Ligand ID: 9RA


Drugbank ID:
DB00307
(Bexarotene)


Indication:
Used orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Also used topically for the treatment of skin lesions in early (stage IA and IB) CTCL in patients who experience refractory or persistent disease with the use of other therapies or are intolerant of other therapies.

Get human targets for 9RA in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '9RA' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
ILE B 136
PHE B 140
HIS B 164
0.88A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.32A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ALA C 316
GLN C 320
LEU C 291
ILE C 200
LEU C 342
1.34A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		6 / 12
ILE E 111
ALA E 107
ALA E 155
ILE E 124
LEU E 108
VAL A  63
1.77A20.09
None
None
None
GOL  A2003 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
GLN E 401
ILE E 405
LEU E 412
ALA E 398
VAL E 337
1.33A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2ajf ACE2
(Homo
sapiens)		5 / 12
ALA A 443
GLN A 442
LEU A 439
ILE A 436
LEU A 444
1.13A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.32A21.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.38A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ALA B 135
GLN B 139
LEU B 110
ILE B 154
LEU B 161
1.32A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
ILE A 152
PHE A 128
HIS A 172
1.23A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLN A 238
LEU A 235
LEU A 200
ALA A 205
ILE A 223
1.41A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
ALA A  65
ALA A  65
ARG A  62
LEU A  66
ALA A  65
1.18A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		3 / 3
ILE B 321
PHE B 315
HIS B 335
0.89A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.43A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.43A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2zu5 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.29A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
ALA C  50
ALA C  51
LEU C  33
ILE C  29
LEU B 100
1.17A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
ILE B 291
PHE B 428
HIS B 540
1.01A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 443
GLN B 442
LEU B 439
ILE B 436
LEU B 444
1.15A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.43A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.39A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ALA D  43
LEU D  42
LEU D  29
ALA D  30
VAL D 110
1.44A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B  70
GLN B  69
LEU B  67
ILE B  78
LEU B  89
1.33A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.28A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A  70
GLN A  69
LEU A  67
ILE A  78
LEU A  89
1.42A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 211
ALA A 210
LEU A 253
LEU A 208
ILE A 200
1.41A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ALA B 150
ALA B 154
LEU B  88
ALA B  87
LEU B 133
1.44A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3sci ACE2
(Homo
sapiens)		3 / 3
ILE B 291
PHE B 428
HIS B 540
0.95A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3scj ACE2
(Homo
sapiens)		5 / 12
ALA A 443
GLN A 442
LEU A 439
ILE A 436
LEU A 444
1.06A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A 443
GLN A 442
LEU A 439
ILE A 436
LEU A 444
1.07A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
ILE B 291
PHE B 428
HIS B 540
0.86A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A 443
GLN A 442
LEU A 439
LEU A 444
LEU A 595
1.37A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		3 / 3
ILE A 130
PHE A  79
HIS A 135
1.11A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B  70
GLN B  69
LEU B  67
ILE B  78
LEU B  89
1.44A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
ILE B 338
PHE B 350
HIS B 314
1.11A19.92
G3A  B 606 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
ILE B 338
PHE B 350
HIS B 314
1.04A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		3 / 3
ILE C 338
PHE C 350
HIS C 314
1.12A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA D 150
ALA D 154
LEU D  88
ALA D  87
VAL D  12
1.40A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		6 / 12
ILE A  33
ALA A  36
ALA A  32
LEU A  31
LEU A  37
VAL B  29
1.63A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
ILE C 704
PHE C 909
HIS C1030
1.16A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE A 674
ALA A 658
ALA A 676
LEU A 636
ILE A 637
1.30A10.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA A 753
ALA A 754
LEU A 843
VAL C 583
ILE C 584
1.18A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE B 652
ALA B 676
ALA B 658
LEU B 636
ALA B 639
1.19A10.04
ILE  B 652 ( 0.7A)
ALA  B 676 ( 0.0A)
ALA  B 658 ( 0.0A)
LEU  B 636 ( 0.6A)
ALA  B 639 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ILE A 704
PHE A 909
HIS A1030
0.89A10.01
ILE  A 704 ( 0.7A)
PHE  A 909 ( 1.3A)
HIS  A1030 ( 1.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 656
ALA A 676
ALA A 658
ILE A 299
ALA A 639
1.10A10.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ILE B 704
PHE B 909
HIS B1030
0.86A10.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
ILE C 704
PHE C 909
HIS C1030
1.06A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA C 874
LEU C 876
ALA C 875
VAL B 893
ILE B 891
1.35A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
ILE B 704
PHE B 909
HIS B1030
0.86A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA B 875
LEU B1016
LEU B 876
ALA B 866
VAL A1050
1.38A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6cs2 ACE2
(Homo
sapiens)		3 / 3
ILE D 544
PHE D 314
HIS D 535
1.14A17.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE C 674
ALA C 658
ALA C 676
LEU C 636
ILE C 637
1.19A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6lzg ACE2
(Homo
sapiens)		3 / 3
ILE A 291
PHE A 438
HIS A 417
0.96A16.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ALA A 282
ALA A 498
VAL A 103
ILE A 107
LEU A  88
1.34A15.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
ILE C 545
ALA C 271
ALA C 273
GLN C 274
PHE C 276
LEU C  77
1.70A15.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6m17 ACE2
(Homo
sapiens)		5 / 12
ALA B 443
GLN B 442
LEU B 439
ILE B 436
LEU B 444
1.15A15.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6m17 ACE2
(Homo
sapiens)		5 / 12
ALA B 714
ALA D 714
LEU D 642
ILE D 704
LEU D 722
1.35A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6m1d ACE2
(Homo
sapiens)		3 / 3
ILE B 544
PHE B 314
HIS B 535
0.94A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ILE A 704
PHE A 909
HIS A1030
1.02A10.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 874
LEU A 876
ALA A 875
VAL B 893
ILE B 891
1.38A10.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE B 652
ALA B 676
ALA B 658
LEU B 636
ALA B 639
1.29A10.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 12
ALA B 152
ALA B 150
LEU A 387
ILE B 106
LEU A 270
1.38A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		6nur NSP8
(SARSr-CoV)		5 / 12
ALA D 150
PHE D 147
ALA D 152
VAL D 186
CYH D 114
1.31A20.51
None