Ligand ID: VK3


Drugbank ID:
DB00170
(Menadione)


Indication:
The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.

Get human targets for VK3 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'VK3'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
TYR A  37
TYR A 101
LEU A  30
TYR A 182
1.72A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
PHE D 314
GLY D 230
GLY D 229
ASN B 283
1.32A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2ajf ACE2
(Homo
sapiens)		4 / 7
ARG B 169
LEU B 456
TRP B 477
TYR B 180
1.71A15.91
 CL  B1902 (-4.3A)
None
CL  B1902 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2ajf ACE2
(Homo
sapiens)		4 / 6
TRP B 461
ARG B 514
TYR B 207
LEU B 222
1.64A15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ARG B 131
TYR B 239
LEU B 268
ASN B 203
1.64A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		4 / 6
PHE L  98
TRP H 103
GLY H  50
GLY H  49
1.47A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		4 / 5
TRP H 103
GLY H  50
GLY H  49
PHE L  98
1.39A23.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		4 / 6
PHE B 133
GLY B  49
GLY B  48
ASN C 102
1.26A22.88
APR  B 477 (-3.5A)
APR  B 477 (-3.5A)
APR  B 477 (-3.6A)
APR  B 477 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
PHE B 133
GLY B  47
GLY B  52
ASN B  38
1.24A22.88
APR  B 477 (-3.5A)
APR  B 477 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2gri NSP3
(SARSr)		4 / 6
PHE A  99
PHE A  54
GLY A  48
GLY A  48
1.28A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2gri NSP3
(SARSr)		4 / 6
PHE A   8
PHE A   8
GLY A   5
GLY A   5
1.47A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 5
GLY A 238
GLY A 247
PHE A 232
PHE A 302
1.76A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 7
TYR A 324
TYR A 178
LEU A 189
ASN A 177
1.56A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 6
ASN A 177
TYR A 324
TYR A 178
LEU A 189
1.66A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		2kqv NSP3
(SARSr-CoV)		4 / 7
TYR A  61
LEU A  81
MET A 102
ILE A  71
1.68A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
TYR A 324
TYR A 178
LEU A 189
ASN A 177
1.48A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
ASN B 177
TYR B 324
TYR B 178
LEU B 189
1.58A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 7
ARG B 131
TYR B 239
LEU B 268
ASN B 203
1.69A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
GLY B 238
GLY B 247
PHE B 232
PHE B 302
1.74A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
PHE A 302
PHE A 232
GLY A 247
GLY A 238
1.30A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
TYR D 324
TYR D 178
LEU D 189
ASN D 177
1.49A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
ASN D 177
TYR D 324
TYR D 178
LEU D 189
1.58A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		2w2g NSP3
(SARSr-CoV)		4 / 7
TYR A 583
LEU A 603
MET A 624
ILE A 593
1.34A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		2zu4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.43A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLY B 146
GLY B  29
PHE B 150
PHE B 159
1.79A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
ARG A 514
TYR A 207
LEU A 222
TRP A 461
1.63A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
TRP A 461
ARG A 514
TYR A 207
LEU A 222
1.56A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
ARG A 514
TYR A 207
LEU A 222
TRP A 461
1.77A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
GLU A 479
TYR A 454
MET A 462
ILE A 468
1.69A10.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLY A 146
GLY A  29
PHE A 150
PHE A 159
1.64A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A 291
GLY B 138
GLY A   2
ASN A 214
1.52A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		3e9s NSP3
(SARSr-CoV)		4 / 7
HIS A 176
LEU A 133
TYR A  73
ILE A 152
1.57A16.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE B 291
GLY A 138
GLY B   2
ASN B 214
1.43A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A 291
GLY B 138
GLY A   2
ASN A 214
1.53A22.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		4 / 7
TYR D  99
HIS D 114
LEU D 126
TYR F   6
1.60A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLY C 146
GLY C  29
PHE C 150
PHE C 159
1.71A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3sci ACE2
(Homo
sapiens)		4 / 5
ARG B 514
TYR B 207
LEU B 222
TRP B 461
