Ligand ID: BEP


Drugbank ID:
DB01244
(Bepridil)


Indication:
For the treatment of hypertension, and chronic stable angina (classic effort-associated angina).

Get human targets for BEP in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'BEP' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE B  91
PHE B  40
LEU B   9
LEU B  45
LEU B  88
1.29A18.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA F 912
ILE F 913
PHE F 909
PHE D 909
LEU F 920
1.47A26.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 11
LEU B  60
MET B  57
LEU F 108
VAL B  27
LEU B  76
1.58A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
ALA C  53
ILE C  44
LEU G 127
LEU C  61
LEU G 108
1.42A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		2ajf ACE2
(Homo
sapiens)		4 / 8
MET B 323
ASP B 350
ARG B 393
MET B 383
1.61A14.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 189
GLU A 166
ARG A 188
MET A  49
1.68A20.06
9IN  A1001 (-3.7A)
9IN  A1001 (-4.1A)
None
9IN  A1001 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
PHE B 287
ILE A 321
LEU A 332
LEU B 353
MET A 323
1.55A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 11
ILE C  20
LEU C  55
LEU D  53
LEU D  15
LEU D  47
1.65A18.12
D10  C1099 ( 4.8A)
None
D10  C1099 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE B 148
ILE B 152
LEU B 173
MET B 170
CYH B 261
1.41A13.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 11
LEU A  96
LEU A  53
VAL A 110
GLU A  44
LEU A  45
1.46A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 350
LEU A 374
PHE A 364
LEU A 421
LEU A 499
1.38A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
PHE B 287
ILE A 321
LEU A 332
LEU B 353
MET A 323
1.53A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
PHE A 287
ILE B 321
LEU B 332
LEU A 353
MET B 323
1.65A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 189
GLU A 166
ARG A 188
MET A  49
1.67A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr)		5 / 12
ILE A 322
LEU A 297
ILE A 305
GLU A 304
VAL A 320
1.42A14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE A 305
LEU A 227
PHE A 232
LEU A 250
MET A 209
1.51A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
ALA A 306
PHE A 308
PHE A 287
LEU A 292
PHE A 275
1.34A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE C 322
LEU C 297
ILE C 305
GLU C 304
VAL C 320
1.18A14.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE A 327
LEU A 331
PHE A 240
LEU A 250
LEU A 297
1.47A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
GLN D 130
PRO D 111
ASP D 124
ARG D 126
1.77A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE A 322
LEU A 297
ILE A 305
GLU A 304
VAL A 320
1.29A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE C 305
LEU C 227
PHE C 232
LEU C 250
MET C 209
1.41A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ALA A 168
ILE A 128
MET A 184
LEU A 161
LEU A  59
1.38A18.69
None
None
None
None
NA  A1295 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ALA A 168
ILE A 128
MET A 184
LEU A 161
LEU A  59
1.35A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		2z9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 110
PRO A 108
GLU A 240
GLU A 290
1.52A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
PHE A 525
ILE A 407
LEU A 529
LEU A 570
ILE A 544
1.63A11.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE F 325
PHE F 451
LEU F 412
MET F 417
PHE F 387
1.42A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
PHE A 438
ILE A 291
VAL A 293
MET A 366
LEU A 410
1.29A14.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLU A 457
GLU A 467
ASP A 198
ARG A 192
1.57A14.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN B 110
PRO B 108
GLU B 240
GLU B 290
1.80A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		3e9s NSP3
(SARSr-CoV)		5 / 12
PHE A 148
ILE A 152
LEU A 173
MET A 170
CYH A 261
1.48A13.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 110
PRO A 108
GLU A 240
GLU A 290
1.69A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 189
GLU A 166
ARG A 188
MET A  49
