo
sapiens)		5 / 12
GLN A  62
GLU A  55
TYR A   7
VAL A  34
TYR A  59
1.52A19.38
SO4  A4003 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		3 / 3
ALA A  40
THR A  13
PHE A  31
1.04A10.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
ALA A  40
THR A  13
PHE A  31
1.14A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
HIS D 227
THR D 239
HIS D 268
GLU D 246
HIS D 276
1.52A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		3 / 3
ALA G  59
THR E  73
PHE G  11
1.41A16.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 4
SER A 140
VAL A 156
PHE A 117
VAL A  96
1.78A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
HIS C  46
THR C  58
HIS C  87
GLU C  65
HIS C  95
1.49A15.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER A 116
THR A 169
PHE A 128
1.00A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
ALA A 150
THR A  91
PHE A  80
1.46A19.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 4
SER B 246
VAL B 301
PHE B 305
VAL B 117
1.70A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ALA P   9
THR P  39
PHE N  16
1.64A13.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A  94
THR A  35
PHE A 159
1.21A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
ALA A 590
THR A 594
PHE A 615
1.65A12.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
ALA A  92
THR A  94
PHE A  54
1.02A11.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2kqw NSP3
(SARSr-CoV)		5 / 12
THR A 140
GLU A 139
HIS A 173
VAL A 161
TYR A 152
1.79A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2w2g NSP3
(SARSr-CoV)		3 / 3
ALA A 590
THR A 594
PHE A 615
1.62A18.63
None
SO4  A1653 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
SER L  93
THR H  58
PHE H  63
1.30A16.01
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
SER B 124
VAL B 172
PHE B 504
VAL B 343
1.57A42.83
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
HIS B 505
TYR B 515
1.02A42.51
 ZN  B 901 (-3.8A)
ZN  B 901 (-3.3A)
ZN  B 901 (-3.8A)
ZN  B 901 (-2.8A)
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		7 / 12
THR B 371
HIS B 374
GLU B 375
HIS B 378
GLU B 402
HIS B 505
TYR B 515
0.96A36.20
None
ZN  B 901 (-3.8A)
ZN  B 901 (-3.3A)
ZN  B 901 (-3.8A)
ZN  B 901 (-2.8A)
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
HIS B 505
TYR B 515
1.00A42.51
 ZN  B 901 (-3.8A)
ZN  B 901 (-3.3A)
ZN  B 901 (-3.8A)
ZN  B 901 (-2.8A)
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		7 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
PHE B 274
HIS B 505
TYR B 515
1.30A42.83
 ZN  B 901 (-3.8A)
ZN  B 901 (-3.3A)
ZN  B 901 (-3.8A)
ZN  B 901 (-2.8A)
None
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
HIS B 505
TYR B 515
1.13A35.96
 ZN  B 901 (-4.4A)
ZN  B 901 (-3.3A)
ZN  B 901 (-4.0A)
ZN  B 901 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		3e9s NSP3
(SARSr-CoV)		4 / 4
SER A 246
VAL A 301
PHE A 305
VAL A 117
1.69A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		3e9s NSP3
(SARSr-CoV)		3 / 3
SER A 116
THR A 169
PHE A 128
1.10A19.41
OCS  A 112 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3e9s NSP3
(SARSr-CoV)		3 / 3
ALA A 150
THR A  91
PHE A  80
1.47A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
ALA D  15
THR D  24
PHE D  56
1.44A11.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A  94
THR A  35
PHE A 159
1.03A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3i6l HLA, A-24
(Homo
sapiens)		3 / 3
ALA D  69
THR D  73
PHE D  36
1.47A17.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
SER B 116
THR B 169
PHE B 128
1.03A19.57
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
SER A 105
THR A  78
PHE A  32
1.04A36.33
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
HIS B 505
TYR B 515
1.33A36.33
 ZN  B 901 (-3.8A)
ZN  B 901 (-3.6A)
ZN  B 901 (-3.7A)
ZN  B 901 (-2.2A)
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		7 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
PHE B 274
HIS B 505
TYR B 515
1.34A42.86
 ZN  B 901 (-3.9A)
ZN  B 901 (-3.6A)
ZN  B 901 (-4.1A)
ZN  B 901 (-2.6A)
None
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
SER B 124
VAL B 172
PHE B 504
VAL B 343
1.45A42.86
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
THR A 371
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.65A36.67
None
ZN  A 901 (-3.5A)
ZN  A 901 (-3.7A)
ZN  A 901 (-3.5A)
ZN  A 901 (-2.8A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
HIS B 505
TYR B 515
1.09A42.41
 ZN  B 901 (-3.9A)
ZN  B 901 (-3.6A)
ZN  B 901 (-4.1A)
ZN  B 901 (-2.6A)
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
HIS B 505
TYR B 515
1.13A42.41
 ZN  B 901 (-3.9A)
ZN  B 901 (-3.6A)
ZN  B 901 (-4.1A)
ZN  B 901 (-2.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ALA A  69
THR A  73
PHE A  36
1.47A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
ALA A 150
THR A  91
PHE A  80
1.48A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 4
SER A 246
