Ligand ID: GNT


Drugbank ID:
DB00674
(Galantamine)


Indication:
For the treatment of mild to moderate dementia of the Alzheimer's type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer's disease.

Get human targets for GNT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'GNT' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.57A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.49A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.56A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
GLY A 149
SER A 147
PHE A 112
HIS A 163
1.41A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 138
GLY B   2
SER B   1
PHE B 291
PHE B   3
1.64A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 153
GLY B1124
GLU B1014
SER B1010
PHE A 150
1.69A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B1138
GLY A   2
SER A   1
PHE A 291
PHE A   3
1.62A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B1124
GLU B1014
SER B1010
PHE A 150
1.61A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
GLY B   2
GLY A 138
TYR A 126
GLU A 166
TYR A 118
1.72A21.85
None
None
None
AZP  A 307 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.67A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ASP D 287
GLY D 261
GLY D 260
GLY D 279
PHE D 314
1.61A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 7
TRP A 349
GLN A  42
TYR E 484
TYR A  41
1.50A16.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
ASP F 414
GLY F 418
SER F 500
PHE F 416
PHE F 451
1.73A13.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
GLY A 149
SER A 147
PHE A 112
HIS A 163
1.58A20.00
None
None
None
None
9IN  A1001 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 176
GLY A 149
SER A 147
PHE A 112
HIS A 163
1.60A20.00
None
None
None
None
9IN  A1001 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
GLY A 149
SER A 147
PHE A 112
HIS A 163
1.55A20.00
None
None
None
None
9IN  A1001 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.57A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.55A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
GLY F 285
GLY E 317
SER E 319
PHE E 315
PHE E 316
1.68A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ASP A 106
GLY A  80
GLY A  79
GLY A  98
PHE A 133
1.71A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  80
GLY B  79
GLY B  98
PHE B 133
1.61A15.13
None
None
None
None
APR  B 477 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
GLN B 134
TYR B 137
TYR B 155
ILE B 152
1.70A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ASP A  23
GLY A  29
GLY A  33
GLU B  71
SER B  67
1.19A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASP A  23
GLY A  29
GLY A  33
GLU B  71
SER B  67
1.38A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY P  34
GLY P  35
SER P  33
PHE P  16
TYR P  27
1.31A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ASP G 106
GLY G  34
GLY G  35
SER G  33
PHE G  16
1.52A13.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY P  34
GLY P  35
SER P  33
PHE P  16
TYR P  27
1.30A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ASP U 106
GLY U  34
GLY U  35
SER U  33
PHE U  16
1.61A13.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.68A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.69A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.71A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
GLY A   2
GLY B 138
TYR B 126
SER A   1
TYR B 118
1.57A22.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.66A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.49A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.47A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.42A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.68A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.67A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.70A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2xyq NSP10
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.40A12.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		2xyq NSP10
(SARSr-CoV)		5 / 12
GLY B  34
GLY B  35
SER B  33
PHE B  16
TYR B  27
1.13A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		2xyq NSP10
(SARSr-CoV)		5 / 12
GLY B  34
GLY B  35
SER B  33
PHE B  16
TYR B  27
1.13A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		2xyq NSP10
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.37A12.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		2xyv NSP10
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.39A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		2xyv NSP10
(SARSr-CoV)		5 / 12
GLY B  34
GLY B  35
SER B  33
PHE B  16
TYR B  27
1.12A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		2xyv NSP10
(SARSr-CoV)		5 / 12
GLY B  34
GLY B  35
SER B  33
PHE B  16
TYR B  27
1.12A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		2xyv NSP10
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.42A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		2z9l 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A   2
GLY B 138
TYR B 126
SER A   1
TYR B 118
1.46A21.85
None
None
None
DMS  B 603 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.59A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.58A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.54A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		4 / 7
