Ligand ID: CXX


Drugbank ID:
DB01242
(Clomipramine)


Indication:
May be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder).

Get human targets for CXX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CXX' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
PRO B   6
VAL B   7
ALA A 107
SER B 105
GLY A 104
1.58A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
ILE A1164
LEU A 927
VAL C 934
LEU C 930
LEU A 930
1.49A15.89
20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
ILE F   5
LEU E  41
VAL C  45
LEU A  48
LEU C  41
1.52A10.04
14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU A  41
VAL E  45
LEU E  44
LEU A  48
LEU E  41
1.48A11.40
20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		1zva E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
ILE A  55
LEU A  23
VAL A  65
LEU A  62
LEU A  19
1.60A12.11
18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C  27
LEU C  24
ARG C  26
ILE B  23
LEU A  20
1.44A5.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU A   2
VAL C   6
LEU C   5
LEU A   9
LEU C   2
1.54A7.89
14.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C  27
LEU C  24
ARG C  26
ILE B  23
LEU A  20
1.39A5.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER A  11
PHE A  13
ILE C  16
PHE C  13
1.58A5.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 7
ILE H 112
LEU D  61
VAL D  21
LEU H  96
LEU D  64
1.36A20.36
21.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		2ajf ACE2
(Homo
sapiens)		5 / 7
LEU B 585
VAL B 447
LEU B 236
LEU B 591
LEU B 584
1.47A18.77
13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
ILE E1151
LEU C 948
LEU C 944
LEU C 941
LEU A 948
1.56A9.39
16.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU B 920
GLN B 915
ILE A 916
LEU D1179
ASP F1181
1.65A4.87
None
None
None
ACE  B 913 ( 4.8A)
ACE  B 913 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU B 941
VAL A 945
LEU A 944
LEU B 948
LEU A 941
1.45A8.42
12.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
LEU D 354
ILE D 305
LEU D 292
ASP D 291
ASP D 289
1.54A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
LEU D 354
ILE D 305
LEU D 292
ASP D 291
ASP D 289
1.52A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 11
LEU F  82
LEU F  13
VAL F  94
PHE E  70
ASP F  90
1.59A11.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 11
LEU G  82
LEU G  13
VAL G  94
PHE H  70
ASP G  90
1.63A10.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2dd8 IGG LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
SER L  93
ARG S 395
ILE S 405
PHE S 387
1.59A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H  25
ARG H  94
PHE H  29
ILE H  34
1.61A18.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 7
ILE A 154
LEU A 127
VAL A  96
LEU A 123
LEU A 128
1.41A20.88
19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 134
ILE A 152
PHE A 148
LEU A 121
1.53A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
TYR A  84
ALA A  69
TYR A  72
PHE A  57
THR A  11
1.58A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 7
LEU A 200
VAL A 221
LEU A 186
LEU A 235
MET A 245
1.63A22.07
18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 134
ILE A 152
PHE A 148
LEU A 121
1.53A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ARG S  78
PHE O  19
ILE O  81
PHE W  19
1.59A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
LEU A 292
GLN A 290
ILE A 305
PHE A 287
LEU A 354
1.44A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
LEU A 292
GLN A 290
ILE A 305
PHE A 287
LEU A 354
1.44A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		2gri NSP3
(SARSr-CoV)		5 / 11
VAL A  45
PHE A  54
SER A 100
SER A 101
THR A  49
1.51A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
LEU A 265
LEU A 254
ILE A 280
LEU A 245
ASP A 282
1.48A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
LEU A 265
LEU A 254
ILE A 280
LEU A 245
ASP A 282
1.46A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 7
SER B 319
PHE B 316
ILE A 305
PHE A 308
1.30A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 6
SER B 319
PHE B 316
ILE A 305
PHE A 308
1.26A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
ILE A 556
PHE A 582
ILE A 567
PHE A 580
1.33A12.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2jze REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
SER A 598
ARG A 579
PHE A 581
ILE A 573
1.68A12.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE C 322
PHE C 329
ILE C 235
PHE C 302
1.34A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU D 214
GLN D 208
ILE D 252
PHE D 221
ASP D 300
1.61A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE B  26
ARG A  90
ILE B  42
PHE B  55
1.41A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU C 254
ARG C 257
ILE C 280
LEU C 245
ASP C 282
