Ligand ID: SHH


Drugbank ID:
DB02546
(Vorinostat)


Indication:
For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.

Get human targets for SHH in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SHH'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
ILE B 136
HIS B 164
PHE B 140
GLY B 146
PHE B 112
1.54A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		3 / 3
PRO A 108
MET A 130
TYR A 182
1.74A23.19
MPD  A 307 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A23.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.69A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.79A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A23.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 172
HIS B 163
MET A   6
GLY B 138
TYR B 126
1.50A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 176
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.75A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.51A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
HIS B 172
HIS B 163
MET A   6
GLY B 138
TYR B 126
1.51A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.40A23.26
I12  A1145 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.67
None
I12  A1145 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 12
SER B  28
HIS B  31
GLY B  29
PHE B  30
LEU B  54
1.61A12.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		4 / 8
PHE B  22
HIS B  13
ASP A 238
GLY A 237
1.04A13.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
HIS A  58
PHE A  50
ASP A  54
GLY A  55
1.27A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B1041
GLY B1146
HIS B1163
GLY B1174
TYR B1161
1.75A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B1041
PRO B1039
GLY B1174
ASP B1176
GLY B1179
1.35A23.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1115
HIS B1172
HIS B1163
GLY B1138
TYR B1126
1.37A23.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B1041
GLY B1146
HIS B1163
GLY B1174
TYR B1161
1.71A23.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B1115
HIS B1172
HIS B1163
GLY B1138
TYR B1126
1.37A23.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1115
HIS B1172
HIS B1163
GLY B1138
TYR B1126
1.33A23.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		2a5i 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.37A23.66
AZP  A 307 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
SER A   1
HIS B 163
HIS B 172
GLY B 170
LEU B 141
1.79A21.35
None
AZP  B 307 (-4.0A)
AZP  B 307 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.40A21.09
CY6  A1145 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.56A22.14
CY6  A1145 (-3.8A)
None
CY6  A1145 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A21.67
CY6  A1145 (-3.8A)
None
CY6  A1145 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A   1
HIS B 163
HIS B 172
GLY A  -1
TYR B 126
1.60A21.76
None
9IN  B2001 (-3.8A)
9IN  B2001 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
LEU B 354
ILE A 321
PHE B 287
PHE A 315
GLY B 296
1.76A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B 108
MET B 130
TYR B 182
1.73A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B  58
ILE B  43
HIS B 164
GLY B 179
PHE B  66
1.50A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.57A23.26
ENB  B1145 (-3.4A)
None
ENB  B1145 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.62A20.67
ENB  B1145 (-3.4A)
None
ENB  B1145 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 163
GLY B 149
MET A   6
GLY B 138
TYR B 126
1.52A22.14
ENB  B1145 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.53A22.62
ENB  B1145 (-3.4A)
None
ENB  B1145 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 115
HIS B 172
HIS B 163
GLY B 138
TYR B 126
1.50A22.08
None
ENB  B1145 (-3.8A)
ENB  B1145 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA C  69
HIS C 176
PHE C  80
LEU C  59
TYR C 155
1.49A18.07
None
SO4  C 320 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
HIS C 273
ASP C 287
HIS C 290
GLY C 288
1.41A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
HIS A  70
GLY A   1
HIS A  70
ASP A  64
LEU A  66
1.38A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
SER A  67
HIS A  72
HIS A  72
GLY A  71
HIS A  70
1.29A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A20.59
None
AZP  A 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A23.66
AZP  A 401 (-3.4A)
None
AZP  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A21.85
AZP  A 401 (-3.4A)
None
AZP  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.34A23.66
AZP  A 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.52A22.33
AZP  A 401 (-3.4A)
None
AZP  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.55A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A20.59
AZP  A 401 (-3.4A)
None
AZP  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU A  72
ASP A 272
ILE A  69
GLY A 156
TYR A 178
1.40A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
ASP A  16
GLY A  17
PHE A  15
GLY A  20
TYR A   7
1.37A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 6
ASP B 298
HIS B 357
ASP B 289
ASP B 291
1.75A13.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		2jze REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
PRO A 607
MET A 606
TYR A 610
1.48A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 12
PRO A  11
SER A  71
HIS A  69
PHE A  74
ASP A   8
1.43A13.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
HIS A 163
GLY A 149
MET B   6
GLY A 138
TYR A 126
1.61A22.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.71A20.50
WR1  B 602 (-3.9A)
None
WR1  B 602 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.68A21.15
WR1  B 602 (-3.9A)
None
WR1  B 602 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
HIS B  41
PRO B  39
GLY B 174
ASP B 176
GLY B 179
1.41A21.15
WR1  B 602 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
LEU B  58
ILE B  43
HIS B 164
GLY B 179
PHE B  66
1.57A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
ILE D 327
HIS D 234
ASP D 239
HIS D 249
GLY D 246
1.58A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
TYR B 237
PHE B 232
PHE B 302
ASP B 300
MET B 209
1.76A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
TYR B 237
PHE B 232
PHE B 302
ASP B 300
MET B 209
1.76A23.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU A  72
ASP A 272
ILE A  69
GLY A 156
TYR A 178
1.37A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
HIS D 234
ASP D 239
HIS D 249
GLY D 246
1.27A20.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU C 248
