Ligand ID: HQE


Drugbank ID:
DB09526
(Hydroquinone)


Indication:
Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.

Get human targets for HQE in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HQE' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.10A19.80
MPD  A 307 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.47A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 10
LEU A  16
LEU A  62
THR A  44
THR A  46
VAL A  14
1.46A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B1250
VAL B1261
LEU B1202
THR B1201
VAL B1247
1.47A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.46A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 7
HIS A 268
HIS A 276
ASN A 219
ALA A 271
1.64A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 7
HIS A 268
HIS A 276
ASN A 219
ALA A 271
1.62A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 10
VAL C  16
LEU F  96
THR F  94
THR F  98
VAL B  21
1.46A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 10
VAL G 164
LEU G 189
VAL G 191
THR G 146
VAL G 137
1.32A22.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		2ajf ACE2
(Homo
sapiens)		4 / 7
HIS A 373
ASN A 546
HIS A 417
ALA A 412
1.42A17.77
None
NAG  A1546 (-1.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		2ajf ACE2
(Homo
sapiens)		4 / 7
HIS A 373
ASN A 546
HIS A 417
ALA A 412
1.38A17.77
None
NAG  A1546 (-1.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.12A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL B  77
PHE B  66
LEU B  89
VAL B  91
VAL B  36
1.46A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 7
HIS A  87
HIS A  95
ASN A  38
ALA A  90
1.66A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 7
HIS B  87
HIS B  46
ASN B  38
HIS B  95
1.63A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE E 364
LEU C 377
LEU E 499
PHE E 501
ASP E 376
1.56A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE E 345
PHE E 329
LEU E 421
PHE E 364
1.10A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
PHE E 379
LEU E 499
LEU E 421
THR E 363
VAL E 498
1.35A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 10
LEU B 165
VAL B 161
LEU B 136
THR B 134
THR B 135
1.47A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.13A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 10
VAL A  52
PHE A  54
VAL A  62
LEU A  36
VAL A  86
1.30A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.46A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
ILE A 222
LEU A 227
LEU A 299
PHE A 302
1.18A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ILE A  71
PRO A  67
LEU A  75
LEU A 122
ASP A  78
1.74A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
ILE B 200
TYR B 239
LEU B 242
PHE B 230
1.18A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.20A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.46A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.46A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.21A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
PHE C 232
LEU C 227
TYR C 225
LEU C 299
ASP C 212
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 7
ASN B 142
HIS B 163
VAL B 171
ALA B 173
1.78A19.34
None
XP1  B1304 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 8
ILE B 200
TYR B 239
LEU B 242
PHE B 230
1.13A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 7
ASN B 142
HIS B 163
VAL B 171
ALA B 173
1.79A19.34
None
XP1  B1304 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		2z3d REPLICASE
POLYPROTEIN 1AB
(PP1AB)
(SARSr-CoV)		4 / 7
HIS A  41
HIS A 164
HIS A 163
ALA I 904
1.53A20.37
OCQ  I 905 (-3.5A)
None
OCQ  I 905 (-3.8A)
OCQ  I 905 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		2z3d REPLICASE
POLYPROTEIN 1AB
(PP1AB)
(SARSr-CoV)		4 / 7
HIS A  41
HIS A 164
HIS A 163
ALA I 904
1.50A20.37
OCQ  I 905 (-3.5A)
None
OCQ  I 905 (-3.8A)
OCQ  I 905 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
HIS A 239
ASN A 601
VAL A 604
ALA A 242
1.38A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
HIS A 373
ASN A 546
HIS A 417
ALA A 412
1.35A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3e9s NSP3
(SARSr-CoV)		5 / 10
VAL A 206
PHE A 242
LEU A 179
LEU A 174
THR A 171
1.38A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE B 200
TYR B 239
LEU B 242
PHE B 230
