Ligand ID: AZZ


Drugbank ID:
DB00495
(Zidovudine)


Indication:
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.

Get human targets for AZZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'AZZ' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		1uk4 3C-LIKE PROTEINASE
5-MER PEPTIDE OF
INHIBITOR
(SARSr-CoV)		4 / 8
SER H   2
GLN B 189
HIS B  41
CYH B  44
1.34A6.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
PHE B 140
ALA B 116
GLY B 124
TYR B 126
1.13A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LEU B 927
ILE B1164
GLY A 928
LYS A 929
1.29A13.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 11
THR B  68
LEU B  65
TYR B  10
VAL B   9
SER B  11
1.62A12.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		1x7q HLA, A-11
(Homo
sapiens)		5 / 10
GLU A  63
PHE A  33
VAL A  34
MET A  45
ALA A  24
1.55A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
LEU G 100
PHE G  97
GLN G  93
VAL C  71
MET C  67
1.74A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 11
THR B  14
LEU B  19
VAL B  63
MET B  57
LEU F 100
1.74A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2ajf ACE2
(Homo
sapiens)		4 / 8
LEU B 222
ILE B 513
TYR B 516
LYS B 458
1.35A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
SER A 113
GLN A 127
VAL A 297
ARG A 298
1.38A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER B 113
GLN B 127
VAL B 297
ARG B 298
1.61A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A 167
HIS A 163
GLY A 138
LYS B   1
1.31A18.57
None
PJE  C   5 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
ILE F 338
LEU F 354
PHE F 287
ALA E 312
PHE E 315
1.56A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 11
THR L 115
LEU L 118
VAL L 147
ILE L 137
SER L 177
1.80A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 11
THR H 165
LEU L 136
TYR L 179
SER H 177
PHE H 166
1.63A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU B 133
TYR B 155
SER B 156
PHE B 148
LEU B 114
1.72A22.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 355
TYR C 352
PHE C 329
VAL C 328
ALA C 384
1.72A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
ILE B 338
LEU B 354
PHE B 287
ALA A 312
PHE A 315
1.63A17.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
LEU A 227
VAL A 236
ILE A 252
PHE A 221
LEU A 214
1.72A23.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 8
GLU A  68
SER A 197
GLN A 159
VAL A 172
0.88A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
ASN A 616
ALA A 620
GLY A 609
TYR A 610
1.47A9.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE C  71
VAL C  77
MET A 330
ALA C  94
MET C 271
1.69A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
GLU A  68
SER A 197
GLN A 159
VAL A 172
0.74A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
LEU D 331
ILE D 235
HIS D 234
GLY D 246
1.33A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
SER B 113
GLN B 127
VAL B 297
ARG B 298
1.69A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 8
SER B 113
GLN B 127
VAL B 297
ARG B 298
1.67A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU A 227
VAL A 236
ILE A 252
PHE A 221
LEU A 214
1.76A23.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
GLU D  68
SER D 197
GLN D 159
VAL D 172
0.94A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
HIS E  14
PHE E  15
TYR E   7
GLY E  17
1.25A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
GLN A 127
VAL A 297
ARG A 298
1.62A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 5
PHE B 140
ALA B 116
GLY B 124
TYR B 126
1.14A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2w2g NSP3
(SARSr-CoV)		4 / 8
LEU B 627
ILE B 593
ARG B 625
GLY B 491
1.32A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2wct NSP3
(SARSr-CoV)		5 / 11
THR A 605
VAL A 589
ILE A 593
MET A 624
LEU A 627
1.78A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
LEU A 275
ILE A 281
ARG A 279
GLY A 256
1.36A18.31
None
None
CL  A1291 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A  40
MET A 247
PHE A 250
GLN A  87
ALA A  83
1.76A23.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
