Ligand ID: DCF


Drugbank ID:
DB00552
(Pentostatin)


Indication:
For the treatment of hairy cell leukaemia refractory to alpha interferon.

Get human targets for DCF in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'DCF' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.21A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 4
HIS B  41
LEU B 177
TYR B  37
GLY B  29
1.53A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU B  88
LEU B   9
PHE B  90
0.89A14.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 205
LEU A 220
PHE A 230
1.10A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.27A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.21A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 12
ASP A 116
PHE B  56
ILE A  95
ASP A  74
HIS B  31
1.66A19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
HIS A  58
PHE A  39
PHE A  31
ALA A  49
HIS A   4
1.58A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
HIS A  58
PHE A  39
PHE A  31
ALA A  49
HIS A   4
1.57A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.65A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.16A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.10A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS B1041
LEU B1177
TYR B1037
GLY B1029
1.54A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B1205
LEU B1220
PHE B1230
0.99A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		2a5i 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.43A23.31
AZP  A 307 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 5
HIS B 227
LEU B 270
LEU B 264
GLY B 267
1.58A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 4
HIS B 268
LEU C 192
LEU C 194
LEU C 319
1.69A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		3 / 3
LEU D 309
LEU D 257
PHE D 298
1.10A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 4
HIS A  41
LEU E  96
LEU A  64
LEU A  33
1.65A12.57
None
None
None
GOL  A2003 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		2ajf ACE2
(Homo
sapiens)		4 / 4
HIS A 374
LEU A 554
LEU A 529
LEU A 539
1.31A21.19
 ZN  A 901 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.19A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.24A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
ASP F 298
GLY F 296
HIS F 357
ASP F 289
ASP F 291
1.69A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS B  64
LEU B  89
LEU B  87
LEU B  57
1.79A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.45A22.76
ENB  A 307 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 5
HIS C  46
LEU C  89
LEU C  83
GLY C  86
1.59A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		3 / 3
LEU A 128
LEU A  76
PHE A 117
1.10A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		3 / 3
LEU B 128
LEU B  54
PHE B 117
1.21A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		3 / 3
LEU C 128
LEU C  76
PHE C 117
1.14A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		3 / 3
LEU A 128
LEU A  54
PHE A 117
1.24A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		3 / 3
LEU C 128
LEU C  54
PHE C 117
1.29A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 4
HIS A  46
LEU A  83
LEU A  94
LEU A 128
1.63A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		3 / 3
LEU B 128
LEU B  76
PHE B 117
1.16A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU B 124
LEU B 102
PHE B 305
0.97A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU E 421
LEU E 355
PHE E 379
0.99A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 5
LEU D  20
LEU D  18
SER D 116
GLY D  10
1.27A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2gri NSP3
(SARSr)		3 / 3
LEU A  28
LEU A  80
PHE A 107
1.36A14.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2gri NSP3
(SARSr)		3 / 3
LEU A  28
LEU A  73
PHE A  88
1.24A14.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.21A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.44A23.04
AZP  A 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		3 / 3
LEU A 214
LEU A 248
PHE A 203
1.09A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 5
LEU A 299
SER A 258
LEU A 200
GLY A 253
1.38A23.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 205
LEU A 220
PHE A 230
0.95A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.22A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.53A23.16
WR1  A 601 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 4
HIS D 249
LEU D 265
LEU D 200
LEU D 214
1.44A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		3 / 3
LEU B 299
LEU B 254
PHE B 232
0.90A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASP D 282
ILE D 280
HIS D 249
HIS D 234
ASP D 239
1.66A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
LEU B 299
SER B 258
LEU B 200
GLY B 253
1.37A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU D 299
LEU D 250
ALA D 255
GLU D 210
ASP D 296
1.52A24.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.23A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.19A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.21A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
LEU B 299
SER B 258
LEU B 200
GLY B 253
1.23A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASP D 296
LEU D 263
LEU D 200
ILE D 252
ALA D 255
1.69A24.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
LEU B 299
SER B 258
LEU B 200
GLY B 253
1.23A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		3 / 3
LEU B 214
LEU B 248
PHE B 203
