Ligand ID: DM2


Drugbank ID:
DB00445
(Epirubicin)
DB00997
(Doxorubicin)


Indication:
For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.;Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

Get human targets for DM2 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'DM2' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 11
PHE B   3
THR B 111
GLY B 109
ASP B 289
GLN B 110
1.68A15.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 8
SER B 113
ILE A 152
VAL A 157
PHE A 150
1.17A15.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU A  88
PHE A  90
GLU A  70
VAL A 102
ASN A  98
1.79A16.20
14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.59A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
LEU A 202
THR A 111
ALA A 129
GLN A 127
1.55A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
VAL A 212
GLN A 299
PHE A   3
VAL A 296
TRP A 207
1.50A21.70
7.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 299
PHE B 140
GLY A 283
GLU A 288
ILE A 281
1.57A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1uw7 NSP9
(SARS-COV
HKU-39849)		5 / 9
LEU A  88
PHE A  90
GLU A  70
VAL A 102
ASN A  98
1.64A19.41
15.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL B1158
GLN C 931
ASN C1159
LEU A 930
VAL B 933
1.67A17.59
13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.60A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
PHE B 298
GLY B 260
GLY B 261
ASN B 297
ILE B 223
1.58A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
GLN C 323
ASN C 353
LEU C 308
SER C 310
VAL C 346
1.32A20.11
10.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
GLY C 260
GLY C 261
ASN C 297
ILE C 223
PHE C 298
1.57A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 11
VAL C  21
ASN C  74
LEU G  96
PHE G  97
VAL C  71
1.66A12.57
20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 9
GLN E 163
LEU E 174
SER E 175
GLU E 176
VAL E 191
1.77A21.08
12.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 11
ASN G 123
LEU G 122
THR G 192
ALA G 193
GLN G 162
1.59A11.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 11
GLN E 163
LEU E 174
SER E 175
GLU E 176
VAL E 191
1.73A21.08
12.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2ajf ACE2
(Homo
sapiens)		4 / 8
GLN A 442
GLU A 406
PHE A 369
VAL A 293
1.11A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2ajf ACE2
(Homo
sapiens)		5 / 9
LEU B 584
PHE B 588
GLU B 589
LEU B 439
VAL B 447
1.57A22.00
6.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
GLN B 110
SER B 158
GLY B 174
ILE B 136
PHE B   8
1.74A15.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 299
SER B   1
PHE A 140
GLU A 166
VAL A 114
1.74A21.20
7.99
None
None
None
PJE  C   5 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 202
THR A 111
ALA A 129
ARG A 298
GLN A 127
1.62A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER B 113
ILE A 152
VAL A 157
PHE A 150
1.08A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 11
GLN L  89
PHE L  98
TRP H 103
GLY H  50
GLY H  49
1.67A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
SER A 113
ILE B 152
VAL B 157
PHE B 150
1.17A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
PHE B 117
GLY B  79
GLY B  80
ASN B 116
ILE B  42
1.59A22.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
GLY B  47
GLY B  52
ASN B  38
PHE B 133
ILE B 132
1.51A22.88
APR  B 477 (-3.7A)
None
None
APR  B 477 (-3.5A)
APR  B 477 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU C 179
PHE C 242
GLU C 125
LEU C 124
VAL C 206
1.66A24.14
10.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
SER A 156
ASN A 111
LEU A 114
THR A  91
ARG A 139
1.64A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2fxp SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C  41
SER C  40
GLU C  39
VAL A  33
ASN C  31
1.49A10.12
20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
GLY A  87
GLY A  87
THR A  92
GLU A  80
GLN A  55
1.50A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 326
ASN C 330
ILE C 345
PHE C 361
PHE C 360
1.56A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE C 361