VAL A 301
PHE A 305
VAL A 117
1.72A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr)		3 / 3
SER A 116
THR A 169
PHE A 128
1.04A19.80
 NA  A 402 (-2.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		3 / 3
ALA B 150
THR B  91
PHE B  80
1.40A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		4 / 4
SER A 246
VAL A 301
PHE A 305
VAL A 117
1.65A19.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		3 / 3
ALA A 265
THR A 119
PHE A 312
1.30A19.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		3 / 3
SER A 167
THR A 172
PHE A 148
0.99A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B  94
THR B  35
PHE B 159
1.23A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
ALA D  79
THR D  75
PHE D 286
1.39A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr)		3 / 3
SER B 448
THR B 522
PHE B 514
1.28A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
ALA D 150
THR D  91
PHE D  80
1.36A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 4
SER D 246
VAL D 301
PHE D 305
VAL D 117
1.71A19.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER D 116
THR D 169
PHE D 128
1.06A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5ko3 ORF1A
(MERS-CoV)		3 / 3
SER A 167
THR A 172
PHE A 148
1.13A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 4
SER D 507
VAL D 312
PHE D 401
VAL D 405
1.73A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER D 116
THR D 169
PHE D 128
0.99A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 4
SER D 246
VAL D 301
PHE D 305
VAL D 117
1.67A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
ALA B 150
THR B  91
PHE B  80
1.47A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ALA A1037
THR A 856
PHE A 805
1.31A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5x4r S PROTEIN
(MERS-CoV)		3 / 3
ALA A 146
THR A 206
PHE A 313
1.33A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER A 173
THR A 148
PHE A  22
1.20A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5x59 S PROTEIN
(MERS-CoV)		3 / 3
SER B 426
THR B 574
PHE B 446
0.69A18.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5x59 S PROTEIN
(MERS-CoV)		3 / 3
ALA B 146
THR B 206
PHE B 313
1.33A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
SER B1003
THR B1009
PHE C1024
1.12A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER C1003
THR C1009
PHE B1024
1.06A19.20
SER  C1003 ( 0.0A)
THR  C1009 ( 0.8A)
PHE  B1024 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
SER A 116
THR A 169
PHE A 128
1.09A19.31
 NA  A 403 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
ALA A 150
THR A  91
PHE A  80
1.46A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 4
SER A 246
VAL A 301
PHE A 305
VAL A 117
1.76A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER B1003
THR B1009
PHE A1024
0.89A19.20
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6acg ACE2
(Homo
sapiens)		5 / 12
HIS D 374
GLU D 375
HIS D 378
GLU D 402
TYR D 515
1.02A42.58
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6acg ACE2
(Homo
sapiens)		5 / 12
HIS D 374
GLU D 375
HIS D 378
GLU D 402
TYR D 515
0.96A42.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
SER B 211
VAL B  66
PHE B  62
VAL B  40
1.64A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN B1036
THR B 706
HIS B1046
GLU B 707
VAL B 763
1.55A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ALA C 250
THR C 247
PHE C 253
1.20A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
ALA B 422
THR B 363
PHE B 334
1.55A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
SER C  35
THR C  67
PHE C 231
1.19A19.16
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ALA D 348
GLU D 375
HIS D 374
GLU D 402
HIS D 401
1.38A42.35
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6cs2 ACE2
(Homo
sapiens)		5 / 12
HIS D 374
GLU D 375
HIS D 378
GLU D 402
TYR D 515
1.54A42.35
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		6cs2 ACE2
(Homo
sapiens)		5 / 12
HIS D 374
GLU D 375
HIS D 378
GLU D 402
TYR D 515
1.51A42.83
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		6cs2 ACE2
(Homo
sapiens)		5 / 12
THR D 347
GLU D 375
HIS D 374
GLU D 402
HIS D 401
1.41A36.13
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		6cs2 ACE2
(Homo
sapiens)		5 / 12
HIS D 374
GLU D 375
HIS D 378
GLU D 402
TYR D 515
1.46A36.44
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6lzg ACE2
(Homo
sapiens)		5 / 12
HIS A 345
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.47A42.67
None
ZN  A 704 (-3.3A)
ZN  A 704 ( 4.3A)
ZN  A 704 (-3.3A)
ZN  A 704 (-2.1A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		6lzg ACE2
(Homo
sapiens)		6 / 12
HIS A 345
THR A 371
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.49A36.20
None
None
ZN  A 704 (-3.3A)
ZN  A 704 ( 4.3A)
ZN  A 704 (-3.3A)
ZN  A 704 (-2.1A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		6lzg ACE2
(Homo
sapiens)		5 / 12
HIS A 345
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.41A42.81
