Ligand ID: 6V8


Drugbank ID:
DB09570
(Ixazomib)


Indication:
Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.

Get human targets for 6V8 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '6V8' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.32A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR B 921
THR B 922
THR B 923
SER B 914
ALA B1171
1.30A18.75
20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR B 921
THR B 922
THR B 923
SER B 914
ALA B1171
1.32A22.77
22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B1026
THR B1025
THR B1024
SER B1144
GLY B1143
1.34A20.92
20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR K  21
THR K  22
THR K  23
SER K  14
ALA J  23
1.32A9.75
11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.29A21.50
20.85
None
AZP  A 307 (-4.0A)
None
AZP  A 307 (-3.4A)
AZP  A 307 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
ALA C 238
THR C 239
VAL C 206
GLY C 233
ALA C 234
1.22A18.98
20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
ALA D 238
THR D 239
ALA D 232
GLY D 233
ALA D 234
1.58A22.82
21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
THR F 485
THR F 486
THR F 487
GLY F 434
ALA F 430
1.33A21.40
23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.27A20.66
20.39
None
None
None
CY6  A1145 (-4.0A)
CY6  A1145 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR B 921
THR B 922
THR B 923
SER B 914
ALA D1172
1.26A12.74
10.78
None
None
None
ACE  B 913 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2bx4 3C-LIKE PROTEINASE
(SARS-COV
Sin2774)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.18A20.92
20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
THR E 264
ALA F 312
ALA E 265
GLY E 296
LEU E 353
1.54A20.18
22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  26
THR B  25
THR B  24
SER B 144
GLY B 143
1.25A20.90
20.58
None
ENB  B1145 ( 4.7A)
None
ENB  B1145 (-3.7A)
ENB  B1145 (-2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 11
ALA L  71
THR L  72
GLY L  68
GLY L  29
ASP L  51
1.49A22.03
22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
ALA C  40
ALA B 103
GLY C  47
ALA C  51
LEU C  89
1.54A23.36
20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
ALA A  57
THR A  58
VAL A  25
GLY A  52
ALA A  53
1.24A19.47
20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ALA P  54
THR P  56
GLY P  69
GLY P  70
ASP P  91
1.28A23.76
25.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
THR A  68
THR A  68
GLY A  71
ALA A  65
THR A  68
1.41A21.30
21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.32A21.12
20.92
None
None
None
WR1  A 601 (-3.5A)
WR1  A 601 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 11
THR A 169
THR A 199
GLU A 240
ALA A 193
GLY A 195
1.48A20.90
20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
THR B  26
THR B  25
THR B  24
SER B 144
GLY B 143
1.29A20.92
20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
THR B  26
THR B  25
THR B  24
SER B 144
GLY B 143
1.24A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.32A20.53
20.46
None
CYV  A 302 ( 4.6A)
None
CYV  A 302 ( 4.2A)
CYV  A 302 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA A 210
GLU A 288
CYH A 300
ALA A   1
GLY A   2
1.58A20.53
20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
ALA A 160
THR A 174
ALA C 283
GLY C 286
THR C 281
1.49A23.94
20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.26A20.92
20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2wct NSP3
(SARSr-CoV)		5 / 11
ALA B 590
VAL B 589
GLY B 491
GLY B 494
ALA B 493
1.20A21.56
21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ALA A  83
ALA A 107
VAL B  42
GLY A  73
ALA A  79
1.53A19.08
20.00
None
None
None
SAH  A1293 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ALA A  79
THR A  82
ALA B  71
GLY B  70
LEU B  45
1.52A24.59
21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
THR A 110
ALA A  79
THR A  82
ALA A  83
ALA B  71
1.33A19.08
19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ALA A  79
THR A  82
ALA B  71
GLY B  70
LEU B  45
1.51A24.52
22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  26
THR B  25
THR B  24
SER B 144
GLY B 143
1.34A20.92
20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR E 485
THR E 486
THR E 487
GLY E 434
ALA E 430
1.29A21.72
23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
ALA B 384
ALA B 386
MET B 557
GLY B 561
ASP B 382
1.44A16.53
15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  26
THR B  25
THR B  24
SER B 144
GLY B 143
1.25A20.53
20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		3e9s NSP3
(SARSr-CoV)		5 / 11
ALA A 146
CYH A 149
GLY A 143
ALA A 140
THR A 103
1.53A21.85
21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.16A20.53
21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  26
THR B  25
THR B  24
SER B 144
GLY B 143
1.36A20.92
20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
THR A 169
THR A 199
GLU A 240
ALA A 193
GLY A 195
1.45A20.78
21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.25A20.39
20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
ALA A 146
CYH A 149
GLY A 143
ALA A 140
THR A 103
1.59A21.98
21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 11
ALA A  79
THR A  82
ALA B  71
GLY B  70
LEU B  45
1.54A21.63
21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 11
ALA A  83
ALA A 107
VAL B  42
GLY A  73
ALA A  79
1.50A19.17
18.16
None
None
None
SAM  A 302 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR F 485
THR F 486
THR F 487
GLY F 434
ALA F 430
