Ligand ID: EVP


Drugbank ID:
DB00773
(Etoposide)


Indication:
For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.

Get human targets for EVP in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'EVP' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		4 / 6
GLU B  36
GLY A  18
ARG A  17
GLY A  16
1.30A12.53
19.27
None
GOL  A5001 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
SER D 247
GLU D 246
GLY D 279
GLY D 261
1.18A17.37
22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 5
GLY H 118
ASP H 117
ARG H 116
MET D  57
1.65A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 4
GLY E 118
ASP E 117
ARG E 116
MET A  57
1.34A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 5
GLY E 118
ASP E 117
ARG E 116
MET A  57
1.38A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 4
GLY E 118
ASP E 117
ARG E 116
MET A  57
1.32A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 5
GLY E 118
ASP E 117
ARG E 116
MET A  57
1.34A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
GLU B  35
GLY F 490
ASP F 392
GLY B 354
1.11A21.81
15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
GLY A 215
ASP A 216
GLN A 299
MET A   6
1.79A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
SER C  66
GLU C  65
GLY C  98
GLY C  80
1.24A17.39
22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ASP C 303
HIS C 276
TYR C 274
ALA C 250
GLY C 272
1.49A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
GLY C 164
ASP C 165
MET A 209
MET A 245
1.75A17.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 5
GLY A  83
ASP A  82
ARG A  88
GLN A  52
1.22A9.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
GLU D 133
ASP C 480
ARG D 162
GLY D 200
1.20A19.75
21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2gz9 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
GLY A 215
ASP A 216
GLN A 299
MET A   6
1.72A17.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 6
SER A 154
GLY A 125
ASP A 124
ARG A 126
1.28A21.21
22.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 6
SER A 154
GLY A 125
ASP A 124
ARG A 126
1.16A20.93
22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		2hsx LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		4 / 5
GLY A  83
ASP A  82
ARG A  88
GLN A  52
1.80A9.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 6
GLU A 254
GLY A 279
ARG A 278
GLY A 285
1.27A13.35
23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
GLY A 577
ASP A 575
ARG A 579
MET A 551
1.54A11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
SER C 154
GLY C 125
ASP C 124
ARG C 126
1.21A21.05
21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
SER D 154
GLY D 125
ASP D 124
ARG D 126
1.16A21.13
21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
GLY A 215
ASP A 216
GLN A 299
MET A   6
1.73A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
SER B 154
GLY B 125
ASP B 124
ARG B 126
1.18A21.29
22.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
SER D 197
GLY F 286
ASP F 282
GLY D 169
1.11A21.41
22.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		2w2g NSP3
(SARSr-CoV)		4 / 5
GLY B 577
ASP B 575
ARG B 579
MET B 551
1.55A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLY B 215
ASP B 216
GLN B 299
MET B   6
1.70A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		4 / 6
SER C  34
GLY A 490
ASP A 392
GLY B  96
1.39A19.48
19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
SER B  76
ASP B 101
ARG B 100
GLY B  96
1.21A18.88
24.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
GLY B 272
ASP B 269
ARG B 273
MET B 123
1.77A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
GLY B 272
ASP B 269
ARG B 273
MET B 123
1.78A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
GLY B 272
ASP B 269
ARG B 273
MET B 123
1.66A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		3d0i ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
SER A  40
GLY E 490
ASP E 392
GLY E 488
1.17A21.51
15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		3e9s NSP3
(SARSr-CoV)		5 / 10
ASP A 303
HIS A 276
TYR A 274
ALA A 250
GLY A 272
1.45A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 248
ALA A 193
GLN A 192
HIS A 164
GLY A 174
1.24A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 197
ARG B 131
CYH B 128
ALA B 129