0.96A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.15A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.22A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 4
HIS B  41
LEU B 177
TYR B  37
GLY B  29
1.50A24.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		2w2g NSP3
(SARSr-CoV)		5 / 12
LEU B 429
LEU B 413
ILE B 484
GLU B 432
ASP B 453
1.49A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2w2g NSP3
(SARSr-CoV)		3 / 3
LEU B 412
LEU B 471
PHE B 511
0.82A23.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		2wct NSP3
(SARSr-CoV)		4 / 4
HIS A 613
LEU A 596
LEU A 627
LEU A 648
1.77A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.18A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.25A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS B  64
LEU B  89
LEU B  87
LEU B  57
1.72A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
HIS B 535
LEU B 439
SER B 409
LEU B 370
1.50A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 558
MET A 408
HIS A 378
HIS A 401
ASP A 382
1.71A21.19
None
None
ZN  A 901 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
HIS B 417
LEU B 370
ILE B 421
HIS B 373
ASP B 543
1.75A20.37
None
None
None
None
NDG  B 618 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
HIS A 265
LEU A 156
LEU A 281
LEU A 444
1.60A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 267
SER A 280
LEU A 281
GLY A 268
1.27A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
PHE A 525
MET A 408
GLY A 405
HIS A 378
GLU A 402
1.80A21.19
None
None
None
ZN  A 901 (-3.7A)
ZN  A 901 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.50A23.16
959  A 350 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.68A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.24A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.17A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		3e9s NSP3
(SARSr-CoV)		3 / 3
LEU A 124
LEU A 102
PHE A 305
1.06A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.51A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.23A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A 134
LEU B 202
LEU B 242
LEU B 262
1.70A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr)		3 / 3
LEU D 106
LEU D 112
PHE D  75
1.15A14.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS B  64
LEU B  89
LEU B  87
LEU B  57
1.74A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.28A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.49A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.21A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.69A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.56A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.22A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.28A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		3 / 3
LEU C   1
LEU A 156
PHE A   9
0.96A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		4 / 5
LEU B  65
SER A 207
LEU A 206
GLY A 237
1.31A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		4 / 5
LEU B  65
SER A 207
LEU A 206
GLY A 237
1.27A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3i6k HLA, A-2
(Homo
sapiens)		4 / 4
HIS E  70
LEU E 156
LEU E 160
LEU E 168
1.43A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		3i6k HLA, A-2
MEMBRANE
GLYCOPROTEIN PEPTIDE
(Homo
sapiens;
SARS-COV
TJF)		3 / 3
LEU G   1
LEU E 160
PHE E   9
1.07A6.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3i6k HLA, A-2
(Homo
sapiens)		4 / 5
HIS E  70
LEU E 156
LEU E 168
GLY E 100
1.57A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.70A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.17A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.23A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.77A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
LEU B  76
LEU A 133
PHE A  70
0.94A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 124
LEU A 260
ILE A 277
ALA A 262
HIS A 276
1.71A22.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3sci ACE2
(Homo
sapiens)		4 / 5
LEU B 558
LEU B 554
SER B 409
LEU B 410
1.28A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 278
SER A 155
LEU A 156
GLY A 268
1.17A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
HIS A 265
LEU A 156
LEU A 281
LEU A 444
1.61A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
HIS A 417
LEU A 370
ILE A 421
HIS A 373
ASP A 543
1.67A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.21A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.16A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		3snc 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.16A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3snc 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.22A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.72A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.20A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.49A24.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 205
LEU A 220
PHE A 230
1.08A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.25A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
LEU A 124
LEU A 102
PHE A 305
1.02A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 124
LEU A 260
ILE A 277
ALA A 262
HIS A 276
1.76A23.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.20A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 4
HIS A 239
LEU A 179
LEU A 204
LEU A 170
1.48A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		3 / 3
LEU D  47
LEU D  65
PHE D  57
1.32A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		3 / 3
LEU A  47
