Ligand ID: ZLD


Drugbank ID:
DB00601
(Linezolid)


Indication:
For the treatment of bacterial infections caused by susceptible strains of vancomycin resistant Enterococcus faecium, Staphylococcal aureus (methicillin resistant and susceptible strains), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae.

Get human targets for ZLD in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'ZLD'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 138
PHE B 140
TYR B 161
ASN B 142
LEU B 141
1.76A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A  36
TYR A  47
THR A  48
VAL A  84
LEU A 239
1.58A22.71
None
SAH  A1293 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A  36
TYR A  47
THR A  48
VAL A  84
LEU A 239
1.58A22.56
None
SFG  A1298 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 12
GLY A 482
TYR A 438
VAL A 388
ASN A 479
LEU S 478
1.59A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY B 466
ILE B 468
TRP B 461
VAL B 184
TRP B 459
1.65A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY A 466
ILE A 468
TRP A 461
VAL A 184
TRP A 459
1.70A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
GLY A 255
ILE A 256
PHE A 147
TYR A 316
LEU A 149
1.58A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY A 246
PHE A  22
MET A 151
THR A 236
VAL A  97
1.66A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY A 246
PHE A  22
MET A 151
THR A 236
VAL A  97
1.54A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY B 255
ILE B 256
PHE B 147
TYR B 316
LEU B 149
1.59A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B1113
ILE B1114
TYR A 899
VAL B1110
ASN B1116
1.76A10.80
GLY  B1113 ( 0.0A)
ILE  B1114 ( 0.7A)
TYR  A 899 ( 1.3A)
VAL  B1110 ( 0.5A)
ASN  B1116 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY A 298
ILE A 584
THR A 302
VAL A 290
LEU A 636
1.40A10.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 246
PHE C  22
MET C 151
THR C 236
VAL C  97
1.46A11.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 246
PHE A  22
MET A 151
THR A 236
VAL A  97
1.53A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		6lzg ACE2
(Homo
sapiens)		5 / 12
GLY A 466
ILE A 468
TRP A 461
VAL A 184
TRP A 459
1.67A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		6m0j ACE2
(Homo
sapiens)		5 / 12
GLY A 466
ILE A 468
TRP A 461
VAL A 184
TRP A 459
1.67A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 311
ILE C 598
THR C 299
VAL C 308
LEU C 650
1.71A10.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLY A 230
ILE A 201
TYR A 289
VAL A 234
LEU A  89
1.70A13.76
None