Ligand ID: TLF


Drugbank ID:
DB09216
(Tolfenamic Acid)


Indication:
For the treatment of migraine.

Get human targets for TLF in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TLF'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
VAL B  73
VAL B  91
LEU B  89
VAL B  20
GLY B  29
1.49A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.48A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1uw7 NSP9
(SARS-COV
HKU-39849)		5 / 12
VAL A  41
LEU A  -8
VAL A 102
ALA A  43
LEU A  44
1.56A14.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU D 941
ALA F 938
VAL F1157
ALA E 940
1.09A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1x7q HLA, A-11
(Homo
sapiens)		5 / 12
VAL A  28
VAL A 103
LEU A 110
GLY A   1
LEU A 172
1.27A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU I  41
ALA G  38
VAL L   9
ALA K  40
1.16A9.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
VAL B  73
VAL B  91
LEU B  89
VAL B  20
GLY B  29
1.49A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
VAL A 337
VAL A 198
TYR A 191
ALA A 306
LEU A 308
1.47A17.92
GOL  A1010 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
VAL C 198
LEU C 309
LEU C 235
VAL C 218
ALA C 306
1.31A17.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
VAL A  38
VAL A  27
LEU A  65
VAL A  63
LEU A  19
1.52A9.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
VAL C  21
SER G  90
GLY C  69
ALA C  70
LEU C  64
1.46A9.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU B 941
ALA A 938
VAL F1158
ALA C 940
1.16A8.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL S 354
LEU S 355
SER S 353
ALA S 350
LEU S 322
1.28A17.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL S 349
VAL S 354
TYR S 352
GLY S 326
LEU S 322
1.52A17.43
None
None
None
NAG  S1330 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H  67
ARG H  66
VAL H  18
TYR H  90
GLY H  15
1.55A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU B 141
TYR B 126
SER B 147
1.33A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
VAL A 156
VAL A  17
TYR A  10
ALA A 125
LEU A 127
1.47A16.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
VAL A  17
LEU A 128
LEU A  54
VAL A  37
ALA A 125
1.29A16.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL B 126
LEU B 124
SER B 241
MET B 207
VAL B 206
1.50A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU A  76
TYR C  36
SER C  86
0.86A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		3 / 3
TYR B 168
TYR A 436
SER B 101
1.71A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 7
LEU D   4
HIS D  35
ALA D  97
TYR D  95
ALA D 175
1.70A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 496
PHE A 329
PHE A 325
ILE A 345
PHE A 501
1.50A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL A 303
VAL A 236
VAL A 338
GLY A 229
LEU A 227
1.56A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		5 / 12
VAL A 296
VAL A 212
GLY A 215
ALA A 211
LEU A 282
1.50A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		5 / 12
VAL A 296
VAL A 212
GLY A 215
ALA A 211
LEU A 282
1.52A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		3 / 3
LEU A 160
TYR A  88
SER A  52
1.40A13.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL A  68
LEU A  67
VAL A  73
GLY A  71
ALA A  70
1.32A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE C  79
LEU C 119
VAL C  96
ALA C 108
0.95A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		6 / 12
VAL A  77
VAL A  42
LEU A  27
MET A  17
VAL A  18
LEU A  89
1.79A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.52A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  73
VAL A  91
LEU A  89
VAL A  20
GLY A  29
1.50A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2w2g NSP3
(SARSr-CoV)		5 / 12
TYR A 495
VAL A 445
GLY A 446
ALA A 474
LEU A 475
1.35A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 7
ILE A 207
LEU A  54
ALA A 168
VAL A 169
ALA A 209
1.22A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
PHE A 156
ILE A  68
VAL A  96
PHE A  70
HIS A 119
1.54A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 7
ILE A 207
LEU A  54
ALA A 168
VAL A 169
ALA A 209
1.22A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2z9l 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B  68
LEU B  67
VAL B  73
GLY B  71
ALA B  70
1.33A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		3 / 3
LEU B 100
TYR A 491
SER C  30
1.51A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3d0h ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
LEU B  24
TYR F 475
SER F 461
1.37A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
VAL A 487
LEU A 444
LEU A 281
VAL A 244
LEU A 267
1.50A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL A 110
SER A 105
LEU B  42
ALA B   8
LEU B 112
1.38A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL A 110
SER A 105
LEU B  42
ALA B   8
LEU B 112
1.38A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.55A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3i6g HLA, A-2
(Homo
sapiens)		5 / 12
VAL D  28
VAL D 103
LEU D 110
GLY D   1
LEU D 172
1.21A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3i6k HLA, A-2
(Homo
sapiens)		3 / 3
LEU A  81
TYR A 116
SER A  11
1.12A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3i6k BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		3 / 3
TYR B  66
TYR A  27
SER B  55
1.42A11.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3i6l HLA, A-24
(Homo
sapiens)		5 / 12
VAL D  28
VAL D 103
LEU D 110
GLY D   1
LEU D 172
1.21A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B  68
LEU B  67
VAL B  73
GLY B  71
ALA B  70
1.29A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  77
VAL A  42
LEU A  27
MET A  17
VAL A  18
LEU A  89
1.79A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.52A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
PHE A 156
ILE A  68
SER A  98
PHE A  70
HIS A 119
1.55A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 7
ILE A 207
LEU A  54
ALA A 168
VAL A 169
ALA A 209
1.23A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
VAL F 496
PHE F 329
PHE F 325
ILE F 345
VAL F 382
PHE F 501
1.67A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
LEU B  24
TYR F 475
SER F 461
1.49A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
LEU A 163
TYR A 265
SER A 112
1.58A19.41
None
None
NA  A 402 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL A 126
LEU A 124
SER A 241
MET A 207
VAL A 206
1.49A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE B 305
ILE B 213
VAL B 296
SER B 301
VAL B 303
1.37A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL B 381
LEU B 442
MET B 315
VAL B 316
ALA B 320
1.27A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL B 381
LEU B 442
MET B 315
VAL B 316
ALA B 320
1.18A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 269
SER D 271
VAL D  91
GLY D  93
LEU D 152
1.36A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
VAL D 269
SER D 271
VAL D  91
GLY D  93
LEU D 152
1.31A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
PHE D  89
ILE D  87
VAL D 181
VAL D 115
PHE D 111
1.49A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.50A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.73A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.77A14.52