1.62A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3i6g HLA, A-2
(Homo
sapiens)		4 / 8
GLN A 253
PRO A 250
GLU A 222
ASP A 220
1.71A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN B 189
ASP B 187
ARG B 188
MET B  49
1.64A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN B 110
PRO B 108
GLU B 240
GLU B 290
1.76A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
MET A 209
GLU A 204
GLU A 168
ASP B 165
1.70A17.74
GRM  B 801 (-4.1A)
None
None
GRM  B 801 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ALA A 168
ILE A 128
MET A 184
LEU A 161
LEU A  59
1.38A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		3scj ACE2
(Homo
sapiens)		5 / 12
PHE B 369
ILE B 307
LEU B 418
GLU B 312
MET B 376
1.64A11.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
PHE A  28
LEU A  97
LEU A  79
ILE A  88
GLU A  87
1.52A11.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
PHE B 438
ILE B 291
VAL B 293
MET B 366
LEU B 410
1.54A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
MET A 323
ASP A 350
ARG A 393
MET A 383
1.73A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4m0w UBIQUITIN
(Bos
taurus)		5 / 12
PHE B  45
ILE B  61
LEU B  67
ILE B  23
GLU B  51
1.62A23.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 12
PHE A 148
ILE A 152
LEU A 173
MET A 170
CYH A 261
1.45A13.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
PHE B 148
ILE B 152
LEU B 173
MET B 170
CYH B 261
1.46A13.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		6 / 12
ILE A 126
PHE A 128
PHE A 148
LEU A 170
LEU A 311
LEU A 122
1.70A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 11
LEU A 204
LEU A 245
VAL A 129
LEU A 169
LEU A 170
1.49A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLN A 110
PRO A 108
GLU A 240
GLU A 290
1.77A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PRO A   9
GLU B  14
ARG A   4
MET A   6
1.78A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
PHE D 198
ILE D 166
LEU D 109
VAL D 115
LEU D 185
1.63A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
PHE D 514
ILE D 510
LEU D 442
LEU D 519
CYH D 340
1.64A10.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
PHE D 514
ILE D 510
LEU D 442
LEU D 519
CYH D 340
1.60A10.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
PHE D 198
ILE D 166
LEU D 109
VAL D 115
LEU D 185
1.57A14.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE D 148
ILE D 152
LEU D 173
MET D 170
CYH D 261
1.51A13.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5e6j UBIQUITIN
(synthetic
construct)		5 / 12
PHE B  45
ILE B  61
LEU B  67
ILE B  23
GLU B  51
1.66A23.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
PHE B 198
ILE B 166
LEU B 109
VAL B 115
LEU B 185
1.60A15.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
PHE C 514
ILE C 510
LEU C 442
LEU C 519
CYH C 340
1.52A10.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ILE D 105
LEU D 114
LEU D 151
LEU D 174
LEU D 173
1.62A17.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE D 148
ILE D 152
LEU D 173
MET D 170
CYH D 261
1.34A13.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ILE A 296
PHE A 313
LEU A 180
LEU A 169
LEU A 149
1.30A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
PHE B 571
ILE B 480
LEU B 415
LEU B 389
LEU B 488
1.58A8.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
GLN C1095
PRO C1094
GLU C1074
ARG B1073
1.73A8.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE A 219
PHE A 168
PHE A 187
LEU A 194
LEU A 222
1.29A8.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
ILE C 296
PHE C 313
LEU C 180
LEU C 169
LEU C 149
1.30A8.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5x5f S PROTEIN
(MERS-CoV)		4 / 8
GLN C 544
PRO C 547
GLU C 549
ARG C 542
1.76A8.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA C 866
ILE A 687
PHE C 870
LEU C 788
LEU C 776
1.50A8.15
ALA  C 866 ( 0.0A)
ILE  A 687 ( 0.7A)
PHE  C 870 ( 1.3A)
LEU  C 788 ( 0.6A)
LEU  C 776 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLN B 549
PRO B 507
GLU B 569
ARG A  48
1.69A8.15
GLN  B 549 ( 0.6A)