1.55A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU C 254
ARG C 257
ILE C 280
LEU C 245
ASP C 282
1.56A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2w2g NSP3
(SARSr-CoV)		4 / 7
ILE B 556
ARG B 562
ILE B 567
PHE B 582
1.46A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		2w2g NSP3
(SARSr-CoV)		5 / 11
PRO A 588
VAL A 589
ALA A 590
GLY B 465
THR A 612
1.64A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
TYR B  96
VAL A  44
SER B  67
GLY B  69
THR A  48
1.36A12.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ASP A  97
VAL A 118
ALA A 116
GLY A 113
THR A 120
1.64A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		3bgf F26G19 FAB
(Mus
musculus)		5 / 11
PRO H 123
VAL H 121
SER H 181
SER H 180
GLY H 141
1.34A16.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 7
LEU B 585
VAL B 447
LEU B 236
LEU B 591
LEU B 584
1.51A19.29
13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.52A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.57A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		3e9s NSP3
(SARSr-CoV)		5 / 11
TYR A  84
ALA A  69
TYR A  72
PHE A  57
THR A  11
1.58A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		3e9s NSP3
(SARSr-CoV)		5 / 7
LEU A 200
VAL A 221
LEU A 186
LEU A 235
MET A 245
1.59A20.84
18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU C  42
ARG C  99
VAL C 102
ILE C  91
LEU C  69
1.63A13.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU C  42
ARG C  99
VAL C 102
ILE C  91
LEU C  69
1.64A13.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		3i6k HLA, A-2
(Homo
sapiens)		4 / 6
SER E  42
ARG E  35
PHE E  36
ILE E  23
1.46A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 134
ILE A 152
PHE A 148
LEU A 121
1.61A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 134
ILE A 152
PHE A 148
LEU A 121
1.60A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 11
TYR B  96
VAL A  44
SER B  67
GLY B  69
THR A  48
1.36A13.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		3scj ACE2
(Homo
sapiens)		4 / 7
ILE A 407
SER A 409
ILE A 446
PHE A 523
1.42A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 7
LEU A 558
VAL A 318
LEU A 320
MET A 408
LEU A 554
1.48A19.29
14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.56A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.61A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
TYR A 269
ASP A 165
PRO A 300
TYR A 274
GLY A 267
1.56A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A 151
GLN A 134
ILE A 152
PHE A 148
LEU A 121
1.61A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 11
TYR A  84
ALA A  69
TYR A  72
PHE A  57
THR A  11
1.48A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 7
LEU A 200
VAL A 221
LEU A 186
LEU A 235
MET A 245
1.60A20.95
18.87
None
None
GOL  A 904 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 7
LEU A 245
VAL A 215
LEU A 246
MET A 185
LEU A 244
1.40A20.16
20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 11
ASP A 217
PRO A 250
VAL A 307
SER A 247
GLY A 248
1.62A19.61
None
None
PO4  A 404 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
ARG D 163
PHE D 198
ILE D 166
PHE D  89
1.45A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
ARG D 163
PHE D 198
ILE D 166
PHE D  89
1.30A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		5 / 11
LEU C  71
LEU C  69
ARG C  42
GLN C  49
ILE C  36
1.65A10.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
TYR A 269
ASP A 165
PRO A 300
TYR A 274
GLY A 267
1.51A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		5 / 11
LEU C  71
LEU C  69
ARG C  42
GLN C  49
ILE C  36
1.65A10.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 7
LEU B 100
VAL A  58
LEU A  61
LEU A  65
LEU B 108
1.42A16.97
18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		5f22 NSP7
(SARSr-CoV)		5 / 7
ILE A  73
LEU A  65
VAL A  21
LEU A  76
LEU A  64
1.57A18.58
20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
LEU B 117
LEU B 109
ILE B 166
PHE B 198
LEU B 170
1.56A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
LEU B 117
LEU B 109
ILE B 166
PHE B 198
LEU B 170
1.54A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
ARG B 163
PHE B 198
ILE B 166
PHE B  89
1.34A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
TYR D 269
ASP D 165
PRO D 300
TYR D 274
GLY D 267
1.51A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5x4r S PROTEIN
(MERS-CoV)		4 / 7
ILE A  56
ARG A  62
PHE A 327
ILE A  69
1.42A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE A 125
ARG A 232
PHE A 103
PHE A 187
1.19A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
ILE A 125
ARG A 232
PHE A 103
PHE A 187
1.42A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
LEU C 421
LEU C 499
VAL C 382
PHE C 325
ASP C 351
1.57A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
LEU C 421
LEU C 499