GLY B 138
1.73A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ASP A 197
ARG A 131
CYH A 128
ALA A 129
GLY A 138
1.67A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3i6k HLA, A-2
(Homo
sapiens)		4 / 6
SER A  88
GLY A  18
ARG A  17
GLY A  16
1.38A18.60
20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3i6l HLA, A-24
(Homo
sapiens)		4 / 6
GLU D 128
GLY D 167
ASP D 166
ARG D 169
1.17A20.68
21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 6
SER A 123
GLU A  14
GLY B   2
ARG B   4
GLY A 138
1.66A20.50
19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3sci ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
GLU B  35
GLY F 490
ASP F 392
GLY B 354
1.13A21.81
15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		3scj ACE2
(Homo
sapiens)		4 / 5
GLY B 272
ASP B 269
ARG B 273
MET B 123
1.59A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
GLU B  35
GLY F 490
ASP F 392
GLY B 354
1.27A21.23
15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
GLU B  35
GLY F 490
ASP F 392
GLY B 354
1.35A22.00
15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
GLY B 272
ASP B 269
ARG B 273
MET B 123
1.74A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
HIS A 417
SER A 545
ALA A 532
GLN A 531
GLY A 537
1.58A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
GLY B 272
ASP B 269
ARG B 273
MET B 123
1.60A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLY A 104
ASP A 106
ARG A 169
GLN A 180
1.60A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		3to2 BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLY A  16
ARG A  14
GLN A  87
MET B   0
1.46A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
ASP A 303
HIS A 276
TYR A 274
ALA A 250
GLY A 272
1.47A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 10
ASP B 303
HIS B 276
TYR B 274
ALA B 250
GLY B 272
1.50A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		4 / 5
ASP B  77
ARG B  83
MET A 244
MET A 245
1.33A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
SER A  85
ASP A  42
ARG A  27
GLY A  31
1.40A19.64
20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
SER B 123
GLU B  14
GLY A   2
GLY B 138
1.30A20.04
18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ASP D 303
HIS D 276
TYR D 274
ALA D 250
GLY D 272
1.48A18.88
None
None
None
None
AYE  E  76 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5e6j POLYUBIQUITIN-B
UBIQUITIN
(synthetic
construct)		4 / 6
SER B  65
GLU B  64
GLY C  75
ASP B  58
1.03A10.53
20.69
None
None
5MW  B  48 ( 2.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		4 / 5
GLY D 164
ASP D 165
ARG E  72
GLN D 175
1.69A17.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		5f22 NSP8
NSP7
(SARSr-CoV)		4 / 5
GLY B 118
ASP B 117
ARG B 116
MET A  57
1.39A10.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		5f22 NSP8
NSP7
(SARSr-CoV)		4 / 4
GLY B 118
ASP B 117
ARG B 116
MET A  57
1.33A10.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5f22 NSP8
NSP7
(SARSr-CoV)		4 / 5
GLY B 118
ASP B 117
ARG B 116
MET A  57
1.34A10.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		5f22 NSP8
NSP7
(SARSr-CoV)		4 / 4
GLY B 118
ASP B 117
ARG B 116
MET A  57
1.31A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ASP B 303
HIS B 276
TYR B 274
ALA B 250
GLY B 272
1.45A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		5x4r S PROTEIN
(MERS-CoV)		4 / 6
SER A 328
GLY A  55
ASP A  54
GLY A 276
1.20A20.25
19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5x4r S PROTEIN
(MERS-CoV)		4 / 5
GLY A 276
ASP A 272
ARG A 269
GLN A 280
1.74A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5x4r S PROTEIN
(MERS-CoV)		4 / 6
SER A 328
GLY A  55
ASP A  54
GLY A 276
1.05A20.53
19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
GLU B 647
GLY C 871
ASP B1023
GLY C 873
1.24A17.66
10.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5x59 S PROTEIN
(MERS-CoV)		4 / 6
SER A 328
GLY A  55
ASP A  54
GLY A 276
1.05A17.04
9.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 10
HIS A1146
TYR A1142
SER B 856
ALA B 851
HIS A1138
1.74A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
ASP A 932
ARG A 996
GLN B 756
MET B 713
1.76A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
GLY C1028
ASP C1023
GLN A1018
MET A 884