1.37A21.79
21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3scj ACE2
(Homo
sapiens)		5 / 11
ALA B 384
ALA B 386
MET B 557
GLY B 561
ASP B 382
1.48A16.61
16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
ALA A 384
ALA A 386
MET A 557
GLY A 561
ASP A 382
1.50A16.53
16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR F 485
THR F 486
THR F 487
GLY F 434
ALA F 430
1.37A21.20
22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  26
THR B  25
THR B  24
SER B 144
GLY B 143
1.25A20.45
20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A  26
THR A  25
THR A  24
SER A 144
GLY A 143
1.33A20.72
20.33
None
DMS  A 402 (-4.4A)
DMS  A 402 (-4.2A)
23H  A 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
GLU D 302
CYH D 309
GLY D 505
ALA D 504
ASP D 301
1.39A18.36
16.98
None
G3A  D 606 (-3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 11
ALA B  23
THR B  25
GLY A  69
GLY A  70
ALA A  71
1.59A18.92
17.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
GLU D 302
CYH D 309
GLY D 505
ALA D 504
ASP D 301
1.40A18.63
17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5c8t NSP10
(SARSr-CoV)		5 / 11
ALA C  54
THR C  56
GLY C  69
GLY C  70
ASP C  91
1.21A17.79
23.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 11
ALA B  23
THR B  25
GLY A  69
GLY A  70
ALA A  71
1.53A18.92
17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
GLU A 135
CYH A 149
GLY A 143
ALA A 140
THR A 103
1.40A21.98
21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
THR M  12
ALA M   9
MET A  57
GLY A  59
GLY A   6
1.60A18.10
22.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
ALA B  23
THR B  25
GLY N  69
GLY N  70
ALA N  71
1.61A16.77
17.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
GLU B 302
CYH B 309
GLY B 505
ALA B 504
ASP B 301
1.51A18.68
16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 11
THR C 147
GLU C 127
CYH D 227
ALA D 231
LEU D 186
1.29A16.30
18.84
None
None
ZN  D 401 (-2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
GLU D 135
CYH D 149
GLY D 143
ALA D 140
THR D 103
1.45A21.78
21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
THR A 302
ALA B 748
GLY B 751
ALA B 753
LEU B 846
1.52A12.27
9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 11
ALA A  32
THR A  30
ALA A  40
ALA A  36
LEU E  37
1.58A18.30
14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
THR A  92
ALA A 250
VAL A  98
GLY A  68
ASP A  77
1.45A21.86
22.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
ALA A 874
ALA A 872
GLY A 862
GLY A 867
ALA A 866
1.50A10.26
10.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
ALA A 866
THR A 863
ALA A 872
GLY A 873
ALA A 875
1.55A11.63
9.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR A 485
THR A 486
THR A 487
GLY A 434
ALA A 430
1.20A12.27
10.67
THR  A 485 ( 0.8A)
THR  A 486 ( 0.8A)
THR  A 487 ( 0.8A)
GLY  A 434 ( 0.0A)
ALA  A 430 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR C 485
THR C 486
THR C 487
GLY C 434
ALA C 430
1.24A12.27
10.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
THR B 585
ALA B 595
ALA B 676
VAL B 596
GLY B 298
1.58A10.42
10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA B 233
ALA B 251
ALA B  91
THR B  92
LEU B 216
1.50A12.27
9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA A 866
THR A 863
ALA A 872
GLY A 871
ALA A 875
1.39A11.47
10.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA B 866
THR B 863
ALA B 872
GLY B 871
ALA B 875
1.44A12.27
10.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA C 874
ALA C 872
GLY C 862
GLY C 867
ALA C 866
1.49A10.43
11.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
THR C 485
THR C 486
THR C 487
GLY C 434
ALA C 430
1.27A12.27
10.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6cs2 ACE2
(Homo
sapiens)		5 / 11
ALA D 384
ALA D 386
GLY D 561
GLY D 395
ASP D 382
1.52A16.61
16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6jyt HELICASE
(SARSr-CoV)		5 / 11
ALA A 403
VAL A 563
GLY A 400
GLY A 282
ASP A 458
1.34A16.47
18.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6jyt HELICASE
(SARSr-CoV)		5 / 11
THR A 127
GLU A 128
ALA A 110
ALA A 134
THR A 137
1.21A16.92
16.20
None
None
ZN  A 703 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
THR A 267
ALA A 271
GLY A  67
GLY A  68
ALA A  69
1.35A15.24
15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6m17 ACE2
(Homo
sapiens)		5 / 11
ALA B 384
ALA B 386
MET B 557
GLY B 561
ASP B 382
1.48A13.76
15.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
THR C 121
ALA C 282
ALA C 489
GLY C 490
LEU C  77
1.50A17.13
13.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A 866
THR A 863
ALA A 872
GLY A 871
ALA A 875
1.57A11.90
9.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6nur NSP7
(SARSr-CoV)		5 / 11
ALA C  48
THR C  46
VAL C   6
ALA C  42
ASP C  38
1.63A18.28
15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6nur NSP12
(SARSr-CoV)		5 / 11
ALA A 866
VAL A 880
GLY A 841
GLY A 839
ASP A 833
1.55A12.51
13.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 11
ALA B 102
ALA A 383
GLY A 385
ALA B 125
LEU B 189
1.60A21.14
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		6vw1 ACE2
(Homo
sapiens)		5 / 11
ALA B 384
ALA B 386
MET B 557
GLY B 561
ASP B 382
1.44A16.61
15.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
THR H 114
THR H 113
SER B   7
GLY B   8
THR B 113
1.77A
None
None
None
MLI  H 305 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
THR H 114
THR H 113
SER B   7
GLY B   8
THR B 113
1.78A
None
None
None
MLI  H 305 (-3.2A)
None