Ligand ID: AXI


Drugbank ID:
DB06626
(Axitinib)


Indication:
Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.

Get human targets for AXI in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'AXI' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
LEU A  99
ALA A  97
THR A  93
GLY A  63
ALA A 116
1.15A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 259
LEU A  -2
VAL A 296
GLY A   2
LEU A 282
1.28A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 200
LEU A 167
VAL A 171
LYS A 137
GLU A 290
1.23A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.30A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		6 / 12
LEU A 167
VAL A 171
LYS A 137
GLU A 290
PHE A 185
GLY A 195
1.62A23.95
AZP  A 307 (-3.8A)
None
None
None
AZP  A 307 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
VAL A 333
ALA A 306
VAL A 277
VAL A 218
LEU A 309
1.22A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
LEU E 100
VAL A  21
VAL A  17
LEU A  64
PHE E  97
1.41A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		6 / 11
LEU A  45
TYR E 484
LYS A 353
ASN E 435
ALA E 430
PHE E 483
1.76A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2ajf ACE2
(Homo
sapiens)		5 / 12
LEU A 558
GLU A 549
VAL A 318
LEU A 320
PHE A 555
1.42A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
LEU E 355
VAL E 497
PHE E 364
LEU E 499
PHE E 325
1.30A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A 167
VAL A 171
ALA A 173
LYS A 137
ASP A 197
1.45A20.80
CY6  A1145 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  75
VAL A  91
LYS A  90
MET A  17
ASP A  33
1.51A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B  67
VAL B  36
VAL B  18
LEU B  89
CYH B  38
1.46A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.29A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 227
MET B 264
ASN B 203
LEU B 205
ALA B 206
1.47A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL S 496
THR S 363
PHE S 364
GLY S 418
ALA S 398
1.36A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
VAL C 152
ALA C 125
VAL C  96
VAL C  37
LEU C 128
1.20A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 11
ALA B 154
MET B  85
GLY B  82
LEU B  81
ALA B  69
PHE B  70
1.75A24.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
LEU A 124
ALA A 120
LEU A 114
VAL A 117
LEU A 174
PHE A 128
1.78A22.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
TYR C  36
PHE A  70
GLY C  82
LEU C  59
PHE C  56
1.44A24.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU E 421
VAL E 496
PHE E 364
GLY E 418
ALA E 398
1.44A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU E 374
VAL C 497
PHE C 364
LEU C 499
PHE C 325
1.11A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL E 496
THR E 363
PHE E 364
GLY E 418
ALA E 398
1.35A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL E 382
ALA E 384
LEU E 412
LEU E 421
PHE E 379
1.39A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		6 / 12
LEU D 145
VAL D 236
ALA D 151
LEU D 179
GLY D 148
PHE D 215
1.02A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
LEU D 145
VAL D 236
ALA D 151
GLY D 148
PHE D 215
1.06A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 200
LEU A 167
VAL A 171
LYS A 137
GLU A 290
1.39A20.77
None
AZP  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		5 / 12
VAL A 204
THR A 199
GLY A 275
LEU A 272
ALA A 234
1.51A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.45A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 286
LEU A 202
ALA A 206
GLU A 288
LEU A 268
1.37A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 12
TYR A  88
THR A 166
LEU A 160
ALA A 174
PHE A 172
1.54A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 12
LEU A 122
TYR A  87
ALA A 126
GLY A 115
LEU A 114
1.52A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
LEU B  67
VAL B  36
VAL B  18
LEU B  89
CYH B  38
1.43A23.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
MET B 264
ASN B 203
LEU B 205
ALA B 206
PHE B 294
1.34A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.30A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.35A21.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
LEU B  67
VAL B  36
VAL B  18
LEU B  89
CYH B  38
1.45A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.35A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A  36
VAL B  42
ALA A  83
VAL A  84
GLY A  73
1.22A20.87
None
None
None
None
SAH  A1293 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
THR A 191
MET A 184
GLY A 185
ASN A 210
ALA A 209
1.48A23.08
None
None
None
NA  A1295 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
THR A 191
MET A 184
GLY A 185
ASN A 210
ALA A 209
1.47A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
LEU A 126
ALA A 168
VAL A 169
GLY A 165
LEU A 161
1.46A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A  36
VAL B  42
ALA A  83
VAL A  84
GLY A  73
1.23A18.90
None
None
None
None
SAH  A1300 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		2zu4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 167
VAL A 171
ALA A 173