1.78A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
ASP B 560
SER B 541
ALA C 834
GLN C 835
GLY B 536
1.64A17.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5x5c S PROTEIN
(MERS-CoV)		4 / 5
GLY B 276
ASP B 272
ARG B 269
GLN B 280
1.77A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		5x5f S PROTEIN
(MERS-CoV)		4 / 6
SER A 328
GLY A  55
ASP A  54
GLY A 276
1.21A16.70
9.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
GLY C 871
ASP A1023
GLN C1018
MET C 884
1.70A21.07
GLY  C 871 ( 0.0A)
ASP  A1023 ( 0.5A)
GLN  C1018 ( 0.6A)
MET  C 884 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER A 516
GLY A 536
ASP A 572
GLY A 534
1.01A17.49
10.03
SER  A 516 ( 0.0A)
GLY  A 536 ( 0.0A)
ASP  A 572 ( 0.6A)
GLY  A 534 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
GLU B 972
GLY B 839
ASP B 719
ARG C 306
1.32A17.69
10.27
GLU  B 972 ( 0.5A)
GLY  B 839 ( 0.0A)
ASP  B 719 ( 0.6A)
ARG  C 306 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER A1019
GLU A1013
ARG C 887
GLY C 890
1.36A17.58
10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6acg ACE2
(Homo
sapiens)		4 / 5
GLY D 272
ASP D 269
ARG D 273
MET D 123
1.66A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		6acj ACE2
(Homo
sapiens)		4 / 5
GLY D 200
ASP D 198
ARG D 219
MET D 579
1.75A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		6acj ACE2
(Homo
sapiens)		4 / 4
GLY D 200
ASP D 198
ARG D 219
MET D 579
1.75A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6ack ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
GLU D 312
GLY C 490
ARG C 426
GLY C 488
1.36A21.45
16.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ASP C 560
SER C 541
ALA A 834
GLN A 835
GLY C 536
1.42A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
SER B1019
GLU B1013
GLY C 871
GLY C1017
1.13A17.60
10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
SER C1019
GLU C1013
GLY A 871
GLY A1017
1.12A17.00
10.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
GLY B  86
ASP B  85
ARG A 449
MET B 107
1.75A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
GLY A1026
ASP A1023
GLN A1018
MET A 884
1.50A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6cs2 ACE2
(Homo
sapiens)		4 / 6
GLU D 150
GLY D 448
ARG D 273
GLY D 272
1.32A21.73
16.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		6cs2 ACE2
(Homo
sapiens)		4 / 5
GLY D 354
ASP D 355
GLN D 380
MET D 408
1.79A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6cs2 ACE2
(Homo
sapiens)		4 / 5
GLY D 352
ASP D 355
GLN D 380
MET D 408
1.80A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6cs2 ACE2
(Homo
sapiens)		4 / 6
GLU D 150
GLY D 448
ARG D 273
GLY D 272
1.17A22.08
15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER A  88
GLY A  18
ARG A  17
GLY A  16
1.38A20.25
21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6jyt HELICASE
(SARSr)		4 / 6
SER A 486
GLY A 206
ASP A 207
GLY A 203
1.20A22.80
16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6jyt HELICASE
(SARSr)		4 / 6
SER B 486
GLY B 206
ASP B 207
GLY B 203
1.05A22.80
16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6jyt HELICASE
(SARSr-CoV)		4 / 6
SER B 486
GLY B 206
ASP B 207
GLY B 203
1.12A22.61
16.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6lzg ACE2
(Homo
sapiens)		4 / 5
GLY A 272
ASP A 269
ARG A 273
MET A 123
1.71A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6m17 ACE2
(Homo
sapiens)		4 / 5
GLY D 272
ASP D 269
ARG D 273
MET D 123
1.69A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		6m18 ACE2
(Homo
sapiens)		4 / 5
GLY D 272
ASP D 269
ARG D 273
MET D 123
1.78A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6m18 ACE2
(Homo
sapiens)		4 / 6
SER D 167
GLU D 171
GLY D 272
ASP D 269
1.36A21.15
12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		6m18 ACE2
(Homo
sapiens)		4 / 4
GLY D 272
ASP D 269
ARG D 273
MET D 123
1.78A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		6m18 ACE2
(Homo
sapiens)		5 / 10
HIS D 417
SER D 545
ALA D 532
GLN D 531
GLY D 537
1.50A21.35
NAG  D 910 ( 4.6A)
NAG  D 910 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
SER A  64
GLU A 261
GLY A 397
GLY A 395
1.30A20.78
14.00
None
NAG  A 703 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
SER A 134
GLY A 395
ASP A 486
GLY A 397
1.37A20.83