LEU A 262
ILE A 282
TYR A 272
GLY A 213
1.34A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A  50
ILE A 167
SER A 166
PHE A 205
LEU A 180
1.73A21.93
None
None
NA  A1294 (-2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A  40
MET A 247
PHE A 250
GLN A  87
ALA A  83
1.77A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2z9k 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 167
HIS B 163
GLY B 138
LYS A   1
1.24A18.70
None
DMS  B 802 (-3.8A)
None
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3avz 3C-LIKE PROTEINASE
PEPTIDE
ACE-SER-ALA-VAL-ALC-
HIS-H
(SARSr-CoV)		4 / 8
SER B   2
GLN A 189
HIS A  41
CYH A  44
1.51A44.44
ACE  B   1 ( 4.5A)
None
ALC  B   5 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLU B 398
SER B 511
VAL B 404
HIS B 378
1.59A20.30
None
None
None
ZN  B 901 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
LEU B 222
ILE B 513
TYR B 516
LYS B 458
1.32A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ILE A 544
VAL A 404
LEU A 558
ALA A 311
PHE A 314
1.33A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
GLN A 127
VAL A 297
ARG A 298
1.54A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
GLN A 127
VAL A 297
ARG A 298
1.44A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER B 113
GLN B 127
VAL B 297
ARG B 298
1.68A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER B 113
GLN B 127
VAL B 297
ARG B 298
1.57A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		3i6g HLA, A-2
(Homo
sapiens)		5 / 12
GLU D  63
PHE D  33
VAL D  34
MET D  45
ALA D  24
1.64A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		3i6g HLA, A-2
(Homo
sapiens)		5 / 10
GLU D  63
PHE D  33
VAL D  34
MET D  45
ALA D  24
1.64A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3i6g HLA, A-2
(Homo
sapiens)		4 / 8
GLU D 173
GLN D 180
VAL D 103
HIS D   3
1.55A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		4 / 8
LEU D 206
HIS E  13
TYR E  10
GLY D 237
1.39A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		3i6k BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 11
THR F  68
LEU F  65
TYR F  10
VAL F   9
SER F  11
1.60A11.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		3i6k HLA, A-2
(Homo
sapiens)		5 / 10
GLU A  63
PHE A  33
VAL A  34
MET A  45
ALA A  24
1.54A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		5 / 8
LEU D 206
HIS E  13
PHE E  22
TYR E  10
GLY D 237
1.67A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3i6l HLA, A-24
(Homo
sapiens)		4 / 8
TYR D 159
GLN D 156
VAL D  67
HIS D  70
1.49A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
LEU A 262
ILE A 282
TYR A 272
GLY A 213
1.31A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		4 / 8
SER A  74
HIS B  80
CYH B  77
ARG B  78
1.47A18.94
SAM  A 302 ( 4.4A)
None
ZN  B 998 (-2.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A  50
ILE A 167
SER A 166
PHE A 205
LEU A 180
1.76A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A  40
MET A 247
PHE A 250
GLN A  87
ALA A  83
1.75A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		3scj ACE2
(Homo
sapiens)		5 / 11
THR A 414
LEU A 370
VAL A 293
ILE A 291
LYS A 441
1.67A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3scj ACE2
(Homo
sapiens)		4 / 8
LEU B 222
ILE B 513
TYR B 516
LYS B 458
1.33A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ILE A 544
VAL A 404
LEU A 558
ALA A 311
PHE A 314
1.42A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLU B 398
SER B 511
VAL B 404
HIS B 378
1.69A20.18
None
None
None
ZN  B 901 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
LEU A 222
ILE A 513
TYR A 516
LYS A 458
1.39A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
SER A 113
GLN A 127
VAL A 297
ARG A 298
1.48A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 10
ILE B 152
GLN B 134
VAL B 126
ALA B 177
PHE B 128
1.79A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 133
TYR B 155
SER B 156
PHE B 148
LEU B 114
1.71A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
LEU A  71
TYR B 265
ARG A  74
GLY B 164
1.30A8.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 8
