Ligand ID: DSM


Drugbank ID:
DB01151
(Desipramine)


Indication:
For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management.

Get human targets for DSM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'DSM' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B  94
LEU B  42
ILE B  91
ALA B  30
LEU B  69
1.49A12.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 12
LEU B  23
VAL B   9
ILE B  46
ALA B  79
ASP B  38
1.50A11.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1271
LEU B1272
VAL B1233
ALA B1234
LEU B1205
1.40A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU F  26
ILE A  16
PHE A   9
ALA C  12
LEU B  26
1.51A6.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C  27
LEU C  24
ARG C  26
ILE B  23
LEU A  20
1.43A5.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C  27
LEU C  24
ARG C  26
ILE B  23
LEU A  20
1.42A5.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		2ajf ACE2
(Homo
sapiens)		5 / 12
LEU B 558
LEU B 554
ALA B 528
PHE B 525
LEU B 570
1.36A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		2ajf ACE2
(Homo
sapiens)		5 / 11
LEU B 558
LEU B 554
ALA B 528
PHE B 525
LEU B 570
1.38A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
LEU D 354
ILE D 305
LEU D 292
ASP D 291
ASP D 289
1.51A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU C 151
GLN C 175
ALA C 177
PHE C 128
LEU C 121
1.27A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU C 151
GLN C 175
ALA C 177
PHE C 128
LEU C 121
1.28A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
LEU A 292
GLN A 290
ILE A 305
PHE A 287
LEU A 354
1.44A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
LEU A 292
GLN A 290
ILE A 305
PHE A 287
LEU A 354
1.45A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		2gri NSP3
(SARSr)		5 / 12
LEU A  36
VAL A  63
ILE A  24
ALA A  59
LEU A  90
1.41A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU A 265
LEU A 254
ILE A 280
LEU A 245
ASP A 282
1.48A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
LEU A 265
LEU A 254
ILE A 280
LEU A 245
ASP A 282
1.48A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 7
SER B 319
PHE B 316
ILE A 305
PHE A 308
1.31A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
ILE A 556
PHE A 582
ILE A 567
PHE A 580
1.33A12.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE C 322
PHE C 329
ILE C 235
PHE C 302
1.31A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE E 295
PHE E 302
ILE E 306
PHE E 341
1.44A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		6 / 12
LEU A  50
VAL A   9
GLN A   6
ILE A 207
ALA A  10
LEU A  57
1.77A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A 161
GLN A 159
ILE A 167
LEU A 180
ASP A 179
1.17A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.50A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		3e9s NSP3
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.25A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		3e9s NSP3
(SARSr-CoV)		5 / 12
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.21A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 106
LEU A  45
PHE A  90
ALA A  30
LEU A   9
1.52A13.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		3i6k BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 12
LEU B  23
VAL B   9
ILE B  46
ALA B  79
ASP B  38
1.47A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		3i6k HLA, A-2
(Homo
sapiens)		4 / 7
SER E  42
ARG E  35
PHE E  36
ILE E  23
1.39A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 271
LEU B 272
VAL B 233
ALA B 234
LEU D 205
1.44A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		6 / 12
LEU A  50
VAL A   9
GLN A   6
ILE A 207
ALA A  10
LEU A  57
1.80A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		3scj ACE2
(Homo
sapiens)		5 / 12
LEU B 558
LEU B 554
ALA B 528
PHE B 525
LEU B 570
1.37A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		3scj ACE2
(Homo
sapiens)		5 / 11
LEU B 558
LEU B 554
ALA B 528
PHE B 525
LEU B 570
1.39A21.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		3scj ACE2
(Homo
sapiens)		4 / 7
ILE A 421
SER A 420
ILE A 544
PHE A 314
1.42A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.20A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.17A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 151
GLN B 175
ALA B 177
PHE B 128
LEU B 121
1.19A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 151
GLN B 175
ALA B 177
PHE B 128
LEU B 121
1.23A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 12
LEU A 113
ILE A 152
ALA A 115
LEU A 120
ASP A 121
1.44A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
ARG D 163
PHE D 198
ILE D 166
PHE D  89
1.37A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
ARG D 163
PHE D 198
ILE D 166
PHE D  89
1.23A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU D 151
GLN D 175
ALA D 177
PHE D 128
LEU D 121
1.21A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D 151
GLN D 175
ALA D 177
PHE D 128
LEU D 121
1.20A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
ARG B 163
PHE B 198
ILE B 166
PHE B  89
1.27A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 151
GLN B 175
ALA B 177
PHE B 128
LEU B 121
1.21A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU B 151
GLN B 175
ALA B 177
PHE B 128
LEU B 121
1.23A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
GLN C  60
ILE C  56
PHE C 279
PHE C  75
LEU C 325
1.42A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLN C  60
ILE C  56
PHE C 279
PHE C  75
LEU C 325
1.45A17.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.20A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.23A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
LEU c  32
ILE C 916
PHE C 909
ALA B 912
LEU b  32
1.49A5.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 11
LEU b  32
ILE B 916
PHE B 909
ALA A 912
LEU a  32
1.44A5.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 905
ARG B 887
PHE B 888
ILE B 891
1.04A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 510
PHE B 501
ALA B 350
PHE B 325
LEU B 355
1.33A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN A 550
ILE A 573
PHE A 529
LEU A 571
ASP A 564
1.49A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ILE C 955
SER C 956
ARG C 982
ILE C 979
1.26A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU C 597
GLN C 301
ILE C 652
LEU A 846
ASP A 757
1.50A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6jyt HELICASE
(SARSr-CoV)		4 / 7
ILE A 525
ARG A 595
ILE A 575
PHE A 511
1.29A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6lzg ACE2
(Homo
sapiens)		4 / 7
ILE A 421
SER A 420
ILE A 544
PHE A 314
1.37A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		6m17 ACE2
(Homo
sapiens)		5 / 11
LEU D 418
LEU D 424
ILE D 291
PHE D 428
ASP D 431
1.48A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  52
VAL A  55
PHE A 277
LEU A 482
ASP A 486
1.01A26.79
None
None
LEU  A 707 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 11
LEU C  52
ARG C  57
ILE C 132
PHE C 277
LEU C 482
ASP C 486
1.05A26.62
None
None
None
LEU  C 707 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		6m17 ACE2
(Homo
sapiens)		5 / 12
LEU B 558
LEU B 554
ALA B 528
PHE B 525
LEU B 570
1.53A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
ILE C 287
SER C 291
ARG C  97
ILE C  15
1.35A26.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6m18 ACE2
(Homo
sapiens)		4 / 7
ILE D 704
ARG D 697
PHE D 683
PHE D 643
1.25A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE C 905
ARG C 887
PHE C 888
ILE C 891
1.37A17.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 12
LEU C  56
VAL C  66
GLN C  63
ILE D 107
ASP D 112
1.50A10.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6nur NSP12
(SARSr)		4 / 7
ILE A 632
SER A 635
ARG A 654
PHE A 348
1.21A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		6nus NSP12
(SARSr-CoV)		5 / 11
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.46A20.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		6nus NSP12
(SARSr-CoV)		5 / 12
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.46A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE H  51
SER H  71
ILE H  76
PHE H  29
1.74A
None