Ligand ID: LCR


Drugbank ID:
DB00341
(Cetirizine)
DB06282
(Levocetirizine)


Indication:
For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria;Levocetirizine is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.

Get human targets for LCR in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LCR' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 9
LEU B 253
GLY B 251
LEU B 250
LEU B 202
ALA B 206
1.45A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.39A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.43A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.44A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.41A17.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 9
LEU B 253
GLY B 251
LEU B 250
LEU B 202
ALA B 206
1.41A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.40A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.42A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.44A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.41A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3aw0 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.38A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.33A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B 253
GLY B 251
LEU B 250
LEU B 202
ALA B 206
1.39A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.41A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU C 253
GLY C 251
LEU C 250
LEU A 202
ALA A 206
1.42A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B 253
GLY B 251
LEU B 250
LEU B 202
ALA B 206
1.41A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.42A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A 253
GLY A 251
LEU A 250
LEU A 202
ALA A 206
1.43A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU D 253
GLY D 251
LEU D 250
LEU B 202
ALA B 206
1.37A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B 253
GLY B 251
LEU B 250
LEU B 202
ALA B 206
1.40A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B 253
GLY B 251
LEU B 250
LEU B 202
ALA B 206
1.41A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B 253
GLY B 251
LEU B 250
LEU B 202
ALA B 206
1.45A17.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 9
LYS B 929
LEU B 930
LEU C 930
LEU b  18
ALA C 926
1.37A8.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASP B 351
LEU B 374
GLY B 512
LEU B 377
LEU B 499
1.28A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6jyt HELICASE
(SARSr-CoV)		5 / 9
LEU B 412
LEU B 122
GLY B 118
LEU B 138
ALA B 123
1.30A22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 9
LEU B  95
ASP A 377
LEU B  98
LEU B 103
ALA A 383
1.38A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 9
LYS C 113
LEU C  84
GLY C  16
LEU C  15
ALA C  86
1.77A16.67
None
None
None
None
DMS  C 302 ( 4.1A)