Ligand ID: EU7


Drugbank ID:
DB00478
(Rimantadine)


Indication:
For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults.

Get human targets for EU7 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'EU7' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A   7
SER A 113
VAL A  13
VAL A 148
GLY A 124
1.52A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA B1007
SER B1113
VAL B1013
VAL B1148
GLY B1124
1.58A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 9
ALA D 209
VAL D 216
ALA D 271
VAL D 218
GLY D 267
1.54A10.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		2ajf ACE2
(Homo
sapiens)		5 / 9
SER B 128
ALA B 501
SER B 507
SER B 502
GLY B 173
1.59A4.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		4 / 6
SER A 144
SER A 121
ALA A 116
SER A 123
1.43A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 9
ALA F 274
GLY F 296
ALA E 314
GLY E 317
SER E 311
1.28A10.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 9
SER L  30
VAL L  33
ALA L  71
VAL L  90
GLY L  24
1.65A6.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
ALA A  28
VAL A  35
ALA A  90
VAL A  37
GLY A  86
1.53A10.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
SER T  15
SER W  15
ALA N  18
ALA T  18
1.27A11.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
ALA B 306
ALA A 314
SER A 313
GLY A 317
SER A 311
1.51A12.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 9
SER A 144
SER A 139
GLY A 138
SER B   1
GLY A 170
1.52A6.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		2wct NSP3
(SARSr-CoV)		5 / 9
ALA C 493
ALA C 464
GLY B 465
SER C 461
GLY C 466
1.08A6.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
ALA A 107
ALA B  71
SER A 105
GLY B  94
GLY B  69
1.53A6.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
ALA A 107
ALA B  71
SER A 105
GLY B  94
GLY B  69
1.51A6.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
SER L  72
SER L  63
ALA L  51
SER L  52
1.22A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
SER A 545
SER A 411
ALA A 533
VAL A 318
SER A 547
1.46A4.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
SER B 411
SER B 545
ALA B 550
SER B 547
1.40A4.24
None
NDG  B 619 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
SER B 411
SER B 545
ALA B 550
SER B 547
GLY B 551
1.56A4.24
None
NDG  B 619 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
SER B 121
ALA B 116
SER B 123
SER B 144
GLY B  29
1.64A6.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
ALA A 107
VAL A 104
ALA A  79
SER A 105
GLY A  73
1.66A5.81
None
None
None
None
SAM  A 302 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 9
ALA A 107
ALA B  71
SER A 105
GLY B  94
GLY B  69
1.48A5.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 6
SER A  98
ALA A 107
ALA A  79
SER A 105
1.42A5.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		3sci ACE2
(Homo
sapiens)		4 / 6
SER A  43
ALA A  71
SER A  70
ALA A  65
1.23A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		3scj ACE2
(Homo
sapiens)		5 / 9
SER B 545
SER B 411
ALA B 533
VAL B 318
SER B 547
1.50A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
SER B 545
SER B 411
ALA B 533
VAL B 318
SER B 547
1.52A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
SER A 411
SER A 545
ALA A 550
SER A 547
1.37A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 9
ALA B 250
ALA B 247
VAL B 304
SER B 246
GLY B 210
1.57A5.96
None
P85  A 902 ( 4.6A)
None
None
P85  A 902 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA B 145
SER B 144
VAL B 148
VAL B 114
GLY B 174
1.68A5.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 9
ALA C   1
SER C   0
GLY C  -1
ALA C   4
GLY D   6
1.41A10.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ALA A 250
ALA A 247
VAL A 304
SER A 246
GLY A 210
1.62A5.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ALA B 250
ALA B 247
VAL B 304
SER B 246
GLY B 210
1.60A6.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		5x4r S PROTEIN
(MERS-CoV)		5 / 9
SER A 133
SER A 135
ALA A 138
SER A 137
GLY A 128
1.38A6.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
SER C 685
ALA A 866
GLY A 862
ALA A 874
GLY A 871
1.57A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
SER C  95
SER C 173
ALA C 250
SER C 248
1.36A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		5x5c S PROTEIN
(MERS-CoV)		5 / 9
SER A 133
SER A 135
ALA A 138
SER A 137
GLY A 128
1.38A2.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
SER A 133
SER A 135
ALA A 138
SER A 137
1.45A2.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		5x5f S PROTEIN
(MERS-CoV)		5 / 9
SER C1091
ALA C1096
SER C1095
SER C 845
SER C1089
1.54A2.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		6acg ACE2
(Homo
sapiens)		5 / 9
SER D 545
ALA D 550
SER D 547
GLY D 319
SER D 411
1.46A5.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER C 964
ALA C 954
SER C 956
ALA C 971
1.37A1.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA C 590
GLY C 587
ALA C 658
GLY C 298
SER C 659
1.39A1.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
SER B 701
GLY B1028
ALA C 874
GLY C 873
SER B1052
1.37A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
SER B 686
ALA C 858
ALA C 864
SER C 861
1.37A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
SER B 685
ALA C 866
GLY C 862
ALA C 874
GLY C 871
1.46A1.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		6lzg ACE2
(Homo
sapiens)		5 / 9
SER A 545
SER A 411
ALA A 533
VAL A 318
SER A 547
1.53A4.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		6m18 ACE2
(Homo
sapiens)		4 / 6
SER D 411
SER D 545
ALA D 550
SER D 547
1.39A2.75
None
NAG  D 910 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER B 659
SER B 673
ALA B 639
ALA B 658
1.40A1.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 9
SER H 187
SER H 132
GLY H 133
ALA H 136
SER H 130
1.71A7.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H 187
SER H 132
ALA H 136
SER H 130
1.68A7.43
None