ILE C 235
PHE C 302
ASP C 296
PHE C 329
1.26A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
TYR B 237
PHE B 232
PHE B 302
ASP B 300
LEU B 299
1.42A23.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.74A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
SER B   1
HIS A 163
HIS A 172
GLY B   2
TYR A 126
1.79A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
LEU B 115
HIS B 172
HIS B 163
GLY B 138
TYR B 126
1.39A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
HIS B 163
GLY B 149
MET A   6
GLY B 138
TYR B 126
1.58A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
HIS B 163
GLY B 149
MET A   6
GLY B 138
TYR B 126
1.52A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
ILE B 136
HIS B 164
PHE B 140
GLY B 146
PHE B 112
1.47A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
HIS A 163
GLY A 149
MET B   6
GLY A 138
TYR A 126
1.62A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
ASP B 176
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.74A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A23.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.56A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.76A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.39A21.15
CYV  A 302 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A21.82
CYV  A 302 ( 3.8A)
None
CYV  A 302 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A22.30
CYV  A 302 ( 3.8A)
None
CYV  A 302 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU D  72
ASP D 272
ILE D  69
GLY D 156
TYR D 178
1.39A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASP F  16
GLY F  17
PHE F  15
GLY F  20
TYR F   7
1.49A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.42A21.76
BEZ  A1303 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A23.82
BEZ  A1303 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
PRO B 108
MET B 130
TYR B 182
1.75A23.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A20.04
None
BEZ  A1303 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.57A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.80A22.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A23.35
BEZ  A1303 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A21.76
BEZ  A1303 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A 153
ILE A 127
HIS A  69
PHE A  70
ASP A  99
1.61A21.29
None
None
None
None
SAH  A1293 (-2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 129
GLY A  71
PHE A  70
ASP A 114
TYR A 152
1.65A21.93
None
SAH  A1293 (-3.8A)
None
SAH  A1293 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 129
GLY A  71
PHE A  70
ASP A 114
TYR A 152
1.64A22.16
None
SAH  A1300 (-3.8A)
None
SAH  A1300 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A 153
ILE A 127
HIS A  69
PHE A  70
ASP A  99
1.62A21.18
None
None
None
None
SAH  A1300 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 115
HIS A 172
HIS A 163
GLY A 138
TYR A 126
1.43A22.54
None
None
HSV  B   6 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 115
HIS A 172
HIS A 163
GLY A 138
TYR A 126
1.40A22.54
None
None
HSV  B   6 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3aw0 3C-LIKE PROTEINASE
PEPTIDE
ACE-SER-ALA-VAL-LEU-
HIS-H
(SARSr-CoV)		5 / 12
SER A 144
GLY A 146
HIS A  41
ASP A 187
LEU B   5
1.76A21.24
HSV  B   6 (-3.5A)
None
None
None
HSV  B   6 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 176
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.77A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		3bgf F26G19 FAB
(Mus
musculus)		4 / 8
HIS B 166
PHE C 139
ASP C 167
PHE B 168
1.55A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 331
ASP A 382
PHE A 327
ASP A 350
LEU A 351
1.68A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
TYR B 515
1.20A22.17
 ZN  B 901 (-3.8A)
ZN  B 901 (-3.3A)
ZN  B 901 (-3.8A)
ZN  B 901 (-2.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 554
ILE B 407
GLY B 405
HIS B 401
ASP B 382
0.93A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A22.54
959  A 350 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A22.06
959  A 350 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.44A20.41
959  A 350 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 163
GLY B 149
MET A   6
GLY B 138
TYR B 126
1.59A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		3e9s NSP3
(SARSr-CoV)		5 / 12
ALA A  69
HIS A 176
PHE A  80
LEU A  59
TYR A 155
1.69A18.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		3e9s NSP3
(SARSr-CoV)		4 / 8
HIS A 273
ASP A 287
HIS A 290
GLY A 288
1.47A20.42
OCS  A 112 ( 3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.76A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B  58
ILE B  43
HIS B 164
GLY B 179
PHE B  66
1.57A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.67A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A21.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.55A21.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.50A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.40A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 108
MET A 130
TYR A 182
1.68A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.58A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.76A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
GLY A 149
PRO A 108
GLY A 174
TYR A 182
1.70A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
HIS A  41
PRO A  39
HIS A 172
HIS A 163
GLY A 174
1.47A23.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
PRO B  39
GLY B 174
ASP B 176
GLY B 179
1.41A23.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
GLY A 149
PRO A 108
GLY A 174
TYR A 182
1.70A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
HIS B  41
PRO B  39
HIS B 172
HIS B 163
GLY B 174
1.51A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 108
MET A 130
TYR A 182
1.76A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 176
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.76A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 108
MET A 130
TYR A 182
1.75A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.63A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.60A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 172
HIS A 163
GLY A 146
GLY A 138
TYR A 126
1.76A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 144
HIS A 163
GLY A 146
HIS A 172
TYR A 126
1.37A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3i6g HLA, A-2
(Homo
sapiens)		5 / 12
HIS A  70
HIS A  74
PHE A   9
ASP A  77
TYR A 116