LYS A 137
ASP A 197
1.35A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET B 264
ASN B 203
LEU B 205
ALA B 206
PHE B 294
1.27A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3aw0 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  67
VAL A  36
VAL A  18
LEU A  89
CYH A  38
1.46A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 12
VAL S 496
THR S 363
PHE S 364
GLY S 418
ALA S 398
1.39A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 12
LEU S 421
VAL S 496
PHE S 364
GLY S 418
ALA S 398
1.39A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 12
LEU S 355
VAL S 497
PHE S 364
LEU S 499
PHE S 325
1.36A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL F 496
THR F 363
PHE F 364
GLY F 418
ALA F 398
1.45A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 440
ALA A 443
LEU A 584
VAL A 447
LEU A 595
1.38A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 236
VAL B 581
PHE B 588
GLY B 448
LEU B 450
1.43A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3d0h ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
TYR E 484
LYS A 353
ASN E 435
ALA E 430
PHE E 483
1.50A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU E 421
VAL E 496
PHE E 364
GLY E 418
ALA E 398
1.47A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL E 496
THR E 363
PHE E 364
GLY E 418
ALA E 398
1.40A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL F 496
THR F 363
PHE F 364
GLY F 418
ALA F 398
1.48A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.31A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 157
LEU B 115
VAL B 148
LEU B  32
CYH B  16
1.41A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 227
MET A 264
ASN A 203
LEU A 205
ALA A 206
1.41A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3e9s NSP3
(SARSr-CoV)		5 / 11
LEU A  88
THR A  11
GLY A  82
LEU A  81
ALA A  69
1.44A23.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B  67
VAL B  36
VAL B  18
LEU B  89
CYH B  38
1.46A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B 227
MET B 264
ASN B 203
LEU B 205
ALA B 206
1.47A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
MET A 264
ASN C 203
LEU C 205
ALA C 206
PHE A 294
1.33A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.29A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU C  67
VAL C  36
VAL C  18
LEU C  89
CYH C  38
1.42A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE B 200
LEU B 167
VAL B 171
ALA B 173
LYS B 137
1.24A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.35A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  67
VAL A  36
VAL A  18
LEU A  89
CYH A  38
1.46A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.36A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 12
ILE A  36
VAL B  42
ALA A  83
VAL A  84
GLY A  73
1.27A21.17
None
None
None
None
SAM  A 302 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL E 496
THR E 363
PHE E 364
GLY E 418
ALA E 398
1.42A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3sci ACE2
(Homo
sapiens)		5 / 12
LEU B 236
VAL B 581
PHE B 588
GLY B 448
LEU B 450
1.44A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU E 355
VAL E 497
PHE E 364
LEU E 499
PHE E 325
1.46A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3scj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		6 / 11
LEU B  45
TYR F 484
LYS B 353
ASN F 435
ALA F 430
PHE F 483
1.74A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL E 496
THR E 363
PHE E 364
GLY E 418
ALA E 398
1.49A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU E 421
VAL E 496
PHE E 364
GLY E 418
ALA E 398
1.52A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 167
VAL A 171
ALA A 173
LYS A 137
ASP A 197
1.43A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
MET A 264
ASN A 203
LEU A 205
ALA A 206
PHE A 294
1.30A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
LEU A 167
VAL A 171
LYS A 137
GLU A 290
PHE A 185
GLY A 195
1.67A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ILE A 200
LEU A 167
VAL A 171
LYS A 137
GLU A 290
GLY A 195
1.72A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		6 / 11
ALA A 154
MET A  85
GLY A  82
LEU A  81
ALA A  69
PHE A  70
1.71A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ILE B 105
LEU A  73
LEU B 119
GLY B 272
CYH B 112
1.28A21.26
None
None
None
None
GLZ  A  76 ( 1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
VAL A 226
GLY B 272
ASN B 111
LEU B 163
ASP B 109
1.47A23.95
None
None
OCS  B 112 ( 4.0A)
P85  B 902 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 227
MET A 264
ASN A 203
LEU A 205
ALA A 206
1.45A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
MET B 264
ASN B 203
LEU B 205
ALA B 206
PHE B 294
1.43A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ILE D 397
VAL D 346
ALA D 344
VAL D 341
LEU D 322
1.37A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B 119
GLY B 123
ASN B 137
LEU B 105
ALA B 138
1.27A19.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
ALA B 119
GLY B 123
ASN B 137
LEU B 105
ALA B 138
1.34A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B 119
