Ligand ID: 68P


Drugbank ID:
DB00215
(Citalopram)
DB01175
(Escitalopram)


Indication:
For the treatment of depression. Off-label indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [FDA label]. ;Labeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients.

Get human targets for 68P in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '68P' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.74A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.75A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.72A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA B 906
GLN B 908
GLU C1183
LEU B1184
ILE B1179
1.72A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 9
GLN A  80
GLU A  76
LEU A  71
ILE A  73
PHE A  72
1.46A9.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA B1173
TYR B1182
PHE B1140
LEU B1167
GLY B1149
VAL B1114
1.78A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
TYR B1126
ILE B1136
ALA B1173
PHE B1112
SER B1139
GLY B1109
1.78A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ajf SPIKE PROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.76A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.55
None
None
None
CY6  A1145 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.80A20.55
None
None
None
CY6  A1145 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
PHE C  70
GLU D  91
PRO D  89
LEU D  88
ILE D  46
1.35A9.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr)		5 / 9
PHE B  70
GLU A  91
PRO A  89
LEU A  88
ILE A  46
1.38A9.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr)		5 / 9
PHE G  70
GLU H  91
PRO H  89
LEU H  88
ILE H  46
1.31A9.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
PHE A  70
GLU B  91
PRO B  89
LEU B  88
ILE B  46
1.45A9.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.59A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.57A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.56A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
ILE A  91
ALA A  65
PHE A  59
LEU A  66
GLY A  87
1.21A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
ALA A  65
GLY A   1
SER A  67
LEU A  66
GLY A 116
1.31A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP C 407
ILE C 397
ALA C 398
PHE C 387
GLY C 391
VAL C 389
1.78A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP C 407
ILE C 397
ALA C 398
PHE C 387
GLY C 391
VAL C 389
1.76A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.66
None
None
None
AZP  A 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A20.66
None
None
None
AZP  A 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.66
None
None
None
AZP  A 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
ALA A  78
PHE A  74
PRO A   6
LEU A   9
ILE A  85
1.71A11.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2kaf NSP3
(SARSr)		5 / 12
PHE A   6
SER A  67
LEU A  65
GLY A  14
VAL A  10
1.45A8.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.77A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.80A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.79A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2qc2 3C-LIKE PROTEINASE
(-)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.72A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2qc2 3C-LIKE PROTEINASE
(-)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.70A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		6 / 12
TYR E 230
ILE E 305
TYR E 193
PHE E 341
LEU E 250
VAL E 318
1.76A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2rnk REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ILE A 549
TYR A 583
PHE A 580
LEU A 533
GLY A 572
VAL A 574
1.79A15.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.75A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.75A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.73A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		6 / 12
ASP A 407
ILE A 397
ALA A 398
PHE A 387
GLY A 391
VAL A 389
1.77A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		6 / 12
ASP A 407
ILE A 397
ALA A 398
PHE A 387
GLY A 391
VAL A 389
1.78A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP E 407
ILE E 397
ALA E 398
PHE E 387
GLY E 391
VAL E 389
1.77A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.73A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP E 407
ILE E 397
ALA E 398
PHE E 387
GLY E 391
VAL E 389
1.76A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.77A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP E 407
ILE E 397
ALA E 398
PHE E 387
GLY E 391
VAL E 389
1.78A15.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
ASP B 295
ILE B 291
TYR B 279
PHE B 428
LEU B 418
GLY B 286
1.68A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ILE A 213
ALA A 211
GLY A 302
SER A   1
LEU A 282
VAL A 297
1.73A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.75A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.73A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.75A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.75A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.77A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.73A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.75A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP E 407
ILE E 397
ALA E 398
PHE E 387
GLY E 391
VAL E 389
1.80A18.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP E 407
ILE E 397
ALA E 398
PHE E 387
GLY E 391
VAL E 389
1.77A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.69A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.70A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.71A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.78A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP F 407
ILE F 397
ALA F 398
PHE F 387
GLY F 391
VAL F 389
1.71A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP E 407
ILE E 397
ALA E 398
PHE E 387
GLY E 391
VAL E 389
1.79A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.80A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.79A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.79A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		6 / 12
ASP C  22
ILE D 201
TYR D 237
PHE C  16
GLY D  68
VAL D  66
1.67A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		6 / 12
ASP C  22
ILE D 201
TYR D 237
PHE C  16
GLY D  68
VAL D  66
1.66A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		6 / 12
ASP C  22
ILE D 201
TYR D 237
PHE C  16
GLY D  68
VAL D  66
1.67A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ILE D 397
ALA D 396