LEU A 104
ILE A 117
HIS A 140
PHE A 137
1.29A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
LEU D 495
ILE D 502
SER D 503
PHE D 444
LEU D 508
1.37A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
GLN B 254
VAL B 269
HIS B 268
CYH B 272
1.57A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
TYR D 235
SER D 220
VAL D 162
ARG D 163
1.56A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ILE B 166
VAL B 181
TRP B 227
LEU B 174
ALA B 225
1.76A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
LEU B 495
ILE B 502
SER B 503
PHE B 444
LEU B 508
1.31A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
ILE A  38
GLU A   6
VAL A   7
ARG A  78
ALA B  23
1.70A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A 133
TYR A 155
SER A 156
PHE A 148
LEU A 114
1.75A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 12
LEU B 100
PHE B  97
GLN B  93
VAL A  71
MET A  67
1.68A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLU O   6
VAL O   7
ARG O  78
ALA D  23
MET O  44
1.79A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
LEU A 495
ILE A 502
SER A 503
PHE A 444
LEU A 508
1.33A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
TYR D 235
SER D 220
VAL D 162
ARG D 163
1.59A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		4 / 8
LEU A 152
TYR B 265
ARG A 155
GLY B 164
1.20A10.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		4 / 8
LEU A 150
TYR B 265
ARG A 153
GLY B 164
1.34A11.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 707
LEU B1045
VAL B1042
MET B 709
ALA B1007
1.65A11.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
THR A 257
LEU A 149
VAL A 315
PHE A 112
LEU A 318
1.79A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5x4r S PROTEIN
(MERS-CoV)		4 / 8
TYR A 201
SER A 191
VAL A  33
HIS A 194
1.70A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
ILE B 985
PHE C 967
TYR B1192
ARG B1179
1.31A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
GLU C 549
SER C 546
VAL C 514
ARG C 505
1.50A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
VAL C1127
LEU C1134
PHE C 850
ALA C 946
MET C 939
1.72A10.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLU C 162
LEU C 224
ARG C 126
ALA C 156
PHE C 130
1.59A11.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
SER C 964
VAL B 349
CYH B 511
ARG B 315
1.55A17.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLU C 162
LEU C 224
ARG C 126
ALA C 156
PHE C 130
1.61A11.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
ASN A 910
PHE A 909
ALA A 906
GLY A 781
1.38A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
LEU A 734
PHE A 741
ARG C 977
GLY C 981
1.37A17.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
LEU C 479
TYR C 469
VAL C 396
ILE C 464
MET C 452
1.60A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		5x5f S PROTEIN
(MERS-CoV)		5 / 10
VAL C1149
GLN A 857
VAL C 770
ALA A 968
PHE A 967
1.57A10.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		5x5f S PROTEIN
(MERS-CoV)		4 / 5
ASN B1002
PHE B1001
ALA B 998
GLY B 867
1.47A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU C 900
VAL C 897
LEU C 898
MET C 882
ALA A1069
1.76A11.86
GLU  C 900 ( 0.6A)
VAL  C 897 ( 0.6A)
LEU  C 898 ( 0.5A)
MET  C 882 ( 0.0A)
ALA  A1069 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
ASN A 910
PHE A 909
ALA A 906
GLY A 781
1.45A20.45
ASN  A 910 ( 0.6A)
PHE  A 909 ( 1.3A)
ALA  A 906 ( 0.0A)
GLY  A 781 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LEU C 994
ILE C 752
TYR C 989
ARG C 996
1.37A17.22
LEU  C 994 ( 0.6A)
ILE  C 752 ( 0.7A)
TYR  C 989 ( 1.3A)
ARG  C 996 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
LEU A 133
TYR A 155
SER A 156
PHE A 148
LEU A 114
1.72A22.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE B 905
PHE C1071
GLN B 895
ALA B 885
PHE B 888
1.71A11.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU A 707
LEU A1045
VAL A1042
MET A 709
ALA A1007
1.54A11.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
ASN B 910
PHE B 909
ALA B 906
GLY B 780
1.16A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLU C 801