GLY B 123
ASN B 137
LEU B 105
ALA B 138
1.31A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ILE D 397
VAL D 346
ALA D 344
VAL D 341
LEU D 322
1.31A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B 119
GLY B 123
ASN B 137
LEU B 105
ALA B 138
1.31A19.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
ALA B 119
GLY B 123
ASN B 137
LEU B 105
ALA B 138
1.39A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
ILE C  38
LEU D  18
GLU C   6
LEU C  14
GLY C  94
1.37A18.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B 119
GLY B 123
ASN B 137
LEU B 105
ALA B 138
1.36A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
ILE A 105
LEU B  73
LEU A 119
GLY A 272
CYH A 112
1.31A22.46
None
None
None
None
AYE  B  76 ( 1.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5f22 NSP7
(SARSr-CoV)		5 / 12
LEU A  22
VAL A  21
LEU A  76
VAL A  71
LEU A  61
1.37A15.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA A 119
GLY A 123
ASN A 137
LEU A 105
ALA A 138
1.26A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
ALA A 119
GLY A 123
ASN A 137
LEU A 105
ALA A 138
1.34A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ILE C 397
VAL C 346
ALA C 344
VAL C 341
LEU C 322
1.31A22.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA A 119
GLY A 123
ASN A 137
LEU A 105
ALA A 138
1.30A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU D  88
THR D  11
GLY D  82
LEU D  81
ALA D  69
1.49A24.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
ILE D 105
LEU C 154
LEU D 119
GLY D 272
CYH D 112
1.29A21.26
None
None
None
None
AYE  C 157 ( 1.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
TYR A 252
VAL A  98
ALA A 250
GLY A  68
ALA A  90
PHE A 185
1.72A18.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
LEU C 421
VAL C 496
PHE C 364
GLY C 418
ALA C 398
1.43A11.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL C 496
THR C 363
PHE C 364
GLY C 418
ALA C 398
1.51A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE A 913
ALA A 926
LEU A1045
VAL A1043
LEU A 803
1.27A14.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5x5c S PROTEIN
(MERS-CoV)		6 / 11
ALA C 760
THR C 741
GLY C 716
ASN C 719
LEU C 673
ALA C 671
1.75A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
TYR C 469
VAL C 396
PHE C 571
GLY C 572
LEU C 479
1.43A11.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
TYR C 469
VAL C 396
PHE C 571
GLY C 572
LEU C 479
1.43A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 355
VAL B 497
PHE B 364
LEU B 499
PHE B 325
1.42A12.33
LEU  B 355 ( 0.5A)
VAL  B 497 ( 0.6A)
PHE  B 364 ( 1.3A)
LEU  B 499 ( 0.6A)
PHE  B 325 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR C 819
VAL C 842
ALA C 714
ASN C 942
ALA C 938
1.45A12.00
TYR  C 819 ( 1.3A)
VAL  C 842 ( 0.6A)
ALA  C 714 ( 0.0A)
ASN  C 942 ( 0.6A)
ALA  C 938 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE B 979
LEU B 840
VAL B 718
LEU B 983
LEU B 948
1.35A14.30
ILE  B 979 ( 0.7A)
LEU  B 840 ( 0.6A)
VAL  B 718 ( 0.6A)
LEU  B 983 ( 0.6A)
LEU  B 948 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 355
VAL A 354
PHE A 364
LEU A 499
ALA A 384
1.47A12.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE C 979
LEU C 840
VAL C 718
LEU C 983
LEU C 948
1.34A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 355
VAL C 497
PHE C 364
LEU C 499
PHE C 325
1.25A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR C 436
THR C 487
ASN C 435
ALA C 430
PHE C 483
1.46A13.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR C 598
VAL C 601
ASN C 304
LEU C 615
PHE C 578
1.49A13.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A 374
VAL A 328
VAL A 354
GLY A 418
LEU A 499
1.14A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA B 350
LYS B 509
GLY B 418
LEU B 499
ALA B 384
1.29A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A 377
VAL A 510
ALA A 350
GLY A 418
LEU A 499
1.12A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C 510
ALA C 350
GLY C 418
LEU C 499
ALA C 384
1.18A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C 510
ALA C 350
GLY C 418
LEU C 499
ALA C 384
1.08A11.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6cs2 ACE2
(Homo
sapiens)		5 / 12
LEU D 262
VAL D 487
LYS D 481
LEU D 456
GLY D 268
1.38A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6jyt HELICASE
(SARSr-CoV)		5 / 12
VAL B 371
ALA B 393
GLY B 273
LEU B 252
ALA B 302
1.36A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6jyt HELICASE
(SARSr-CoV)		5 / 12
LEU A  83
VAL A  60
GLY A  91
LEU A  14
CYH A  30
1.34A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6jyt HELICASE
(SARSr-CoV)		5 / 12
LEU A  83
VAL A  60
GLY A  91
LEU A  14
CYH A  30
1.32A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6jyt HELICASE
(SARSr-CoV)		5 / 12
VAL B 371
ALA B 393
GLY B 273
LEU B 252
ALA B 302
1.35A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m17 ACE2
(Homo
sapiens)		5 / 12
LEU D 558
GLU D 549
VAL D 318
LEU D 320
PHE D 555
1.36A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ILE A  72
