Ligand ID: HFZ


Drugbank ID:
DB00774
(Hydroflumethiazide)


Indication:
Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Get human targets for HFZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HFZ' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 5
PRO A   9
SER B 123
LEU A 115
SER A 113
1.55A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO A   9
SER B1123
LEU A 115
SER A 113
1.42A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		1zva E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 10
SER A  46
LEU A  34
SER A  32
ILE A  37
GLY A  43
1.36A13.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		1zva E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE A  37
GLY A  43
SER A  46
LEU A  34
SER A  32
1.32A13.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.50A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 10
PRO G 310
SER H 319
ILE G 338
SER G 319
GLY G 336
1.78A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
ILE G 338
SER G 319
GLY G 336
PRO G 310
SER H 319
1.75A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO A   9
SER B 123
LEU A 115
SER A 113
1.46A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		5 / 11
PRO H 213
SER H 187
GLY H 190
SER H 136
SER H 132
1.80A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 10
SER L  52
LEU L   5
ILE L  28
SER L  32
GLY L  29
1.45A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 11
ILE L  28
SER L  32
GLY L  29
SER L  52
LEU L   5
1.40A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		4 / 5
PRO H 126
SER H 215
LEU H 124
SER L 122
1.54A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 5
LYS A 136
PRO A 137
LEU A 101
SER A 129
1.64A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
PRO A 137
SER A 140
ILE B 122
SER A 129
GLY A 131
1.76A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 11
PRO A 469
SER B 199
GLY B 198
PRO A 459
LEU A 443
1.56A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 10
PRO C 459
LEU C 443
PRO C 469
SER D 199
GLY D 198
1.61A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		2jze REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ILE A 608
PRO A 607
GLY A 609
LEU A 627
SER A 626
1.36A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		2jze REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A 627
SER A 626
ILE A 608
PRO A 607
GLY A 609
1.35A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 5
PRO A   9
SER B 123
LEU A 115
SER A 113
1.52A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.55A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.45A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
PRO E 111
LEU E 119
SER E 117
ILE E 107
SER E 114
1.79A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.57A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.49A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		3bgf F26G19 FAB
(Mus
musculus)		5 / 11
SER H 182
PRO H 169
SER L 174
LEU H 179
SER H 180
1.72A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		3bgf F26G19 FAB
(Mus
musculus)		5 / 10
PRO H 169
SER L 174
LEU H 179
SER H 180
SER H 182
1.70A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		3bgf F26G19 FAB
(Mus
musculus)		5 / 11
ILE L  48
SER L  65
GLY L  64
SER L  20
LEU L  47
1.75A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		3bgf F26G19 FAB
(Mus
musculus)		5 / 10
LEU L  47
ILE L  48
SER L  65
SER L  20
GLY L  64
1.76A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3bgf F26G19 FAB
(Mus
musculus)		4 / 5
PRO H 169
SER L 174
LEU H 179
SER H 180
1.74A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
PRO B 612
ILE B 256
PRO B 263
SER B 607
GLY B 260
1.72A17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.46A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.51A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO A   9
SER B 123
LEU A 115
SER A 113
1.46A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.36A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO A   9
SER B 123
LEU A 115
SER A 113
1.53A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.43A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO B   9
SER A 123
LEU B 115
SER B 113
1.52A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PRO A   9
SER B 123
LEU A 115
SER A 113
1.54A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
SER C 364
GLY A 931
PRO C 658
LEU A 935
SER C 362
1.78A11.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		5x5c S PROTEIN
(MERS-CoV)		5 / 10
PRO A 658
SER A 365
LEU B 935
SER A 362
GLY B 931
1.63A11.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE C 656
SER C 659
LYS C 675
PRO C 651
LEU C 597
1.65A12.95
ILE  C 656 ( 0.7A)
SER  C 659 ( 0.0A)
VAL  C 675 ( 0.0A)
PRO  C 651 ( 1.1A)
LEU  C 597 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 10
SER b   7
LEU B 959
ILE B 955
SER B 949
GLY B 953
1.44A10.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 11
ILE B 955
SER B 949
GLY B 953
SER b   7
LEU B 959
1.41A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		6acj ACE2
(Homo
sapiens)		5 / 10
SER D  70
LEU D 116
SER D 113
SER D 106
GLY D 104
1.77A17.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		6acj ACE2
(Homo
sapiens)		5 / 11
SER D 106
GLY D 104
SER D  70
LEU D 116
SER D 113
1.78A17.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PRO C 844
SER C 750
SER C 717
LEU A 597
SER A 582
1.74A12.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
SER C 717
LEU A 597
SER A 582
PRO C 844
SER C 750
1.74A12.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
LEU B 959
ILE B 979
SER B 985
SER B 950
GLY B 981
1.59A11.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ILE B 979
SER B 985
SER B 950
GLY B 981
LEU B 959
1.58A11.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
LYS A 112
SER A 504
LEU A 116
SER A 118
1.74A16.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
PRO A 442
SER A 122
SER A 288
SER A 118
GLY A 115
1.78A16.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE A 979
SER A 985
SER A 950
GLY A 981
LEU A 959
1.61A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A 959
ILE A 979
SER A 985
SER A 950
GLY A 981
1.62A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 11
ILE L  53
SER L  20
GLY L  69
SER L  22
LEU L  52
1.67A24.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 10
SER L  22
LEU L  52
ILE L  53
SER L  20
GLY L  69
1.67A24.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
PRO H 167
SER L 174
LEU H 178
SER H 179
1.73A19.44
None
None
GOL  L 301 (-4.9A)
GOL  L 301 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 5
LYS H  13
PRO H  14
SER H  85
SER H  82
1.79A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
LYS L 149
SER L 177
LEU L 154
SER L 156
1.58A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
LYS B  87
GLY B  15
LYS B  12
SER B 119
LEU B  18
1.76A23.55
None
None
DMS  H 302 (-3.4A)
MLI  B 301 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
PRO H 171
SER L 180
LEU H 182
SER H 183
1.80A23.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 5
LYS C 155
SER C 183
LEU C 160
SER C 162
1.62A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
PRO B 171
SER C 180
LEU B 182
SER B 183
1.79A23.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 10
PRO C  65
LEU C  79
SER C  69
ILE C  81
SER C  83
1.71A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 5
LYS L 155
SER L 183
LEU L 160
SER L 162
1.63A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 5
LYS L 155
SER L 183
LEU L 160
SER L 162
1.61A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 5
LYS L 155
SER L 183
LEU L 160
SER L 162
1.64A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 5
LYS C 155
SER C 183
LEU C 160
SER C 162
1.64A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
PRO H 171
SER L 180
LEU H 182
SER H 183
1.80A23.55
None