PHE C 360
GLY C 326
ASN C 330
ILE C 345
1.66A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
LEU A 202
THR A 111
ALA A 129
GLN A 127
1.59A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.71A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 8
SER A 308
GLN A 309
ILE A 295
VAL A 275
0.98A15.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		5 / 9
GLN A 299
SER A 301
GLN A 256
GLY A 251
ILE A 249
1.46A7.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2kaf NSP3
(SARSr-CoV)		5 / 11
VAL A  40
LEU A  62
PHE A   6
GLU A   3
VAL A  10
1.43A13.03
20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2kqw NSP3
(SARSr-CoV)		5 / 11
VAL A 171
LEU A 193
PHE A 137
GLU A 134
VAL A 141
1.59A18.33
19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 12
GLY A  72
THR A 136
GLN A 161
ILE A  75
PHE A  54
1.47A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 8
SER B 113
ILE A 152
VAL A 157
PHE A 150
1.19A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
PHE B   3
THR B 111
GLY B 109
ASP B 289
GLN B 110
1.67A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
LEU A 202
THR A 111
ALA A 129
ARG A 298
GLN A 127
1.66A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
SER D 308
GLN D 309
ILE D 295
VAL D 275
1.21A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
PHE B 123
THR B 120
ASP B 183
GLY B 184
1.75A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 9
LEU A 141
SER A 139
PHE A 140
GLU A 290
VAL A 114
1.75A21.70
7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.64A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
SER A 113
ILE B 152
VAL B 157
PHE B 150
1.19A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
LEU B 202
THR B 111
ALA B 129
ARG B 298
GLN B 127
1.64A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.61A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 11
LEU A 202
THR A 111
ALA A 129
ARG A 298
GLN A 127
1.67A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 8
SER B 113
ILE A 152
VAL A 157
PHE A 150
1.20A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
VAL A 114
GLN A 127
PHE A 294
GLY A 109
ILE A 106
1.61A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
VAL A 114
ASN A 133
LEU A 141
SER A 139
GLU A 290
1.54A21.74
7.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
SER E 197
GLN E 159
SER E 161
GLY E  76
PHE E 176
1.77A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLY F  13
ASN F  11
GLU E 266
PHE F  55
ILE F  42
1.63A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
SER A 308
GLN A 309
ILE A 295
VAL A 275
0.96A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 202
THR B 111
ALA B 129
ARG B 298
GLN B 127
1.62A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 8
SER B 113
ILE A 152
VAL A 157
PHE A 150
1.17A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		2w2g NSP3
(SARSr-CoV)		4 / 8
SER A 516
GLN A 490
ILE A 593
VAL A 589
1.05A13.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
ILE B 152
VAL B 157
PHE B 150
1.18A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE B   3
THR B 111
GLY B 109
ASP B 289
GLN B 110
1.67A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
TRP B 606
GLY B 448
THR B 449
ILE B 446
ILE B 233
1.57A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLN A 442
GLU A 406
PHE A 369
VAL A 293
1.18A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU A 584
PHE A 588
GLU A 589
LEU A 439
VAL A 447
1.69A21.84
6.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
TYR A 207
PHE A 400
THR A 517
ASP A 225
1.42A14.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 202
THR A 111
ALA A 129
ARG A 298
GLN A 127
1.60A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 299
SER B   1
PHE A 140
GLU A 166
VAL A 114
1.72A21.95
7.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3e9s NSP3
(SARSr-CoV)		5 / 9
LEU A 179
PHE A 242
GLU A 125
LEU A 124
VAL A 206
1.66A23.81
10.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
ILE B 152
VAL B 157
PHE B 150
