Ligand ID: EF2


Drugbank ID:
DB01041
(Thalidomide)


Indication:
For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.

Get human targets for EF2 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'EF2' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 7
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.69A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 7
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.74A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 7
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.78A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 8
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.72A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 7
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.71A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 7
ASN A  66
PRO C   4
PHE C   3
PHE A  22
1.74A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 7
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.72A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
TRP B  94
PHE B  96
THR C 201
TRP B 107
1.73A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
THR C 201
TRP B 107
TRP B  94
PHE B  96
1.71A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
TRP B  94
PHE B  96
THR C 201
TRP B 107
1.71A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		2fyg REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
PRO A 107
PHE A  68
SER A  67
TRP A 123
1.60A23.70
GOL  A 301 ( 4.7A)
GOL  A 301 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
PRO O 107
PHE O  68
SER O  67
TRP O 123
1.49A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN E 457
PRO E 477
PHE E 460
TRP E 476
1.79A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
TYR A 484
THR A 487
TRP B  47
TRP B 226
1.71A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
PRO B 191
PHE B 194
SER B 195
TYR A 475
1.74A19.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 8
ASN A  49
PRO A 152
SER A  52
TYR A 112
1.69A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
HIS E  14
TRP E  58
PHE E  55
THR D 281
1.70A14.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
THR D 281
HIS E  14
TRP E  58
PHE E  55
1.72A14.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
HIS E  14
TRP E  58
PHE E  55
THR D 281
1.73A14.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		2xyq NSP10
(SARSr-CoV)		4 / 8
PRO B 107
PHE B  68
SER B  67
TRP B 123
1.55A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
THR A  93
HIS A  69
TRP A 124
PHE A 156
1.76A15.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
THR A  93
HIS A  69
TRP A 124
PHE A 156
1.73A15.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		2xyv NSP10
(SARSr-CoV)		4 / 8
PRO B 107
PHE B  68
SER B  67
TRP B 123
1.60A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.60A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.67A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ASN A 473
PRO A 462
PHE A 460
TYR S 442
1.61A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.66A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.55A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 8
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.71A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.69A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		3r24 NSP10 AND NSP11
(SARSr-CoV)		4 / 8
PRO B 107
PHE B  68
SER B  67
TRP B 123
1.62A24.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
THR A  93
HIS A  69
TRP A 124
PHE A 156
1.76A16.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A 116
THR A 143
HIS A 114
PHE A  22
1.68A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
PRO B 393
PHE B 384
TRP B 509
PHE B 431
1.67A12.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		5c8t NSP10
(SARSr-CoV)		4 / 8
PRO A 107
PHE A  68
SER A  67
TRP A 123
1.60A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
PRO D 393
PHE D 384
TRP D 509
PHE D 431
1.61A11.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
PRO C 393
PHE C 384
TRP C 509
PHE C 431
1.51A12.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
PRO M 107
PHE M  68
SER M  67
TRP M 123
1.70A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ASN A  78
PRO A  79
PHE A  76
PHE A  69
1.34A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
ASN C  78
PRO C  79
PHE C  76
PHE C  69
1.44A8.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		5x59 S PROTEIN
(MERS-CoV)		4 / 7
ASN B1132
PRO B1131
PHE B 895
TYR B 905
1.77A7.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
ASN C  73
PHE C 238
SER C 239
TRP C 245
1.64A8.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PRO A1094
PHE A1057
PHE A1085
TRP A1084
1.43A8.08
PRO  A1094 ( 1.1A)
PHE  A1057 ( 1.3A)
PHE  A1085 ( 1.3A)
TRP  A1084 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN B1090
PRO B1051
TRP A 868
TYR A 886
1.70A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN B1090
PRO B1051
TRP A 868
TYR A 886
1.72A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN B1090
PRO B1051
TRP A 868
TYR A 886
1.68A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN B1090
PRO B1051
TRP A 868
TYR A 886
1.68A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PRO A1094
PHE A1057
PHE A1085
TRP A1084
1.35A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN B1090
PRO B1051
TRP A 868
TYR A 886
1.71A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PRO B1094
PHE B1085
SER B1083
TRP B1084
1.39A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ASN C  78
PRO C  79
PHE C  76
PHE C  69
1.54A8.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ASN B  29
PRO B  28
PHE B  69
PHE B 179
1.67A7.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ASN A 457
PRO A 477
PHE A 460
TRP A 476
1.76A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ASN C 381
PHE C 501
SER C 500
TYR C 410
1.59A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ASN C  78
PRO C  79
PHE C  76
PHE C  69
1.46A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
THR A 134
HIS A 113
TRP B  60
PHE B  56
1.69A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.71A13.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.75A13.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		6nur NSP12
NSP8
(SARSr-CoV)		4 / 8
ASN B 118
PRO A 328
PHE A 396
TYR A 453
1.65A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		6nus NSP12
(SARSr-CoV)		4 / 8
PRO A 322
PHE A 396
PHE A 275
TYR A 346
1.44A8.74
None