Ligand ID: CIO


Drugbank ID:
DB03849
(Cilomilast)


Indication:
Investigated for use/treatment in chronic obstructive pulmonary disease (COPD).

Get human targets for CIO in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CIO' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.71A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.71A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B1041
MET B1162
THR B1026
SER B1121
GLN B1019
1.79A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A   9
ASN C  12
ILE A  16
SER B  17
PHE B  13
1.63A9.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.74A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
MET D  57
LEU H 100
ILE D  73
MET D  67
GLN H  93
1.74A13.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
MET D  57
LEU H 100
ILE D  73
MET D  67
GLN H  93
1.78A13.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2ajf ACE2
(Homo
sapiens)		5 / 12
TYR B 381
HIS B 401
MET B 408
LEU B 554
MET B 383
1.71A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.71A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 164
MET B  82
LEU B  58
THR B  21
PHE B  66
1.69A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		5 / 12
HIS A  41
MET A 162
THR A  26
SER A 121
GLN A  19
1.72A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2hob REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.66A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
HIS A 335
LEU B 354
ILE B 338
GLN A 261
PHE B 308
1.68A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
TYR D 193
LEU D 331
THR D 321
ILE D 322
PHE D 329
1.76A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
HIS B 164
MET B  82
LEU B  58
THR B  21
PHE B  66
1.73A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.71A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2wct NSP3
(SARSr-CoV)		5 / 12
LEU B 407
THR D 605
ILE D 549
MET D 547
PHE D 580
1.79A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3atw 3C-LIKE PROTEINASE
PEPTIDE
ACE-THR-VAL-ALC-HIS-
H
(SARSr-CoV)		5 / 12
MET A 130
THR C   2
MET A 165
GLN A 192
PHE A 185
1.70A21.52
None
ACE  C   1 ( 4.3A)
ALC  C   4 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3atw 3C-LIKE PROTEINASE
PEPTIDE
ACE-THR-VAL-ALC-HIS-
H
(SARSr-CoV)		5 / 12
MET A 130
THR C   2
MET A 165
GLN A 192
PHE A 185
1.75A21.74
None
ACE  C   1 ( 4.3A)
ALC  C   4 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.74A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.65A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
MET A  17
LEU A 115
SER A 158
PHE A 150
1.74A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
MET A  17
LEU A 115
SER A 158
PHE A 150
1.78A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
MET A  17
LEU A 115
SER A 158
PHE A 150
1.75A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
MET A  17
LEU A 115
SER A 158
PHE A 150
1.79A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
MET A 162
THR A  26
SER A 121
GLN A  19
1.73A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.73A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		5 / 12
TYR D 123
ASP D  77
LEU D  78
MET E   0
GLN D  87
1.60A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 164
MET B  82
LEU B  58
THR B  21
PHE B  66
1.70A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.72A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU F 355
ASN F 357
THR F 359
SER F 362
PHE F 361
1.58A18.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
MET A 130
ASP A 197
MET A 165
GLN A 192
PHE A 185
1.64A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.71A21.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.69A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS D 276
LEU D 291
ILE D 277
PHE D 259
SER D 295
1.78A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS D 276
LEU D 291
ILE D 277
PHE D 259
SER D 295
1.76A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
LEU A 180
THR A 257
ILE A 256
PHE A 116
PHE A 254
1.69A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
HIS B1030
MET B 884
ILE B 704
PHE B1034
SER B 785
1.62A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
LEU C 180
THR C 257
ILE C 256
PHE C 116
PHE C 254
1.67A14.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR C 771
LEU C 876
THR C 865
ILE A 687
SER A 690
1.67A15.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR A 865
PHE A1034
MET A1032
GLN A 883
PHE A 880
1.79A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR A 865
PHE A1034
MET A1032
GLN A 883
PHE A 880
1.75A15.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6acj ACE2
(Homo
sapiens)		5 / 12
ILE D 379
PHE D 327
MET D 323
GLN D 380
PHE D 315
1.77A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6acj ACE2
(Homo
sapiens)		5 / 12
ILE D 379
PHE D 327
MET D 323
GLN D 380
PHE D 315
1.80A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR A1029
ILE A 891
PHE A 888
MET A 884
GLN A1018
1.62A14.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR A1029
ILE A 891
PHE A 888
MET A 884
GLN A1018
1.66A14.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR B1029
ILE B 891
PHE B 888
MET B 884
GLN B1018
1.52A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR B1029
ILE B 891
PHE B 888
MET B 884
GLN B1018
1.49A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR B1029
ILE B 891
PHE B 888
MET B 884
GLN B1018
1.47A15.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU C 235
THR C 150
ILE C 117
SER C 120
GLN C 147
1.64A15.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6jyt HELICASE
(SARSr-CoV)		5 / 12
MET B 474
LEU B 585
ILE B 572
GLN B 470
PHE B 587
1.71A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6jyt HELICASE
(SARSr-CoV)		5 / 12
MET B 474
LEU B 585
ILE B 572
GLN B 470
PHE B 587
1.74A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6jyt HELICASE
(SARSr-CoV)		5 / 12
MET B 474
LEU B 585
ILE B 572
GLN B 470
PHE B 587
1.68A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m1d ACE2
(Homo
sapiens)		5 / 12
TYR D 381
HIS D 401
MET D 383
MET D 323
PHE D 315
1.79A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6m1d ACE2
(Homo
sapiens)		5 / 12
TYR D 381
HIS D 401
MET D 383
MET D 323
PHE D 315
1.70A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6m1d ACE2
(Homo
sapiens)		5 / 12
TYR D 381
HIS D 401
MET D 383
MET D 323
PHE D 315
1.72A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 12
MET B  87
ILE A 539
PHE A 504
SER A 501
PHE A 506
1.71A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6nus NSP12
(SARSr-CoV)		5 / 12
HIS A 381
ILE A 539
PHE A 504
SER A 501
PHE A 506
1.66A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
MET B  87
THR A 540
ILE A 539
PHE A 504
SER A 501
1.74A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
HIS A 381
MET B  87
THR A 540
ILE A 539
SER A 501
1.52A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
HIS A 381
MET B  87
THR A 540
ILE A 539
SER A 501
1.49A17.68
None