1.57A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		3i6g HLA, A-2
(Homo
sapiens)		5 / 11
HIS A  70
HIS A  74
PHE A   9
ASP A  77
TYR A 116
1.56A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		4 / 8
PHE B  22
HIS B  13
ASP A 238
GLY A 237
0.90A13.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3i6g HLA, A-2
(Homo
sapiens)		5 / 12
HIS A  70
HIS A  74
PHE A   9
ASP A  77
TYR A 116
1.60A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		3i6g HLA, A-2
(Homo
sapiens)		5 / 11
HIS A  70
HIS A  74
PHE A   9
ASP A  77
TYR A 116
1.56A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		3i6g HLA, A-2
(Homo
sapiens)		5 / 12
HIS D  70
HIS D  74
PHE D   9
ASP D  77
TYR D 116
1.61A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		3i6k BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		5 / 12
GLU A 264
HIS A 263
PHE A 241
LEU B  65
TYR A 209
1.71A17.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3i6k BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 12
SER B  28
HIS B  31
GLY B  29
PHE B  30
LEU B  54
1.60A12.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 176
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.79A20.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A23.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.56A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.40A23.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.58A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 172
GLY A 138
PHE A 140
HIS A 163
GLY A 143
1.79A23.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PRO A   9
GLY A 149
PHE A 150
PHE A 112
ASP A 153
1.61A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B   1
HIS A 163
HIS A 172
GLY A 170
LEU A 141
1.77A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.56A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 172
HIS B 163
MET A   6
GLY B 138
TYR B 126
1.55A21.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
HIS B 172
HIS B 163
MET A   6
GLY B 138
TYR B 126
1.58A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 172
HIS B 163
MET A   6
GLY B 138
TYR B 126
1.57A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 176
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.74A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B 108
MET B 130
TYR B 182
1.78A21.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
HIS B 273
ASP B 287
HIS B 290
GLY B 288
1.44A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 129
GLY A  71
PHE A  70
ASP A 114
TYR A 152
1.69A23.68
None
SAM  A 302 (-3.7A)
None
SAM  A 302 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
LEU A 153
ILE A 127
HIS A  69
PHE A  70
ASP A  99
1.63A20.37
None
None
None
None
SAM  A 302 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		3sci ACE2
(Homo
sapiens)		5 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
TYR B 515
1.19A21.74
 ZN  B 901 (-3.4A)
ZN  B 901 (-3.4A)
ZN  B 901 (-3.5A)
ZN  B 901 (-2.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3scj ACE2
(Homo
sapiens)		5 / 12
ILE B 446
HIS B 378
HIS B 374
GLY B 399
PHE B 274
1.48A21.10
None
ZN  B 901 (-3.5A)
ZN  B 901 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 331
ASP A 382
PHE A 327
ASP A 350
LEU A 351
1.67A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
LEU B 222
TYR B 515
1.66A21.94
 ZN  B 901 (-3.9A)
ZN  B 901 (-3.6A)
ZN  B 901 (-4.1A)
ZN  B 901 (-2.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 554
ILE B 407
GLY B 405
HIS B 401
ASP B 382
1.03A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A21.82
ECC  H   5 ( 4.3A)
None
ECC  H   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.80A20.54
None
ECC  H   5 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A22.30
ECC  H   5 ( 4.3A)
None
ECC  H   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		3snb 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-DSFDQ-H
(SARSr-CoV)		5 / 12
TYR A 118
GLY A 146
ASP A 187
HIS A  41
ASP H   4
1.42A22.86
None
None
None
ECC  H   5 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		3snb 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-DSFDQ-H
(SARSr-CoV)		5 / 12
TYR A 118
GLY A 146
ASP A 187
HIS A  41
ASP H   4
1.47A21.67
None
None
None
ECC  H   5 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		3snb 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-DSFDQ-H
(SARSr-CoV)		5 / 12
ASP H   4
PHE H   3
PRO A  39
HIS A  41
GLY A 143
1.73A1.16
None
None
None
ECC  H   5 ( 4.9A)
ECC  H   5 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		3snb 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-DSFDQ-H
(SARSr-CoV)		5 / 12
SER A 147
GLY A 146
ASP A 187
HIS A  41
ASP H   4
1.73A20.98
None
None
None
ECC  H   5 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		3v3m 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A20.63
0EN  A 401 (-3.6A)
None
0EN  A 401 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		3v3m 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A23.66
0EN  A 401 (-3.6A)
None
0EN  A 401 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 115
HIS B 172
HIS B 163
GLY B 138
TYR B 126
1.45A22.08
None
0JU  F   5 ( 4.7A)
0JU  F   5 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		3vb5 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 108
MET A 130
TYR A 182
1.73A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.41A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A23.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 176
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.79A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.66A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.79A20.63
None
23H  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A21.09
23H  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A22.30
23H  A 401 (-3.7A)
None
23H  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 12
ALA A  69
HIS A 176
PHE A  80
LEU A  59
TYR A 155
1.63A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.54A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.60A20.63
SDJ  B 401 (-4.1A)
None
SDJ  B 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
PRO B  39
GLY B 174
ASP B 176
GLY B 179
1.38A21.09
SDJ  B 401 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.56A21.90
SDJ  B 401 (-4.1A)
None
SDJ  B 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.52A22.38
SDJ  B 401 (-4.1A)
None
SDJ  B 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.57A21.09
SDJ  B 401 (-4.1A)
None