PRO  B 507 ( 1.1A)
GLU  B 569 ( 0.5A)
ARG  A  48 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE A 148
ILE A 152
LEU A 173
MET A 170
CYH A 261
1.40A13.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5yvd NSP15
(MERS-CoV)		5 / 12
ILE A 137
LEU A  72
ILE A 135
MET A 148
CYH A 189
1.39A15.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5yvd NSP15
(MERS-CoV)		5 / 12
ILE B 137
LEU B  72
ILE B 135
MET B 148
CYH B 189
1.44A15.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 11
LEU B 941
LEU b   8
VAL a  13
LEU c   8
LEU C 948
1.59A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
ALA B 912
ILE B 913
PHE A 909
LEU c  32
LEU B 920
1.43A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE C 652
LEU C 636
VAL C 675
GLU C 593
LEU C 283
1.53A8.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		6acg ACE2
(Homo
sapiens)		5 / 12
ALA D 550
ILE D 544
MET D 408
LEU D 320
MET D 557
1.35A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PRO B 507
GLU B 569
ASP B 564
ARG B 315
1.49A8.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6acg ACE2
(Homo
sapiens)		5 / 11
PHE D 438
ILE D 291
VAL D 293
MET D 366
LEU D 410
1.44A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 219
PHE A 168
PHE A 187
LEU A 194
LEU A 222
1.38A8.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		6ack ACE2
(Homo
sapiens)		4 / 8
GLU D 457
GLU D 467
ASP D 198
ARG D 192
1.52A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
GLN B 835
PRO A 575
GLU B 821
ASP A 600
1.68A8.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE C 704
PHE C1034
PHE C 784
PHE C 888
MET C 884
1.45A8.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
PHE C 187
ILE C  87
LEU C 194
ILE C  81
VAL C 254
1.67A5.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
PHE B 451
LEU B 412
MET B 417
VAL B 337
LEU B 499
1.59A8.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
MET A   5
GLU C   2
GLU A  55
ARG A  48
1.55A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		6jyt HELICASE
(SARSr-CoV)		4 / 8
GLN B 548
PRO B 514
GLU B 551
ASP B 578
1.55A12.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ILE B 512
LEU B 405
ILE B 572
VAL B 544
CYH B 441
1.62A8.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		6m17 ACE2
(Homo
sapiens)		5 / 12
PHE D 369
ILE D 307
LEU D 418
GLU D 312
MET D 376
1.65A7.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ILE C  92
LEU C  96
LEU C  21
ILE C 107
VAL C 505
1.28A9.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6m17 ACE2
(Homo
sapiens)		5 / 11
PHE B 724
ILE B 618
VAL B 685
MET B 651
LEU D 642
1.52A11.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
LEU C 269
LEU C  77
VAL C 551
LEU C 540
LEU C 541
1.36A13.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
GLN A  94
GLU A  28
GLU A  20
MET A 521
1.52A13.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE B 784
ILE B 787
VAL B1047
MET B1032
LEU B 898
1.58A8.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_2
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
TROPONIN I, CARDIAC
MUSCLE)		6nur NSP12
(SARSr-CoV)		4 / 4
ARG A 331
ILE A 333
ALA A 379
MET A 380
1.45A1.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 12
PHE D  92
ILE D 107
LEU D  95
MET C  52
CYH C  32
1.66A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		6nur NSP12
(SARSr-CoV)		5 / 12
ALA A 702
PHE A 782
LEU A 749
PHE A 745
LEU A 727
1.42A9.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 11
ILE B 107
LEU B 103
VAL A 330
LEU B  91
LEU B  95
1.40A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		6nur NSP12
(SARSr-CoV)		4 / 8
MET A 566
GLN A 524
ASP A 523
MET A 519
1.69A9.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 12
ALA C  48
ILE C  39
LEU D 122
LEU C  56
LEU D 103
1.47A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		6nus NSP12
(SARSr-CoV)		5 / 12
LEU A 673
LEU A 388
MET A 666
ILE A 539
GLU A 665
1.39A6.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6vw1 ACE2
(Homo
sapiens)		5 / 11
PHE B 438
ILE B 291
VAL B 293
MET B 366
LEU B 410
1.48A14.82
None