 |
| Ligand ID: DP0 Drugbank ID: DB00280(Disopyramide) Indication:For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug. |
| DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 1uj1 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | PHE A 150VAL A 13PHE B 150ALA A 7SER A 113 | 1.72A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 1uj1 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | VAL A 125PHE A 291PHE A 3ARG A 298PHE B 140 | 1.57A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2a5k | 3C-LIKE PEPTIDASE (SARSr-CoV) | 5 / 12 | PHE A 150VAL A 13PHE B 150ALA A 7SER A 113 | 1.72A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2ajf | SPIKE PROTEIN (SARSr-CoV) | 5 / 12 | VAL F 382ILE F 345PHE F 364LEU F 421TYR F 352 | 1.63A | 19.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2ajf | SPIKE PROTEIN (SARSr-CoV) | 5 / 12 | PHE E 501VAL E 382ILE E 345PHE E 329PHE E 361 | 1.65A | 19.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2amd | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | PHE A 150VAL A 13PHE B 150ALA A 7SER A 113 | 1.72A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2d2d | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | VAL A 125PHE A 291PHE A 3ARG A 298ALA B 116 | 1.67A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2ghw | SPIKE GLYCOPROTEIN (SARSr-CoV) | 5 / 12 | VAL C 394ILE C 397PHE C 329PHE C 360SER C 362 | 1.67A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2k87 | NSP3 OF REPLICASEPOLYPROTEIN 1A (SARSr) | 5 / 12 | PHE A 74ILE A 7GLU A 4SER A 73TYR A 2 | 1.30A | 21.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2ofz | NUCLEOCAPSID PROTEIN (SARS-COVTor2) | 5 / 12 | ILE A 75PHE A 111ALA A 139SER A 79TYR A 113 | 1.55A | 18.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2ofz | NUCLEOCAPSID PROTEIN (SARS-COVTor2) | 5 / 12 | ILE A 75PHE A 111ALA A 139SER A 79TYR A 113 | 1.57A | 18.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2q6g | REPLICASEPOLYPROTEIN 1AB (SARS-COVBJ01) | 5 / 12 | ILE B 106PHE B 291GLN B 110ARG B 298ALA B 7 | 1.58A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2q6g | REPLICASEPOLYPROTEIN 1AB (SARS-COVBJ01) | 5 / 12 | PHE A 150PHE B 150ALA A 7SER A 113SER A 10 | 1.73A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2qc2 | 3C-LIKE PROTEINASE (-) | 5 / 12 | VAL A 13LEU B 115GLU B 14ALA B 7SER A 113 | 1.61A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2rhb | URIDYLATE-SPECIFICENDORIBONUCLEASE (SARSr-CoV) | 5 / 12 | PHE A 43VAL A 51ILE E 26GLU E 3ALA A 59 | 1.58A | 20.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 2vj1 | MAIN PROTEINASE (SARSr-CoV) | 5 / 12 | PHE A 112GLU A 290PHE A 140SER A 139TYR A 126 | 1.68A | 22.73 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3aw1 | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | PHE A 150VAL A 13PHE B 150ALA A 7SER A 113 | 1.72A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3bgf | F26G19 FAB (Musmusculus) | 5 / 12 | TYR C 91ILE C 2GLU C 28ALA C 50TYR C 71 | 1.52A | 21.52 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3bgf | SPIKE PROTEIN S1 (SARSr-CoV) | 5 / 12 | PHE A 329VAL A 497PHE A 501PHE A 379ALA A 350 | 1.66A | 19.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3f9f | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | PHE B 150VAL B 13PHE A 150ALA B 7SER B 113 | 1.70A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3f9g | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | VAL B 125PHE B 291PHE B 3ARG B 298ALA A 116 | 1.56A | 21.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3m3v | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | VAL A 125PHE A 291PHE A 3ARG A 298ALA B 116 | 1.63A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3m3v | 3C-LIKE PROTEINASE (SARSr-CoV) | 5 / 12 | PHE B 150VAL B 13PHE A 150ALA B 7SER B 113 | 1.71A | 20.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3scj | SPIKE GLYCOPROTEIN (SARSr-CoV) | 5 / 12 | VAL E 382ILE E 345PHE E 364LEU E 421TYR E 352 | 1.54A | 21.76 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 3sck | SPIKE GLYCOPROTEIN (SARSr-CoV) | 5 / 12 | VAL E 382ILE E 345PHE E 364LEU E 421TYR E 352 | 1.67A | 22.