SER C 798
GLN C1036
VAL C1015
1.63A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LEU A 994
ILE A 752
TYR A 989
ARG A 996
1.29A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		6ack ACE2
(Homo
sapiens)		4 / 8
GLU D 406
SER D 409
GLN D 522
VAL D 447
1.59A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLU B 162
VAL B 124
ARG B 126
ALA B 127
PHE B 130
1.42A11.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 162
VAL B 124
ARG B 126
ALA B 127
PHE B 130
1.43A11.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
ASN C 951
PHE C 952
GLY A 739
TYR A 738
1.20A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
THR A  31
TYR A 256
VAL A 254
SER A  64
PHE A  69
1.66A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE A1114
GLU B 900
MET B 882
GLN B 895
PHE A1071
1.55A11.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLU B 707
LEU B1045
VAL B1042
MET B 709
ALA B1007
1.65A11.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
GLU C 801
SER C 798
GLN C1036
VAL C1015
1.67A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
LEU C 994
ILE C 752
TYR C 989
ARG C 996
1.38A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
ASN A 910
PHE A 909
ALA A 906
GLY A 781
1.20A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
GLU A 162
VAL A 124
ARG A 126
ALA A 127
PHE A 130
1.73A11.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 8
LEU A 206
HIS B  13
PHE B  22
TYR B  10
GLY A 237
1.66A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLU A 154
LEU A 126
VAL A 152
ARG A 151
ALA A 150
1.67A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		6jyt HELICASE
(SARSr-CoV)		4 / 8
GLU A 551
SER A 577
GLN A 548
VAL A 456
1.52A21.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
ILE A 544
VAL A 404
LEU A 558
ALA A 311
PHE A 314
1.39A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		6m17 ACE2
(Homo
sapiens)		5 / 11
VAL D 620
ILE D 679
SER D 623
PHE D 715
MET D 640
1.80A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		6m18 ACE2
(Homo
sapiens)		5 / 12
ILE B 544
VAL B 404
LEU B 558
ALA B 311
PHE B 314
1.47A14.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
THR A 228
LEU A 234
VAL A  50
SER A 430
LEU A  43
1.45A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
LEU C 482
ILE C 132
TYR C 129
GLY C  53
1.06A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU A 900
VAL A 897
LEU A 898
MET A 882
ALA B1069
1.76A11.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
ASN C 951
PHE C 952
GLY B 739
TYR B 738
1.24A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LEU C 978
ILE C 724
PHE C 741
TYR C 723
1.28A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 11
THR C   9
LEU C  14
VAL C  58
MET C  52
LEU D  95
1.68A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		6nur NSP12
(SARSr-CoV)		5 / 8
GLU A 658
SER A 635
HIS A 642
CYH A 646
ARG A 654
1.78A20.27
None
None
ZN  A1002 (-3.6A)
ZN  A1002 (-2.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6nus NSP12
(SARSr-CoV)		4 / 8
LEU A 308
ILE A 632
PHE A 348
ARG A 651
1.29A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
ILE B 544
VAL B 404
LEU B 558
ALA B 311
PHE B 314
1.41A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		6vw1 ACE2
(Homo
sapiens)		5 / 11
THR A 414
LEU A 370
VAL A 293
ILE A 291
LYS A 441
1.48A22.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
LEU L  11
ILE L  21
TYR L  86
GLY L 101
1.78A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU C  11
ILE C  21
ARG C  18
GLY C  70
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU L  11
ILE L  21
TYR L  92
GLY L 107
1.72A
None
None
None
1PE  L1603 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU C  11
ILE C  21
TYR C  92
GLY C 107
1.75A
None
None
None
1PE  C 301 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU L  11
ILE L  21
TYR L  92
GLY L 107
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
LEU C  11
ILE C  21
TYR C  92
GLY C 107
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
LEU L  11
ILE L  21
TYR L  92
GLY L 107
1.73A
None