1.80A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3sci ACE2
(Homo
sapiens)		4 / 6
TRP B 461
ARG B 514
TYR B 207
LEU B 222
1.54A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3sci ACE2
(Homo
sapiens)		4 / 7
ARG B 514
TYR B 207
LEU B 222
TRP B 461
1.60A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
ARG B 514
TYR B 207
LEU B 222
TRP B 461
1.66A16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
TRP B 461
ARG B 514
TYR B 207
LEU B 222
1.57A16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A 381
LEU A 554
MET A 408
ILE A 407
1.79A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN F 473
TYR F 442
TYR F 475
LEU F 443
1.77A23.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		4 / 7
HIS B 176
LEU B 133
TYR B  73
ILE B 152
1.56A16.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.44A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.50A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
ARG D 525
TYR D 447
ASN D 518
TYR D 511
1.26A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
ARG D 525
TYR D 447
ASN D 518
TYR D 511
1.22A16.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
TRP B 520
GLY B 480
GLY B 481
PHE B 523
1.74A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
TYR A  73
TYR A  84
ASN A 147
TYR D 138
1.70A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
TYR B 511
LEU B 439
ASN B 395
TYR B 368
1.47A16.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
HIS B 176
LEU B 133
TYR B  73
ILE B 152
1.55A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR A  53
TYR A 266
LEU A 264
TYR A 197
1.76A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
GLY B 862
GLY B 867
PHE B 784
PHE B 880
1.62A11.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
TYR C 442
TYR C 475
LEU C 443
ASN C 473
1.66A9.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
PHE A 784
GLY A 780
GLY A 781
ASN A 910
1.28A11.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
ASN C 473
TYR C 442
TYR C 475
LEU C 443
1.61A9.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
TYR C 886
LEU C 876
TYR B1029
ILE B 696
1.46A5.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		5x5c S PROTEIN
(MERS-CoV)		4 / 7
TYR B 409
LEU B 443
TYR B 438
ILE B 480
1.76A6.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
ASN C 832
TYR B 361
TYR B 351
LEU B 347
1.73A9.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		5x5f S PROTEIN
(MERS-CoV)		4 / 5
GLY C 984
GLY C 982
PHE C 786
PHE C 788
1.69A10.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
TYR A 361
TYR A 351
LEU A 347
ASN B 832
1.71A9.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
PHE C 187
PHE C 185
GLY C 100
ASN C  96
1.47A11.39
PHE  C 187 ( 1.3A)
PHE  C 185 ( 1.3A)
GLY  C 100 ( 0.0A)
ASN  C  96 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN A 473
TYR A 442
TYR A 475
LEU A 443
1.70A9.17
ASN  A 473 ( 0.6A)
TYR  A 442 ( 1.3A)
TYR  A 475 ( 1.3A)
LEU  A 443 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR A  53
TYR A 266
LEU A 264
TYR A 197
1.72A9.17
TYR  A  53 ( 1.3A)
TYR  A 266 ( 1.3A)
LEU  A 264 ( 0.6A)
TYR  A 197 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
HIS A 176
LEU A 133
TYR A  73
ILE A 152
1.49A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN C 951
ARG C 977
TYR B 738
LEU B 734
1.61A9.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6acg ACE2
(Homo
sapiens)		4 / 7
GLU D 430
HIS D 540
LEU D 439
ILE D 291
1.46A11.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
GLY A 780
GLY A 781
PHE A1034
PHE A 784
1.59A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR A  88
GLU A 184
LEU A 209
ILE A 203
1.61A5.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ack ACE2
(Homo
sapiens)		4 / 5
TRP D  69
GLY D 352
GLY D 354
PHE D 390
1.72A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR A1049
LEU A1031
ASN A 901
TYR A 899
1.71A9.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
PHE A 784
GLY A 780
GLY A 781
ASN A 910
1.28A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
PHE A 784
GLY A 780
GLY A 781
ASN A 910
1.44A11.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
TYR A 886
LEU A 876
TYR C1029
ILE C 696
1.78A6.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
GLY C 862
GLY C 867
PHE C 784
PHE C 880
1.79A11.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
TYR C 442
TYR C 475