None
None
DMS  A 402 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  77
VAL A  42
LEU A  27
MET A  17
LEU A  89
1.78A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 296
VAL A 202
LEU A 242
VAL A 261
GLY A 251
1.75A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.57A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 262
HIS A 246
VAL A 202
TYR A 209
1.64A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ILE A 200
HIS A 246
VAL A 202
ALA A 129
1.56A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  35
LEU A  89
LEU A  27
VAL A  18
GLY A  29
1.77A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.58A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		5 / 12
VAL A  86
VAL A  98
LEU A  82
SER A  83
GLY A 141
1.51A10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		5 / 12
VAL A 102
VAL A 146
SER A 123
GLY A 139
LEU A 135
1.34A10.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		5 / 12
VAL A 102
VAL A 146
SER A 123
GLY A 139
LEU A 135
1.32A10.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 718
VAL A 945
TYR A 989
LEU A 810
LEU A 840
1.50A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU C 636
ALA C 595
VAL C 594
ALA C 658
1.07A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 307
VAL A 537
LEU A 538
LEU A 532
GLY A 534
1.37A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 12
VAL C  62
VAL D  24
LEU D  27
VAL D  47
LEU C  65
1.43A8.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
VAL A  33
PHE A  39
ILE A 131
SER A 299
VAL A 102
1.54A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL A 497
VAL A 510
PHE A 501
VAL A 328
PHE A 325
1.56A12.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 7
ILE A 852
ALA A1037
VAL A1042
TYR A 855
ALA A 854
1.74A14.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
SER C 856
VAL C 958
GLY C 957
ALA C 968
LEU B 780
1.42A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
VAL C  33
ILE C 131
VAL C 130
SER C 299
VAL C 102
1.46A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x59 S PROTEIN
(MERS-CoV)		3 / 3
LEU C 840
TYR B 361
SER B 358
1.08A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x59 S PROTEIN
(MERS-CoV)		3 / 3
TYR B1192
TYR B1141
SER C 966
1.30A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
SER C 856
VAL C 958
GLY C 957
ALA C 968
LEU B 780
1.44A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL C 642
SER C 659
LEU C 597
GLY C 638
ALA C 639
1.33A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL C 642
SER C 659
LEU C 597
GLY C 638
ALA C 639
1.30A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 497
VAL C 510
PHE C 501
VAL C 328
PHE C 325
1.38A12.35
VAL  C 497 ( 0.6A)
VAL  C 510 ( 0.5A)
PHE  C 501 ( 1.3A)
VAL  C 328 ( 0.6A)
PHE  C 325 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU A 216
TYR A  88
SER A  36
0.80A18.31
LEU  A 216 ( 0.5A)
TYR  A  88 ( 1.3A)
SER  A  36 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
TYR A 738
TYR C 738
SER A 985
1.21A18.31
TYR  A 738 ( 1.3A)
TYR  C 738 ( 1.3A)
SER  A 985 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 114
VAL B 196
LEU B 257
GLY B  86
LEU B 194
1.43A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 496
PHE B 329
PHE B 325
ILE B 345
PHE B 501
1.46A12.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6acg ACE2
(Homo
sapiens)		4 / 7
LEU D 108
VAL D 184
TYR D 199
ALA D 191
1.14A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE C 674
ALA C 595
VAL C 596
ALA C 676
0.95A14.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
TYR B 367
TYR B 494
SER B 362
1.66A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6acg ACE2
(Homo
sapiens)		3 / 3
TYR D  50
TYR D 510
SER D 124
1.75A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ack ACE2
(Homo
sapiens)		5 / 12
VAL D 447
VAL D 244
LEU D 248
GLY D 268
LEU D 444
1.39A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ack ACE2
(Homo
sapiens)		5 / 12
SER D 502
TYR D 127
LEU D 267
GLY D 272
LEU D 456
1.51A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 307
VAL C 537
LEU C 538
LEU C 532
GLY C 534
1.37A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ack ACE2
(Homo
sapiens)		3 / 3
LEU D 120
TYR D 199
SER D 105
1.34A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ILE A 674
ALA A 595
VAL A 596
ALA A 676
1.13A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LEU B 182
TYR B  88
SER B  35
1.38A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ILE B 674
ALA B 595
VAL B 596
ALA B 676
1.00A14.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
TYR B 622
TYR B 660
SER B 591
1.33A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B 420
PHE B 325
ILE B 345
VAL B 510
VAL B 498
1.39A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6cs2 ACE2
(Homo
sapiens)		4 / 7
LEU D 108
VAL D 184
TYR D 199
ALA D 191
1.12A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LEU A 147
TYR A 116
SER A  77
0.93A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
VAL A  28
VAL A 103
LEU A 110
GLY A   1
LEU A 172
1.42A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6jyt HELICASE
(SARSr-CoV)		3 / 3
TYR A  93
TYR A  70
SER A  44
1.54A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6jyt HELICASE
(SARSr-CoV)		5 / 12
VAL A 154
VAL A 226
GLY A 150
ALA A 152
LEU A 165
1.55A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
VAL F 976
LEU F 977
SER F 974
LEU D1166
LEU E1166
1.28A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.61A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.60A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 12
VAL E 362
VAL E 367
TYR E 365
GLY E 339
LEU E 335
1.42A17.52
None
None
None
NAG  E 601 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.61A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.60A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.59A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.61A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6m17 ACE2
(Homo
sapiens)		5 / 12
PHE D 684
ILE D 694
SER D 692
VAL D 691
HIS D 493
1.56A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
TYR A 129
TYR A 231
SER A 227
1.28A20.37
LEU  A 707 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
VAL E 433
PHE E 338
ILE E 358
SER E 514
VAL E 512
1.49A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL C 585
SER C 188
LEU C 181
GLY C 478
LEU C 484
1.45A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL C 585
SER C 188
LEU C 181
GLY C 478
LEU C 484
1.44A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m18 ACE2
(Homo
sapiens)		3 / 3
TYR D 515
TYR D 180
SER D 507
1.55A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  42
VAL C  36
VAL C  77
GLY C  79
LEU C  87
1.59A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  42
VAL C  36
VAL C  77
GLY C  79
LEU C  87
1.61A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D  42
VAL D  36
VAL D  77
GLY D  79
LEU D  87
1.62A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B  42
VAL B  36
VAL B  77
GLY B  79
LEU B  87
1.57A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.57A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B  42
