Ligand ID: FVX


Drugbank ID:
DB00176
(Fluvoxamine)


Indication:
Indicated predominantly for the management of depression and for Obsessive Compulsive Disorder (OCD) [FDA Label]. Has also been used in the management of bulimia nervosa [A250].

Get human targets for FVX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'FVX' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 9
ASP A 153
SER A 158
SER B 123
GLY B 124
THR A 292
1.68A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 220
ILE B 259
ALA B 260
THR B 224
ALA B 267
1.26A21.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		6 / 12
LEU A 927
ILE A1160
ALA B 926
THR B 923
ALA C 926
THR C 923
1.69A13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 11
ALA A  49
TYR A  60
PHE A  31
SER A  29
GLY A  27
1.63A10.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		6 / 12
LEU C  27
ILE B  12
ALA E  26
THR E  23
ALA A  26
THR A  23
1.63A7.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
LEU C 235
ILE C 217
ALA C 271
ALA C 238
THR C 239
1.23A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 267
1.29A21.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 292
1.61A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
LEU B 927
ILE D1161
ALA C 926
THR C 923
ALA A 926
THR A 923
1.63A5.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 9
SER L 178
SER H 179
SER H 180
GLY H 139
THR L 115
1.55A15.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA S 406
TYR S 410
PHE S 416
GLY S 400
ASP S 385
1.22A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
LEU A  54
ILE A  36
ALA A  90
ALA A  57
THR A  58
1.23A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA C 140
TYR C 137
GLY C 101
SER C 104
GLY C 143
1.58A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA E 406
TYR E 410
PHE E 416
GLY E 400
ASP E 385
1.27A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
ASN C 479
SER D 163
PHE D 203
SER D 184
SER D 195
1.71A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		2gri NSP3
(SARSr)		5 / 11
VAL A  62
ALA A  61
PHE A  88
SER A  84
ASP A  29
1.33A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		6 / 12
PHE A 329
LEU A 297
ILE A 295
ILE A 305
THR A 192
ALA A 325
1.71A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 9
ASP A  21
SER A  47
PHE A  42
GLY A  41
THR A  26
1.48A11.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		6 / 12
PHE C 329
LEU C 297
ILE C 295
ILE C 305
THR C 321
ALA C 325
1.43A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
ALA A 193
THR A 196
GLY A 138
ALA A 173
THR A 135
1.25A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 267
1.30A21.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 292
1.62A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		6 / 12
PHE B 302
LEU B 331
ILE B 306
ALA B 234
GLY B 246
THR B 340
1.56A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP F 267
ILE D  42
SER F 273
GLY D  13
THR D  33
1.69A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 292
1.73A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		3aw0 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 282
ILE A 281
ALA A 206
GLY A 258
ALA A 211
1.27A21.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 11
ALA S 406
TYR S 410
PHE S 416
GLY S 400
ASP S 385
1.22A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3bgf F26G19 FAB
(Mus
musculus)		5 / 9
ASN C 161
SER B 180
SER B 181
GLY B 141
THR C 114
1.19A15.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 292
1.60A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		3e9s NSP3
(SARSr-CoV)		5 / 11
ALA A 140
TYR A 137
GLY A 101
SER A 104
GLY A 143
1.51A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 267
1.30A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 193
THR A 196
GLY A 138
ALA A 173
THR A 135
1.27A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
VAL A 157
GLY A  11
SER A 113
GLY A 149
ASP A 155
1.44A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 292
1.73A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 216
ALA B 140
GLY A 283
PHE A   3
GLY A   2
1.62A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		3i6l HLA, A-24
(Homo
sapiens)		5 / 11
ASP D 102
VAL D  28
GLY D 100
GLY D 167
ASP D  30
1.59A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 292
1.70A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 220
ILE B 259
ALA B 260
THR B 224
ALA B 267
1.18A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 292
1.55A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 12
ALA A 107
THR A  82
ALA A  79
GLY A  77
ALA B  71
1.30A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3snd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 153
SER A 158
SER B 123
GLY B 124
THR A 292
1.64A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
ALA A 140
TYR A 137
GLY A 101
SER A 104
GLY A 143
1.56A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 11
ALA B 140
TYR B 137
GLY B 101
SER B 104
GLY B 143
1.51A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		6 / 12
PHE A  79
LEU A 133
ILE A 130
ALA A 150
GLY A  12
ALA A 132
1.80A22.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 267
1.28A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 153
SER B 158
SER A 123
GLY A 124
THR B 111
1.64A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA D 140
TYR D 137
GLY D 101
SER D 104
GLY D 143
1.60A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA B 140
TYR B 137
GLY B 101
SER B 104
GLY B 143
1.42A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE B 741
ILE B 724
ILE B 975
GLY A 981
THR B 980
1.25A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ILE A 143
ILE A 300
ALA A  89
ALA A 138
GLY A 128
1.30A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
VAL A 315
TYR A  85
GLY A 115
GLY A 255
ASP A  83
1.65A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
PHE A 185
ALA A 250
ALA A 233
TRP A 101
GLY A 100
ALA A  90
1.69A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
ASP B 518
PHE B 529
SER B 310
GLY B 311
THR B 539
1.71A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ILE A 143
ILE A 300
ALA A  89
ALA A 138
GLY A 128
1.29A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
VAL A 562
GLY A 534
PHE A 527
GLY A 531
ASP A 560
1.62A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		5x5c S PROTEIN