SDJ  B 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
HIS B 268
HIS B 148
ASP B 273
ASP B  90
1.79A21.79
None
None
None
MG  B 604 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
HIS B 268
HIS B 148
ASP B 273
ASP B  90
1.77A21.79
None
None
None
MG  B 604 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
HIS B 268
GLY B  93
PHE B 190
ASP B 273
ASP B  90
1.73A20.45
None
None
None
None
MG  B 604 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
HIS B  95
HIS B 268
HIS B 148
ASP B 273
ASP B  90
1.74A20.45
None
None
None
None
MG  B 604 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
HIS B 268
GLY B  93
PHE B 190
ASP B 273
ASP B  90
1.79A20.45
None
None
None
None
MG  B 604 (-2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
LEU B 109
GLY B  93
PHE B 190
GLY B 123
TYR B 197
1.56A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5e6j POLYUBIQUITIN-B
UBIQUITIN
(synthetic
construct)		5 / 12
ASP E  52
GLY E  53
ASP E  58
GLY F  75
TYR E  59
1.54A11.93
None
None
None
5MW  E  48 ( 2.5A)
5MW  E  48 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 11
LEU D 200
HIS E  68
PHE E  45
GLY D 210
TYR D 208
1.63A22.73
5MW  E  48 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
HIS D 273
ASP D 287
HIS D 290
GLY D 288
1.56A20.05
AYE  E  76 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA D  69
HIS D 176
PHE D  80
LEU D  59
TYR D 155
1.75A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ASP A 375
HIS A 330
PHE A 377
PRO B 158
GLY A 380
1.64A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA A 308
GLU A 302
PHE A 506
LEU A 508
TYR A 420
1.66A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
PRO O  59
HIS D  19
PHE D  33
GLY O  69
TYR O  96
1.78A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.00
RZS  A1001 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A22.34
RZS  A1001 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		5r83 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A20.00
None
K0G  A1001 ( 3.9A)
CL  A1005 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.68A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.68A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.55A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.80A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA D  69
HIS D 176
PHE D  80
LEU D  59
TYR D 155
1.50A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
LEU B 153
ASP B  38
GLY B 161
GLY A 154
TYR B 113
1.60A21.58
None
None
None
AYE  A 155 ( 2.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
TYR B  84
GLY B  39
HIS B  90
ASP B 109
GLY B 161
1.40A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		5 / 11
LEU C 140
ILE C  82
HIS C 149
PHE C 124
GLY C 126
1.68A12.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
TYR B  84
GLY B  39
HIS B  90
ASP B 109
GLY B 161
1.42A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
HIS C1030
PHE C1024
HIS C1046
GLY C1026
1.19A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ASP A  83
PHE A 313
PRO A  76
GLY A  82
TYR A 316
1.62A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ASP A  83
PHE A 313
PRO A  76
GLY A  82
TYR A 316
1.63A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ASP A  83
HIS A  81
GLY A  82
GLY A  79
TYR A  77
1.62A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
LEU C1006
HIS C1030
PHE C1024
HIS C1046
PHE C1044
1.74A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
TYR A 256
HIS A  70
GLY A  68
PHE A  69
PHE A 253
1.77A15.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ASP A  83
PHE A 313
PRO A  76
GLY A  82
TYR A 316
1.63A15.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
SER C 985
GLY C 981
ASP C 976
LEU C 735
TYR C 738
1.30A14.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
PHE A 837
PHE C 527
ASP A 727
GLY A 726
1.47A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASP B  85
GLY B  86
PHE B  83
GLY B 255
TYR B 256
1.60A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASP C 600
GLY C 579
ASP A 727
PHE C 305
GLY A 726
1.53A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5x5c S PROTEIN
(MERS-CoV)		5 / 11
LEU B1098
HIS B1122
PHE B1116
HIS B1138
GLY B1118
1.47A14.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		5x5c S PROTEIN
(MERS-CoV)		3 / 3
PRO B 449
MET B 452
TYR B 499
1.53A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
LEU B1098
HIS B1122
PHE B1116
HIS B1138
GLY B1118
1.52A14.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
ASP A  83
PHE A 313
PRO A  76
GLY A  82
TYR A 316
1.62A15.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
ASP B  83
HIS B  81
GLY B  82
GLY B  79
TYR B  77
1.61A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		5x5f S PROTEIN
(MERS-CoV)		5 / 11
TYR B 632
PHE B 630
ASP B 645
LEU B 608
TYR B 609
1.70A14.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		5x5f S PROTEIN
(MERS-CoV)		4 / 8
HIS B1122
PHE B1116
HIS B1138
GLY B1118
1.40A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR B 383
PHE A 193
ASP A  57
PHE B 416
TYR A 195
1.77A15.74
TYR  B 383 ( 1.3A)
PHE  A 193 ( 1.3A)
ASP  A  57 ( 0.6A)
PHE  B 416 ( 1.3A)
TYR  A 195 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C 876
ILE C 878
ASP A1023
PHE C 870
TYR A1029
1.65A14.85
LEU  C 876 ( 0.6A)
ILE  C 878 ( 0.6A)
ASP  A1023 ( 0.5A)
PHE  C 870 ( 1.3A)
TYR  A1029 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP B 572
GLY B 536
ASP B 312
PHE B 527
GLY B 311
1.66A15.49
ASP  B 572 ( 0.6A)
GLY  B 536 ( 0.0A)
ASP  B 312 ( 0.5A)
PHE  B 527 ( 1.3A)
GLY  B 311 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR C 383
PHE B 193
ASP B  57
PHE C 416
TYR B 195
1.77A15.78
TYR  C 383 ( 1.3A)
PHE  B 193 ( 1.3A)
ASP  B  57 ( 0.6A)
PHE  C 416 ( 1.3A)
TYR  B 195 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 519
ILE B 570
PHE B 527
ASP B 312
GLY B 311
1.50A14.85
LEU  B 519 ( 0.6A)
ILE  B 570 ( 0.7A)
PHE  B 527 ( 1.3A)
ASP  B 312 ( 0.5A)
GLY  B 311 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ALA A  69
HIS A 176
PHE A  80
LEU A  59
TYR A 155
1.75A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP B 267
PHE B 213
PRO B  43
GLY B 270
TYR B  42
1.68A16.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PRO A 575
ASP A 600
GLY A 579
PHE A 578
GLY C 726
1.16A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR A  88
HIS A  70
HIS A  33
ASP A 208
LEU A 209
1.59A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU B 898
ILE B 905
HIS B1030
PHE B 888
GLY B 890
1.59A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PRO B 575
