Ligand ID: 5OG


Drugbank ID:
DB05015
(Belinostat)


Indication:
Belinostat is indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL) with manageable safety profile. It is a potential alternative therapy for patients who did not experience adequate response to first-line drugs for PTCL. It can be used in patients with baseline thrombocytopenia [A19161].

Get human targets for 5OG in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '5OG' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 147
HIS B 172
HIS B 163
GLY B 138
TYR B 126
1.59A21.76
None
9IN  B2001 (-4.2A)
9IN  B2001 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 172
SER B 139
PHE A   3
ASP A 216
GLY A 215
1.80A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 331
ASP A 382
PHE A 327
ASP A 350
LEU A 351
1.73A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 172
SER A 139
PHE B   3
ASP B 216
GLY B 215
1.79A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
PRO B  39
HIS B 172
HIS B 163
GLY B 174
1.59A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
PRO B  39
HIS B 172
HIS B 163
GLY B 174
1.58A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		5 / 12
SER B  20
PHE B  22
HIS B  13
ASP A 238
GLY A 237
1.40A12.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 172
SER B 139
PHE A   3
ASP A 216
GLY A 215
1.80A20.98
PJE  F   5 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		3scj ACE2
(Homo
sapiens)		5 / 12
SER B 331
ASP B 382
PHE B 327
ASP B 350
LEU B 351
1.70A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 331
ASP A 382
PHE A 327
ASP A 350
LEU A 351
1.71A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
PRO O  59
HIS D  19
PHE D  33
GLY O  69
TYR O  96
1.75A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER B1012
HIS B1030
PHE B1024
HIS B1046
GLY B1026
1.70A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 985
PHE B 952
ASP C 976
PHE C 741
GLY B 953
1.58A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.78A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.74A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		6m18 ACE2
(Homo
sapiens)		5 / 12
SER B 331
ASP B 382
PHE B 327
ASP B 350
LEU B 351
1.63A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		6vw1 ACE2
(Homo
sapiens)		5 / 12
SER A 331
ASP A 382
PHE A 327
ASP A 350
LEU A 351
1.70A20.16
None