Ligand ID: 0LA


Drugbank ID:
DB00821
(Carprofen)


Indication:
For use as a pain reliever in the treatment of joint pain and post-surgical pain.

Get human targets for 0LA in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '0LA' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 6
LEU B 268
LEU B 287
ILE B 286
THR B 199
1.07A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ARG B  55
TYR B  66
LEU B  44
VAL B  41
MET B  12
1.80A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.88A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.42A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.96A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
LEU B 268
LEU B 287
ILE B 286
THR B 199
0.97A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.98A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU B  27
THR B  25
ILE B  43
MET B  49
1.38A20.32
ENB  B1145 (-4.2A)
ENB  B1145 ( 4.7A)
None
ENB  B1145 (-2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 7
LEU A 345
ILE A 280
LEU A 248
MET A 251
1.40A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		2hsx LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		5 / 9
ARG A 108
LEU A  10
PRO A   8
VAL A  97
VAL A  15
1.75A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 272
LEU A 268
MET A 276
TRP A 207
1.72A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.30A22.81
WR1  A 601 ( 4.5A)
None
None
WR1  A 601 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
LEU B 268
LEU B 287
ILE B 286
THR B 199
1.01A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.38A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.01A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.01A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.87A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.07A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.37A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.09A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 7
LEU D  49
THR D  48
PRO D  93
ILE E  38
MET A 104
1.65A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.06A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 7
LEU B  27
THR B  25
ILE B  43
MET B  49
1.27A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.85A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3e9s NSP3
(SARSr-CoV)		4 / 7
LEU A  17
THR A  11
LEU A  81
MET A  85
1.43A24.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.36A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.35A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU B 268
LEU B 287
ILE B 286
THR D 199
0.99A10.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
ARG C  55
TYR C  66
LEU C  44
VAL C  41
MET C  12
1.60A14.95
GOL  C 126 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.43A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.98A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.35A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.38A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.03A18.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.90A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.28A20.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 268
LEU B 287
ILE B 286
THR B 199
1.00A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU B  27
THR B  25
ILE B  43
MET B  49
1.40A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.36A20.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.04A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.40A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3sn8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.23A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.35A20.66
ECC  H   5 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
0.99A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 268
LEU A 287
ILE A 286
THR A 199
1.05A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.29A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 268
LEU A 208
MET A 276
TRP A 207
1.55A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A 272
LEU A 268
MET A 276
TRP A 207
1.74A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.42A20.66
None
DMS  A 402 (-4.4A)
None
23H  A 401 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		5c5n 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
LEU A  27
THR A  25
ILE A  43
MET A  49
1.31A20.05
None
None
None
SLH  A 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
LEU D  18
PRO D  24
ILE D  55
LEU D  54
1.44A21.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
THR M   5
PRO A  24
LEU A   7
MET A  57
1.40A14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 9
ARG B 135
TYR A 511
GLY A 380
LEU A 329
VAL A 346
1.64A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		5x4r S PROTEIN
(MERS-CoV)		4 / 7
LEU A 325
PRO A  59
ILE A  57
LEU A 318
1.23A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
ARG C 887
THR C 863
GLY C 867
LEU C 859
VAL C 767
1.75A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
LEU A 325
PRO A  59
ILE A  57
LEU A 318
1.42A13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ARG A 887
THR A 863
GLY A 867
LEU A 859
VAL A 767
1.70A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ARG A 887
THR A 863
GLY A 867
LEU A 859
VAL A 767
1.56A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
LEU A 201
THR A 131
ILE A 472
LEU A 485
1.17A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		6nur NSP12
(SARSr-CoV)		4 / 5
LEU A 614
MET A 756
THR A 817
TRP A 598
1.69A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 9
TYR A 273
GLY A 327
PRO B 116
VAL A 398
MET A 666
1.51A16.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR B  78
ILE B  34
LEU B   4
MET B   2
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LYS C  51
LEU C  53
PRO C  65
LEU C  84
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LYS L  51
LEU L  53
PRO L  65
LEU L  84
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H  78
ILE H  34
LEU H   4
MET H   2
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H  78
ILE H  34
LEU H   4
MET H   2
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
THR H  78
ILE H  34
LEU H   4
MET H   2
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LYS C  51
LEU C  53
PRO C  65
LEU C  84
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
THR B  78
ILE B  34
LEU B   4
MET B   2
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LYS L  51
LEU L  53
PRO L  65
LEU L  84
1.78A
None