TYR S 491
GLN S 492
TYR L  94
ILE L  29
1.68A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
TYR L  94
GLN L  90
TYR L  91
ILE H  97
1.59A23.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 12
ASP B  56
GLY A 490
GLY A 391
TYR A 494
PHE A 483
1.77A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 12
TRP C  96
GLY A 488
GLY A 490
TYR A 491
TYR C  91
1.71A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 12
ASP B  56
GLY A 490
GLY A 391
TYR A 494
PHE A 483
1.80A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR E 494
GLN E 492
TYR E 491
ILE E 405
1.69A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP F 414
GLY F 418
SER F 500
PHE F 416
PHE F 451
1.69A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A 521
TYR A 217
TYR A 516
ILE A 513
1.55A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR E 494
GLN E 492
TYR E 491
ILE E 405
1.69A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		3d0h ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY E 490
GLY E 488
GLY A 354
SER E 487
PHE A 356
1.62A15.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
ASP B 225
GLY B 575
TYR B 521
GLU B 571
PHE B 400
1.63A22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3d0h ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASP F 393
GLY F 488
GLY B 354
SER F 487
PHE F 483
1.74A14.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3d0i ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASP E 393
GLY E 488
GLY A 354
SER E 487
PHE E 483
1.76A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASP A 350
GLY A 395
GLY A 561
TYR A 385
PHE A 390
1.76A22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 138
TYR A 126
SER A 139
TYR A 161
PHE A 112
1.66A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.60A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.59A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.56A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 138
GLY A   2
SER A   1
PHE A 291
PHE A   3
1.57A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.67A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.64A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.65A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 283
GLY B   2
PHE B 291
PHE B   3
TYR A 126
1.73A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.68A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_D_GNTD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3i6g HLA, A-2
(Homo
sapiens)		5 / 10
TYR A   7
TYR A  59
THR A 163
TYR A 159
GLN D 155
1.57A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		5 / 10
TRP C   3
GLY C   0
TYR A  99
GLU A  63
PHE A   9
1.76A2.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3i6k HLA, A-2
(Homo
sapiens)		4 / 7
TYR A 118
TYR A  84
TYR A 116
ILE A 124
1.41A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B   2
GLY A 138
TYR A 126
SER B   1
TYR A 118
1.68A21.85
None
None
None
PJE  H   5 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.63A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.56A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.56A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 187
GLY B 143
GLY B 146
SER B 144
HIS B 172
1.68A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.54A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.55A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 187
GLY B 143
GLY B 146
SER B 144
HIS B 172
1.69A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 153
GLY A 124
GLU A  14
SER A  10
PHE B 150
1.51A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 12
GLY B  34
GLY B  35
SER B  33
PHE B  16
TYR B  27
1.28A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 10
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.80A13.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 12
GLY B  34
GLY B  35
SER B  33
PHE B  16
TYR B  27
1.27A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.73A13.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.49A13.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 12
ASP B 106
GLY B  34
GLY B  35
SER B  33
PHE B  16
1.45A13.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3scj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 7
TRP B 349
GLN B  42
TYR F 484
TYR B  41
1.39A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3scj ACE2
(Homo
sapiens)		5 / 12
ASP B 350
GLY B 395
GLY B 561
TYR B 385
PHE B 390
1.73A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP F 414
GLY F 418
SER F 500
PHE F 416
PHE F 451
1.60A14.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR B 521
TYR B 217
TYR B 516
ILE B 513
1.55A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
ASP B 225
GLY B 575
TYR B 521
GLU B 571
PHE B 400
1.67A23.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		3snd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.56A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		3vb6 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.52A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.68A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
ASP A 303
GLY B  76