LEU A  75
VAL A 315
GLY A 250
LEU A 254
1.33A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A 127
PHE A 473
GLY A 470
LEU A 201
ALA A 204
1.52A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
ALA A 273
GLY A 490
LEU A 494
ALA A 498
PHE A 499
1.50A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
PHE C 433
MET C 432
GLY C 428
ASN C  54
PHE C 279
1.43A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m1d ACE2
(Homo
sapiens)		6 / 12
ILE D 544
LEU D 560
ALA D 569
LEU D 529
VAL D 573
GLY D 395
1.66A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 979
LEU A 840
VAL A 718
LEU A 983
LEU A 948
1.41A14.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		6 / 12
TYR H 208
VAL H 225
ALA H 139
GLY H 204
LEU H 203
ALA H 150
1.59A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		6 / 12
TYR H 208
VAL H 225
ALA H 139
GLY H 204
LEU H 203
ALA H 150
1.57A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H 225
ALA H 139
LEU L 140
GLY H 204
LEU H 203
1.31A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 12
LEU D  95
VAL C  16
VAL C  12
LEU C  59
PHE D  92
1.33A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6nur NSP12
(SARSr-CoV)		5 / 12
TYR A 884
ALA A 423
GLY A 839
LEU A 838
PHE A 881
1.41A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6nur NSP12
NSP7
(SARSr-CoV)		5 / 12
VAL C  33
ALA A 443
PHE A 442
ASN A 447
ALA A 448
1.43A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6nur NSP12
(SARSr-CoV)		5 / 11
TYR A 884
ALA A 423
GLY A 839
LEU A 838
PHE A 881
1.43A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6nur NSP12
(SARSr-CoV)		5 / 12
VAL A 535
ALA A 660
GLY A 352
LEU A 351
PHE A 652
1.41A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6nur NSP12
(SARSr-CoV)		5 / 12
VAL A 535
ALA A 660
GLY A 352
LEU A 351
PHE A 652
1.45A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 211
ALA H 125
GLY H 190
LEU H 189
ALA H 136
1.68A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 211
ALA H 125
GLY H 190
LEU H 189
ALA H 136
1.64A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
TYR H 194
VAL H 211
GLY H 190
LEU H 189
ALA H 136
1.37A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU H 138
VAL H 211
ALA H 125
GLU L 123
PHE L 118
1.73A17.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
TYR H 194
VAL H 211
GLY H 190
LEU H 189
ALA H 136
1.45A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL H 211
ALA H 125
LEU L 135
GLY H 190
LEU H 189
1.57A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
TYR H 194
VAL H 211
GLY H 190
LEU H 189
ALA H 136
1.46A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR B 198
VAL B 215
GLY B 194
LEU B 193
ALA B 140
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR B 198
VAL B 215
GLY B 194
LEU B 193
ALA B 140
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR H  32
THR H   0
GLY H  98
ASN H  77
LEU H   4
1.69A
None
MLI  B 303 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 215
ALA H 129
GLY H 194
LEU H 193
ALA H 140
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
LEU B 145
VAL B 125
VAL B 156
VAL B 154
GLY B 143
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR H 198
VAL H 215
GLY H 194
LEU H 193
ALA H 140
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR B 198
VAL B 215
GLY B 194
LEU B 193
ALA B 140
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR H 198
VAL H 215
GLY H 194
LEU H 193
ALA H 140
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR B  32
THR B   0
GLY B  98
ASN B  77
LEU B   4
1.67A
None
MLI  B 303 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR H  32
THR H   0
GLY H  98
ASN H  77
LEU H   4
1.75A
None
MLI  B 303 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR B  32
THR B   0
GLY B  98
ASN B  77
LEU B   4
1.72A
None
MLI  B 303 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR H 198
ALA H 129
GLY H 194
LEU H 193
ALA H 140
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR H 198
VAL H 215
GLY H 194
LEU H 193
ALA H 140
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR H  32
THR H   0
GLY H  98
ASN H  77
LEU H   4
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR B 198
VAL B 215
GLY B 194
LEU B 193
ALA B 140
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
VAL H 215
ALA H 129
GLY H 194
LEU H 193
ALA H 140
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR B  32
THR B   0
GLY B  98
ASN B  77
LEU B   4
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR H 198
VAL H 215
GLY H 194
LEU H 193
ALA H 140
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR H 198
VAL H 215
GLY H 194
LEU H 193
ALA H 140
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR H  32
THR H   0
GLY H  98
ASN H  77
LEU H   4
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR B 198
VAL B 215
GLY B 194
LEU B 193
ALA B 140
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
VAL B 215
ALA B 129
GLY B 194
LEU B 193
ALA B 140
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR B  32
THR B   0
GLY B  98
ASN B  77
LEU B   4
1.69A
None