1.19A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.65A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A  88
PHE A  90
GLU A  70
VAL A 102
ASN A  98
1.65A16.07
14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
LEU A  88
PHE A  90
GLU A  70
VAL A 102
ASN A  98
1.67A16.07
14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER B 113
ILE A 152
VAL A 157
PHE A 150
1.17A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE B   3
THR B 111
GLY B 109
ASP B 289
GLN B 110
1.61A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.69A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 202
THR B 111
ALA B 129
ARG B 298
GLN B 127
1.67A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 202
THR A 111
ALA A 129
ARG A 298
GLN A 127
1.64A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.75A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
ILE B 152
VAL B 157
PHE B 150
1.19A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
VAL A 114
ASN A 133
LEU A 141
SER A 139
GLU A 290
1.59A21.74
7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
VAL A 212
GLN A 299
PHE A   3
VAL A 296
TRP A 207
1.54A21.95
7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.65A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
ILE B 152
VAL B 157
PHE B 150
1.14A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
SER B 156
ASN B 111
LEU B 114
THR B  91
ARG B 139
1.58A14.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3sci ACE2
(Homo
sapiens)		4 / 8
GLN A 442
GLU A 406
PHE A 369
VAL A 293
1.10A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		3scj ACE2
(Homo
sapiens)		5 / 11
GLN B 429
PHE B 428
GLY B 286
ASN B 290
GLU B 433
1.67A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
SER E 461
PHE A  32
LEU A  24
THR A  82
GLN A  81
1.63A10.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
TRP A 606
GLY A 448
THR A 449
ILE A 446
ILE A 233
1.63A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU A 584
PHE A 588
GLU A 589
LEU A 439
VAL A 447
1.65A21.63
6.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
TYR A  41
ARG A 357
ASP A 350
GLY A 352
1.47A13.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 202
THR A 111
ALA A 129
ARG A 298
GLN A 127
1.62A14.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
ILE B 152
VAL B 157
PHE B 150
1.21A15.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.78A14.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 11
VAL A 301
GLN B 270
ASN B 268
LEU A 212
SER A 246
1.52A24.07
10.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 11
ASN A 251
LEU A 284
PHE A 266
VAL A 255
TRP A 303
1.71A24.04
8.81
None
None
PO4  A 404 ( 4.4A)
PO4  A 404 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 299
SER B   1
PHE A 140
GLU A 166
VAL A 114
1.73A21.70
7.82
None
None
None
3A7  A 401 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE A   3
THR A 111
GLY A 109
ASP A 289
GLN A 110
1.71A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
VAL B 312
SER B 507
PHE B 506
VAL B 305
ASN B 422
1.74A20.65
7.29
None
None
G3A  B 606 (-3.8A)
None
G3A  B 606 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
PHE B 377
PHE B 350
ASN D 306
LEU D 303
ALA D 497
1.31A19.23
None
None
G3A  D 606 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
PHE B 377
PHE B 350
ASN D 306
LEU D 303
ALA D 497
1.34A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
SER A 156
ASN A 111
LEU A 114
THR A  91
ARG A 139
1.67A15.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 9
GLU A 264
GLY B  75
HIS A 273
CYH A 112
TYR A 265
1.71A12.83
None
AYE  B  76 ( 2.5A)
AYE  B  76 ( 4.7A)
AYE  B  76 ( 1.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU A 179
PHE A 242
GLU A 125
LEU A 124
VAL A 206
1.65A24.16
8.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
MET D 207
PHE D 242
LEU D 212
ALA D 279
GLN D 123
1.62A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
GLN B 134
LEU B 173
PHE B 128
VAL B 126
ASN B 178
1.77A24.07
7.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
GLN A1018
SER A1033
PHE A 909
GLY A 781
ILE A 905