GLY B  75
GLY A 272
TYR A 265
1.67A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
GLN A 238
TYR A 214
TYR A 311
ILE A 315
1.52A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		4 / 7
GLN B 238
TYR B 214
TYR B 311
ILE B 315
1.51A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 10
ASP A 164
GLY A 248
TYR A 279
SER A 247
HIS A 171
1.48A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 12
ASP A 164
GLY A 248
TYR A 279
SER A 247
HIS A 171
1.50A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 153
GLY B 124
GLU B  14
SER B  10
PHE A 150
1.71A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A   2
GLY B 138
TYR B 126
SER A   1
TYR B 118
1.67A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
GLY D 416
GLY D 417
GLY D 413
SER D 418
HIS D 264
1.64A21.65
None
None
None
None
ZN  D 602 (-2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
ASP D  41
GLY C  70
GLY C  69
SER C  72
PHE D  33
1.69A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
TRP D 385
TYR D 392
SER D 507
PHE D 431
PHE D 436
1.76A21.65
G3A  D 606 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
TRP D 385
TYR D 392
SER D 507
PHE D 431
PHE D 436
1.70A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
TRP D 385
TYR D 392
SER D 507
PHE D 431
PHE D 436
1.67A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		5c8u NSP10
(SARSr-CoV)		5 / 12
ASP A 106
GLY A  34
GLY A  35
SER A  33
PHE A  16
1.30A13.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		5c8u NSP10
(SARSr-CoV)		5 / 12
GLY A  34
GLY A  35
SER A  33
PHE A  16
TYR A  27
1.17A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		5c8u NSP10
(SARSr-CoV)		5 / 12
GLY A  34
GLY A  35
SER A  33
PHE A  16
TYR A  27
1.19A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		5c8u NSP10
(SARSr-CoV)		5 / 12
ASP A 106
GLY A  34
GLY A  35
SER A  33
PHE A  16
1.28A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
GLN A 238
TYR A 214
TYR A 311
ILE A 315
1.59A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ASP O 106
GLY O  34
GLY O  35
SER O  33
PHE O  16
1.34A11.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLY O  34
GLY O  35
SER O  33
PHE O  16
TYR O  27
1.15A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
TRP B 385
TYR B 392
SER B 507
PHE B 431
PHE B 436
1.73A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ASP O 106
GLY O  34
GLY O  35
SER O  33
PHE O  16
1.36A12.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLY O  34
GLY O  35
SER O  33
PHE O  16
TYR O  27
1.16A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
TRP B 385
TYR B 392
SER B 507
PHE B 431
PHE B 436
1.76A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
GLN D 238
TYR D 214
TYR D 311
ILE D 315
1.53A21.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
ASP D 109
GLY D 272
GLY C 154
GLY D 164
TYR D 113
1.31A21.42
None
AYE  C 155 ( 4.7A)
AYE  C 155 (-2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP A  24
GLY A 246
SER A 239
PHE A 137
PHE A  76
1.48A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP A  24
GLY A 246
SER A 239
PHE A 137
PHE A  76
1.52A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5x59 S PROTEIN
(MERS-CoV)		4 / 7
TYR C  58
GLN B 628
TYR C  71
ILE C  69
1.37A9.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY B 780
GLY B 781
PHE B1034
PHE B 909
PHE B 784
1.59A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY A 781
GLY A 780
TYR C 689
PHE A 880
TYR A 899
1.68A17.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY B 780
GLY B 781
PHE B1034
PHE B 909
PHE B 784
1.59A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
GLY A 552
GLY A 551
GLY A 550
SER A 546
SER A 508
1.27A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
GLN A 238
TYR A 214
TYR A 311
ILE A 315
1.53A22.08
None
None
NA  A 402 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 780
GLY B 781
PHE B1034
PHE B 909
PHE B 784
1.47A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 255
GLY C  86
PHE C 103
PHE C  83
PHE C 231
1.74A18.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 780
GLY B 781
PHE B1034
PHE B 909
PHE B 784
1.46A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		6ack ACE2
(Homo
sapiens)		5 / 12
ASP D 225
GLY D 575
TYR D 521
GLU D 571
PHE D 400
1.37A23.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		6ack ACE2
(Homo
sapiens)		5 / 10
ASP D 225
GLY D 575
TYR D 521
GLU D 571
PHE D 400
1.28A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
TRP C1084
GLN A 895
TYR A 899
ILE C1115
1.73A11.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP B 727
GLY A 536
PHE A 527
PHE B 837
PHE A 558
1.74A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 780
GLY A 781
TYR A 778
PHE A 784
TYR C 689
1.56A18.02
None
None
NAG  A1314 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 780
GLY A 781
TYR A 778
PHE A 784
TYR C 689
1.55A18.02
None
None
NAG  A1314 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		6cs2 ACE2
(Homo
sapiens)		5 / 11
ASP D 292
GLY D 422
SER D 420
PHE D 369
HIS D 417
1.48A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ASP D 292
GLY D 422
SER D 420
PHE D 369
HIS D 417
1.51A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6cs2 ACE2
(Homo
sapiens)		4 / 7
TYR D 521
TYR D 217
