Ligand ID: BUW


Drugbank ID:
DB00392
(Ethopropazine)


Indication:
For use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine.

Get human targets for BUW in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'BUW' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 8
GLY A 125
SER A  56
PHE A  88
TYR A  64
1.52A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY B  23
THR B  25
SER B  65
TYR B  54
1.54A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 8
GLY B  23
THR B  25
SER B  65
TYR B  54
1.52A21.35
None
AZP  B 307 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
GLY A 352
THR E 487
SER A  44
TYR E 436
1.51A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 8
GLY C 296
GLN C 295
SER D 313
TRP C 302
0.98A13.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
GLY S 488
GLN S 492
THR S 487
SER H  35
1.32A17.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2fyg REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
GLY A  35
GLN A  36
SER A  33
PHE A  16
1.39A13.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
GLY C  35
GLN C  36
SER C  33
PHE C  16
1.39A14.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 8
GLY A 296
GLN A 295
SER B 313
TRP A 302
1.16A11.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 8
GLY A  23
THR A  25
SER A  65
TYR A  54
1.43A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 8
GLY B 124
THR A 304
SER B  10
PHE A 150
1.51A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2xyr NSP10
(SARSr-CoV)		4 / 8
GLY B  35
GLN B  36
SER B  33
PHE B  16
1.31A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		2xyv NSP10
(SARSr-CoV)		4 / 8
GLY B  35
GLN B  36
SER B  33
PHE B  16
1.36A13.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 8
GLY S 490
GLN S 492
THR S 487
TYR S 440
1.36A16.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLY A 352
THR E 487
SER A  44
PHE A 390
1.44A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A 215
GLN A 306
THR A 304
PHE A 219
1.33A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A  23
THR A  25
SER A  65
TYR A  54
1.45A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A  23
THR A  25
SER A  65
TYR A  54
1.52A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3i6l HLA, A-24
NUCLEOPROTEIN
PEPTIDE
(Homo
sapiens;
SARSr-CoV)		4 / 8
GLN D  72
THR D  73
SER D   9
PHE F   2
1.25A19.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A  23
THR A  25
SER A  65
TYR A  54
1.52A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		4 / 8
GLY B  35
GLN B  36
SER B  33
PHE B  16
1.29A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLY E 490
GLN E 492
THR E 487
TYR E 440
1.42A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		3v3m 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A 215
GLN A 306
THR A 304
PHE A 219
1.02A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A  23
THR A  25
SER A  65
TYR A  54
1.54A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A 215
GLN A 306
THR A 304
PHE A 219
1.25A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY B  23
THR B  25
SER B  65
TYR B  54
1.37A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
GLY B 110
GLN B 108
PHE B 198
TYR B 197
1.40A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		5c8s NSP10
(SARSr-CoV)		4 / 8
GLY C  35
GLN C  36
SER C  33
PHE C  16
1.28A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
GLY B 110
GLN B 108
PHE B 198
TYR B 197
1.21A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
GLY C 110
GLN C 108
PHE C 198
TYR C 197
1.28A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
GLY C 579
GLN A 835
THR A 841
TYR C 598
1.42A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		5x5f S PROTEIN
(MERS-CoV)		4 / 8
GLY A 572
GLN A 471
THR A 574
TYR B 287
1.05A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6acg ACE2
(Homo
sapiens)		4 / 8
GLY D 448
THR D 445
PHE D 512
TYR D 515
1.42A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TRP A 619
GLY A 580
GLN A 599
SER A 303
1.23A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
GLY B 490
GLN B 492
THR B 487
TYR B 440
1.30A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6jyt HELICASE
(SARSr-CoV)		4 / 8
GLY A 213
THR A 215
PHE A 225
TYR A 185
1.52A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6m18 ACE2
(Homo
sapiens)		4 / 8
GLY B 326
GLN B 325
THR B 324
SER B 331
1.54A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
GLN A 194
TRP A 138
PHE A 175
TYR A 174
1.39A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLN A 984
SER B 985
PHE B 741
TYR B 738
1.41A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6nur NSP12
(SARSr-CoV)		4 / 8
GLY A 559
GLN A 541
THR A 540
TYR A 456
1.48A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY F 447
GLN F 498
THR F 444
TYR F 451
1.27A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
GLN L  89
THR L  97
TRP L  35
PHE L  71
1.64A16.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TRP L 148
GLN H 171
THR L 180
SER L 176
1.75A16.44
None
None
None
GOL  L 301 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
GLN H 171
THR L 180
SER L 127
PHE H 122
1.64A13.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TRP L  35
GLY L  68
SER L  25
TYR L  91
1.64A16.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TRP L 148
GLN H 171
THR L 180
SER H 179
1.77A16.44
None
None
None
GOL  L 301 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN C  95
THR C 103
TRP C  41
TYR C  98
1.72A19.15
None
DMS  B 305 ( 4.7A)
None
DMS  C 303 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP H  47
GLY H  99
THR H 104
TYR L  42
1.76A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP L  41
GLY L  74
SER L  25
TYR L  97
1.47A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN B 175
THR C 186
SER C 133
PHE B 126
1.72A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP C 154
GLN B 175
THR C 186
SER B 183
1.77A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP C 154
GLN B 175
THR C 186
SER C 182
1.71A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
GLY B  98
THR B 104
PHE B  29
TYR B  52
1.78A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN L  95
THR L 103
TRP L  41
TYR L  98
1.69A19.15
None
DMS  L1602 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP B  47
GLY B  99
THR B 104
TYR C  42
1.76A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN H 175
THR L 186
SER L 133
PHE H 126
1.71A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN L  95
THR L 103
TRP L  41
PHE L  77
1.70A19.15
None
DMS  L1602 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN C  95
THR C 103
TRP C  41
PHE C  77
1.69A19.15
None
DMS  B 305 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP C  41
GLY C  74
SER C  25
TYR C  97
1.48A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP L 154
GLN H 175
THR L 186
SER L 182
1.72A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP L  41
GLY L  74
SER L  25
TYR L  97
1.41A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP L 154
GLN H 175
THR L 186
SER H 183
1.73A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN L  95
THR L 103
TRP L  41
PHE L  77
1.71A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP L 154
GLN H 175
THR L 186
SER L 182
1.70A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN L  95
THR L 103
TRP L  41
TYR L  98
1.73A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLN H 175
THR L 186
SER L 133
PHE H 126
1.67A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
GLN C  95
THR C 103
TRP C  41
PHE C  77
1.70A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP L  41
GLY L  74
SER L  25
TYR L  97
1.47A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
GLN H 175
THR L 186
SER L 133
PHE H 126
1.71A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
GLN L  95
THR L 103
TRP L  41
TYR L  98
1.69A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP B  47
GLY B  99
THR B 104
TYR C  42
1.76A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
GLN B 175
THR C 186
SER C 133
PHE B 126
1.71A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP C 154
GLN B 175
THR C 186
SER C 182
1.71A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
GLN L  95
THR L 103
TRP L  41
PHE L  77
1.69A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP C  41
GLY C  74
SER C  25
TYR C  97
1.47A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP L 154
GLN H 175
THR L 186
SER H 183
1.80A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP C 154
GLN B 175
THR C 186
SER B 183
1.80A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP H  47
GLY H  99
THR H 104
TYR L  42
1.76A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP L 154
GLN H 175
THR L 186
SER L 182
1.72A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
GLN C  95
THR C 103
TRP C  41
TYR C  98
1.70A19.15
None