1.29A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE A 364
THR C 402
GLY C 400
ASP B 967
GLU B 970
1.66A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE A 179
GLY A 145
ASP A 171
ARG A  99
ASN A  96
1.70A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
VAL C 196
GLY C 104
MET C 107
ASN C 230
ILE C 115
1.49A11.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
SER C 950
GLN C 947
GLN C 984
GLY A 981
ILE A 724
1.50A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY B 862
GLY B 867
GLN B 786
PHE B 784
PHE B 880
1.55A11.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
PHE A 253
PHE A  69
ASN A  78
THR A  75
ARG A 207
1.34A22.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
VAL B 363
GLN B 346
LEU B 347
SER B 345
ASN B 719
1.71A15.04
2.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
SER B 852
PHE B1136
LEU B1134
ARG B1113
GLN C1097
1.25A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		5x59 S PROTEIN
(MERS-CoV)		5 / 11
VAL B 983
PHE B1001
GLY B1140
GLY B 789
MET B1008
1.60A10.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 8
SER B 500
GLU B 502
ILE C 226
VAL C 114
PHE C 161
1.51A22.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
PHE C1024
THR A1009
ARG A1021
GLY A1017
1.46A8.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		5x5c S PROTEIN
(MERS-CoV)		5 / 9
SER B 859
GLN A 772
SER B 975
PHE B1126
PHE B 869
1.74A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
GLN A 786
GLN A1036
ILE A 704
VAL A1047
PHE A 909
1.65A21.76
GLN  A 786 ( 0.6A)
GLN  A1036 ( 0.6A)
ILE  A 704 ( 0.7A)
VAL  A1047 ( 0.6A)
PHE  A 909 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
SER A1105
PHE C1091
ASN C1090
THR C1087
ARG C1055
1.50A21.76
SER  A1105 ( 0.0A)
PHE  C1091 ( 1.3A)
ASN  C1090 ( 0.6A)
THR  C1087 ( 0.8A)
ARG  C1055 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL B1015
PHE B 880
PHE B 782
ASN B 910
ILE B 800
1.47A11.39
VAL  B1015 ( 0.6A)
PHE  B 880 ( 1.3A)
PHE  B 782 ( 1.3A)
ASN  B 910 ( 0.6A)
ILE  B 800 ( 0.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL C 767
ASN A1090
GLN C 766
SER C1012
GLU C1013
1.62A15.16
3.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
TYR C 266
THR C  51
ASP C 267
GLY C 270
1.26A8.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6acg ACE2
(Homo
sapiens)		5 / 12
TRP D 606
GLY D 448
THR D 449
ILE D 446
ILE D 233
1.54A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
GLN B1018
SER B1033
PHE B 909
GLY B 780
ILE B 905
1.54A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6acj ACE2
(Homo
sapiens)		4 / 6
TYR D 207
PHE D 400
THR D 517
ASP D 225
1.41A12.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		6acj ACE2
(Homo
sapiens)		5 / 9
GLN D 442
GLY D 405
ILE D 407
PHE D 523
PHE D 588
1.60A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
GLN B 786
GLN B1036
ILE B 704
VAL B1047
PHE B 909
1.65A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE C1092
PHE C1091
ASN C1090
THR C 894
GLN C1095
1.48A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6ack ACE2
(Homo
sapiens)		5 / 9
LEU D 584
PHE D 588
GLU D 589
LEU D 439
VAL D 447
1.51A21.79
6.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL A 196
GLY A 104
MET A 107
ASN A 230
ILE A 115
1.41A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY A 780
GLY A 781
ASN A 783
GLN A 883
PHE A 784
1.44A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
PHE C  89
ASN C  78
THR C 236
ALA C 139
GLN C 147
1.58A23.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASN C1056
GLN C1095
SER C1093
PHE C1092
VAL C1078
1.36A15.01
3.69
NAG  C1310 (-1.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
TYR A 266
THR A  51
ASP A 267
GLY A 270
1.74A8.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
PHE C 179
GLY C 145
ASP C 171
ARG C  99
ASN C  96
1.74A23.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
VAL A 172
PHE A  76
GLY A 100
ASN A  78
ILE A 117
1.66A11.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
GLN A1053
GLN A 904
VAL A 893
PHE A1091
0.94A23.11
NAG  A1312 (-3.7A)
