Ligand ID: CBL


Drugbank ID:
DB00291
(Chlorambucil)


Indication:
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.

Get human targets for CBL in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CBL' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
TYR A  65
PHE A  44
VAL A 111
GLY A  63
GLY A  49
1.55A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 9
PHE D 314
PRO D 280
GLY D 285
ILE B 313
GLY D 315
1.74A26.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 9
PRO F 121
VAL F 120
GLY F 118
ARG F 116
GLY B  69
1.63A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 9
PHE F 483
GLY F 488
ARG F 426
TYR F 494
GLY F 391
1.70A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 9
PHE H 275
VAL H 271
GLY H 296
ILE H 305
GLY H 288
1.78A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE S 483
GLY S 488
ARG S 426
TYR S 494
GLY S 391
1.67A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE A 483
GLY A 488
ARG A 426
TYR A 494
GLY A 391
1.65A21.46
None
CL  A  88 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 9
PRO A  74
VAL A  73
ILE A  -3
TYR A 124
GLY A  86
1.56A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 9
PHE S 483
GLY S 488
ARG S 426
TYR S 494
GLY S 391
1.72A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE E 483
GLY E 488
ARG E 426
TYR E 494
GLY E 391
1.62A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE E 483
GLY E 488
ARG E 426
TYR E 494
GLY E 391
1.64A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE E 483
GLY E 488
ARG E 426
TYR E 494
GLY E 391
1.59A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE F 483
GLY F 488
ARG F 426
TYR F 494
GLY F 391
1.63A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE E 483
GLY E 488
ARG E 426
TYR E 494
GLY E 391
1.64A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE E 483
GLY E 488
ARG E 426
TYR E 494
GLY E 391
1.59A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE F 483
GLY F 488
ARG F 426
TYR F 494
GLY F 391
1.59A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
PHE B 483
GLY B 488
ARG B 426
TYR B 494
GLY B 391
1.75A10.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		5x5c S PROTEIN
(MERS-CoV)		5 / 9
PHE C 786
PRO C1143
GLY C1140
ILE C 976
GLY C 984
1.66A9.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
PHE B 483
GLY B 488
ARG B 426
TYR B 494
GLY B 391
1.67A10.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
PHE C 483
GLY C 488
ARG C 426
TYR C 494
GLY C 391
1.57A9.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
PHE E 497
GLY E 502
ARG E 439
TYR E 508
GLY E 404
1.62A23.43
None