ASP B 600
GLY B 579
PHE B 578
GLY A 726
1.15A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		6acg ACE2
(Homo
sapiens)		3 / 3
PRO D  84
MET D  82
TYR D  83
1.73A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 787
PHE A 784
PHE A 909
GLY A 780
PHE A1034
1.56A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE B 573
GLY B 536
ASP B 312
PHE B 527
GLY B 311
1.55A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
HIS B1030
PHE B1024
HIS B1046
MET B 709
GLY B1026
1.64A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR B  88
GLY B  68
PHE B 253
HIS B  33
ASP B 208
1.65A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B1017
ASP C1023
PRO C1051
GLY C1028
TYR C1029
1.64A16.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6acj ACE2
(Homo
sapiens)		5 / 12
SER D 409
HIS D 401
HIS D 378
GLY D 405
TYR D 515
1.60A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
HIS C1030
PHE C1024
HIS C1046
GLY C1026
1.34A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU C 571
GLY C 536
PHE C 527
ASP C 312
GLY C 311
1.61A14.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
HIS C1030
PHE C1024
HIS C1046
GLY C1026
1.26A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
HIS A1030
PHE A1024
HIS A1046
GLY A1026
1.15A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A 571
GLY A 536
PHE A 527
ASP A 312
GLY A 311
1.46A14.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU B1006
HIS B1030
PHE B1024
HIS B1046
PHE B1044
1.74A14.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP A 719
GLY A 839
PHE C 578
ASP A 727
GLY A 726
1.42A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR C 256
HIS C  70
GLY C  68
PHE C  69
PHE C 253
1.66A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 985
GLY B 981
PHE B 952
LEU C 983
TYR C 738
1.47A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6cs2 ACE2
SPIKE
GLYCOPROTEIN,FIBRITI
N
(Homo
sapiens;
SARSr-CoV)		5 / 12
PHE D  28
ASP D  30
PHE D  32
TYR B 475
PHE D  72
1.51A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
LEU D 558
HIS D 378
GLY D 377
HIS D 401
TYR D 385
1.25A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A 117
TYR A  74
GLU C   2
TRP B  60
PHE B  56
1.62A18.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.73A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6jyt HELICASE
(SARSr-CoV)		5 / 12
HIS A 290
GLY A 287
PHE A 291
LEU A 295
TYR A 269
1.54A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU D 962
ASP F1168
ILE F1169
GLY F1167
GLY D 971
1.57A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.70A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A21.04
ALC  D   2 ( 4.1A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A23.10
ALC  D   2 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.54A21.28
ALC  D   2 ( 4.1A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.44A19.95
ALC  D   2 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A21.04
ALC  D   2 ( 4.1A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.55A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.65A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
LEU A 554
ILE A 407
GLY A 405
HIS A 401
ASP A 382
1.08A21.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A21.23
N0A  D   2 ( 4.0A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A20.99
N0A  D   2 ( 4.0A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A23.04
N0A  D   2 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A20.99
N0A  D   2 ( 4.0A)
None
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.44A22.19
N0A  D   2 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.69A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m18 ACE2
(Homo
sapiens)		5 / 11
LEU B 722
ILE B 711
PHE B 724
PHE B 683
GLY B 726
1.77A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m18 ACE2
(Homo
sapiens)		5 / 12
LEU D 558
HIS D 378
GLY D 377
HIS D 401
TYR D 385
1.51A17.98
None
ZN  D 914 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
LEU A 262
ILE A  72
HIS A  65
PHE A  70
ASP A 266
1.65A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6m1d ACE2
(Homo
sapiens)		5 / 12
PRO D 492
SER D 617
PHE D 684
PHE D 683
ASP D 669
1.66A16.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU C 424
ILE C 136
PHE C 400
GLY C 395
PHE C 421
1.53A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
ALA D 264
GLU D 479
TRP D 165
GLU D 489
LEU D 162
1.60A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 163
GLY D 149
MET B   6
GLY D 138
TYR D 126
1.72A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE B 136
HIS B 164
PHE B 140
GLY B 146
PHE B 112
1.69A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR D 126
GLY D 149
PHE D 112
ASP D 176
TYR D 182
1.73A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS D  41
HIS D 164
PHE D 181
GLY D 146
1.74A22.99
3WL  D 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A20.89
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.61A20.89
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.62A20.89
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A21.13
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  58
ILE D  43
HIS D 164
GLY D 179
PHE D  66
1.56A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 163
GLY D 149
MET B   6
GLY D 138
TYR D 126
1.67A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.61A22.34
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.68A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS B  41
HIS B 164
PHE B 181
GLY B 146
1.72A22.99
3WL  B 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C  58
ILE C  43
HIS C 164
GLY C 179
PHE C  66
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
PRO B  39
GLY B 174
ASP B 176
GLY B 179
1.45A22.34
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B 163
GLY B 149
MET D   6
GLY B 138
TYR B 126
1.68A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR B 126
GLY B 149
PHE B 112
ASP B 176
TYR B 182
1.72A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.71A22.99
3WL  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.58A20.89
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS C  41
HIS C 164
PHE C 181
GLY C 146
1.72A22.99
3WL  C 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 163
GLY C 149
MET A   6
GLY C 138
TYR C 126
1.62A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE C 136
HIS C 164
PHE C 140
GLY C 146
PHE C 112
1.67A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.55A21.13