NAG  A1312 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
PHE B1044
LEU B 859
THR B 863
ALA B 866
GLN B 883
1.39A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN A 883
PHE A 784
GLY A 780
GLY A 781
ASN A 783
1.43A11.60
None
None
None
None
NAG  A1317 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
PHE B 179
GLY B 145
ASP B 171
ARG B  99
ASN B  96
1.65A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 780
GLY A 781
ASN A 783
GLN A 883
PHE A 784
1.39A11.60
None
None
NAG  A1313 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
PHE C1034
ILE C 704
VAL C1047
PHE C 909
0.96A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
TYR B 266
THR B  51
ASP B 267
GLY B 270
1.48A8.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
SER A 985
GLN A 947
GLN B 987
GLY B 981
ILE B 979
1.46A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6cs2 ACE2
(Homo
sapiens)		4 / 6
THR D 449
ARG D 273
ASP D 269
GLY D 268
1.72A12.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASN A1056
GLN A1095
SER A1093
PHE A1092
VAL A1078
1.42A15.01
3.69
NAG  A1319 (-1.8A)
None
None
NAG  A1321 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
TYR A 209
THR A  31
ARG A 239
ASP A 238
1.62A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
SER A  67
MET A   5
PHE A  33
ARG A 170
GLN A  54
1.45A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6jyt HELICASE
(SARSr-CoV)		4 / 8
GLN A 404
GLU A 375
ILE A 512
VAL A 544
1.10A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6jyt HELICASE
(SARSr-CoV)		4 / 6
PHE A 422
ARG A 409
ASP A 119
GLY A 118
1.27A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		6jyt HELICASE
(SARSr-CoV)		5 / 9
SER A 536
PHE A 472
GLY A 571
ILE A 545
PHE A 546
1.67A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6jyt HELICASE
(SARSr-CoV)		5 / 11
VAL A 305
LEU A 391
GLU A 365
VAL A 360
ASN A 361
1.37A19.64
8.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6lzg ACE2
(Homo
sapiens)		5 / 12
TRP A 606
GLY A 448
THR A 449
ILE A 446
ILE A 233
1.55A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6lzg ACE2
(Homo
sapiens)		4 / 6
TYR A 207
PHE A 400
THR A 517
ASP A 225
1.45A13.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6m17 ACE2
(Homo
sapiens)		5 / 9
LEU D 584
PHE D 588
GLU D 589
LEU D 439
VAL D 447
1.61A18.72
4.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
PHE C 283
GLY C 126
MET C 432
ASN C 435
ILE C 132
1.60A17.68
LEU  C 707 (-3.8A)
None
LEU  C 707 ( 4.7A)
LEU  C 707 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6m18 ACE2
(Homo
sapiens)		5 / 12
THR B 686
ASN B 690
GLU B 699
GLN B 661
ILE B 663
1.53A14.18
None
NAG  B 912 (-1.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
GLN C 556
SER C 487
GLY C 272
ILE C 545
PHE C 549
1.51A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY A 284
THR A 121
ASN A 435
GLU A 501
ILE A 497
1.41A17.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6m18 ACE2
(Homo
sapiens)		4 / 6
TYR D 207
PHE D 400
THR D 517
ASP D 225
1.39A11.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		6m1d ACE2
(Homo
sapiens)		5 / 9
SER D 507
GLY D 200
ILE D 513
PHE D 512
PHE D 504
1.72A22.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL B 581
GLN B 630
LEU B 597
VAL B 601
ASN B 602
1.66A15.01
3.68
None
NAG  B1323 (-3.5A)
None
None
NAG  B1323 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
SER A1105
PHE C1091
ASN C1090
THR C1087
ARG C1055
1.54A23.54
None
None
None
None
NAG  C1344 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
SER C 950
GLN C 947
GLN C 984
GLY B 981
ILE B 724
1.57A23.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
GLN C 786
GLN C1036
ILE C 704
VAL C1047
PHE C 909
1.58A23.54
NAG  C1337 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY A 780
GLY A 781
ASN A 910
ILE B1112
PHE A 909
1.51A11.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE A 909
GLY A 780
GLY A 781
ASN A 910
ILE B1112
1.60A11.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 6
TYR L  31
ARG H 104
ASP L  35
GLY L  34
1.15A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6nur NSP12
