Ligand ID: CZE


Drugbank ID:
DB00341
(Cetirizine)


Indication:
For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria

Get human targets for CZE in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CZE' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ALA A  16
ASP A  47
LEU A  45
LEU A  44
LEU A  69
1.76A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		1uw7 NSP9
(SARS-COV
HKU-39849)		5 / 9
ALA A  16
ASP A  47
LEU A  45
LEU A  44
LEU A  69
1.73A14.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		1x7q HLA, A-11
(Homo
sapiens)		5 / 9
ARG A 131
ALA A 153
ASP A 129
LEU A 130
GLU A 161
1.66A17.41
None
GOL  A5006 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A 206
ASP A 289
LEU A 205
LEU A 250
GLU A 240
1.57A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA J  23
ASP F  17
LEU J  26
LEU K  20
GLU I  18
1.63A5.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 9
ALA C 316
ASP C 287
LEU C 290
LEU C 291
GLU C 286
1.75A12.89
None
None
None
None
GOL  C1008 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A 206
ASP A 289
LEU A 205
LEU A 250
GLU A 240
1.41A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
ARG B  48
ALA B  97
LEU A  55
LEU A  53
LEU B  53
1.55A9.18
None
None
D10  B1099 ( 4.2A)
D10  B1099 ( 4.6A)
D10  B1099 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
ARG E  48
ALA E  97
LEU F  55
LEU F  53
LEU E  53
1.34A9.93
None
None
D10  F1099 ( 4.3A)
D10  F1099 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
ARG C  48
ALA C  97
LEU D  55
LEU D  53
LEU C  53
1.32A9.58
None
None
D10  C1099 ( 4.1A)
D10  C1099 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A 206
ASP A 289
LEU A 205
LEU A 250
GLU A 240
1.51A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 9
ALA A 206
ASP A 289
LEU A 205
LEU A 250
GLU A 240
1.44A17.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP F 300
LEU F 298
LEU F 297
LEU F 250
GLU F 210
1.65A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3aw0 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A 206
ASP A 289
LEU A 205
LEU A 250
GLU A 240
1.47A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU A 560
GLY A 561
LEU A 392
LEU A  95
GLU A 564
1.67A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA B 206
ASP B 289
LEU B 205
LEU B 250
GLU B 240
1.49A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ALA A 206
ASP C 289
LEU A 205
LEU C 250
GLU C 240
1.28A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
ALA D  16
ASP D  47
LEU D  45
LEU D  44
LEU D  69
1.76A13.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A 206
ASP A 289
LEU A 205
LEU A 250
GLU A 240
1.40A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA B 206
ASP B 289
LEU B 205
LEU B 250
GLU B 240
1.47A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3i6g HLA, A-2
(Homo
sapiens)		6 / 9
ARG D 131
ALA D 153
ASP D 129
LEU D 130
LEU D 156
GLU D 161
1.69A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A 206
ASP C 289
LEU A 205
LEU C 250
GLU C 240
1.45A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ALA A 206
ASP A 289
LEU A 205
LEU A 250
GLU A 240
1.54A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 9
ARG B  66
ALA B  69
ASP B  63
LEU B  65
LEU B  81
1.62A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ASP B 179
LEU B 174
GLY B 176
LEU B 177
LEU B 411
1.52A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ASP B 179
LEU B 174
GLY B 176
LEU B 177
LEU B 411
1.52A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 9
ASP A 179
LEU A 174
GLY A 176
LEU A 177
LEU A 411
1.64A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ASP B  41
GLY B  82
LEU B  81
LEU B  65
GLU B  78
1.76A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 9
ARG A  38
ALA A  40
LEU A  37
LEU A  34
LEU A  31
1.66A8.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
ASP A 191
GLY A 225
LEU A 224
LEU A 222
GLU C 502
1.69A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA B 926
GLY B 928
LEU B 927
LEU B 920
GLU B 707
1.50A19.37
ALA  B 926 ( 0.0A)
GLY  B 928 ( 0.0A)
LEU  B 927 ( 0.6A)
LEU  B 920 ( 0.6A)
GLU  B 707 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 9
ALA C 926
ASP b  17
LEU B 927
LEU b  25
GLU b  19
1.76A8.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ARG C 342
ALA C 384
GLY C 418
LEU C 499
GLU C 502
1.64A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASP B 351
LEU B 374
GLY B 512
LEU B 377
LEU B 499
1.28A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
ARG A 131
ALA A 153
ASP A 129
LEU A 130
LEU A 156
1.77A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
LEU A  85
GLY A  82
LEU A  86
LEU A 286
GLU A 501
1.12A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA A 926
LEU A 803
LEU A 804
LEU A 927
LYS A 807
1.71A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		6nur NSP12
(SARSr-CoV)		5 / 9
ALA A 130
ASP A 140
LEU A 142
LEU A 127
GLU A 144
1.71A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		6vw1 ACE2
(Homo
sapiens)		5 / 9
LEU B 560
GLY B 561
LEU B 392
LEU B  95
GLU B 564
1.65A22.32
None