LEU C 443
ASN C 473
1.47A9.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASN C 473
TYR C 442
TYR C 475
LEU C 443
1.56A9.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
PHE C 784
GLY C 780
GLY C 781
ASN C 910
1.14A11.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS B  51
LEU B  64
MET A  12
ILE A  23
1.25A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6jyt HELICASE
(SARSr-CoV)		4 / 7
TYR A 149
TYR A 180
LEU A 227
ASN A 177
1.76A15.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6lu7 MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.50A22.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
PHE A 927
PHE C 927
GLY C 932
ASN C 928
1.53A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 7
TYR F 917
LEU F 916
ASN D 919
TYR D 917
1.62A23.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.57A22.68

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.56A22.68

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6m1d ACE2
(Homo
sapiens)		4 / 7
ARG B 514
TYR B 207
LEU B 222
TRP B 461
1.70A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6m1d ACE2
(Homo
sapiens)		4 / 6
TRP D 461
ARG D 514
TYR D 207
LEU D 222
1.72A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6m1d ACE2
(Homo
sapiens)		4 / 7
TYR B 381
LEU B 554
MET B 408
ILE B 407
1.53A9.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6m1d ACE2
(Homo
sapiens)		4 / 6
PHE B 356
GLY B 561
GLY B 395
ASN B 394
1.29A14.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE B 291
PHE B   3
GLY B 283
ASN B 214
1.56A22.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE D 291
PHE D   3
GLY D 283
ASN D 214
1.66A22.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.55A22.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE C 291
PHE C   3
GLY C 283
ASN C 214
1.58A22.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 237
TYR A 238
LEU A 241
TRP A 216
1.65A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
TRP A 216
TYR A 237
TYR A 238
LEU A 241
1.72A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A 237
TYR A 238
LEU A 241
TRP A 216
1.67A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASN A 705
ARG A 132
TYR A 732
LEU A 731
1.57A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6m71 NSP12
(SARS-CoV-2)		4 / 6
PHE A 192
GLY A 200
GLY A 230
ASN A 198
1.64A13.38

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ARG A 132
TYR A 732
LEU A 731
ASN A 705
1.44A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
TRP A 423
GLY A 326
PHE A 360
PHE A 361
1.78A11.24
None
NAG  A1316 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C  53
TYR C 266
LEU C 264
TYR C 197
1.75A9.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
PHE C 784
GLY C 780
GLY C 781
ASN C 910
1.44A11.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TRP H 117
GLY L  96
PHE L  41
PHE L 103
1.71A23.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6nur NSP12
(SARSr-CoV)		4 / 7
ARG A 132
TYR A 732
LEU A 731
ASN A 705
1.44A12.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6nur NSP12
(SARSr-CoV)		4 / 6
PHE A 415
GLY A 839
GLY A 841
ASN A 416
1.37A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6nus NSP12
(SARSr-CoV)		4 / 5
TYR A 237
TYR A 238
LEU A 241
TRP A 216
1.53A12.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6nus NSP12
(SARSr-CoV)		4 / 6
ASN A 705
ARG A 132
TYR A 732
LEU A 731
1.56A12.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE C 802
GLY C 798
GLY C 799
ASN C 928
1.55A10.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR B  91
LEU B  56
ASN B  30
TYR B  28
1.68A10.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TRP B 353
GLY C 232
GLY C 199
PHE B 464
1.58A10.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ASN B 178
TYR B 325
TYR B 179
LEU B 190
1.61A21.49
ACY  B 407 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR B 325
TYR B 179
LEU B 190
ASN B 178
1.53A21.49
None
None
None
ACY  B 407 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  51
ASN B  37
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  46
ASN A  40
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  51
ASN A  37
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  46
GLY A  51
ASN A  37
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.56A
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY B  51