TYR D 516
ILE D 513
1.68A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		6cs2 ACE2
SPIKE
GLYCOPROTEIN,FIBRITI
N
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLY D 354
GLY B 488
GLU D  37
PHE B 483
TYR B 484
1.63A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		6cs2 ACE2
(Homo
sapiens)		5 / 10
ASP D 295
GLY D 422
SER D 420
PHE D 369
HIS D 417
1.75A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
TRP C1084
GLN A 895
TYR A 899
ILE C1115
1.46A11.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ASP D 292
GLY D 422
SER D 420
PHE D 369
HIS D 417
1.52A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ASP D 292
GLY D 422
SER D 420
PHE D 369
HIS D 417
1.50A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLY B  67
GLY B  66
PHE B  90
PHE B  81
TYR B  48
1.55A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLY B  67
GLY B  66
PHE B  90
PHE B  81
TYR B  48
1.55A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6jyt HELICASE
(SARSr-CoV)		4 / 7
GLN B 270
TYR B 298
TYR B 269
ILE B 304
1.61A17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLY A  67
GLY A  66
TYR A  70
PHE A  81
PHE A  90
1.80A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY C  66
GLY C  67
GLY C  68
TYR C 322
PHE C  58
1.59A22.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY C  66
GLY C  67
GLY C  68
TYR C 322
PHE C  58
1.58A22.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
GLY A  67
GLY A  68
TYR A 322
GLU A 261
HIS A  65
1.67A22.24
None
None
None
NAG  A 703 (-2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
TRP A 176
GLY A 397
PHE A 420
TYR A 139
PHE A 421
1.63A22.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6m18 ACE2
(Homo
sapiens)		4 / 7
TYR B 521
TYR B 217
TYR B 516
ILE B 513
1.61A14.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ASP C 173
TRP C 176
GLY C 395
GLY C 397
PHE C 420
1.68A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY C  66
GLY C  67
GLY C  68
PHE C 255
PHE C  58
1.63A22.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		6m1d ACE2
(Homo
sapiens)		5 / 11
GLY B 561
GLY B 395
TYR B 381
GLU B 564
PHE B 400
1.65A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
GLY B 561
GLY B 395
TYR B 381
GLU B 564
PHE B 400
1.66A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
GLY B 561
GLY B 395
TYR B 381
GLU B 564
PHE B 400
1.68A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
GLN A 883
TYR A 886
TYR B1029
ILE B 891
1.48A10.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 780
GLY C 781
TYR C 778
PHE C 909
PHE C 784
1.78A17.89
None
None
NAG  C1328 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		6nur NSP12
(SARSr-CoV)		5 / 10
ASP A 865
GLY A 839
GLY A 841
TYR A 884
PHE A 859
1.75A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		6nur NSP12
(SARSr-CoV)		5 / 12
ASP A 865
GLY A 839
GLY A 841
TYR A 884
PHE A 859
1.53A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		6nur NSP12
(SARSr-CoV)		5 / 12
ASP A 865
GLY A 839
GLY A 841
TYR A 884
PHE A 859
1.53A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		6nur NSP12
(SARSr-CoV)		5 / 12
ASP A 865
GLY A 839
GLY A 841
TYR A 884
PHE A 859
1.49A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
ASP B 350
GLY B 395
GLY B 561
TYR B 385
PHE B 390
1.74A22.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
TRP H  47
TYR L  27
TYR L  91
ILE H  50
1.64A22.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6xhn 3C-LIKE PROTEINASE
(SARSr)		4 / 7
TRP B 207
GLN B 256
TYR B 209
ILE B 281
1.25A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR L  97
TRP L  56
TYR L  98
ILE L  34
1.77A24.03
None
DMS  L1601 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR C  97
TYR C  31
TYR C 102
ILE B 102
1.66A24.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TRP H  47
TYR L  31
TYR L  97
ILE H  50
1.66A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR C  97
TRP C  56
TYR C  98
ILE C  34
1.74A24.03
None
DMS  A 905 (-4.1A)
DMS  C 303 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TRP H  47
GLN L  27
TYR L  98
ILE H  50
1.73A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TRP B  47
GLN C  27
TYR C  98
ILE B  50
1.74A22.22
None
None
DMS  C 303 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR L  97
TRP L  56
TYR L  98
ILE L  34
1.77A24.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TRP H  47
GLN L  27
TYR L  98
ILE H  50
1.73A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TRP H  47
GLN L  27
TYR L  98
ILE H  50
1.73A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR C  97
TRP C  56
TYR C  98
ILE C  34
1.77A24.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TRP B 109
GLY B  35
GLY B  98
TYR B  32
PHE B  29
1.80A18.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TRP H 109
GLY H  35
GLY H  98
TYR H  32
PHE H  29
1.80A18.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TRP B  47
TYR C  31
TYR C  97
ILE B  50
1.65A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TRP H  47
TYR L  31
TYR L  97
ILE H  50
1.66A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TRP B  47
GLN C  27
TYR C  98
ILE B  50
1.73A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR L  97
TRP L  56
TYR L  98
ILE L  34
1.77A24.03
None