Ligand ID: RWF


Drugbank ID:
DB00682
(Warfarin)


Indication:
For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.

Get human targets for RWF in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RWF'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
PHE B  90
LEU B  45
LEU B   9
SER A 105
ALA B 107
1.53A11.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A  40
LEU C  41
LEU A  41
LEU E  44
ALA E  38
1.59A6.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA B 940
LEU C 941
LEU B 941
LEU A 944
ALA A 938
1.58A5.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA B 132
LEU B 133
LEU B 173
SER B 156
ALA B 154
1.57A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		2gdt LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		5 / 11
PHE A  20
ALA A  31
LEU A  77
LEU A  96
LEU A  42
1.51A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		2gri NSP3
(SARSr)		5 / 11
LEU A  28
LEU A  66
LEU A  80
SER A  84
ALA A  59
1.23A12.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
TYR A  47
LEU A  95
HIS A  69
LEU A  89
ALA A  83
1.66A18.31
SAH  A1293 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
TYR A  47
LEU A  95
HIS A  69
LEU A  89
ALA A  83
1.64A17.32
SFG  A1298 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
ALA A  99
LEU A 100
LEU A 391
ARG A 393
ALA A  36
1.56A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		3e9s NSP3
(SARSr-CoV)		6 / 11
ALA A 132
LEU A 133
HIS A 176
LEU A 173
SER A 156
ALA A 154
1.68A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
TYR A  47
LEU A  95
HIS A  69
LEU A  89
ALA A  83
1.65A18.94
SAM  A 302 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		3to2 MD3-C9 PEPTIDE
DERIVED FROM
MEMBRANE
GLYCOPROTEIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARS-COV
TJF)		5 / 11
ALA A 153
LEU A 156
HIS A 114
ARG A  97
ALA C   7
1.46A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
ALA A 132
LEU A 133
HIS A 176
SER A 156
ALA A 154
1.60A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 11
ALA B 132
LEU B 133
HIS B 176
SER B 156
ALA B 154
1.50A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA A 132
LEU A 133
HIS A 176
LEU A 173
ALA A 154
1.56A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A 242
LEU A 205
LEU A 208
SER A 267
ALA A 266
1.60A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA D 132
LEU D 133
LEU D 173
SER D 156
ALA D 154
1.53A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
PHE A 116
LEU A 169
LEU A 171
LEU A 180
ALA A 282
1.53A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
PHE A 116
LEU A 169
LEU A 171
LEU A 180
ALA A 282
1.52A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA B 926
LEU B 927
LEU B 920
LEU B 803
SER B 798
1.52A17.22
ALA  B 926 ( 0.0A)
LEU  B 927 ( 0.6A)
LEU  B 920 ( 0.6A)
LEU  B 803 ( 0.6A)
SER  B 798 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
ALA A 132
LEU A 133
HIS A 176
SER A 156
ALA A 154
1.59A18.71
 NA  A 406 (-4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A 940
LEU C 941
LEU A 941
LEU B 944
ALA B 938
1.54A9.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA B 971
ARG B 977
LEU B 959
SER B 957
ALA B 954
1.44A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ack ACE2
(Homo
sapiens)		5 / 11
ALA D  80
LEU D  29
LEU D 100
LEU D 391
ALA D  36
1.41A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA B 748
LEU B 749
LEU B 745
LEU B 986
SER B 985
1.61A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA B 926
LEU B 927
LEU B 920
LEU B 803
SER B 798
1.45A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6cs2 ACE2
(Homo
sapiens)		5 / 11
ALA D 443
LEU D 440
LEU D 444
LEU D 278
SER D 280
1.39A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 11
ALA E 942
LEU E 945
LEU F1186
SER D 940
ALA D 942
1.24A11.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6m1d ACE2
(Homo
sapiens)		5 / 11
ALA B 569
LEU B 560
ARG B 559
LEU B 568
LEU B  91
1.54A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 11
PHE B 147
TRP B 154
ALA B 188
SER A 672
ALA A 400
1.79A15.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6m71 NSP12