ASN B  37
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE B 116
GLY B  78
GLY B  79
ASN B 115
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  46
ASN B  40
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TRP C 353
GLY A 232
GLY A 199
PHE C 464
1.66A10.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE C 802
GLY C 798
GLY C 799
ASN C 801
1.44A10.62
None
None
None
NAG  C1314 (-1.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE A 802
GLY A 798
GLY A 799
ASN A 928
1.45A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
GLY B 248
GLY B 247
PHE B 264
PHE B 241
1.63A21.81
CIT  B 408 (-3.5A)
CIT  B 408 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w02 NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY B  51
ASN B  37
1.32A21.81
APR  B 201 (-3.5A)
APR  B 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 6
PHE C 497
GLY C 504
GLY C 502
ASN C 501
1.65A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY B  51
ASN B  37
1.32A21.90
MES  B 201 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE B 116
GLY B  97
GLY B  78
ASN B 115
1.79A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  51
ASN A  37
1.71A21.90
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE B 116
GLY B  78
GLY B  79
ASN B 115
1.58A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.59A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  51
ASN B  37
1.44A21.90
MES  B 201 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  46
ASN A  40
1.44A21.90
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  46
GLY A  51
ASN A  37
1.56A21.90
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  46
ASN B  40
1.78A21.90
MES  B 201 ( 3.4A)
None
None
MES  B 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR C  83
TYR C  56
LEU C  87
TYR C  95
1.76A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
GLU B  67
LEU B  16
TYR B  56
ILE B  14
1.53A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
GLU A  67
LEU A  16
TYR A  56
ILE A  14
1.48A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR B  83
TYR B  56
LEU B  87
TYR B  95
1.71A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
GLU A  67
HIS A  17
LEU A  16
ILE A  14
1.45A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A 175
LEU A 132
TYR A  72
ILE A 151
1.55A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wcf NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  46
GLY A  51
ASN A  37
1.33A
MES  A 201 (-2.5A)
MES  A 202 (-4.7A)
MES  A 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wcf NSP3
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wcf NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  51
ASN A  37
1.45A
MES  A 201 (-2.5A)
MES  A 202 (-3.4A)
MES  A 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wen NSP3
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  46
ASN A  40
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wen NSP3
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wey NSP3
(SARS-CoV-2)		4 / 6
PHE A 336
GLY A 251
GLY A 255
ASN A 241
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wey NSP3
(SARS-CoV-2)		4 / 6
PHE A 336
GLY A 251
GLY A 250
ASN A 244
1.46A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wey NSP3
(SARS-CoV-2)		4 / 6
PHE A 320
GLY A 282
GLY A 283
ASN A 319
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wey NSP3
(SARS-CoV-2)		4 / 6
PHE A 336
GLY A 250
GLY A 255
ASN A 241
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
GLY B 248
GLY B 247
PHE B 264
PHE B 241
1.67A22.88
U5P  B 401 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR B 325
TYR B 179
LEU B 190
ASN B 178
1.56A22.16
None
None
None
ACT  B 407 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ASN B 178
TYR B 325
TYR B 179
LEU B 190
1.64A22.16
ACT  B 407 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR A 325
TYR A 179
LEU A 190
ASN A 178
1.55A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
GLY B 239
GLY B 248
PHE B 233
PHE B 303
1.77A22.88
None
U5P  B 401 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
GLY A 239
GLY A 248
PHE A 233
PHE A 303
1.77A22.88
None
U5P  A 401 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
GLY A 248
GLY A 247
PHE A 264
PHE A 241
1.67A22.88
U5P  A 401 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ASN A 178
TYR A 325
TYR A 179
LEU A 190