1.12A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.13A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
ILE B 200
TYR D 239
LEU D 242
PHE D 230
1.14A13.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
HIS B 172
HIS B 163
ASN B  28
ALA B 140
1.51A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
HIS B 172
HIS B 163
ASN B  28
ALA B 140
1.48A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.13A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.44A23.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
HIS B 172
HIS B 163
ASN B  28
ALA B 140
1.63A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
HIS B 172
HIS B 163
ASN B  28
ALA B 140
1.60A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.45A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.44A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.15A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.40A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL B  77
PHE B  66
LEU B  89
VAL B  91
VAL B  36
1.46A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE B 200
TYR B 239
LEU B 242
PHE B 230
1.10A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE B 200
TYR B 239
LEU B 242
PHE B 230
1.12A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
VAL A 117
PHE A 148
LEU A 121
LEU A 173
THR A 171
1.46A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
HIS A 239
ASN A 601
VAL A 604
ALA A 242
1.31A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
HIS A 239
ASN A 601
VAL A 604
ALA A 242
1.29A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.46A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A  70
HIS A  74
VAL A  67
ALA A  24
1.49A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A  70
HIS A  74
VAL A  67
ALA A  24
1.48A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3vb6 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.09A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.18A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		4 / 7
HIS B 176
HIS B  74
ASN B 129
ALA B 132
1.65A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		4 / 7
HIS B 176
HIS B  74
ASN B 129
ALA B 132
1.66A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL B  77
PHE B  66
LEU B  89
VAL B  91
VAL B  36
1.44A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		4twy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.17A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A  77
PHE A  66
LEU A  89
VAL A  91
VAL A  36
1.47A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
ILE A 200
TYR A 239
LEU A 242
PHE A 230
1.18A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
HIS B 148
ASN B 266
VAL B 269
ALA B 270
1.70A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
HIS B 148
ASN B 266
VAL B 269
ALA B 270
1.66A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
ILE B  14
GLN B  22
ARG B  53
GLU B 128
1.73A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		4 / 7
HIS A  80
HIS A  83
ASN B 130
ALA A  71
1.50A20.69
None
ZN  A 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
HIS B 148
ASN B 266
VAL B 269
ALA B 270
1.49A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
HIS B 148
ASN B 266
VAL B 269
ALA B 270
1.54A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
HIS D 176
HIS D  74
ASN D 129
ALA D 132
1.65A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
HIS D 176
HIS D  74
ASN D 129
ALA D 132
1.64A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5f22 NSP8
(SARSr-CoV)		5 / 10
VAL B 164
LEU B 189
VAL B 191
THR B 146
VAL B 137
1.40A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
ASN A 104
HIS M   0
VAL A 101
ALA M   1
1.48A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
HIS B 148
ASN B 266
VAL B 269
ALA B 270
1.77A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
HIS B 176
HIS B  74
ASN B 129
ALA B 132
1.72A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
VAL B 206
PHE B 242
LEU B 179
LEU B 174
THR B 171
1.38A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN C 627
HIS C 641
VAL C 675
ALA C 676
1.60A13.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN C 627
HIS C 641
VAL C 675
ALA C 676
1.61A13.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
ILE A 637
LEU A 597
LEU A 615
PHE A 305
