Ligand ID: HAE


Drugbank ID:
DB00551
(Acetohydroxamic Acid)


Indication:
Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.

Get human targets for HAE in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HAE' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.61A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.59A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.56A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.50A20.45
None
AZP  A 307 (-3.5A)
AZP  A 307 (-4.3A)
AZP  A 307 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.56A19.43
None
AZP  A 307 (-3.5A)
AZP  A 307 (-4.3A)
AZP  A 307 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.54A20.07
None
AZP  A 307 (-3.5A)
AZP  A 307 (-4.3A)
AZP  A 307 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 7
HIS B 227
HIS B 276
LEU B 270
THR B 239
1.57A25.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
ILE D 251
HIS D 224
HIS D 276
HIS D 227
1.34A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2ajf ACE2
(Homo
sapiens)		3 / 3
HIS A 401
GLU A 402
HIS A 374
1.27A21.02
None
ZN  A 901 (-2.2A)
ZN  A 901 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.64A20.13
None
CY6  A1145 (-3.5A)
CY6  A1145 (-4.2A)
CY6  A1145 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.59A20.45
None
CY6  A1145 (-3.5A)
CY6  A1145 (-4.2A)
CY6  A1145 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.66A19.49
None
CY6  A1145 (-3.5A)
CY6  A1145 (-4.2A)
CY6  A1145 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A20.45
None
PJE  C   5 (-3.7A)
PJE  C   5 (-4.5A)
PJE  C   5 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.69A19.18
None
PJE  C   5 (-3.7A)
PJE  C   5 (-4.5A)
PJE  C   5 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
HIS B 163
GLU B 166
HIS B 172
1.56A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
ILE A  70
HIS A  43
HIS A  95
HIS A  46
1.33A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
HIS B 273
LEU C 200
THR C 198
THR C 199
1.59A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
HIS J  48
LEU J  45
THR M  49
THR M  47
1.51A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 5
HIS A  70
HIS A  70
HIS A  70
HIS A  72
1.45A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A 111
HIS A   2
HIS A  70
HIS A  70
1.37A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 5
HIS A  70
HIS A  70
HIS A  70
HIS A  70
1.28A10.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 5
HIS A  70
HIS A  72
HIS A  72
HIS A  70
1.45A10.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 7
HIS A   2
LEU A  66
THR A  68
THR A  68
1.36A22.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 5
HIS A  70
HIS A  70
HIS A  70
HIS A  72
1.50A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 7
HIS A  70
LEU A  66
THR A  68
THR A  68
1.21A22.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
HIS A  70
HIS A  70
HIS A  70
HIS A  72
1.39A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 5
HIS A  72
HIS A  70
HIS A  70
HIS A  70
0.97A14.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.59A20.74
None
WR1  A 601 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A20.07
None
WR1  A 601 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.64A19.67
None
WR1  A 601 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		3 / 3
HIS A 163
GLU A 166
HIS A 172
1.56A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.59A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.62A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 5
LEU B 141
HIS B 163
GLU B 166
HIS B 172
1.65A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 6
LEU B 141
HIS B 163
GLU B 166
HIS B 172
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.61A20.13
None
CYV  A 302 (-3.1A)
CYV  A 302 (-4.5A)
CYV  A 302 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A19.74
None
CYV  A 302 (-3.1A)
CYV  A 302 (-4.5A)
CYV  A 302 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.58A20.74
None
CYV  A 302 (-3.1A)
CYV  A 302 (-4.5A)
CYV  A 302 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
HIS B 172
GLU B 166
HIS B 163
1.68A19.43
None
XP1  B1304 (-1.6A)
XP1  B1304 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.53A20.45
None
HSV  C   5 (-3.9A)
None
HSV  C   5 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.57A20.13
None
HSV  C   5 (-3.9A)
None
HSV  C   5 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.60A14.01
None
ZN  A 901 (-3.2A)
None
ZN  A 901 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.58A13.40
None
ZN  A 901 (-3.2A)
None
ZN  A 901 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.54A13.40
None
ZN  A 901 (-3.2A)
None
ZN  A 901 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
HIS A 374
GLU A 375
HIS A 378
0.10A15.58
 ZN  A 901 (-4.3A)
ZN  A 901 (-3.1A)
ZN  A 901 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.61A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.56A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.60A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.57A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.60A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 167
HIS B 172
HIS B 164
HIS B  41
1.60A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 167
HIS A 172
HIS A 164
HIS A  41
1.62A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 167
HIS A 172
HIS A 164
HIS A  41
1.60A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3i6g HLA, A-2
(Homo
sapiens)		4 / 7
HIS A 192
LEU A 201
THR A 200
TRP A 274
1.52A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		4 / 7
HIS E  31
LEU D  95
THR D  94
THR D  10
1.34A12.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.57A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.61A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
HIS A 163
GLU A 166
HIS A 172
1.63A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
HIS A 163
GLU A 166
HIS A 172
1.62A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
HIS A 163
