Ligand ID: C7H


Drugbank ID:
DB00434
(Cyproheptadine)


Indication:
For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.

Get human targets for C7H in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'C7H' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.36A19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.32A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.35A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.37A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.35A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
TYR S 481
GLY S 391
TYR S 440
GLY S 403
1.38A24.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
TYR E 481
GLY E 391
TYR E 440
GLY E 403
1.36A23.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.38A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.38A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.36A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.37A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.37A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.36A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.36A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.36A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.37A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.36A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 161
GLY B 138
TYR B 126
GLY B 124
1.20A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.37A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.37A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR A 182
GLY A 179
TYR A 161
GLY A 146
1.36A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
TYR A 116
GLY A  79
TYR A 123
TYR A  84
1.07A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		4 / 5
TYR B 185
GLY B 182
TYR B 164
GLY B 149
1.39A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		4 / 5
TYR D 185
GLY D 182
TYR D 164
GLY D 149
1.38A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		4 / 5
TYR A 185
GLY A 182
TYR A 164
GLY A 149
1.40A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
TYR B 182
GLY B 179
TYR B 161
GLY B 146
1.37A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		5x4r S PROTEIN
(MERS-CoV)		4 / 5
TYR A  71
GLY A  61
TYR A  64
GLY A 331
1.20A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
TYR B1029
GLY C 867
TYR C 886
GLY C 890
1.30A12.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		5x59 S PROTEIN
(MERS-CoV)		4 / 5
TYR C  71
GLY C  61
TYR C  64
GLY C 331
1.20A11.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
TYR A 118
GLY A  83
TYR A 123
TYR A  84
1.33A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
TYR A 128
GLY A 395
TYR A 129
GLY A  51
1.30A16.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
TYR L  36
GLY H  95
TYR L  96
GLY H  49
1.24A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
TYR L  91
GLY H  97
TYR L  96
GLY H  35
1.79A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
TYR L  36
GLY H  94
TYR L  96
GLY H  49
1.69A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR C  97
GLY B 101
TYR C 102
GLY B  35
1.80A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR C  42
GLY B  99
TYR C 102
GLY B  49
1.34A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR L  42
GLY H  99
TYR L 102
GLY H  49
1.33A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR L  42
GLY H  98
TYR L 102
GLY H  49
1.65A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR C  42
GLY B  98
TYR C 102
GLY B  49
1.67A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR L  42
GLY H  99
TYR L 102
GLY H  49
1.48A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
TYR L  42
GLY H  98
TYR L 102
GLY H  49
1.65A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
TYR L  42
GLY H  99
TYR L 102
GLY H  49
1.33A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
TYR C  42
GLY B  98
TYR C 102
GLY B  49
1.66A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
TYR L  97
GLY H 101
TYR L 102
GLY H  35
1.80A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
TYR C  42
GLY B  99
TYR C 102
GLY B  49
1.34A19.70
None