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 4m0w | REPLICASEPOLYPROTEIN 1A (SARSr-CoV) | 5 / 12 | VAL A 206PHE A 128PHE A 148GLN A 175ALA A 120 | 1.65A | 22.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5c8s | GUANINE-N7METHYLTRANSFERASE (SARSr-CoV) | 5 / 12 | TYR B 498VAL B 316ILE B 397PHE B 436PHE B 431 | 1.67A | 16.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5c8u | GUANINE-N7METHYLTRANSFERASE (SARSr-CoV) | 5 / 12 | VAL B 199ILE B 201GLU B 204ARG B 213ALA B 85 | 1.33A | 16.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5c8u | GUANINE-N7METHYLTRANSFERASE (SARSr-CoV) | 5 / 12 | PHE B 183VAL B 199ILE B 201GLU B 204ALA B 85 | 1.58A | 16.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5nfy | POLYPROTEIN 1AB (SARS-COVFrankfurt1) | 5 / 12 | VAL A 269PHE A 89PHE A 198GLU A 191ALA A 119 | 1.66A | 15.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5nfy | POLYPROTEIN 1AB (SARS-COVFrankfurt1) | 5 / 12 | VAL D 199ILE D 201GLU D 204ARG D 213ALA D 85 | 1.43A | 15.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5tl6 | REPLICASEPOLYPROTEIN 1AB (SARSr-CoV) | 5 / 12 | VAL D 206PHE D 128PHE D 148GLN D 175ALA D 120 | 1.66A | 20.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | TYR A 87VAL A 102ILE A 35PHE A 164ALA A 146 | 1.38A | 18.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | VAL A 263ILE A 290PHE A 228LEU A 187PHE A 183 | 1.54A | 18.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5x58 | SPIKE GLYCOPROTEIN (SARS-COVBJ01) | 5 / 12 | PHE C 187VAL C 196ILE C 219PHE C 168ALA C 91 | 1.59A | 9.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5x59 | S PROTEIN (MERS-CoV) | 5 / 12 | TYR A 87VAL A 102ILE A 35PHE A 164ALA A 146 | 1.36A | 8.97 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5x5b | SPIKE GLYCOPROTEIN (SARS-COVBJ01) | 5 / 12 | PHE C 880PHE C 784GLN C 902ALA C 912PHE C 909 | 1.67A | 9.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5x5f | S PROTEIN (MERS-CoV) | 5 / 12 | ILE B1165ALA C 969PHE B 778SER B1151TYR B1153 | 1.44A | 8.97 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5xlr | SPIKE GLYCOPROTEIN (SARSr-CoV) | 5 / 12 | ILE B 878PHE B 888LEU B1031GLN B 883ALA B 906 | 1.61A | 9.98 | ILE B 878 ( 0.6A)PHE B 888 ( 1.3A)LEU B1031 ( 0.6A)GLN B 883 ( 0.6A)ALA B 906 ( 0.0A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 5y3q | REPLICASEPOLYPROTEIN 1A (SARSr-CoV) | 5 / 12 | VAL A 206PHE A 128PHE A 148GLN A 175ALA A 120 | 1.66A | 22.15 | NoneNoneNoneNone NA A 404 ( 3.8A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6acd | SPIKE GLYCOPROTEIN (SARSr-CoV) | 5 / 12 | TYR B1049PHE B1091VAL B 893ILE B 891PHE B 782 | 1.47A | 9.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6acg | SPIKE GLYCOPROTEIN (SARSr-CoV) | 5 / 12 | VAL B 893ILE B 891PHE B1034GLN B1018PHE B 909 | 1.27A | 9.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6cs0 | SPIKEGLYCOPROTEIN,FIBRITIN (SARSr-CoV) | 5 / 12 | ILE B 891PHE B1034GLN B1018ALA B 906PHE B 909 | 1.34A | 9.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6cs1 | SPIKEGLYCOPROTEIN,FIBRITIN (SARSr-CoV) | 5 / 12 | PHE B 545ILE C 46PHE B 558PHE C 837SER B 541 | 1.21A | 9.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6jyt | HELICASE (SARSr-CoV) | 5 / 12 | ILE A 376LEU A 417ARG A 409ALA A 123SER A 424 | 1.47A | 14.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_A_DP0A190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6m0j | ACE2 (Homosapiens) | 5 / 12 | TYR A 587PHE A 438ILE A 446GLU A 406ALA A 412 | 1.66A | 14.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6m17 | SODIUM-DEPENDENTNEUTRAL AMINO ACIDTRANSPORTER B(0)AT1 (Homosapiens) | 5 / 12 | ILE C 309PHE C 74LEU C 75ALA C 318PHE C 58 | 1.52A | 12.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6nb6 | SPIKE GLYCOPROTEIN (SARSr-CoV) | 5 / 12 | VAL A 382ILE A 345PHE A 329PHE A 361ALA A 371 | 1.65A | 9.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3APW_B_DP0B190_1 (ALPHA-1-ACIDGLYCOPROTEIN 2) | 6nb8 | S230 ANTIGEN-BINDING(FAB) FRAGMENT,LIGHT CHAIN (Homosapiens) | 5 / 12 | VAL L 13ILE L 111GLU L 86ARG L 66TYR L 91 | 1.47A | 19.47 | None |