1.64A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE B 116
GLY B  78
GLY B  79
ASN B 115
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  46
GLY C  51
ASN C  37
1.33A
APR  C 201 (-3.5A)
APR  C 201 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE C 116
GLY C  78
GLY C  79
ASN C 115
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  46
GLY A  51
ASN A  37
1.33A
APR  A 201 (-3.1A)
APR  A 201 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE D 132
GLY D  47
GLY D  48
ASN D  37
1.62A
APR  D 201 (-3.5A)
APR  D 201 (-4.2A)
APR  D 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  48
ASN B  37
1.65A
APR  B 201 (-3.6A)
APR  B 201 (-4.0A)
APR  B 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  46
ASN A  40
1.65A
APR  A 201 (-3.1A)
APR  A 201 (-4.1A)
APR  A 201 (-3.9A)
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE D 116
GLY D  78
GLY D  79
ASN D 115
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY B  51
ASN B  37
1.33A
APR  B 201 (-3.6A)
APR  B 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  47
GLY C  48
ASN C  37
1.62A
APR  C 201 (-3.5A)
APR  C 201 (-4.1A)
APR  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE D 132
GLY D  46
GLY D  51
ASN D  37
1.31A
APR  D 201 (-3.5A)
APR  D 201 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
GLU A  67
HIS A  17
LEU A  16
ILE A  14
1.45A17.02
 CL  A 506 (-3.5A)
CL  A 506 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
HIS A 175
LEU A 132
TYR A  72
ILE A 151
1.55A17.02
PO4  A 504 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE A 497
GLY A 404
GLY A 504
ASN A 501
1.66A
None
DMS  A 903 (-3.5A)
DMS  A 903 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR C  92
LEU C  84
TYR H  27
ILE C 112
1.75A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE E 497
GLY E 404
GLY E 504
ASN E 501
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY E 133
ASN E 101
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  46
GLY C  51
ASN C  37
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  51
ASN B  37
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  51
ASN A  37
1.49A
EDO  A 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY B  51
ASN B  37
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 116
GLY D  78
GLY D  79
ASN D 115
1.56A
None
None
None
EDO  D 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 116
GLY C  78
GLY C  79
ASN C 115
1.55A
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 116
GLY E  78
GLY E  79
ASN E 115
1.59A
None
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 116
GLY B  78
GLY B  79
ASN B 115
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 132
GLY D  47
GLY D  46
ASN D  40
1.66A
EDO  D 205 ( 3.6A)
EDO  D 206 (-4.5A)
EDO  D 206 ( 4.6A)
EDO  D 206 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 132
GLY D  46
GLY D  51
ASN D  37
1.37A
EDO  D 205 ( 3.6A)
EDO  D 206 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 132
GLY E  46
GLY E  51
ASN E  37
1.38A
EPE  E 202 (-3.2A)
EPE  E 202 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.56A
None
None
None
EDO  D 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  46
GLY A  51
ASN A  37
1.34A
EDO  A 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 132
GLY E  47
GLY E  51
ASN E  37
1.50A
EPE  E 202 (-3.2A)
EPE  E 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  46
ASN B  40
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 132
GLY D  47
GLY D  51
ASN D  37
1.49A
EDO  D 205 ( 3.6A)
EDO  D 206 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  47
GLY C  46
ASN C  40
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  47
GLY C  51
ASN C  37
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 132
GLY E  46
GLY E  51
ASN E  37
1.32A
APR  E 201 (-3.5A)
APR  E 201 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 132
GLY D  47
GLY D  48
ASN D  37
1.65A
APR  D 201 (-3.3A)
APR  D 201 ( 4.3A)
EDO  D 204 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  46
GLY C  51
ASN C  37
1.28A
APR  C 201 (-3.5A)
APR  C 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 116
GLY C  78
GLY C  79
ASN C 115
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  46
GLY A  51
ASN A  37
1.29A
APR  A 201 (-3.7A)
APR  A 201 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY B  51
ASN B  37
1.28A