LEU A  65
PHE A  57
1.33A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		3 / 3
LEU B 156
LEU B  65
PHE B  57
0.79A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		3 / 3
LEU D 156
LEU D  65
PHE D  57
0.85A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		3 / 3
LEU A 156
LEU A  65
PHE A  57
0.86A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		3 / 3
LEU C 156
LEU C  65
PHE C  57
0.80A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		3 / 3
LEU E 156
LEU E  65
PHE E  57
0.82A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		4ud1 N PROTEIN
(MERS-CoV)		4 / 4
HIS E 124
LEU D 111
TYR D  77
GLY D 119
1.44A18.66
NH4  E1164 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		3 / 3
LEU D 266
LEU D 287
PHE D 245
1.26A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		3 / 3
LEU C 266
LEU C 287
PHE C 245
1.28A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.20A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS B  64
LEU B  89
LEU B  87
LEU B  57
1.78A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.27A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 205
LEU A 220
PHE A 230
0.96A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 145
GLY B 143
HIS B 163
GLU B 166
HIS B 172
1.77A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
HIS B  41
LEU B 177
TYR B  37
GLY B  29
1.47A23.31
SDJ  B 401 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		3 / 3
LEU D   7
LEU C  75
PHE D  60
1.07A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 4
HIS B 314
LEU B 322
LEU B 519
LEU B 442
1.54A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr)		3 / 3
LEU B 442
LEU B 383
PHE B 514
1.26A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 4
HIS D 314
LEU D 322
LEU D 519
LEU D 442
1.57A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A 124
LEU A 260
ILE A 277
ALA A 262
HIS A 276
1.80A23.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU D 124
LEU D 102
PHE D 305
1.05A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 4
HIS B 314
LEU B 322
LEU B 519
LEU B 442
1.59A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 124
LEU B 260
ILE B 277
ALA B 262
HIS B 276
1.79A22.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU B 124
LEU B 102
PHE B 305
1.02A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B1006
SER B1012
HIS B1046
GLU B 707
ASP B1023
1.76A14.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5x4r S PROTEIN
(MERS-CoV)		3 / 3
LEU A 149
LEU A 180
PHE A 116
1.32A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 5
LEU C 638
LEU C 651
SER C 373
GLY C 613
1.25A13.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 5
HIS B1138
LEU B1098
SER C 852
LEU C 849
1.17A13.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
HIS B 641
SER B 680
LEU B 681
GLY B 655
1.34A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
LEU C 532
LEU C 538
PHE C 551
1.05A14.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
LEU B 388
LEU B 441
PHE B 571
1.10A14.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP C 564
PHE C 527
LEU C 532
PHE C 529
ASP C 572
1.55A14.21
ASP  C 564 ( 0.5A)
PHE  C 527 ( 1.3A)
LEU  C 532 ( 0.5A)
PHE  C 529 ( 1.3A)
ASP  C 572 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
LEU A 124
LEU A 102
PHE A 305
0.96A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 179
ALA C 251
HIS C  70
HIS C  33
ASP C 208
1.56A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 179
ALA C 251
HIS C  70
HIS C  33
ASP C 208
1.61A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 179
ALA C 251
HIS C  70
HIS C  33
ASP C 208
1.64A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 179
ALA C 251
HIS C  70
HIS C  33
ASP C 208
1.64A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		6acg ACE2
(Homo
sapiens)		5 / 12
LEU D 558
MET D 408
HIS D 378
HIS D 401
ASP D 382
1.68A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
HIS B 641
SER B 680
LEU B 681
GLY B 655
1.41A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP A 719
LEU A 736
LEU A 735
SER B 303
ASP A 727
1.63A15.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6acg ACE2
(Homo
sapiens)		4 / 4
HIS D 374
LEU D 554
LEU D 529
LEU D 539
1.28A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		6acj ACE2
(Homo
sapiens)		5 / 12
PHE D 452
ALA D 264
GLU D 489
HIS D 493
ASP D 499
1.52A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU A 803
LEU A1045
PHE A 799
0.98A14.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6acj ACE2
(Homo
sapiens)		4 / 5
HIS D 535
LEU D 439
SER D 409
LEU D 370
1.45A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6acj ACE2
(Homo
sapiens)		5 / 12
LEU D 418
LEU D 423
ILE D 307
HIS D 373
HIS D 417
1.66A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 179
ILE C  72
HIS C  70
HIS C  33
ASP C 208
1.41A14.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU C 847
LEU C 846
LEU A 597
GLY A 655
1.25A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP B 825
ALA A 654
GLY A 655
ASP B 849
ASP B 850
1.67A14.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
HIS C 641
SER C 680
LEU C 681
GLY C 655
1.44A14.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP A  23
PHE A 137
ILE A 244
GLY A 246
HIS A 149
1.78A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
HIS B 641
SER B 680
LEU B 681
GLY B 655
1.31A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP C 825
ALA B 654
GLY B 655
ASP C 849
ASP C 850
1.68A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LEU C 499