14.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6m1d ACE2
(Homo
sapiens)		4 / 6
GLU B 227
ASP B 609
ARG B 482
GLY B 486
1.37A20.87
13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 5
GLY L  62
ASP L  60
ARG L  59
GLN L  42
1.77A12.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		6nur NSP7
NSP8
(SARSr-CoV)		4 / 4
GLY D 113
ASP D 112
ARG D 111
MET C  52
1.50A13.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		6nur NSP7
NSP8
(SARSr-CoV)		4 / 5
GLY D 113
ASP D 112
ARG D 111
MET C  52
1.57A13.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6nur NSP7
NSP8
(SARSr-CoV)		4 / 5
GLY D 113
ASP D 112
ARG D 111
MET C  52
1.53A13.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		6nur NSP12
(SARSr-CoV)		4 / 5
ASP A 235
ARG A 735
MET A 463
MET A 629
1.56A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		6nus NSP12
NSP8
(SARSr-CoV)		4 / 4
GLY A 683
ASP A 684
ARG A 569
MET B  87
1.69A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
SER E 494
GLY A 354
ASP A 355
GLY E 504
1.27A17.21
17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
SER L  26
GLY L 101
ASP L   9
GLY L  99
1.76A16.53
20.71
None
None
SO4  L 303 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
SER L  26
GLY L 101
ASP L   9
GLY L  99
1.80A16.53
20.71
None
None
SO4  L 303 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  94
GLY H  35
1.19A14.14
20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  94
GLY H  35
1.47A14.14
20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  94
GLY H  35
1.19A14.14
20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  94
GLY H  35
1.60A13.87
20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  94
GLY H  35
1.52A14.14
20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER C  62
GLU C  61
GLY H 101
GLY H  98
1.71A
MLI  B 303 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER C  62
GLU C  61
GLY H 101
GLY H  99
1.45A
MLI  B 303 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER C  99
GLY B  98
ASP B 107
GLY B  35
1.79A
DMS  C 303 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B  17
GLU B  16
ASP B  73
GLY H 161
1.68A
None
DMS  H 302 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  99
ASP H 107
GLY H  35
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  99
ASP H 107
GLY H  35
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  98
ASP H 107
GLY H  35
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  98
ASP H 107
GLY H  35
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER C  99
GLY B  99
ASP B 107
GLY B  35
1.79A
DMS  C 303 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  62
GLU L  61
GLY B 101
GLY B  99
1.47A
MLI  B 303 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  62
GLU L  61
GLY B 101
GLY B  98
1.72A
MLI  B 303 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER C  62
GLU C  61
GLY H 101
GLY H  99
1.49A
MLI  B 303 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  62
GLU L  61
GLY B 101
GLY B  99
1.51A
MLI  B 303 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  98
ASP H 107
GLY H  35
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  98
ASP H 107
GLY H  35
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
SER C  99
GLY B  98
ASP B 107
GLY B  35
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
GLU B  46
GLY B  99
ASP B 107
GLY B  98
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
SER C  99
GLY B  98
ASP B 107
GLY B  35
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
GLU H  46
GLY H  99
ASP H 107
GLY H  98
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  98
ASP H 107
GLY H  35
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  98
ASP H 107
GLY H  35
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
SER C  99
GLY B  99
ASP B 107
GLY B  35
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER H   7
GLU H  10
GLY H  98
GLY H  35
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
GLU B  46
GLY B  99
ASP B 107
GLY B  98
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
GLU B  46
GLY B  99
ASP B 107
GLY B  98
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER B   7
GLU B  10
GLY B  98
GLY B  35
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
SER L  99
GLY H  99
ASP H 107
GLY H  35
1.79A
None