1.16A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 7
ASN C 342
HIS C 670
VAL C 661
ALA C 671
1.63A11.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 7
ASN C 342
HIS C 670
VAL C 661
ALA C 671
1.63A11.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE A 962
ASP A 961
LEU A 966
LEU B 377
PHE B 379
1.62A16.93
ILE  A 962 ( 0.7A)
ASP  A 961 ( 0.5A)
LEU  A 966 ( 0.6A)
LEU  B 377 ( 0.6A)
PHE  B 379 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 10
VAL C 497
PHE C 329
LEU C 421
VAL C 496
LEU C 499
VAL C 420
1.77A12.14
VAL  C 497 ( 0.6A)
PHE  C 329 ( 1.3A)
LEU  C 421 ( 0.5A)
VAL  C 496 ( 0.6A)
LEU  C 499 ( 0.6A)
VAL  C 420 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ILE A 962
ASP A 961
LEU A 966
LEU B 377
PHE B 379
1.65A16.93
ILE  A 962 ( 0.7A)
ASP  A 961 ( 0.5A)
LEU  A 966 ( 0.6A)
LEU  B 377 ( 0.6A)
PHE  B 379 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ILE A 962
ASP A 961
LEU A 966
LEU B 377
PHE B 379
1.64A16.93
ILE  A 962 ( 0.7A)
ASP  A 961 ( 0.5A)
LEU  A 966 ( 0.6A)
LEU  B 377 ( 0.6A)
PHE  B 379 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
VAL A 206
PHE A 242
LEU A 179
LEU A 174
THR A 171
1.43A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE B 364
LEU B 355
TYR B 352
LEU B 499
PHE B 501
1.52A16.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		6acg ACE2
(Homo
sapiens)		4 / 7
HIS D 239
ASN D 601
VAL D 604
ALA D 242
1.25A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		6acg ACE2
(Homo
sapiens)		5 / 9
ILE D 256
PRO D 490
LEU D 266
LEU D 162
ASP D 157
1.67A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		6acg ACE2
(Homo
sapiens)		4 / 7
HIS D 239
ASN D 601
VAL D 604
ALA D 242
1.25A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE C 702
PHE C 888
LEU C1031
LEU C 898
1.09A16.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ILE B 979
PHE B 741
LEU B 735
LEU B 986
ASP B 719
1.48A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ILE C 687
PRO A 774
PHE A 779
LEU A 776
1.14A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		6cs2 ACE2
(Homo
sapiens)		5 / 9
ILE D 256
PRO D 490
LEU D 266
LEU D 162
ASP D 157
1.75A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		6cs2 ACE2
(Homo
sapiens)		5 / 9
ILE D 256
PRO D 490
LEU D 266
LEU D 162
ASP D 157
1.75A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		6cs2 ACE2
(Homo
sapiens)		4 / 7
HIS D 378
HIS D 374
VAL D 404
ALA D 403
1.52A18.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		6cs2 ACE2
(Homo
sapiens)		4 / 7
HIS D 378
HIS D 374
VAL D 404
ALA D 403
1.51A18.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
ILE A 309
PHE A 279
LEU A  78
PHE A  74
0.93A21.01
3PH  A 708 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
ILE A  83
PHE A 279
LEU A  78
LEU A 281
PHE A 276
1.78A21.01
3PH  A 708 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		6m1d ACE2
(Homo
sapiens)		4 / 7
HIS B 378
HIS B 374
VAL B 404
ALA B 403
1.55A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		6m1d ACE2
(Homo
sapiens)		4 / 8
ILE D 256
LEU D 248
TYR D 252
LEU D 267
1.20A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		6m1d ACE2
(Homo
sapiens)		4 / 7
HIS B 378
HIS B 374
VAL B 404
ALA B 403
1.55A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ILE B 979
PHE B 741
LEU B 735
LEU B 986
ASP B 719
1.33A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE B 979
PHE B 741
LEU B 735
LEU B 986
1.05A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ILE A 787
PRO A1035
LEU A 788
LEU A 859
PHE A 870
1.76A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR L  37
HIS L  98
ASP L  33
HIS H 109
1.55A23.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 10
VAL B 115
VAL A 330
LEU B 103
THR B 124
VAL A 341
1.35A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		6nur NSP12
(SARSr-CoV)		4 / 7
HIS A 642
ASN A 568
HIS A 572
ALA A 639
1.54A14.94
 ZN  A1002 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		6nus NSP12
(SARSr-CoV)		5 / 10
PHE A 287
LEU A 186
LEU A 245
THR A 246
VAL A 182
1.35A13.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		6nus NSP12
(SARSr-CoV)		4 / 7
HIS A 642
ASN A 568
HIS A 572
ALA A 639
1.56A14.94
 ZN  A1002 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 10
VAL L  27
PHE L  71
LEU L  33
LEU L   4
THR L  97
1.78A22.35
None