VAL C 382
PHE C 325
ASP C 351
1.61A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5x5c S PROTEIN
(MERS-CoV)		4 / 7
ILE B1165
ARG B1179
ILE B 782
PHE C 967
1.26A17.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
GLN C  60
ILE C  56
PHE C 279
PHE C  75
LEU C 325
1.44A17.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
GLN C  60
ILE C  56
PHE C 279
PHE C  75
LEU C 325
1.41A17.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 7
LEU B 389
LEU B 414
LEU B 415
MET B 569
LEU B 388
1.59A13.69
9.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
PRO A 370
VAL A 604
TYR A 606
SER A 612
SER A 607
1.44A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ASP B 757
VAL B 763
ALA B1007
SER B 712
GLY B1041
1.52A18.37
ASP  B 757 ( 0.5A)
VAL  B 763 ( 0.6A)
ALA  B1007 ( 0.0A)
SER  B 712 ( 0.0A)
GLY  B1041 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER C 957
ARG A 553
PHE A 558
PHE C 837
1.69A18.23
SER  C 957 ( 0.0A)
ARG  A 553 ( 0.6A)
PHE  A 558 ( 1.3A)
PHE  C 837 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU A 986
VAL A 990
GLN A 987
ILE A 724
LEU A 735
1.64A18.23
LEU  A 986 ( 0.6A)
VAL  A 990 ( 0.6A)
GLN  A 987 ( 0.6A)
ILE  A 724 ( 0.6A)
LEU  A 735 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 7
ILE b  11
LEU B 941
VAL A 945
LEU C 948
LEU B 944
1.62A9.23
10.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU C 941
VAL A 945
LEU A 944
LEU C 948
LEU A 941
1.43A13.51
18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR A 660
VAL A 642
ALA A 676
TYR A 677
SER A 659
1.41A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C 944
LEU C 948
VAL C 958
PHE C 837
ASP A 554
1.60A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C 944
LEU C 948
VAL C 958
PHE C 837
ASP A 554
1.52A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
SER B 957
ARG B 977
PHE B 952
PHE A 741
1.55A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		6ack ACE2
(Homo
sapiens)		4 / 6
SER D 218
ARG D 219
ARG D 204
ILE D 223
1.57A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 125
ARG B 232
PHE B 103
PHE B 187
1.27A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6ack ACE2
(Homo
sapiens)		5 / 11
ASP D 543
VAL D 293
PHE D 369
SER D 420
GLY D 422
1.45A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN A 550
ILE A 573
PHE A 545
PHE A 527
LEU A 538
1.56A16.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASP B 757
VAL B 763
ALA B1007
SER B 712
GLY B1041
1.64A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ILE A 125
ARG A 232
PHE A 103
PHE A 187
0.97A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASP C 757
VAL C 763
ALA C1007
SER C 712
GLY C1041
1.40A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN A 550
ILE A 573
PHE A 529
LEU A 571
ASP A 564
1.52A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ARG B 887
PHE B 888
ILE B 891
PHE B 700
1.58A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU C 597
GLN C 301
ILE C 652
LEU A 846
ASP A 757
1.50A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6cs2 ACE2
(Homo
sapiens)		5 / 11
LEU D 418
LEU D 424
ILE D 291
PHE D 428
ASP D 431
1.65A21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
PRO A 210
ALA A 182
PHE A 208
GLY A 265
THR A 240
1.64A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6jyt HELICASE
(SARSr-CoV)		4 / 7
ILE A 195
ARG A 337
ARG A 339
PHE A 225
1.31A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6jyt HELICASE
(SARSr-CoV)		5 / 11
LEU B 297
VAL B 272
ILE B 293
LEU B 317
ASP B 374
1.65A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		6jyt HELICASE
(SARSr-CoV)		4 / 6
ARG B 178
ARG B 212
PHE B 200
PHE B 225
1.74A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6lzg ACE2
(Homo
sapiens)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.45A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6lzg ACE2
(Homo
sapiens)		4 / 7
ILE A 421
SER A 420
ILE A 544
PHE A 314
1.37A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6m0j ACE2
(Homo
sapiens)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.45A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6m0j ACE2
(Homo
sapiens)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.49A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		6m0j ACE2
(Homo
sapiens)		5 / 7
LEU A 585
VAL A 447
LEU A 236
LEU A 591
LEU A 584
1.52A18.77
14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
PRO A 493
ALA A 590
TYR A 488
SER A 487
GLY A 490
1.60A27.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 7
ILE A  76
LEU A  77
VAL A 537
LEU A  80
LEU A 541
1.56A19.83
13.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
LEU A  52
VAL A  55
PHE A 277
LEU A 482
ASP A 486
0.98A26.79
None
None
LEU  A 707 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
LEU A  52
VAL A  55
PHE A 277
LEU A 482