VAL B  36
VAL B  77
GLY B  79
LEU B  87
1.59A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.60A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 297
LEU B 268
VAL B 202
ALA B 206
LEU B 253
1.62A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.60A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  73
VAL A  91
LEU A  89
VAL A  20
GLY A  29
1.50A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.59A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
LEU A 160
TYR A  88
SER A  52
1.38A12.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ILE A 307
LEU A 636
VAL A 299
ALA A 311
1.24A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ILE A 632
LEU A 636
ALA A 311
ALA A 656
1.22A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.30A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.31A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 497
VAL A 510
PHE A 501
VAL A 328
PHE A 325
1.30A11.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE C 674
ALA C 595
VAL C 596
ALA C 676
1.06A14.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP12
(SARSr-CoV)		3 / 3
TYR A 149
TYR A 237
SER A 185
1.68A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6nur NSP12
(SARSr-CoV)		5 / 12
PHE A 275
VAL A 353
TRP A 268
SER A 325
PHE A 326
1.47A14.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 12
VAL D 130
LEU C  56
SER C  57
LEU C  71
ALA D 110
1.40A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP7
(SARSr-CoV)		5 / 12
VAL C  16
VAL C  66
GLY C  64
ALA C  65
LEU C  20
1.52A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nus NSP12
(SARSr-CoV)		3 / 3
LEU A 908
TYR A 916
SER A 861
1.20A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nus NSP12
(SARSr-CoV)		5 / 12
LEU A 241
LEU A 187
VAL A 182
ALA A 250
LEU A 316
1.47A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
VAL A 524
PHE A 515
VAL A 341
PHE A 338
1.40A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE B 692
ALA B 609
VAL B 610
ALA B 694
1.04A14.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
TYR A1047
TYR B 789
SER B 884
1.10A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C 860
SER C 730
GLY C 769
ALA C 771
LEU C 861
1.46A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C 860
SER C 730
GLY C 769
ALA C 771
LEU C 861
1.47A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
SER E 366
LEU E 513
ALA E 363
LEU E 335
1.49A17.38
NAG  E 602 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.31A17.38
NAG  E 602 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL F 511
VAL F 524
PHE F 515
VAL F 341
PHE F 338
1.50A22.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		6 / 12
VAL B  16
LEU B 127
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
LEU A 108
1.59A
None
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6vxs NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.28A
None
None
None
SO4  A 203 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
SER B 128
VAL B  96
GLY B  79
LEU B 108
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		6 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		6 / 12
VAL B  16
TYR B 113
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6vxs NSP3
(SARS-CoV-2)		4 / 7
ILE B  23
LEU B 123
ALA B 154
VAL B 155
1.18A
None
None
None
SO4  B 204 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6vxs NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.42A
None
None
SO4  A 203 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6vxs NSP3
(SARS-CoV-2)		4 / 7
ILE B  23
ALA B 154
VAL B 155
ALA B  52
1.41A
None
None
SO4  B 204 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C 615
SER C 596
LEU A 864
GLY C 667
ALA C 647
1.55A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C 510
PHE C 342
PHE C 338
ILE C 358
PHE C 515
1.50A11.87
None
NAG  C1307 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 120
LEU A 110
SER A 116
LEU A  84
LEU A 241
1.49A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 692
ALA A 609
VAL A 610
ALA A 694
1.09A14.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
TYR A1047
TYR B 789
SER B 884
1.40A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 362
VAL A 367
TYR A 365
GLY A 339
LEU A 335
1.39A18.14
None
None
None
NAG  A1307 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 692
ALA A 609
VAL A 610
ALA A 694
1.10A14.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C 510
PHE C 342
PHE C 338
ILE C 358
PHE C 515
1.51A11.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
TYR A1047
TYR B 789
SER B 884
1.41A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 159
TYR B  87
SER B  51
1.43A12.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
LEU C 159
TYR C  87
SER C  51
1.46A12.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A 159
TYR A  87
SER A  51
1.40A12.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
LEU D 159
TYR D  87
SER D  51
1.44A12.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w02 NSP3
(SARS-CoV-2)		5 / 12
VAL B  16
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.18A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
LEU C 368
ALA C 363
VAL C 362
ALA C 397
1.36A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU C 390
TYR L  49
SER C 383
0.99A15.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE L 106
LEU L  78
TYR L 140
ALA L  12
1.58A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE L  75
ALA L  19
TYR L  86
ALA L  84
1.70A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 511
VAL C 524
PHE C 515
VAL C 341
PHE C 338
1.52A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 511
VAL C 524
PHE C 515
VAL C 341
PHE C 338
1.52A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 433
PHE C 338
ILE C 358
VAL C 524
VAL C 512
1.74A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU L  46
TYR L  91
SER C 383
1.57A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L  58
ARG L  54
SER L  76
GLY L  64
LEU L  47
1.66A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L  58
ARG L  54
SER L  76
GLY L  64
LEU L  47
1.73A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 433
PHE C 338
ILE C 358
VAL C 524
VAL C 512
1.75A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w4h NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6924
ALA A6966
TYR A6845
0.76A23.56
None
None
None
SAM  A7102 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w4h NSP16
(SARS-CoV-2)		3 / 3
TYR A6979
TYR A6930
SER A7000
1.47A19.67
None
ACT  A7103 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w4h NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.52A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
ILE A6838
LEU B4298
VAL B4295
ALA A6843
1.77A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6842
SER B4325
VAL A6876
GLY A6871
ALA A6877
1.63A13.06
None
None
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ILE B4291
VAL B4361
PHE B4321
SER B4325
VAL A6876
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6848
ALA A6966
VAL A6965
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 NSP10
(SARS-CoV-2)		5 / 12
VAL B4350
SER B4325
LEU B4284
VAL B4361
GLY B4362