(MERS-CoV)		5 / 11
VAL B 374
ALA B 597
GLY B 615
PHE B 617
GLY B 372
1.47A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
ALA A 140
TYR A 137
GLY A 101
SER A 104
GLY A 143
1.50A22.41
None
None
None
NA  A 405 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ILE B 955
SER C 950
PHE B 952
SER B 957
GLY B 953
1.50A9.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE B 231
LEU B 235
ALA B 251
THR B  92
ALA B  90
1.23A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR B 660
VAL B 642
TYR B 677
SER B 659
ASP B 643
1.29A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASN A 155
ILE A 226
SER A 111
SER A 105
GLY A 104
1.44A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
VAL C 642
ALA C 676
TYR C 677
SER C 659
ASP C 643
1.62A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ILE C 226
PHE C 130
SER C 105
GLY C 104
THR C 160
1.76A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA B 695
ALA C 866
GLY C 862
ALA C 874
THR C 869
1.20A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASN C 692
SER C 690
PHE A 779
GLY A 781
THR A 775
1.40A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASP B 191
ALA A 406
TYR A 410
GLY A 400
ASP A 385
1.35A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU B1045
ILE B 800
ALA B 926
GLY B 928
THR B 706
1.08A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6kl2 NUCLEOPROTEIN
(MERS-CoV)		5 / 11
VAL A 116
ALA A 115
GLY B  76
PHE B 113
ASP A 118
1.38A13.79
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
ASN A  54
SER A 278
PHE A 283
SER A 431
GLY A 434
1.00A32.53
None
None
LEU  A 707 (-3.8A)
LEU  A 707 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
VAL C 125
TYR C 128
TYR C 129
SER C 431
ASP C 486
0.75A27.17
None
None
LEU  C 707 ( 3.9A)
LEU  C 707 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m1d ACE2
(Homo
sapiens)		5 / 9
ASP B 719
ASN B 718
ILE B 704
SER B 721
GLY B 726
1.12A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASN B 692
SER B 690
PHE A 779
GLY A 781
THR A 775
1.55A18.84
NAG  B1326 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL B 642
ALA B 676
TYR B 677
SER B 659
ASP B 643
1.61A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A1045
ILE A 800
ALA A 926
GLY A 928
THR A 706
1.09A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ILE L  21
SER L  25
SER L  70
GLY L  69
THR L 107
1.65A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6nur NSP12
NSP7
(SARSr-CoV)		5 / 11
VAL A 424
ALA A 423
TYR A 420
GLY A 432
ASP C   5
1.65A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 9
ASP A 269
ILE B 106
SER A 325
GLY B 113
THR B 124
1.75A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6vw1 SARS-COV-2 CHIMERIC
RBD
(SARSr)		5 / 11
ALA F 419
TYR F 423
PHE F 429
GLY F 413
ASP F 398
1.22A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6vw1 SARS-COV-2 CHIMERIC
RBD
(SARSr)		5 / 11
ALA E 419
TYR E 423
PHE E 429
GLY E 413
ASP E 398
1.27A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L  62
ILE L  75
ALA L  19
GLY L 101
ALA L  84
1.78A18.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 11
TYR H  90
GLY H  65
SER H  60
GLY H  49
ASP H  86
1.57A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 9
ASP H  54
ILE H  98
SER H  55
GLY H  97
THR L  94
1.65A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 9
ILE H  98
SER H  55
SER H  96
GLY H  95
THR L  94
1.71A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
PHE H  29
ILE H  20
ALA H  93
GLY H  94
ALA H  78
1.71A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 9
ASP L  70
SER L  25
SER L  65
GLY L  64
THR L 102
1.72A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ILE B 102
SER B  56
SER B 100
GLY B  99
THR C 100
1.57A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ILE H 102
SER H  56
SER H 100
GLY H  99
THR L 100
1.53A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 9
ILE C  21
SER C  25
SER C  71
GLY C  70
THR C 108
1.72A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU C  52
THR C  59
ALA C  57
GLY C  72
ALA C  40
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  52
THR L  59
ALA L  57
GLY L  72
ALA L  40
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ASP B  55
ILE B 102
SER B  56
GLY B 101
THR C 100
1.52A15.81
MLI  B 302 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H  66
SER H  61
GLY H  49
ASP H  90
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ASP H  55
ILE H 102
SER H  56
GLY H 101
THR L 100
1.52A15.81
MLI  E 908 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ILE H 102
SER H  56
SER H 100
GLY H  98
THR L 100
1.78A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR B  94
GLY B  66
SER B  61
GLY B  49
ASP B  90
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H  66
SER H  61
GLY H  49
ASP H  90
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  52
THR L  59
ALA L  57
GLY L  72
ALA L  40
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
PHE H  29
ILE H  20
ALA H  97
GLY H  98
ALA H  79
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ILE H 102
SER H  56
SER H 100
GLY H  99
THR L 100
1.60A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 9
ASP H  55
ILE H 102
SER H  56
GLY H 101
THR L 100
1.56A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU L  52
THR L  59
ALA L  57
GLY L  72
ALA L  40
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 9
ILE B 102
SER B  56
SER B 100
GLY B  98
THR C 100
1.77A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 9
ILE H 102
SER H  56
SER H 100
GLY H  99
THR L 100
1.54A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR B  94
GLY B  66
SER B  61
GLY B  49
ASP B  90
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 9
ASP H  55
ILE H 102
SER H  56
GLY H 101
THR L 100
1.52A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 9
ILE H 102
SER H  56
SER H 100
GLY H  98
THR L 100
1.78A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H  66
SER H  61
GLY H  49
ASP H  90
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 9
ASP B  55
ILE B 102
SER B  56
GLY B 101
THR C 100
1.52A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU C  52
THR C  59
ALA C  57
GLY C  72
ALA C  40
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 9
ILE B 102
SER B  56
SER B 100
GLY B  99
THR C 100
1.53A15.81
None