(SARSr-CoV)		5 / 11
VAL A 605
ASN A 769
LEU A 614
VAL A 609
ASN A 767
1.58A17.92
5.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 11
VAL D 115
GLN D  88
LEU C  60
SER C  57
VAL C  66
1.52A20.27
10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 9
LEU A 371
SER A 367
PHE A 368
LEU A 527
VAL B  83
1.71A17.92
5.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6nur NSP12
(SARSr-CoV)		4 / 6
TYR A 483
THR A 582
ASP A 484
GLY A 485
1.66A11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6nus NSP8
(SARSr-CoV)		5 / 9
GLN B 158
LEU B 169
SER B 170
GLU B 171
VAL B 186
1.57A20.27
10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6nus NSP12
(SARSr-CoV)		5 / 11
SER A 814
MET A 756
PHE A 812
ASN A 691
ARG A 583
1.50A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
SER L 121
GLN L 124
GLU L 123
VAL H 150
1.45A10.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
SER L 127
GLN L 124
GLN H 171
VAL H 150
1.57A10.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 11
ASN L  22
GLN L  79
LEU L  78
SER L  77
VAL L 104
1.66A17.07
13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
TYR L  96
THR L  94
ARG H  58
GLY H  35
1.25A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER L 133
GLN L 130
GLN H 175
VAL H 154
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
SER H 157
GLN B  82
ILE B  20
VAL B 115
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER L 127
GLN L 130
GLU L 129
VAL H 154
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
VAL B  37
PHE B  29
GLY B  99
GLY B 101
ILE B 102
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
TYR C 102
THR C 100
ARG B  59
GLY B  35
1.20A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER C 127
GLN C 130
GLU C 129
VAL B 154
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
ASN B 208
GLN H  82
LEU H  18
SER H  17
ASN B 203
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM7_A_DM2A501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 11
ASN C  22
GLN C  85
LEU C  84
SER C  83
VAL C 110
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLY B  98
GLY B  99
THR B 104
ILE B  50
PHE B  29
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLY H  98
GLY H  99
THR H 104
ILE H  50
PHE H  29
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
TYR L 102
THR L 100
ARG H  59
GLY H  35
1.26A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
VAL H  37
PHE H  29
GLY H  99
GLY H 101
ILE H 102
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER C 133
GLN C 130
GLN B 175
VAL B 154
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER L 133
GLN L 130
GLN H 175
VAL H 154
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
TYR L 102
THR L 100
ARG H  59
GLY H  35
1.29A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER L 127
GLN L 130
GLU L 129
VAL H 154
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLY H  98
GLY H  99
THR H 104
ILE H  50
PHE H  29
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
VAL H  37
PHE H  29
GLY H  99
GLY H 101
ILE H 102
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
SER L 133
GLN L 130
GLN H 175
VAL H 154
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
SER C 133
GLN C 130
GLN B 175
VAL B 154
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
TYR C 102
THR C 100
ARG B  59
GLY B  35
1.26A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
SER C 127
GLN C 130
GLU C 129
VAL B 154
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
VAL B  37
PHE B  29
GLY B  99
GLY B 101
ILE B 102
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
SER L 127
GLN L 130
GLU L 129
VAL H 154
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
TYR L 102
THR L 100
ARG H  59
GLY H  35
1.26A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLY H  98
GLY H  99
THR H 104
ILE H  50
PHE H  29
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLY B  98
GLY B  99
THR B 104
ILE B  50
PHE B  29
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
VAL H  37
PHE H  29
GLY H  99
GLY H 101
ILE H 102
1.76A
None