APR  B 201 (-3.5A)
EDO  B 202 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 132
GLY D  46
GLY D  51
ASN D  37
1.32A
APR  D 201 (-3.3A)
APR  D 201 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  48
ASN A  37
1.64A
APR  A 201 (-3.7A)
APR  A 201 (-4.1A)
APR  A 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 116
GLY E  78
GLY E  79
ASN E 115
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.57A
None
None
None
EDO  A 207 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY E 133
ASN E 101
1.60A
APR  B 201 (-3.5A)
EDO  B 202 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 116
GLY D  78
GLY D  79
ASN D 115
1.56A
None
None
EDO  D 203 (-3.1A)
EDO  A 207 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 116
GLY B  78
GLY B  79
ASN B 115
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  47
GLY C  48
ASN C  37
1.64A
APR  C 201 (-3.5A)
APR  C 201 (-4.3A)
APR  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  51
ASN B  37
1.66A
APR  B 201 (-3.5A)
APR  B 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 132
GLY E  47
GLY E  48
ASN E  37
1.64A
APR  E 201 (-3.5A)
APR  E 201 (-4.4A)
APR  E 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  47
GLY B  51
ASN B  37
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  47
GLY A  51
ASN A  37
1.48A
MES  A 201 (-3.5A)
MES  A 201 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 132
GLY B  46
GLY B  51
ASN B  37
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 116
GLY C  78
GLY C  79
ASN C 115
1.57A
None
None
None
EDO  A 202 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 132
GLY A  46
GLY A  51
ASN A  37
1.34A
MES  A 201 (-3.5A)
MES  A 201 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  47
GLY C  51
ASN C  37
1.45A
MES  C 201 (-3.6A)
MES  C 201 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 116
GLY A  78
GLY A  79
ASN A 115
1.57A
None
None
EDO  A 204 (-3.6A)
EDO  A 202 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 132
GLY C  46
GLY C  51
ASN C  37
1.34A
MES  C 201 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 116
GLY B  78
GLY B  79
ASN B 115
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASN A 705
ARG A 132
TYR A 732
LEU A 731
1.50A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 415
GLY A 839
GLY A 841
ASN A 416
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
TYR A 237
TYR A 238
LEU A 241
TRP A 216
1.63A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 192
GLY A 200
GLY A 230
ASN A 198
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
TRP A 216
TYR A 237
TYR A 238
LEU A 241
1.69A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
ARG A 132
TYR A 732
LEU A 731
ASN A 705
1.38A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 694
GLY A 679
GLY A 678
ASN A 628
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
PHE A   3
GLY A 283
ASN A 214
1.56A
None
None
DMS  A 404 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASN A 705
ARG A 132
TYR A 732
LEU A 731
1.56A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 415
GLY A 839
GLY A 841
ASN A 416
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 237
TYR A 238
LEU A 241
TRP A 216
1.70A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 728
TYR A 732
LEU A 708
TYR A 129
1.65A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ARG A 132
TYR A 732
LEU A 731
ASN A 705
1.43A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
TRP A 216
TYR A 237
TYR A 238
LEU A 241
1.74A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 694
GLY A 679
GLY A 678
ASN A 628
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
TYR A 237
TYR A 238
LEU A 241
TRP A 216
1.69A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ARG A 132
TYR A 732
LEU A 731
ASN A 705
1.36A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 275
PHE A 321
GLY A 352
ASN A 314
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
TYR A 237
TYR A 238
LEU A 241
TRP A 216
1.61A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 429
GLY A 839
GLY A 841
ASN A 416
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASN A 705
ARG A 132
TYR A 732
LEU A 731
1.46A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 415
GLY A 839
GLY A 841
ASN A 416
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
TRP A 216
TYR A 237
TYR A 238
LEU A 241
1.66A12.09
None