Ligand ID: 8NU


Drugbank ID:
DB00734
(Risperidone)


Indication:
For the treatment of schizophrenia in adults and in adolescents, ages 13 to 17, and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17. May also be used to manage symptoms of inappropriate behavior due to aggression and/or psychosis in patients with severe dementia.

Get human targets for 8NU in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '8NU' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 254
ILE A 281
LEU A 262
LEU A 242
TYR A 209
1.58A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 4
ASP H  55
ALA H  21
SER H  16
PHE H  11
1.51A18.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
SER E 386
VAL E 382
LEU E 421
PHE E 325
VAL E 328
1.48A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 254
ILE A 281
LEU A 262
LEU A 242
TYR A 209
1.66A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
SER C 319
SER D 311
PHE C 275
PHE D 316
LEU D 332
1.55A13.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 5
ASP D 289
ILE C 321
PHE C 316
TYR D 299
1.41A13.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  35
LEU B 115
PHE B 159
PHE B 103
VAL B 157
1.53A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		6 / 12
SER L 181
VAL H 142
SER H 179
LEU H 175
LEU H 170
VAL H 169
1.75A20.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		5 / 12
VAL A 100
THR A  39
PHE A  20
LEU A  53
VAL A  43
1.54A16.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR A 356
VAL A 349
SER A 380
PHE A 325
LEU A 355
1.49A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 5
ASP A 289
ILE B 321
PHE B 316
TYR A 299
1.42A12.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 171
THR A 135
PHE A 112
PHE A 140
TYR A 118
1.78A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
TYR A 225
VAL A 338
PHE A 302
LEU A 299
VAL A 303
1.52A23.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
SER A 254
ILE A 281
LEU A 262
LEU A 242
TYR A 209
1.68A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
THR B  35
LEU B 115
PHE B 159
PHE B 103
VAL B 157
1.55A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
TYR D 225
VAL D 338
PHE D 302
LEU D 299
VAL D 303
1.56A23.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
PHE A 176
VAL A 172
THR C 285
SER C 288
TYR A  88
1.56A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 254
ILE B 281
LEU B 262
LEU B 242
TYR B 209
1.69A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 12
SER S 386
VAL S 382
LEU S 421
PHE S 325
VAL S 328
1.41A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
ASP B 382
PHE B 390
ASN B 397
TYR B 385
1.25A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
THR B 371
LEU B 558
PHE B 369
PHE B 315
LEU B 320
1.64A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  35
LEU B 115
PHE B 159
PHE B 103
VAL B 157
1.55A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A  35
LEU A 115
PHE A 159
PHE A 103
VAL A 157
1.54A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 254
ILE A 281
LEU A 262
LEU A 242
TYR A 209
1.66A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B 190
LEU B  27
PHE B 181
LEU B  86
TYR B  54
1.71A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  35
LEU B 115
PHE B 159
PHE B 103
VAL B 157
1.54A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		3sci ACE2
(Homo
sapiens)		4 / 4
ASP B  38
ALA B  46
SER B  44
PHE B  72
1.50A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER F 386
VAL F 382
LEU F 421
PHE F 325
VAL F 328
1.54A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER B 124
THR B 125
ILE B 126
LEU B 359
TYR B 510
1.68A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
ASP B 382
PHE B 390
ASN B 397
TYR B 385
1.32A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL E 328
SER E 386
PHE E 361
TRP E 423
THR E 425
1.76A16.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
ASP B 367
ALA B 413
SER B 409
PHE B 274
1.78A23.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 254
ILE A 281
LEU A 262
LEU A 242
TYR A 209
1.60A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3vb6 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  35
LEU B 115
PHE B 159
PHE B 103
VAL B 157
1.54A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 254
ILE A 281
LEU A 262
LEU A 242
TYR A 209
1.64A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 12
SER A  86
TYR A  36
THR A 169
PHE A  80
LEU A  81
1.33A22.19
DMS  B 903 (-2.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A  35
LEU A 115
PHE A 159
PHE A 103
VAL A 157
1.55A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
SER A 246
THR A 302
PHE A 305
LEU A 179
VAL A 206
1.53A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
SER B  86
TYR B  36
THR B 169
PHE B  80
LEU B  81
1.44A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR A 367
VAL A 328
TRP A 423
PHE A 361
PHE A 360
1.48A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 12
THR C  30
ILE C  33
LEU C  21
PHE B  23
LEU B  19
1.43A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ILE A 256
LEU A 273
PHE A 147
LEU A 251
TYR A 144
1.56A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x4r S PROTEIN
(MERS-CoV)		4 / 5
ASP A  83
ILE A 256
ASN A 104
TYR A  85
1.45A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE C 361
TRP C 423
PHE C 334
TYR C 438
THR C 425
1.71A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
ASP B 976
ILE A 955
ASN B 721
TYR B 738
1.03A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
TYR B 356
VAL B 510
THR B 509
LEU B 355
PHE B 501
1.50A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x5c S PROTEIN
(MERS-CoV)		4 / 5
ASP B  83
ILE B 256
ASN B 104
TYR B  85
1.45A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