ASP A 486
1.03A26.79
None
None
LEU  A 707 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6m17 ACE2
(Homo
sapiens)		5 / 11
LEU D 418
LEU D 424
ILE D 291
PHE D 428
ASP D 431
1.51A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		6m18 ACE2
(Homo
sapiens)		5 / 7
LEU D 585
VAL D 447
LEU D 236
LEU D 591
LEU D 584
1.54A17.32
11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
ILE C 319
SER C 323
ARG C 240
ILE C 239
1.24A26.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6m18 ACE2
(Homo
sapiens)		4 / 7
ILE D 704
ARG D 697
PHE D 683
PHE D 643
1.25A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
ARG C 328
PHE C 403
ILE C 407
PHE C 237
1.65A26.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		6m1d ACE2
(Homo
sapiens)		4 / 6
ARG B 678
PHE B 681
ILE B 622
PHE B 643
1.29A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6m1d ACE2
(Homo
sapiens)		5 / 11
ASP D 719
VAL D 620
PHE D 643
SER D 721
SER D 623
1.51A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6m1d ACE2
(Homo
sapiens)		5 / 11
LEU B 585
GLN B 524
ILE B 233
PHE B 523
LEU B 450
1.48A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 11
PRO H 137
VAL H 135
SER H 194
SER H 193
GLY H 153
1.43A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 11
TYR L 178
ASP L 172
PRO L 146
SER L 179
THR L 114
1.58A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9I_B_CXXB707_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 7
ILE D 107
LEU C  56
VAL C  16
LEU D  91
LEU C  59
1.43A19.05
22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		6nus NSP12
(SARSr-CoV)		5 / 11
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.43A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6nus NSP12
(SARSr-CoV)		5 / 11
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.46A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		6vw1 ACE2
(Homo
sapiens)		5 / 11
LEU A 418
LEU A 424
ILE A 291
PHE A 428
ASP A 431
1.48A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 11
PRO H 123
VAL H 121
SER H 180
SER H 179
GLY H 139
1.51A15.78
None
None
None
GOL  L 301 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE L 106
SER L  14
ARG L  18
ILE L  75
1.74A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 11
TYR L 173
ASP L 167
PRO L 141
SER L 174
THR L 109
1.61A13.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 11
VAL H 111
SER H  82
SER H  17
GLY H  15
THR H  87
1.75A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
VAL H 117
SER H  84
SER H  17
GLY H  15
THR H  91
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
PRO H  14
VAL H 117
SER H  84
SER H  17
THR H  91
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 11
TYR C 179
ASP C 173
PRO C 147
SER C 180
THR C 115
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
ILE C 112
SER C  14
ARG C  18
ILE C  81
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
ILE L 112
SER L  14
ARG L  18
ILE L  81
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
PRO B 127
VAL B 125
SER B 184
SER B 183
GLY B 143
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
VAL B 117
SER B  84
SER B  17
GLY B  15
THR B  91
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 11
TYR L 179
ASP L 173
PRO L 147
SER L 180
THR L 115
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE H  51
SER H  71
ILE H  76
PHE H  29
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
VAL H 117
SER H  84
SER H  17
GLY H  15
THR H  91
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 11
TYR L 179
ASP L 173
PRO L 147
SER L 180
THR L 115
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
PRO H  14
VAL H 117
SER H  84
SER H  17
THR H  91
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
ILE L 112
SER L  14
ARG L  18
ILE L  81
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
PRO H 127
VAL H 125
SER H 184
SER H 183
GLY H 143
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
PRO B  14
VAL B 117
SER B  84
SER B  17
THR B  91
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
PRO H  14
VAL H 117
SER H  84
SER H  17
THR H  91
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
ILE C 112
SER C  14
ARG C  18
ILE C  81
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 11
TYR C 179
ASP C 173
PRO C 147
SER C 180
THR C 115
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 11
TYR L 179
ASP L 173
PRO L 147
SER L 180
THR L 115
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
PRO B 127
VAL B 125
SER B 184
SER B 183
GLY B 143
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
VAL B 117
SER B  84
SER B  17
GLY B  15
THR B  91
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
ILE L 112
SER L  14
ARG L  18
ILE L  81
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
VAL H 117
SER H  84
SER H  17
GLY H  15
THR H  91
1.70A
None