TYR D 511
PHE D 445
VAL D 316
1.20A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ILE D 397
ALA D 396
TYR D 511
PHE D 445
VAL D 316
1.19A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA A 872
GLY A 890
GLY A1017
LEU A1016
GLY C 892
1.06A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA A 872
GLY A 890
GLY A1017
LEU A1016
GLY C 892
1.04A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA A 872
GLY A 890
GLY A1017
LEU A1016
GLY C 892
1.09A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		6 / 12
TYR C1142
ILE C1123
GLY C1120
SER C 787
GLY C 789
GLY C 982
1.69A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP B 407
ILE B 397
ALA B 398
PHE B 387
GLY B 391
VAL B 389
1.72A19.01
ASP  B 407 ( 0.5A)
ILE  B 397 ( 0.7A)
ALA  B 398 ( 0.0A)
PHE  B 387 ( 1.3A)
GLY  B 391 ( 0.0A)
VAL  B 389 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ALA B 233
PHE B  89
GLY B 100
LEU B 235
GLY B 255
VAL B 254
1.78A19.01
ALA  B 233 ( 0.0A)
PHE  B  89 ( 1.3A)
GLY  B 100 ( 0.0A)
LEU  B 235 ( 0.5A)
GLY  B 255 ( 0.0A)
VAL  B 254 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 881
PHE A 870
GLY A1017
LEU A 898
GLY A 862
1.20A19.01
ALA  A 881 ( 0.0A)
PHE  A 870 ( 1.3A)
GLY  A1017 ( 0.0A)
LEU  A 898 ( 0.5A)
GLY  A 862 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5yvd NSP15
(MERS-CoV)		5 / 12
ASP A 121
ILE A 115
ALA A 134
GLY A 100
SER A 124
1.21A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA B 406
GLN B 396
PRO B 450
LEU B 448
PHE B 451
1.65A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 104
PHE B 231
GLY B  86
LEU B 257
GLY B 100
0.86A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 104
PHE B 231
GLY B  86
LEU B 257
GLY B 100
0.96A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 104
PHE B 231
GLY B  86
LEU B 257
GLY B 100
0.88A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 104
PHE A 231
GLY A  86
LEU A 257
GLY A 100
1.22A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 104
PHE A 231
GLY A  86
LEU A 257
GLY A 100
1.13A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 104
PHE A 231
GLY A  86
LEU A 257
GLY A 100
1.09A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
GLN C 917
PRO C1035
LEU C1045
ILE C 704
PHE C1034
1.76A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 104
PHE A 231
GLY A  86
LEU A 257
GLY A 100
1.07A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6cs2 ACE2
(Homo
sapiens)		5 / 9
GLN D  96
PHE D  32
GLU D  37
LEU D  73
PHE D  40
1.62A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
TYR A   7
ILE A  52
GLY C   1
GLY A  26
LEU A  32
GLY A  56
1.77A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lzg ACE2
(Homo
sapiens)		5 / 9
GLN A  96
PHE A  32
GLU A  37
LEU A  73
PHE A  40
1.63A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m0j ACE2
(Homo
sapiens)		5 / 9
GLN A  96
PHE A  32
GLU A  37
LEU A  73
PHE A  40
1.66A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m17 ACE2
(Homo
sapiens)		5 / 9
GLN D  96
PHE D  32
GLU D  37
LEU D  73
PHE D  40
1.69A20.99
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
ALA A 273
GLN A 274
LEU A 495
ILE A 545
PHE A 549
1.05A32.53
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
ILE A 462
GLY A 215
GLY A 460
LEU A 464
GLY A 438
VAL A 440
1.75A32.53
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
ILE C 462
GLY C 215
GLY C 460
LEU C 464
GLY C 438
VAL C 440
1.75A32.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP A 407
ILE A 397
ALA A 398
PHE A 387
GLY A 391
VAL A 389
1.74A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ASP A 407
ILE A 397
ALA A 398
PHE A 387
GLY A 391
VAL A 389
1.73A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
ASP H 208
SER H 156
GLY H 157
GLY H 139
VAL H 182
1.75A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
ILE H  51
ALA H  71
GLY H  97
GLY H  53
GLY H  49
1.49A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
ALA L  34
GLY H  44
PHE L  98
GLY L  99
VAL H  37
1.73A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
ILE B  34
ALA B  79
GLY B  26
PHE B  29
GLY B  99
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR H  95
GLY L  47
GLY H 110
LEU H   4
GLY B  26
1.35A
None
1PE  L1603 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR B  95
GLY C  47
GLY B 110
LEU B   4
GLY H  26
1.32A
None
1PE  C 301 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR B  95
GLY C  47
GLY B 110
LEU B   4
GLY H  24
1.32A
None
1PE  C 301 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
ILE H  34
ALA H  79
GLY H  26
PHE H  29
GLY H  99
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR H  95
GLY L  47
GLY H 110
LEU H   4
GLY B  24
1.44A
None
1PE  L1603 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR L  93
GLY L 105
LEU L   4
GLY H  35
VAL H  37
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR H  95
GLY L  47
GLY H 110
LEU H   4
GLY B  26
1.32A
None
1PE  L1603 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR C  93
GLY C 105
LEU C   4
GLY B  35
VAL B  37
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR H  95
GLY L  47
GLY H 110
LEU H   4
GLY B  24
1.38A
None
1PE  L1603 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR B  95
GLY C  47
GLY B 110
LEU B   4
GLY H  26
1.36A
None
1PE  C 301 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR B  95
GLY C  47
GLY B 110
LEU B   4
GLY H  26
1.47A
None
1PE  C 301 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
ILE B  34
ALA B  79
GLY B  26
PHE B  29
GLY B  99
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR H  95
GLY L  47
GLY H 110
LEU H   4
GLY B  24
1.32A
None
1PE  L1603 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR H  95
GLY L  47
GLY H 110
LEU H   4
GLY B  26
1.47A
None
1PE  L1603 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR B  95
GLY C  47
GLY B 110
LEU B   4
GLY H  24
1.38A
None
1PE  C 301 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR B  95
GLY C  47
GLY B 110
LEU B   4
GLY H  24
1.44A
None
1PE  C 301 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
ILE H  34
ALA H  79
GLY H  26
PHE H  29
GLY H  99
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
TYR L  93
GLY L 105
LEU L   4
GLY H  35
VAL H  37
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
ILE H  34
ALA H  79
GLY H  26
PHE H  29
GLY H  99
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
TYR C  93
GLY C 105
LEU C   4
GLY B  35
VAL B  37
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
ILE B  34
ALA B  79
GLY B  26
PHE B  29
GLY B  99
1.45A
None