1.65A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 NSP10
(SARS-CoV-2)		5 / 12
VAL B4350
SER B4325
LEU B4284
VAL B4361
GLY B4362
1.65A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6924
ALA A6966
TYR A6845
0.76A
None
None
None
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A7079
LEU A7073
ALA A6960
ALA A6858
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6969
LEU A6978
TYR A7026
ALA A6990
1.63A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6883
ALA A6877
VAL A6876
ALA A6905
1.59A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w61 NSP10
(SARS-CoV-2)		4 / 7
ILE B4334
LEU B4328
HIS B4333
ALA B4279
1.58A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6842
SER B4325
VAL A6876
GLY A6871
ALA A6877
1.64A13.06
None
None
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
ILE B  23
ALA B 154
VAL B 155
ALA B  27
1.75A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 126
ALA A 134
VAL A 100
ALA A  38
1.67A20.71
AMP  A 201 ( 4.4A)
None
None
AMP  A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A  53
ALA A  27
VAL A  30
ALA A 124
1.63A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A  93
HIS A  45
ALA A  39
ALA A 112
1.62A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
VAL A  49
VAL A  35
ALA A 124
LEU A 127
1.73A14.37
None
AMP  A 201 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  16
TYR B 113
LEU B  53
VAL B  36
ALA B 124
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		6 / 12
VAL B  16
LEU B 127
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
ILE B  23
ALA B 154
VAL B 155
ALA B  52
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
VAL A 147
TYR A 113
VAL A  16
LEU A 122
1.71A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.35A
AMP  A 201 ( 4.0A)
AMP  A 201 ( 4.5A)
AMP  A 201 ( 4.4A)
AMP  A 201 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
ILE B  23
LEU B 123
ALA B 154
VAL B 155
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
LEU A 108
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 126
HIS A 138
VAL A 142
ALA A 124
1.64A20.71
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  16
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 126
HIS B 138
VAL B 142
ALA B 124
1.77A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B  53
ALA B  27
VAL B  30
ALA B 124
1.59A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A 142
LEU A  75
VAL A  77
GLY A  79
ALA A 112
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A 142
LEU A  75
VAL A  77
GLY A  79
ALA A 112
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 126
ALA B 134
VAL B 100
ALA B  38
1.71A20.71
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.33A
AMP  A 201 ( 4.0A)
None
AMP  A 201 ( 4.5A)
AMP  A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
VAL A  49
VAL A  35
ALA A 124
LEU A 127
1.73A14.37
None
AMP  A 201 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
SER B 128
VAL B  96
GLY B  79
LEU B 108
1.60A
None
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 127
HIS A 119
VAL A  82
ALA A  39
1.58A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  36
VAL B 147
TYR B 113
VAL B  16
LEU B 122
1.72A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
SER A 128
LEU A  75
VAL A  95
ALA A  39
1.80A14.37
AMP  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
VAL B  49
VAL B  35
ALA B 124
LEU B 127
1.76A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
VAL B  49
VAL B  35
ALA B 124
LEU B 127
1.76A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6852
ALA A6966
TYR A6845
1.78A18.84
None
None
None
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
ILE C6838
LEU D4298
VAL D4295
ALA C6843
1.77A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6926
LEU C6852
ALA C6966
TYR C6845
1.77A18.84
None
None
None
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6883
ALA A6877
VAL A6876
ALA A6905
1.58A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6969
LEU A6978
TYR A7026
ALA A6990
1.64A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL D4350
SER D4325
LEU D4284
VAL D4361
GLY D4362
1.63A11.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
SER C6896
PHE C6868
HIS C6917
1.60A20.44
None
None
None
None
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
VAL C6894
PHE C6868
HIS C6917
1.54A20.44
None
None
None
None
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C7079
LEU C7073
ALA C6858
ALA C7056
1.78A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6924
ALA A6966
TYR A6845
0.74A18.84
None
None
None
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6848
ALA A6966
VAL A6965
1.41A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
SER C6896
PHE C6868
HIS C6917
1.61A20.44
None
None
None
None
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6926
LEU C6924
ALA C6966
TYR C6845
0.75A18.84
None
None
None
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.64A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
VAL C6894
PHE C6868
HIS C6917
1.56A20.44
None
None
None
None
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ILE B4291
VAL B4361
PHE B4321
SER B4325
VAL A6876
1.80A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP10
(SARS-CoV-2)		4 / 7
ILE D4334
HIS B4333
TYR D4329
ALA D4276
1.70A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A7079
LEU A7073
ALA A6858
ALA A7056
1.80A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP10
(SARS-CoV-2)		4 / 7
ILE B4334
HIS D4333
TYR B4329
ALA B4276
1.76A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6842
SER D4325
VAL C6876
GLY C6871
ALA C6877
1.63A13.07
None
None
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A7079
LEU A7073
ALA A6960
ALA A6858
1.30A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6842
SER B4325
VAL A6876
GLY A6871
ALA A6877
1.66A13.07
None
None
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP10
(SARS-CoV-2)		4 / 7
ILE D4334
LEU D4328
HIS D4333
ALA D4279
1.68A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6883
ALA C6877
VAL C6876
ALA C6905
1.57A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
ILE A6838
LEU B4298
VAL B4295
ALA A6843
1.76A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.60A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C7079
LEU C7073
ALA C6960
ALA C6858
1.31A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL B4350
SER B4325
LEU B4284
VAL B4361
GLY B4362
1.64A11.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL D4350
SER D4325
LEU D4284
VAL D4361
GLY D4362
1.64A11.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL B4350
SER B4325
LEU B4284
VAL B4361
GLY B4362
1.63A11.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL A6916
LEU A6909
SER A7089
LEU A6892
VAL A7087
1.72A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6842
SER D4325
VAL C6876
GLY C6871
ALA C6877
1.64A13.07
None
None
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6842
SER B4325
VAL A6876
GLY A6871
ALA A6877
1.65A13.07
None
None
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.61A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.63A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6926
LEU C6848
ALA C6966
VAL C6965
1.41A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6969