SER C 684
THR C 685
PHE C 674
LEU C 759
VAL C 711
1.34A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
SER B 829
ILE A 333
LEU A 347
PHE A 327
PHE A 354
1.45A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR B 425
LEU B 499
PHE B 361
PHE B 360
LEU B 355
1.47A15.37
THR  B 425 ( 0.8A)
LEU  B 499 ( 0.6A)
PHE  B 361 ( 1.3A)
PHE  B 360 ( 1.3A)
LEU  B 355 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
SER A 246
THR A 302
PHE A 305
LEU A 179
VAL A 206
1.55A22.63
None
GOL  A 408 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6acg ACE2
(Homo
sapiens)		5 / 12
THR D 371
LEU D 529
PHE D 308
PHE D 315
LEU D 320
1.57A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 428
TRP A 423
PHE A 361
PHE A 360
LEU A 355
1.50A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
ASP A  57
ILE A  87
PHE A  83
ASN B 505
1.29A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
ASP C 154
ALA C 127
SER C 113
PHE C 157
1.52A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6acj ACE2
(Homo
sapiens)		4 / 5
ASP D 382
PHE D 390
ASN D 397
TYR D 385
1.25A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR A 236
SER A 239
PHE A  76
PHE A  22
THR A  20
1.62A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 349
THR A 320
LEU A 374
LEU A 499
VAL A 382
1.22A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
ASP A 277
ILE A 272
PHE A 213
ASN A  65
1.44A15.88
None
None
None
NAG  A1301 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 248
THR C  71
ILE C  72
LEU C 170
PHE C 179
1.60A15.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 4
ASP B  23
ALA B 139
SER B 239
PHE B  76
1.67A17.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B1015
THR B 863
PHE B 880
PHE B1034
THR B1048
1.68A17.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		6cs2 ACE2
(Homo
sapiens)		4 / 4
ASP D 367
ALA D 412
SER D 409
PHE D 438
1.28A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 386
VAL B 382
LEU B 421
PHE B 325
VAL B 328
1.37A15.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m17 ACE2
(Homo
sapiens)		4 / 5
ASP B 382
PHE B  40
ASN B 397
TYR B 385
1.36A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m17 ACE2
(Homo
sapiens)		5 / 12
THR B 371
LEU B 558
PHE B 369
PHE B 315
LEU B 320
1.68A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER A 323
THR A 396
LEU A 234
PHE A 420
PHE A 421
1.65A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
SER A 430
VAL A 232
THR A 235
LEU A  43
LEU A  46
VAL A  50
1.70A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
TRP C 205
VAL C 439
SER C 122
PHE C 289
PHE C  48
1.72A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR A 367
VAL A 328
TRP A 423
PHE A 361
PHE A 360
1.37A14.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6nur NSP12
(SARSr-CoV)		5 / 12
VAL A 315
SER A 318
THR A 319
LEU A 308
LEU A 655
1.49A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6nus NSP12
(SARSr-CoV)		5 / 12
SER A 709
ILE A 696
LEU A 775
PHE A 745
LEU A 723
1.49A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vw1 ACE2
(Homo
sapiens)		4 / 5
ASP A 382
PHE A 390
ASN A 397
TYR A 385
1.32A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vw1 ACE2
(Homo
sapiens)		5 / 12
THR B 371
LEU B 558
PHE B 369
PHE B 315
LEU B 320
1.66A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL H 169
SER H 177
LEU L 175
LEU L 135
VAL L 133
1.60A15.22
GOL  L 301 (-4.5A)
GOL  L 301 (-3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L 159
VAL L 163
THR L 164
PHE L 139
VAL L 146
1.62A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L  93
TYR L  96
LEU L   4
LEU L  33
VAL L  27
1.70A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER H 180
THR L 172
LEU H 138
LEU H 159
VAL H 163
1.76A15.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER H 130
THR H 131
PHE L 118
PHE L 116
LEU H 124
1.74A15.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C 165
VAL C 169
THR C 170
PHE C 145
VAL C 152
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER H 184
THR L 178
LEU H 142
LEU H 163
VAL H 167
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 165
VAL L 169
THR L 170
PHE L 145
VAL L 152
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER B 184
THR C 178
LEU B 142
LEU B 163
VAL B 167
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  99
TYR C 102
LEU C   4
LEU C  39
VAL C  29
1.74A
DMS  C 303 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H 173
SER H 181
LEU L 181
LEU L 141
VAL L 139
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  99
TYR L 102
LEU L   4
LEU L  39
VAL L  29
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL B 173
SER B 181
LEU C 181
LEU C 141
VAL C 139
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 165
VAL L 169
THR L 170
PHE L 145
VAL L 152
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H 173
SER H 181
LEU L 181
LEU L 141
VAL L 139
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L 165
VAL L 169
THR L 170
PHE L 145
VAL L 152
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL H 173
SER H 181
LEU L 181
LEU L 141
VAL L 139
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER H 184
THR L 178
LEU H 142
LEU H 163
VAL H 167
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  99
TYR L 102
LEU L   4
LEU L  39
VAL L  29
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER B 184
THR C 178
LEU B 142
LEU B 163
VAL B 167
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  99
TYR C 102
LEU C   4
LEU C  39
VAL C  29
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C 165
VAL C 169
THR C 170
PHE C 145
VAL C 152
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL B 173
SER B 181
LEU C 181
LEU C 141
VAL C 139
1.53A
None