None
ZN  A 704 (-3.3A)
ZN  A 704 ( 4.3A)
ZN  A 704 (-3.3A)
ZN  A 704 (-2.1A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		6lzg ACE2
(Homo
sapiens)		5 / 12
HIS A 345
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.40A35.96
None
ZN  A 704 (-3.3A)
ZN  A 704 ( 4.3A)
ZN  A 704 (-3.3A)
ZN  A 704 (-2.1A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		6m0j ACE2
(Homo
sapiens)		6 / 12
HIS A 345
THR A 371
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.67A36.67
None
None
ZN  A 901 (-3.5A)
ZN  A 901 (-3.9A)
ZN  A 901 (-3.5A)
ZN  A 901 (-2.4A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		6m0j ACE2
(Homo
sapiens)		5 / 12
HIS A 345
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.67A36.33
None
ZN  A 901 (-3.5A)
ZN  A 901 (-3.9A)
ZN  A 901 (-3.5A)
ZN  A 901 (-2.4A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		6m0j ACE2
(Homo
sapiens)		5 / 12
HIS A 345
HIS A 374
GLU A 375
HIS A 378
GLU A 402
0.66A42.83
None
ZN  A 901 (-3.5A)
ZN  A 901 (-3.9A)
ZN  A 901 (-3.5A)
ZN  A 901 (-2.4A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		6m17 ACE2
(Homo
sapiens)		5 / 12
HIS B 345
HIS B 374
GLU B 375
HIS B 378
GLU B 402
0.64A36.78
None
ZN  B 914 (-3.4A)
ZN  B 914 (-4.2A)
ZN  B 914 (-3.5A)
ZN  B 914 (-2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
ALA C 282
THR C 121
PHE C 276
1.38A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		6m18 ACE2
(Homo
sapiens)		5 / 12
HIS B 345
HIS B 374
GLU B 375
HIS B 378
GLU B 402
0.65A28.97
None
None
ZN  B 914 (-3.4A)
ZN  B 914 ( 4.6A)
ZN  B 914 (-4.0A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6m18 ACE2
(Homo
sapiens)		5 / 12
HIS B 345
HIS B 374
GLU B 375
HIS B 378
GLU B 402
0.66A35.10
None
None
ZN  B 914 (-3.4A)
ZN  B 914 ( 4.6A)
ZN  B 914 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		6m18 ACE2
(Homo
sapiens)		6 / 12
HIS B 345
THR B 371
HIS B 374
GLU B 375
HIS B 378
GLU B 402
0.67A28.68
None
None
None
ZN  B 914 (-3.4A)
ZN  B 914 ( 4.6A)
ZN  B 914 (-4.0A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6m18 ACE2
(Homo
sapiens)		5 / 12
HIS D 345
HIS D 374
GLU D 375
HIS D 378
GLU D 402
0.76A35.10
None
None
ZN  D 914 (-3.4A)
ZN  D 914 ( 4.6A)
ZN  D 914 (-4.0A)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6m1d ACE2
(Homo
sapiens)		3 / 3
ALA B 304
THR B 362
PHE B 327
1.36A35.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
SER A 500
VAL A 498
PHE A 416
VAL A 369
1.69A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 4
SER L  28
VAL L   2
PHE L  76
VAL L  56
1.55A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6nus NSP12
(SARSr-CoV)		3 / 3
ALA A 690
THR A 686
PHE A 480
1.18A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		6nus NSP12
(SARSr-CoV)		4 / 4
SER A 778
VAL A 785
PHE A 753
VAL A 764
1.64A20.55
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6vw1 ACE2
(Homo
sapiens)		5 / 12
HIS A 345
HIS A 374
GLU A 375
HIS A 378
GLU A 402
1.07A42.67
None
None
ZN  A 704 ( 3.8A)
ZN  A 704 ( 4.6A)
ZN  A 704 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
SER H 153
THR H 165
PHE L 118
1.64A13.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
SER H 180
THR H 183
PHE L 139
1.76A13.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
SER L 168
THR L 172
PHE H 166
1.64A13.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER B 184
THR B 187
PHE C 145
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 4
ARG C  60
ALA C  57
SER C  58
TYR C  55
1.79A15.97
None
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER B 157
THR B 169
PHE C 124
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 4
ARG C  60
ALA C  57
SER C  58
TYR C  55
1.79A15.97
None
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER H 157
THR H 169
PHE L 124
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER C 174
THR C 178
PHE B 170
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER H 184
THR H 187
PHE L 145
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L 174
THR L 178
PHE H 170
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER H 184
THR H 187
PHE L 145
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6ym0 LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L   7
THR L  78
PHE L  68
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L 174
THR L 178
PHE H 170
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER H 157
THR H 169
PHE L 124
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER H 184
THR H 187
PHE L 145
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER C 174
THR C 178
PHE B 170
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER B 184
THR B 187
PHE C 145
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER B 157
THR B 169
PHE C 124
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER H 157
THR H 169
PHE L 124
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER L 174
THR L 178
PHE H 170
1.72A
None