LEU C 374
PHE C 329
0.59A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP A 312
LEU A 571
LEU A 538
GLU A 569
ASP A 518
1.55A14.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
PHE A 325
LEU A 355
PHE A 329
ALA A 371
ASP A 351
1.72A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6cs2 ACE2
(Homo
sapiens)		4 / 4
HIS D 241
LEU D 267
LEU D 278
LEU D 440
1.68A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
HIS A   9
LEU A 160
LEU A 126
LEU A 147
1.77A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6jyt HELICASE
(SARSr)		3 / 3
LEU A 573
LEU A 528
PHE A 499
1.16A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6jyt HELICASE
(SARSr-CoV)		4 / 4
HIS B  39
LEU B   7
LEU B 130
LEU B 122
1.47A21.22
 ZN  B 703 (-2.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6kl2 NUCLEOPROTEIN
(MERS-CoV)		3 / 3
LEU D 156
LEU D  65
PHE D  57
0.91A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6kl2 NUCLEOPROTEIN
(MERS-CoV)		3 / 3
LEU C 156
LEU C  65
PHE C  57
0.83A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6kl2 NUCLEOPROTEIN
(MERS-CoV)		4 / 4
HIS B 124
LEU A 111
TYR A  77
GLY A 119
1.05A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m17 ACE2
(Homo
sapiens)		4 / 4
HIS B 265
LEU B 156
LEU B 281
LEU B 444
1.67A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
LEU C  43
SER C 280
LEU C 286
GLY C  47
1.56A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		6m18 ACE2
(Homo
sapiens)		5 / 12
LEU B 558
MET B 408
HIS B 378
HIS B 401
ASP B 382
1.77A19.25
None
None
ZN  B 914 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
LEU C   6
LEU C 605
PHE C 503
0.80A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
HIS D 417
ASP D 543
PHE D 369
GLY D 422
GLU D 310
1.74A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
HIS B 374
HIS B 373
PHE B 315
PHE B 314
HIS B 378
1.78A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6m1d ACE2
(Homo
sapiens)		4 / 5
HIS B 241
LEU B 444
LEU B 584
GLY B 448
1.54A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m1d ACE2
(Homo
sapiens)		3 / 3
LEU B 570
LEU B 560
PHE B 525
1.07A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m1d ACE2
(Homo
sapiens)		4 / 5
LEU D 120
LEU D 116
SER D 105
LEU D 108
1.07A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m1d ACE2
(Homo
sapiens)		4 / 5
LEU D 120
LEU D 116
SER D 105
LEU D 108
1.11A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 963
LEU B 959
ALA B 732
GLU B 730
ASP B 727
1.78A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
HIS A 641
SER A 680
LEU A 681
GLY A 655
1.39A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU B 803
LEU B1045
PHE B 799
1.05A14.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU H 173
SER L 179
LEU L 140
GLY H 176
1.55A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6nur NSP12
(SARSr)		3 / 3
LEU A 437
LEU A 862
PHE A 843
0.98A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6nur NSP12
(SARSr-CoV)		3 / 3
LEU A 186
LEU A 205
PHE A 287
0.78A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6nur NSP12
(SARSr)		3 / 3
LEU A 186
LEU A 207
PHE A 287
1.13A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6nur NSP12
(SARSr)		3 / 3
LEU A 437
LEU A 883
PHE A 843
1.29A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6nus NSP12
(SARSr-CoV)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 775
1.49A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6nus NSP12
(SARSr-CoV)		5 / 12
PHE A 793
GLY A 137
GLU A 796
ASP A 161
ASP A 164
1.79A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vw1 SARS-COV-2 CHIMERIC
RBD
(SARSr)		3 / 3
LEU F 368
LEU F 335
PHE F 342
0.73A22.78
None
None
NAG  M   1 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
LEU A 418
LEU A 423
ILE A 307
HIS A 373
HIS A 417
1.63A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
PHE B 525
MET B 408
GLY B 405
HIS B 378
GLU B 402
1.79A21.19
None
None
None
ZN  B 703 ( 4.6A)
ZN  B 703 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6vw1 ACE2
(Homo
sapiens)		4 / 5
HIS B 535
LEU B 439
SER B 409
LEU B 370
1.50A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vw1 SARS-COV-2 CHIMERIC
RBD
(SARSr)		3 / 3
LEU E 368
LEU E 335
PHE E 342
0.93A22.78
None
None
NAG  L   1 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
LEU L 136
LEU L 135
SER H 177
LEU H 141
1.78A18.67
None
None
GOL  L 301 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
LEU H 159
SER L 174
LEU L 135
GLY H 162
1.51A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
LEU H 159
SER L 174
LEU L 135
GLY H 162
1.56A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU H 163
SER L 180
LEU L 141
GLY H 166
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU B 163
SER C 180
LEU C 141
GLY B 166
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU H 163
SER L 180
LEU L 141
GLY H 166
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU B 163
SER C 180
LEU C 141
GLY B 166
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU H 163
SER L 180
LEU L 141
GLY H 166
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU H 163
SER L 180
LEU L 141
GLY H 166
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
LEU H 163
SER L 180
LEU L 141
GLY H 166
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
LEU H 163
SER L 180
LEU L 141
GLY H 166
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
LEU B 163
SER C 180
LEU C 141
GLY B 166
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
LEU B 163
SER C 180
LEU C 141
GLY B 166
1.49A
None