LEU C6978
TYR C7026
ALA C6990
1.63A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w75 NSP10
(SARS-CoV-2)		4 / 7
ILE B4334
LEU B4328
HIS B4333
ALA B4279
1.55A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ILE A 300
LEU A 253
HIS A 275
ALA A 261
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU B  80
ALA B  68
VAL B  66
ALA B 131
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU C  80
ALA C  68
VAL C  66
ALA C 131
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU C  87
ALA C 135
TYR C 154
ALA C 153
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ILE C 300
LEU C 253
HIS C 275
ALA C 261
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ILE B 300
LEU B 253
HIS B 275
ALA B 261
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
VAL A  41
LEU A  -8
VAL A 102
ALA A  43
LEU A  44
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
VAL A  41
LEU A  -8
VAL A 102
ALA A  43
LEU A  44
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wcf NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
LEU A 108
1.60A
None
MES  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wcf NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.39A
None
None
None
MES  A 202 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 142
LEU A  75
VAL A  77
GLY A  79
ALA A 112
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wen NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 142
LEU A  75
VAL A  77
GLY A  79
ALA A 112
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wen NSP3
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wey NSP3
(SARS-CoV-2)		4 / 7
ILE A 227
ALA A 358
VAL A 359
ALA A 256
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 220
TYR A 317
LEU A 257
VAL A 240
ALA A 328
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wey NSP3
(SARS-CoV-2)		4 / 7
ILE A 227
LEU A 327
ALA A 358
VAL A 359
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 346
LEU A 279
VAL A 281
GLY A 283
ALA A 316
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 331
SER A 332
VAL A 300
GLY A 283
LEU A 312
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		6 / 12
VAL A 220
LEU A 331
LEU A 257
VAL A 240
ALA A 328
LEU A 357
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 346
LEU A 279
VAL A 281
GLY A 283
ALA A 316
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 220
LEU A 257
VAL A 240
ALA A 328
LEU A 357
1.20A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wiq NSP8
(SARS-CoV-2)		4 / 7
ILE B 120
LEU B 122
TYR B 149
ALA B 152
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL A  22
LEU A  60
SER A  61
LEU B  95
LEU A  20
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE C6926
LEU C6924
ALA C6966
TYR C6845
0.76A
None
None
None
SAH  C7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE C6926
LEU C6848
ALA C6966
VAL C6965
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE C7079
LEU C7073
ALA C6960
ALA C6858
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6848
ALA A6966
VAL A6965
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A7094
PHE C6954
ILE C6925
VAL C6965
VAL C6894
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A7079
LEU A7073
ALA A6960
ALA A6858
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6924
ALA A6966
TYR A6845
0.75A
None
None
None
SAH  A7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A7094
PHE C6954
ILE C6925
VAL C6965
VAL C6894
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
LEU B 159
TYR B  87
SER B  51
1.45A12.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
LEU C 159
TYR C  87
SER C  51
1.42A12.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
LEU D 159
TYR D  87
SER D  51
1.45A12.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
LEU A 159
TYR A  87
SER A  51
1.43A12.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE C6926
LEU C6924
ALA C6966
TYR C6845
0.76A
None
None
None
SFG  C7103 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL A7094
PHE C6954
ILE C6925
VAL C6965
VAL C6894
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE C6926
LEU C6848
ALA C6966
VAL C6965
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL C7094
PHE A6954
ILE A6925
VAL A6965
VAL A6894
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE A7079
LEU A7073
ALA A6960
ALA A6858
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6848
ALA A6966
VAL A6965
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6924
ALA A6966
TYR A6845
0.76A
None
None
None
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
SER C6896
PHE C6868
HIS C6917
1.64A
None
None
None
None
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
VAL C6894
PHE C6868
HIS C6917
1.54A
None
None
None
None
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL C7094
PHE A6954
ILE A6925
VAL A6965
VAL A6894
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE C7079
LEU C7073
ALA C6960
ALA C6858
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
VAL C6894
PHE C6868
HIS C6917
1.55A
None
None
None
None
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
ILE C6866
SER C6896
PHE C6868
HIS C6917
1.65A
None
None
None
None
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL A7094
PHE C6954
ILE C6925
VAL C6965
VAL C6894
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6842
SER D4325
VAL C6876
GLY C6871
ALA C6877
1.63A
None
None
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A  86
LEU A  73
ALA A  95
ALA A  81
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 295
PHE B 342
ILE B 307
VAL B 339
PHE B 303
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 295
PHE A 342
ILE A 307
VAL A 339
PHE A 303
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  30
VAL C  24
LEU C  53
GLY C  85
ALA C  89
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
VAL C  16
LEU C 127
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.31A
APR  A 201 (-4.0A)
None
APR  A 201 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE C  23
ALA C 154
VAL C 155
ALA C  52
1.37A
APR  C 201 (-3.9A)
APR  C 201 (-4.5A)
None
APR  C 201 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 127
SER C 128
VAL C  96
GLY C  79
LEU C 108
1.62A
None
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 142
LEU D  75
VAL D  77
GLY D  79
ALA D 112
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  16
TYR C 113
LEU C  53
VAL C  36
ALA C 124
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
LEU A 108
1.61A
None
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 127
SER D 128
VAL D  96
GLY D  79
LEU D 108
1.62A
None
APR  D 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE D  23
ALA D 154
VAL D 155
ALA D  52
1.40A
APR  D 201 (-3.8A)
APR  D 201 (-4.4A)
None
APR  D 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE D  23
LEU D 123
ALA D 154
VAL D 155
1.33A
APR  D 201 (-3.8A)
None
APR  D 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  95
VAL D  35
VAL D  49
GLY D  51
ALA D  50
1.58A
None
None
APR  D 201 (-3.6A)
None
APR  D 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  16
TYR B 113
LEU B  53
VAL B  36
ALA B 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  16
LEU D  53
VAL D  36