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.61A20.89
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B  58
ILE B  43
HIS B 164
GLY B 179
PHE B  66
1.58A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
GLY C 146
HIS C 163
GLY C 174
TYR C 161
1.55A21.13
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B  41
GLY B 146
HIS B 163
GLY B 174
TYR B 161
1.57A21.13
3WL  B 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE D 136
HIS D 164
PHE D 140
GLY D 146
PHE D 112
1.74A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.63A20.00
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
PRO D  39
GLY D 174
ASP D 176
GLY D 179
1.43A22.34
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
PRO C  39
GLY C 174
ASP C 176
GLY C 179
1.43A22.34
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 163
GLY C 149
MET A   6
GLY C 138
TYR C 126
1.70A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
GLY C 146
HIS C 163
GLY C 174
TYR C 161
1.59A20.89
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 163
GLY C 149
MET A   6
GLY C 138
TYR C 126
1.68A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
GLY D 146
HIS D 163
GLY D 174
TYR D 161
1.59A20.89
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 163
GLY D 149
MET B   6
GLY D 138
TYR D 126
1.73A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR C 126
GLY C 149
PHE C 112
ASP C 176
TYR C 182
1.73A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
GLY C 146
HIS C 163
GLY C 174
TYR C 161
1.59A20.89
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 149
MET C   6
GLY A 138
TYR A 126
1.64A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.75A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A22.34
3WL  A 401 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.70A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.60A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.46A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.67A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.57A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PRO D 169
GLY D  72
PHE D  67
PHE D 111
LEU D  57
1.76A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
PHE A 134
PHE A 165
ASP A 161
TYR A 163
1.76A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
HIS A  82
PHE A 219
ASP A 221
GLY A 220
1.42A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASP A 833
HIS A 810
PRO A 832
HIS A 816
TYR A 831
1.77A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
HIS A1030
PHE A1024
HIS A1046
GLY A1026
1.15A16.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU B1006
HIS B1030
PHE B1024
HIS B1046
PHE B1044
1.73A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 6
ASP H 113
HIS H 109
ASP L  33
ASP L  35
1.51A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 6
ASP L  35
HIS H 112
ASP H 113
ASP H 101
1.78A16.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6nur NSP12
(SARSr-CoV)		5 / 12
LEU A 862
ILE A 837
GLY A 839
PHE A 419
GLY A 413
1.52A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		6nur NSP12
(SARSr-CoV)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.58A17.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		6nur NSP12
(SARSr-CoV)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.52A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6nus NSP12
(SARSr-CoV)		5 / 12
ASP A 833
HIS A 810
PRO A 832
HIS A 816
TYR A 831
1.69A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B1024
HIS B1048
PHE B1042
HIS B1064
GLY B1044
1.68A14.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE A 543
ASP A 574
PHE A 541
ASP A 586
LEU A 585
1.76A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 999
PHE B 970
ASP C 994
PHE C 759
GLY B 971
1.73A14.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
HIS B1048
PHE B1042
HIS B1064
GLY B1044
1.29A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C1035
PHE C 888
PRO B1069
GLY B1046
TYR B1047
1.74A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A1003
GLY A 999
ASP A 994
LEU A 753
TYR A 756
1.42A14.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
HIS B 374
GLU B 375
HIS B 378
GLU B 402
TYR B 515
1.32A22.32
None
ZN  B 703 (-3.4A)
ZN  B 703 ( 4.6A)
ZN  B 703 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
LEU B 554
ILE B 407
GLY B 405
HIS B 401
ASP B 382
0.97A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6vw1 ACE2
(Homo
sapiens)		5 / 12
SER A 331
ASP A 382
PHE A 327
ASP A 350
LEU A 351
1.65A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
HIS A1048
PHE A1042
HIS A1064
GLY A1044
1.34A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C1069
SER A 884
GLY A 885
PHE A 888
TYR C1047
1.67A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 999
PHE C 970
ASP A 994
PHE A 759
GLY C 971
1.62A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 999
PHE C 970
ASP A 994
PHE A 759
GLY C 971
1.55A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B1024
HIS B1048
PHE B1042
HIS B1064
GLY B1044
1.77A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
HIS C1048
PHE C1042
HIS C1064
GLY C1044
1.19A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 999
PHE C 970
ASP A 994
PHE A 759
GLY C 971
1.54A16.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO B1069
SER C 884
GLY C 885
PHE C 888
TYR B1047
1.66A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
HIS H 164
ASP L 167
PHE L 139
ASP L 170
1.53A16.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU C 513
ILE C 434
PHE C 377
GLY H  28
PHE C 342
1.63A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
PHE L 139
HIS H 164
PHE H 166
ASP L 167
1.61A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
HIS H 164
PHE L 139
ASP L 167
PHE H 166
1.69A16.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.71A23.02
None
SAM  A7102 (-3.8A)
None
SAM  A7102 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAM  A7104 (-3.6A)
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SAM  A7104 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAM  A7104 (-3.6A)
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.71A
KCX  A6935 ( 4.7A)
SAM  A7104 (-4.4A)
None
SAM  A7104 (-3.6A)
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A22.34
X77  A 401 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A
X77  A 401 (-3.2A)
None
X77  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.68A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.73A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A20.89
X77  A 401 (-3.2A)
None