GLU A 166
HIS A 172
1.58A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
HIS A 163
GLU A 166
HIS A 172
1.54A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.60A14.01
None
ZN  A 901 (-3.5A)
None
ZN  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.58A13.40
None
ZN  A 901 (-3.5A)
None
ZN  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
HIS A 374
GLU A 375
HIS A 378
0.50A15.41
 ZN  A 901 (-3.5A)
ZN  A 901 (-3.9A)
ZN  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.53A13.40
None
ZN  A 901 (-3.5A)
None
ZN  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.62A20.13
None
ECC  H   5 ( 4.7A)
None
ECC  H   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.58A20.74
None
ECC  H   5 ( 4.7A)
None
ECC  H   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A19.74
None
ECC  H   5 ( 4.7A)
None
ECC  H   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3snc 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.58A19.49
None
ECC  H   5 ( 3.9A)
ECC  H   5 ( 4.9A)
ECC  H   5 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3sne 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-ESTLQ-H
(SARSr-CoV)		4 / 7
HIS A 163
HIS A 172
LEU A 167
THR H   3
1.57A23.08
ECC  H   5 ( 4.0A)
None
None
ECC  H   5 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 141
GLU B 166
HIS B 172
HIS B 163
1.57A20.13
None
0JU  F   5 (-3.7A)
0JU  F   5 ( 4.7A)
0JU  F   5 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 141
GLU B 166
HIS B 172
HIS B 163
1.51A20.45
None
0JU  F   5 (-3.7A)
0JU  F   5 ( 4.7A)
0JU  F   5 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.56A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.61A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.58A20.52
None
23H  A 401 (-3.8A)
None
23H  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.63A19.55
None
23H  A 401 (-3.8A)
None
23H  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.62A20.13
None
23H  A 401 (-3.8A)
None
23H  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		4 / 7
HIS A 172
HIS B 172
LEU B 174
THR B 171
1.43A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 7
HIS A 171
LEU A 311
THR A 119
TRP A 243
1.60A24.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.53A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.59A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.57A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 141
GLU A 166
HIS A 172
HIS A 163
1.58A19.49
None
SDJ  A 401 (-4.1A)
None
SDJ  A 401 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
HIS D 260
GLU D 284
HIS D 283
1.17A14.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
HIS D 260
GLU D 284
HIS D 283
1.12A14.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		3 / 3
HIS D 487
GLU D 490
HIS D 486
0.97A14.75
 ZN  D 603 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
HIS P  80
LEU C  27
THR P   5
THR C  25
1.77A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
HIS A  33
HIS A  70
THR A  31
THR A  67
1.80A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		6acg ACE2
(Homo
sapiens)		3 / 3
HIS D 241
GLU D 238
HIS D 239
1.45A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
HIS A  33
HIS A  70
THR A  31
THR A  67
1.68A12.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		6ack ACE2
(Homo
sapiens)		4 / 7
HIS D 241
LEU D 444
THR D 282
TRP D 275
1.64A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6ack ACE2
(Homo
sapiens)		4 / 5
ILE D 407
HIS D 374
GLU D 406
HIS D 378
1.55A13.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		6cs2 ACE2
(Homo
sapiens)		4 / 5
ILE D 407
HIS D 374
GLU D 406
HIS D 378
1.54A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		6cs2 ACE2
(Homo
sapiens)		3 / 3
HIS D 374
GLU D 375
HIS D 378
0.27A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6cs2 ACE2
(Homo
sapiens)		4 / 6
ILE D 407
HIS D 374
GLU D 406
HIS D 378
1.53A13.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6cs2 ACE2
(Homo
sapiens)		4 / 5
ILE D 407
HIS D 374
GLU D 406
HIS D 378
1.48A13.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6lzg ACE2
(Homo
sapiens)		4 / 6
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.51A13.40
None
ZN  A 704 (-3.3A)
None
ZN  A 704 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		6lzg ACE2
(Homo
sapiens)		3 / 3
HIS A 374
GLU A 375
HIS A 378
0.17A16.17
 ZN  A 704 (-3.3A)
ZN  A 704 ( 4.3A)
ZN  A 704 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		6lzg ACE2
(Homo
sapiens)		4 / 5
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.53A13.74
None
ZN  A 704 (-3.3A)
None
ZN  A 704 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6lzg ACE2
(Homo
sapiens)		4 / 5
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.51A13.40
None
ZN  A 704 (-3.3A)
None
ZN  A 704 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		6m0j ACE2
(Homo
sapiens)		4 / 5
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.58A13.74
None
ZN  A 901 (-3.5A)
None
ZN  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6m0j ACE2
(Homo
sapiens)		4 / 6
ILE A 407
HIS A 374
GLU A 406
HIS A 378
1.56A13.40
None
ZN  A 901 (-3.5A)
None
ZN  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		6m0j ACE2
(Homo
sapiens)		3 / 3
HIS A 374
GLU A 375
HIS A 378
0.19A16.17
 ZN  A 901 (-3.5A)
ZN  A 901 (-3.9A)
ZN  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		6m18 ACE2
(Homo
sapiens)		3 / 3
HIS D 374
GLU D 375
HIS D 378
0.08A12.50
None
ZN  D 914 (-3.4A)
ZN  D 914 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6m1d ACE2
(Homo
sapiens)		4 / 6
ILE D 407
HIS D 374
GLU D 406
HIS D 378
1.39A12.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		6m1d ACE2
(Homo
sapiens)		4 / 5
ILE D 407
HIS D 374
GLU D 406
HIS D 378
1.40A12.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6m1d ACE2
(Homo
sapiens)		4 / 5
ILE D 407
HIS D 374
GLU D 406
HIS D 378
1.41A12.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		6nur NSP12
(SARSr-CoV)		3 / 3
HIS A 810
GLU A 811
HIS A 816
0.89A13.21
None