ALA D 124
LEU D 153
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 142
LEU D  75
VAL D  77
GLY D  79
ALA D 112
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 142
LEU A  75
VAL A  77
GLY A  79
ALA A 112
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  16
TYR D 113
LEU D  53
VAL D  36
ALA D 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  34
VAL D  95
LEU D 126
ALA D 124
LEU D 122
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.39A
APR  A 201 (-4.0A)
APR  A 201 (-4.6A)
None
APR  A 201 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
VAL B  16
LEU B 127
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 127
SER B 128
VAL B  96
GLY B  79
LEU B 108
1.62A
None
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE C  23
LEU C 123
ALA C 154
VAL C 155
1.31A
APR  C 201 (-3.9A)
None
APR  C 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  16
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
VAL D  16
LEU D 127
LEU D  53
VAL D  36
ALA D 124
LEU D 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE B  23
LEU B 123
ALA B 154
VAL B 155
1.32A
APR  B 201 (-3.8A)
None
APR  B 201 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  95
LEU D  88
VAL D  49
GLY D  51
ALA D  50
1.51A
None
None
APR  D 201 (-3.6A)
None
APR  D 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 142
LEU A  75
VAL A  77
GLY A  79
ALA A 112
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE B  23
ALA B 154
VAL B 155
ALA B  52
1.40A
APR  B 201 (-3.8A)
APR  B 201 (-4.6A)
None
APR  B 201 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.51A
None
None
None
None
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.56A
None
None
None
None
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
VAL A6894
PHE A6868
HIS A6917
1.50A
None
None
None
None
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A7079
LEU A7073
ALA A6960
ALA A6858
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6848
ALA A6966
VAL A6965
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6954
ILE A6866
SER A6896
PHE A6868
HIS A6917
1.55A
None
None
None
None
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6926
LEU A6924
ALA A6966
TYR A6845
0.74A
None
None
None
SAH  A7101 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wqd NSP8
(SARS-CoV-2)		4 / 7
ILE B 120
LEU B 122
TYR B 149
ALA B 152
1.37A
None
None
None
EDO  B 302 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE D 120
LEU D 122
VAL C  58
ALA D 102
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wqd NSP8
(SARS-CoV-2)		4 / 7
ILE D 120
LEU D 122
TYR D 149
ALA D 152
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
TYR B 149
LEU A  13
MET A  52
VAL A  53
1.57A
None
None
None
None
EDO  B 302 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE B 120
LEU B 122
VAL A  58
ALA B 102
1.39A
None
None
None
EDO  B 302 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL D 130
TYR D 149
LEU C  13
MET C  52
VAL C  53
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
ILE A 300
LEU A 253
HIS A 275
ALA A 261
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
LEU A  80
ALA A  68
VAL A  66
ALA A 131
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		3 / 3
LEU A 162
TYR A 264
SER A 111
1.54A22.68
None
GOL  A 508 (-3.5A)
PO4  A 502 (-2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  73
VAL A  91
LEU A  89
VAL A  20
GLY A  29
1.49A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  35
LEU A  89
LEU A  27
VAL A  18
GLY A  29
1.78A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.59A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 296
VAL A 202
LEU A 242
VAL A 261
GLY A 251
1.76A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.58A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  36
LEU A  72
GLY A  71
ALA A  70
LEU A  75
1.79A14.34
None
None
DMS  A 406 ( 4.6A)
DMS  A 406 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.78A14.34
None
None
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  77
VAL A  42
LEU A  27
MET A  17
LEU A  89
1.80A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 262
HIS A 246
VAL A 202
TYR A 209
1.64A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE A 200
HIS A 246
VAL A 202
ALA A 129
1.55A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  71
GLY A  64
ALA A  65
LEU A  59
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE D 120
LEU D 122
VAL C  58
ALA D 102
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  16
SER B  85
GLY A  64
ALA A  65
LEU A  59
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE D 120
LEU D 122
VAL C  58
ALA D 150
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE D 120
LEU D 122
TYR D 149
ALA D 152
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 362
VAL E 367
TYR E 365
GLY E 339
LEU E 335
1.42A
None
None
None
NAG  E 907 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 377
ILE A 434
VAL A 511
PHE A 338
VAL A 382
1.78A
None
None
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
TYR C  42
TYR C  31
SER B 103
1.55A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 347
ILE A 410
VAL A 433
VAL A 401
PHE A 400
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
TYR L  42
TYR L  31
SER H 103
1.55A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
VAL E 524
PHE E 515
VAL E 341
PHE E 338
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
SER A 366
LEU A 513
ALA A 363
LEU A 335
1.44A
NAG  A 904 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
SER A 366
LEU A 513
ALA A 363
LEU A 335
1.47A
NAG  A 904 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 358
LEU E 513
ALA E 363
VAL E 362
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
SER E 366
LEU E 513
ALA E 363
LEU E 335
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
VAL A 524
PHE A 515
VAL A 341
PHE A 338
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU A 390
TYR C  55
SER A 383
1.31A15.94
DMS  A 905 (-4.9A)
DMS  A 905 (-4.3A)
DMS  A 905 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
TYR C  42
TYR B  32
SER A 383
1.27A18.39
None
None
DMS  A 905 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
SER E 366
LEU E 513
ALA E 363
LEU E 335
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 377
ILE A 434
VAL A 511
PHE A 338
VAL A 382
1.78A
None
None
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU E 387
TYR E 369
SER H 100
1.73A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
VAL E 524
PHE E 515
VAL E 341
PHE E 338
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 347
ILE E 410
VAL E 433
VAL E 401
PHE E 400
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU A 387
TYR A 369
SER B 100
1.70A15.94
DMS  A 905 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
LEU A 368
SER A 366
ALA A 363
LEU A 335
1.37A
NAG  A 904 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
VAL A 524
PHE A 515
VAL A 341
PHE A 338
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
TYR L  42
TYR H  32
SER E 383
1.31A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 433
PHE E 338
ILE E 358
VAL E 524
SER E 514
VAL E 512
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
SER E 366
LEU E 513
ALA E 363