X77  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.70A22.99
X77  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A20.89
X77  A 401 (-3.2A)
None
X77  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A20.00
None
X77  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A18.78
None
SAM  C7105 ( 3.8A)
None
SAM  C7105 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.70A18.06
FMT  A7103 ( 4.4A)
SAM  A7102 ( 4.2A)
None
SAM  A7102 ( 3.4A)
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A18.78
None
SAM  A7102 ( 3.8A)
None
SAM  A7102 ( 3.5A)
FMT  A7109 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C6930
GLY C6871
HIS C6867
GLY C6879
TYR C6845
1.69A18.06
FMT  C7107 ( 4.3A)
SAM  C7105 ( 4.2A)
None
SAM  C7105 ( 3.4A)
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6951
GLY C6953
HIS C6984
GLY C7011
TYR C7009
1.69A21.50
None
None
None
NA  C7103 ( 4.1A)
NA  C7103 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6879
ASP C6904
GLY D4322
TYR D4349
1.80A21.50
None
SAM  C7105 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A18.78
None
SAM  C7105 ( 3.8A)
None
SAM  C7105 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A18.78
None
SAM  A7102 ( 3.8A)
None
SAM  A7102 ( 3.5A)
FMT  A7109 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU F 353
ILE E 320
PHE F 286
PHE E 314
GLY F 295
1.73A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU A 353
ILE B 320
PHE A 286
PHE B 314
GLY A 295
1.68A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU D 353
ILE C 320
PHE D 286
PHE C 314
GLY D 295
1.80A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU C 353
ILE D 320
PHE C 286
PHE D 314
GLY C 295
1.70A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.80A
None
None
None
SAH  A7102 (-2.6A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.73A
FMT  A7103 ( 4.3A)
SAH  A7102 (-4.4A)
None
SAH  A7102 (-3.5A)
SAH  A7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6879
ASP C6904
GLY D4322
TYR D4349
1.79A
None
SAH  C7102 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SAH  C7102 (-3.8A)
None
SAH  C7102 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAH  A7102 (-3.8A)
None
SAH  A7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.69A
None
SAH  A7102 (-3.8A)
None
SAH  A7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR C6930
GLY C6871
HIS C6867
GLY C6879
TYR C6845
1.71A
FMT  C7104 ( 4.2A)
SAH  C7102 (-4.4A)
None
SAH  C7102 (-3.5A)
SAH  C7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SAH  C7102 (-3.8A)
None
SAH  C7102 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SAH  A7102 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.78A20.91
None
None
None
SAH  A7102 (-2.6A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE B 171
ASP C  81
HIS B  59
GLY B  60
1.67A16.17
None
None
ZN  C 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
HIS A 145
ASP A  82
HIS D  59
PHE D 171
1.78A16.17
 ZN  A 201 (-3.1A)
ZN  A 201 (-2.4A)
ZN  A 201 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A  59
GLY A  60
ASP B  82
HIS B 145
PRO B 142
1.79A14.35
 ZN  B 202 (-2.6A)
None
ZN  B 202 (-2.3A)
ZN  B 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.72A
FMT  A7105 ( 4.4A)
SFG  A7103 ( 4.2A)
None
SFG  A7103 ( 3.5A)
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP16
(SARS-CoV-2)		5 / 11
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.80A20.91
None
None
None
SFG  A7103 ( 2.7A)
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SFG  A7103 ( 3.8A)
None
SFG  A7103 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SFG  A7103 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.71A
None
SFG  A7103 ( 3.8A)
None
SFG  A7103 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6879
ASP C6904
GLY D4322
TYR D4349
1.79A
None
SFG  C7103 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6951
GLY C6953
HIS C6984
GLY C7011
TYR C7009
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SFG  C7103 ( 3.7A)
None
SFG  C7103 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR C6930
GLY C6871
HIS C6867
GLY C6879
TYR C6845
1.70A
FMT  C7104 ( 4.3A)
SFG  C7103 ( 4.1A)
None
SFG  C7103 ( 3.5A)
SFG  C7103 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6927
GLY C6869
PHE C6868
ASP C6912
TYR C6950
1.70A
None
SFG  C7103 ( 3.7A)
None
SFG  C7103 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.65A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.72A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A20.89
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.58A
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.77A22.99
U5G  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A20.89
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.56A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.67A20.00
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.42A22.34
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A22.34
U5G  A 401 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAH  A7101 (-3.8A)
None
SAH  A7101 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6930
GLY A6871
HIS A6867
GLY A6879
TYR A6845
1.71A
GTA  A7102 ( 3.9A)
SAH  A7101 (-4.3A)
None
SAH  A7101 (-3.5A)
SAH  A7101 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6879
ASP A6904
GLY B4322
TYR B4349
1.79A
None
SAH  A7101 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6927
GLY A6869
PHE A6868
ASP A6912
TYR A6950
1.70A
None
SAH  A7101 (-3.8A)
None
SAH  A7101 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ILE A7088
HIS A6867
PHE A6868
ASP A6897
GLY A6871
1.79A20.91
None
None
None
SAH  A7101 (-2.7A)
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.44A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.64A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.75A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.63A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.67A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ALA A  68
HIS A 175
PHE A  79
LEU A  58
TYR A 154
1.62A20.43
None
PO4  A 504 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		6xez NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.50A16.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS B  41
PRO B  39
GLY B 174
ASP B 176
GLY B 179
1.38A22.34
O6K  B 401 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.54A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A18.54
None
None
