Ligand ID: C04


Drugbank ID:
DB00671
(Cefixime)


Indication:
For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes, (3) pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).

Get human targets for C04 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'C04' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		3 / 3
GLY A  49
GLU A 114
THR A 113
0.97A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
GLY B 928
GLU C1163
THR B 923
1.16A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
GLY I  28
GLU J  15
THR I  23
1.26A15.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		2ajf ACE2
(Homo
sapiens)		3 / 3
GLY A 214
GLU A 571
THR A 567
1.31A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
GLY C 928
GLU F1164
THR C 923
1.27A11.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		3 / 3
GLY D 285
GLU D 281
THR D 283
1.24A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
TYR C 356
GLY C 326
ASN C 330
PHE C 361
LEU E 374
1.71A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		3 / 3
GLY B 285
GLU B 281
THR B 283
1.07A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		2w2g NSP3
(SARSr-CoV)		3 / 3
GLY B 572
GLU B 587
THR B 584
1.65A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 10
PHE A 149
TYR A 152
GLY A 155
PHE A 150
LEU A 180
1.69A19.30
SAH  A1293 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 10
PHE A 149
TYR A 152
GLY A 155
PHE A 150
LEU A 180
1.71A19.30
SAH  A1300 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
GLY B 106
GLU C  38
THR C  43
0.98A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
GLY A 214
GLU A 571
THR A 567
1.28A14.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
TYR E 438
TYR E 436
GLY E 434
ASN E 435
ARG E 479
1.78A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
GLY C  93
GLU C  68
THR A  62
0.89A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		3i6g HLA, A-2
(Homo
sapiens)		3 / 3
GLY A 175
GLU A 177
THR A 178
1.05A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		3i6l BETA-2-MICROGLOBULIN
(Homo
sapiens)		3 / 3
GLY E  18
GLU E  74
THR E  73
1.19A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
GLY A 109
GLU C 290
THR A 111
0.84A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 10
PHE A 149
TYR A 152
GLY A 155
PHE A 150
LEU A 180
1.72A19.42
SAM  A 302 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
GLY A 214
GLU A 571
THR A 567
1.19A14.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		3 / 3
GLY B 164
GLU B 168
THR B 169
0.96A20.67
P85  B 902 ( 3.5A)
DMS  B 906 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
GLY B 123
GLU B 132
THR B 131
0.99A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
GLY D 123
GLU D 132
THR D 131
0.95A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		3 / 3
GLY C 123
GLU C 132
THR C 131
0.91A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		3 / 3
GLY C  10
GLU D   8
THR D   9
1.12A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
GLY A 164
GLU A 168
THR A 169
1.18A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		6acj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		3 / 3
GLY C 488
GLU D 329
THR C 486
1.43A9.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		6ack ACE2
(Homo
sapiens)		3 / 3
GLY D 214
GLU D 571
THR D 567
1.32A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
GLY A 100
GLU C   2
THR C   3
1.20A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		6m1d ACE2
(Homo
sapiens)		3 / 3
GLY D 214
GLU D 571
THR D 567
1.15A10.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
GLY C 215
GLU C 456
THR C 459
1.43A11.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
GLY A 587
GLU A 593
THR A 585
1.59A9.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		6nus NSP12
(SARSr-CoV)		3 / 3
GLY A 616
GLU A 802
THR A 801
1.22A10.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
TYR H  52
PRO H  53
TYR H  32
GLY H 101
LEU H   4
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
TYR B  52
PRO B  53
TYR B  32
GLY B 101
LEU B   4
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
TYR B  52
PRO B  53
TYR B  32
GLY B 101
LEU B   4
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
TYR H  52
PRO H  53
TYR H  32
GLY H 101
LEU H   4
1.68A
None