LEU E 335
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
VAL E 524
PHE E 515
VAL E 341
PHE E 338
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 138
LEU L 185
LEU L 160
VAL L 156
ALA L 199
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
SER E 366
LEU E 513
ALA E 363
LEU E 335
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
VAL E 524
PHE E 515
VAL E 341
PHE E 338
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
ILE E 434
VAL E 511
PHE E 338
PHE E 377
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
ILE E 434
VAL E 511
PHE E 338
PHE E 377
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
TYR L  42
TYR L  31
SER H 103
1.55A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 362
VAL E 367
TYR E 365
GLY E 339
LEU E 335
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU E 387
TYR E 369
SER H 100
1.77A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
VAL A 524
PHE A 515
VAL A 341
PHE A 338
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
VAL E 524
PHE E 515
VAL E 341
PHE E 338
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
LEU A 368
SER A 366
ALA A 363
LEU A 335
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU A 387
TYR A 369
SER B 100
1.74A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
ALA H  88
VAL H 117
TYR A 489
ALA A 475
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
SER E 366
LEU E 513
ALA E 363
LEU E 335
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
TYR C  42
TYR C  31
SER B 103
1.55A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
LEU E 387
TYR E 369
SER H 100
1.73A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
TYR L  42
TYR L  31
SER H 103
1.55A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 362
VAL A 367
TYR A 365
GLY A 339
LEU A 335
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
SER A 366
LEU A 513
ALA A 363
LEU A 335
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
VAL A 524
PHE A 515
VAL A 341
PHE A 338
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
TYR B 180
TYR E 489
SER B 119
1.64A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 347
ILE A 410
VAL A 433
VAL A 401
PHE A 400
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 362
VAL E 367
TYR E 365
GLY E 339
LEU E 335
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 358
LEU A 513
ALA A 363
VAL A 362
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 358
LEU E 513
ALA E 363
VAL E 362
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
SER E 366
LEU E 513
ALA E 363
LEU E 335
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
VAL E 524
PHE E 515
VAL E 341
PHE E 338
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
SER A 366
LEU A 513
ALA A 363
LEU A 335
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  73
VAL A  91
LEU A  89
VAL A  20
GLY A  29
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.62A
None
None
PEG  A 405 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.61A
None
None
PEG  A 405 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 142
LEU E  75
VAL E  77
GLY E  79
ALA E 112
1.56A
None
EPE  E 203 (-3.6A)
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL B  16
LEU B 127
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  16
TYR B 113
LEU B  53
VAL B  36
ALA B 124
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE B  23
ALA B 154
VAL B 155
ALA B  52
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL E  16
LEU E 127
LEU E  53
VAL E  36
ALA E 124
LEU E 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  16
TYR C 113
LEU C  53
VAL C  36
ALA C 124
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE B  23
LEU B 123
ALA B 154
VAL B 155
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE C  23
LEU C 123
ALA C 154
VAL C 155
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL D  16
LEU D 127
LEU D  53
VAL D  36
ALA D 124
LEU D 153
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE D  23
ALA D 154
VAL D 155
ALA D  52
1.34A
EDO  D 208 (-4.0A)
EDO  D 208 (-4.2A)
EDO  D 208 ( 4.2A)
EDO  D 209 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE E  23
ALA E 154
VAL E 155
ALA E  52
1.34A
EDO  E 205 (-4.2A)
EDO  E 205 (-4.4A)
EDO  E 205 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  16
LEU D  53
VAL D  36
ALA D 124
LEU D 153
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  16
TYR D 113
LEU D  53
VAL D  36
ALA D 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  16
TYR E 113
LEU E  53
VAL E  36
ALA E 124
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 142
LEU D  75
VAL D  77
GLY D  79
ALA D 112
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 127
SER E 128
VAL E  96
GLY E  79
LEU E 108
1.62A
None
EPE  E 202 (-4.6A)
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  34
VAL D  95
LEU D 126
ALA D 124
LEU D 122
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  16
LEU E  53
VAL E  36
ALA E 124
LEU E 153
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.36A
None
EDO  A 202 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 142
LEU D  75
VAL D  77
GLY D  79
ALA D 112
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE D  23
LEU D 123
ALA D 154
VAL D 155
1.29A
EDO  D 208 (-4.0A)
None
EDO  D 208 (-4.2A)
EDO  D 208 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  16
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 142
LEU C  75
VAL C  77
GLY C  79
ALA C 112
1.55A
None
EPE  C 202 (-3.4A)
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE C  23
ALA C 154
VAL C 155
ALA C  52
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE E  23
LEU E 123
ALA E 154
VAL E 155
1.27A
EDO  E 205 (-4.2A)
None
EDO  E 205 (-4.4A)
EDO  E 205 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL C  16
LEU C 127
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE E  23
ALA E 154
VAL E 155
ALA E  52
1.29A
APR  E 201 (-4.1A)
APR  E 201 (-4.5A)
APR  E 201 ( 4.9A)
APR  E 201 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  34
VAL D  95
LEU D 126
ALA D 124
LEU D 122
1.61A
None
None
APR  D 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  34
VAL C  95
LEU C 126
ALA C 124
LEU C 122
1.61A
None
None
APR  C 201 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  16
LEU E  53
VAL E  36
ALA E 124
LEU E 153
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  16
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  16
TYR C 113
LEU C  53
VAL C  36
ALA C 124
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  16
TYR D 113
LEU D  53
VAL D  36
ALA D 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL D  16
LEU D 127
LEU D  53
VAL D  36
ALA D 124
LEU D 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  34
VAL D  95
LEU D 126
ALA D 124
LEU D 122
1.59A
None
None
APR  D 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 142
LEU C  75
VAL C  77
GLY C  79
ALA C 112
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 142
LEU D  75
VAL D  77
GLY D  79
ALA D 112
1.59A
None
EDO  D 202 (-4.6A)
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL B  16
LEU B 127
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE B  23
ALA B 154
VAL B 155
ALA B  52
1.30A
APR  B 201 (-4.1A)