DMS  A 405 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.64A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.68A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.57A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.80A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A18.54
None
None
DMS  A 405 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
PHE A 140
HIS A 164
GLY A 146
1.57A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.54A16.84
None
None
DMS  A 405 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.68A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.75A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
PHE C 145
HIS B 168
PHE B 170
ASP C 173
1.73A16.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
ILE E 434
PHE E 377
GLY H  28
PHE E 342
1.62A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
HIS B 168
ASP C 173
PHE C 145
ASP C 176
1.65A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
PHE E 377
PHE E 374
GLY H  28
PHE E 342
1.78A18.65
None
None
DMS  E 901 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
HIS H 168
ASP L 173
PHE L 145
ASP L 176
1.64A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
HIS B 168
PHE C 145
ASP C 173
PHE B 170
1.68A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
HIS H 168
PHE L 145
ASP L 173
PHE H 170
1.75A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 513
ILE A 434
PHE A 377
GLY B  28
PHE A 342
1.62A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
HIS H 168
ASP L 173
PHE L 145
ASP L 176
1.63A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
HIS H 168
PHE L 145
ASP L 173
PHE H 170
1.76A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
ILE E 434
PHE E 377
GLY H  28
PHE E 342
1.69A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.69A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.57A
None
None
P6N  A 502 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.73A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.70A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A21.13
None
None
P6N  A 502 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.62A21.13
None
None
P6N  A 502 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.43A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
HIS B 168
PHE C 145
ASP C 173
PHE B 170
1.75A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
HIS H 168
PHE L 145
ASP L 173
PHE H 170
1.75A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
HIS B 168
ASP C 173
PHE C 145
ASP C 176
1.65A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
ILE E 434
PHE E 377
GLY H  28
PHE E 342
1.63A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 513
PHE E 377
PHE E 374
GLY H  28
PHE E 342
1.79A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 513
ILE A 434
PHE A 377
GLY B  28
PHE A 342
1.62A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
HIS H 168
ASP L 173
PHE L 145
ASP L 176
1.64A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 513
PHE A 377
PHE A 374
GLY B  28
PHE A 342
1.78A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A21.13
PK8  A 401 (-3.2A)
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.52A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.76A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.67A22.99
PK8  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A22.34
PK8  A 401 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A21.13
PK8  A 401 (-3.2A)
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.59A
PK8  A 401 (-3.2A)
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 176
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.78A20.00
None
PK8  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.61A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.58A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.68A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.70A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.42A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
None
None
PJE  C   5 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.80A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A
None
None
PJE  C   5 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.66A20.89
None
None
PJE  C   5 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.65A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7btf NSP12
(SARS-CoV-2)		4 / 8
HIS A  99
ASP A 218
PHE A 101
GLY A 220
1.71A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A 833
HIS A 810
PRO A 832
HIS A 816
TYR A 831
1.80A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 862
ILE A 837
GLY A 839
PHE A 419
GLY A 413
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.42A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.46A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7btf NSP12
(SARS-CoV-2)		4 / 8
HIS A  75
PHE A 219
PHE A 101
GLY A 220
1.78A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.47A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7btf NSP12
(SARS-CoV-2)		4 / 8
HIS A  82
PHE A 219
ASP A 221
GLY A 220
1.42A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  58
ILE A  43
HIS A 164
GLY A 179
PHE A  66
1.59A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.65A20.89
JRY  A 401 (-3.9A)
None
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
GLY A 149
PHE A 112
ASP A 176
TYR A 182
1.70A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.64A20.89
JRY  A 401 (-3.9A)
None
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
HIS A  41
HIS A 164
PHE A 181
GLY A 146
1.73A22.99
JRY  A 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
GLY A 146
HIS A 163
GLY A 174
TYR A 161
1.60A
JRY  A 401 (-3.9A)
None
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
HIS A 164
PHE A 140
GLY A 146
PHE A 112
1.66A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
PRO A  39
GLY A 174
ASP A 176
GLY A 179
1.45A22.34
JRY  A 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.52A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.47A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.51A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PRO B 116
SER A 343
GLY A 345
ASP A 274
TYR A 273
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PRO B 116
SER A 343
GLY A 345
ASP A 274
TYR A 273
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.48A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.50A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 620
MET A 794
TYR A 619
1.46A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
LEU A 544
ASP A 445
HIS C  36
GLY A 413
TYR A 546
1.58A
None