APR  B 201 (-4.5A)
None
APR  B 201 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  34
VAL E  95
LEU E 126
ALA E 124
LEU E 122
1.60A
None
None
APR  E 201 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  16
LEU D  53
VAL D  36
ALA D 124
LEU D 153
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL C  16
LEU C 127
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
LEU D 127
HIS D 119
VAL D  82
ALA D  39
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.27A
APR  A 201 (-3.9A)
None
APR  A 201 (-4.4A)
APR  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  16
TYR E 113
LEU E  53
VAL E  36
ALA E 124
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE C  23
LEU C 123
ALA C 154
VAL C 155
1.27A
APR  C 201 (-3.9A)
None
APR  C 201 (-4.5A)
APR  C 201 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  34
VAL A  95
LEU A 126
ALA A 124
LEU A 122
1.62A
None
None
APR  A 201 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 142
LEU D  75
VAL D  77
GLY D  79
ALA D 112
1.61A
None
EDO  D 202 (-4.6A)
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 142
LEU C  75
VAL C  77
GLY C  79
ALA C 112
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE D  23
ALA D 154
VAL D 155
ALA D  52
1.29A
APR  D 201 (-3.9A)
APR  D 201 (-4.5A)
None
EDO  D 204 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE E  23
LEU E 123
ALA E 154
VAL E 155
1.27A
APR  E 201 (-4.1A)
None
APR  E 201 (-4.5A)
APR  E 201 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  16
TYR B 113
LEU B  53
VAL B  36
ALA B 124
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL E  16
LEU E 127
LEU E  53
VAL E  36
ALA E 124
LEU E 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE C  23
ALA C 154
VAL C 155
ALA C  52
1.30A
APR  C 201 (-3.9A)
APR  C 201 (-4.5A)
APR  C 201 ( 4.9A)
APR  C 201 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  34
VAL B  95
LEU B 126
ALA B 124
LEU B 122
1.62A
None
None
APR  B 201 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  34
VAL B  95
LEU B 126
ALA B 124
LEU B 122
1.59A
None
None
APR  B 201 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 142
LEU E  75
VAL E  77
GLY E  79
ALA E 112
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 142
LEU E  75
VAL E  77
GLY E  79
ALA E 112
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE D  23
LEU D 123
ALA D 154
VAL D 155
1.27A
APR  D 201 (-3.9A)
None
APR  D 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.29A
APR  A 201 (-3.9A)
APR  A 201 (-4.4A)
APR  A 201 ( 4.8A)
APR  A 201 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE B  23
LEU B 123
ALA B 154
VAL B 155
1.26A
APR  B 201 (-4.1A)
None
APR  B 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  16
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL A  16
LEU A 127
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  16
TYR C 113
LEU C  53
VAL C  36
ALA C 124
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE A  23
LEU A 123
ALA A 154
VAL A 155
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE B  23
ALA B 154
VAL B 155
ALA B  52
1.34A
EDO  B 202 (-4.0A)
EDO  B 202 (-4.3A)
EDO  B 202 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 142
LEU C  75
VAL C  77
GLY C  79
ALA C 112
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE C  23
LEU C 123
ALA C 154
VAL C 155
1.27A
EDO  C 206 (-4.1A)
None
EDO  C 206 (-4.4A)
EDO  C 206 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE A  23
ALA A 154
VAL A 155
ALA A  52
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  16
TYR A 113
LEU A  53
VAL A  36
ALA A 124
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 142
LEU B  75
VAL B  77
GLY B  79
ALA B 112
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  16
TYR B 113
LEU B  53
VAL B  36
ALA B 124
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL C  16
LEU C 127
LEU C  53
VAL C  36
ALA C 124
LEU C 153
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE C  23
ALA C 154
VAL C 155
ALA C  52
1.37A
EDO  C 206 (-4.1A)
EDO  C 206 (-4.4A)
EDO  C 206 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
LEU A 108
1.61A
None
MES  A 201 (-4.4A)
None
EDO  A 204 (-3.6A)
EDO  C 205 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 142
LEU C  75
VAL C  77
GLY C  79
ALA C 112
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
ILE B  23
LEU B 123
ALA B 154
VAL B 155
1.28A
EDO  B 202 (-4.0A)
None
EDO  B 202 (-4.3A)
EDO  B 202 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  53
VAL A  36
ALA A 124
LEU A 153
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
VAL B  16
LEU B 127
LEU B  53
VAL B  36
ALA B 124
LEU B 153
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
ILE A 307
LEU A 636
VAL A 299
ALA A 311
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
ILE A 888
LEU A 885
ALA A 863
TYR A 915
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
ILE A 632
LEU A 636
ALA A 311
ALA A 656
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A 376
VAL A 373
TYR A 515
ALA A 502
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP7
(SARS-CoV-2)		5 / 12
VAL C  33
VAL C  22
LEU C  60
VAL C  58
LEU C  14
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 708
HIS A 725
ALA A  43
ALA A  46
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 297
LEU A 268
VAL A 202
ALA A 206
LEU A 253
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
VAL A  36
VAL A  77
GLY A  79
LEU A  87
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ILE A 307
LEU A 636
VAL A 299
ALA A 311
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 398
SER A 397
TYR A 674
ALA A 400
LEU A 401
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 472
ILE A 757
VAL A 587
PHE A 480
VAL A 700
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP7
(SARS-CoV-2)		5 / 12
VAL C  33
VAL C  22
LEU C  60
VAL C  58
LEU C  14
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 708
HIS A 725
ALA A  43
ALA A  46
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ARG A 836
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ARG A 836
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP7
(SARS-CoV-2)		5 / 12
VAL C  33
VAL C  22
LEU C  60
VAL C  58
LEU C  14
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 472
ILE A 757
VAL A 587
PHE A 480
VAL A 700
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 472
ILE A 757
VAL A 587
PHE A 480
VAL A 700
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ALA A 376
VAL A 373
TYR A 515
ALA A 502
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 708
HIS A 725
ALA A  43
ALA A  46
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.39A
None
None
None
U  P  18 ( 3.4A)
U  P  17 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ILE A 307
LEU A 636
VAL A 299
ALA A 311
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 844
LEU A 437
GLY A 839
ALA A 840
LEU A 862
1.42A
None
None
None
U  P  18 ( 3.4A)
U  P  17 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 472
ILE A 757
VAL A 587
PHE A 480
VAL A 700
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7jmp COVA2-39 HEAVY CHAIN
SPIKE PROTEIN S1
(SARS-CoV-2;
homo
sapiens)		3 / 3
LEU A 455
TYR H  33
SER H  31
1.37A17.49
None