(SARS-CoV-2)		5 / 11
PHE A 571
ALA A 639
LEU A 636
LEU A 655
LEU A 351
1.34A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6m71 NSP12
(SARS-CoV-2)		5 / 11
PHE A 157
TRP A 162
LEU A 142
LEU A 146
LEU A 178
1.69A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A 926
LEU A 927
LEU A 920
LEU A 803
SER A 798
1.34A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 11
ALA H 124
HIS H 214
LEU H 189
SER H 191
ALA H 182
1.57A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6nur NSP12
(SARSr-CoV)		5 / 11
PHE A 571
ALA A 639
LEU A 636
LEU A 655
LEU A 351
1.38A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6nus NSP12
(SARSr-CoV)		5 / 9
TYR A 787
PHE A 157
LEU A 146
LEU A 178
ALA A 130
1.65A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ALA B 944
LEU B 945
LEU B 938
LEU B 821
SER B 816
1.59A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6vw1 ACE2
(Homo
sapiens)		5 / 11
LEU B 281
ARG B 161
LEU B 156
SER B 155
ALA B 153
1.49A20.67
EDO  B 705 (-4.7A)
EDO  B 705 (-3.4A)
EDO  B 705 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6vxs NSP3
(SARS-CoV-2)		5 / 11
PHE B 168
LEU B 153
LEU B 164
LEU B 160
ALA B 129
1.79A
None
None
None
SO4  B 204 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ALA C 944
LEU C 945
LEU C 938
LEU C 821
SER C 816
1.50A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6w4h NSP16
(SARS-CoV-2)		5 / 9
TYR A6845
LEU A6893
HIS A6867
LEU A6887
ALA A6881
1.66A18.29
SAM  A7102 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
TYR A6845
LEU A6893
HIS A6867
LEU A6887
ALA A6881
1.66A
SAM  A7104 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ALA A6966
LEU A6852
LEU A6924
LEU A6887
ALA A6858
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B 154
LEU B 153
LEU B 140
SER B 139
ALA B 129
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
PHE A 116
ALA A 124
LEU A 153
LEU A 140
ALA A 129
1.72A
None
None
None
None
AMP  A 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
PHE B 116
ALA B 124
LEU B 153
LEU B 140
ALA B 129
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 9
TYR A6845
LEU A6893
HIS A6867
LEU A6887
ALA A6881
1.65A13.08
SAM  A7102 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
ALA A6966
LEU A6852
LEU A6924
LEU A6887
ALA A6858
1.70A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 9
TYR C6845
LEU C6893
HIS C6867
LEU C6887
ALA C6881
1.65A13.08
SAM  C7105 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
ALA C6966
LEU C6852
LEU C6924
LEU C6887
ALA C6858
1.71A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
ALA A 116
LEU A 120
LEU A 172
LEU A 132
ALA A 176
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
ALA C 116
LEU C 120
LEU C 172
LEU C 132
ALA C 176
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wcf NSP3
(SARS-CoV-2)		5 / 11
PHE A 116
ALA A 124
LEU A 153
LEU A 140
ALA A 129
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wcf NSP3
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
LEU A 140
SER A 139
ALA A 129
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wen NSP3
(SARS-CoV-2)		5 / 11
PHE A 116
ALA A 124
LEU A 153
LEU A 140
ALA A 129
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wen NSP3
(SARS-CoV-2)		5 / 11
ALA A 134
HIS A 138
ARG A 141
LEU A 140
SER A 167
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wey NSP3
(SARS-CoV-2)		5 / 11
PHE A 320
ALA A 328
LEU A 357
LEU A 344
ALA A 333
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ALA A6966
LEU A6852
LEU A6924
LEU A6887
ALA A6858
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
TYR C6845
LEU C6893
HIS C6867
LEU C6887
ALA C6881
1.65A
SAH  C7102 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ALA C6966
LEU C6852
LEU C6924
LEU C6887
ALA C6858
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
TYR A6845
LEU A6893
HIS A6867
LEU A6887
ALA A6881
1.64A
SAH  A7102 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wkq NSP16
(SARS-CoV-2)		5 / 11
ALA A6966
LEU A6852
LEU A6924
LEU A6887
ALA A6858
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wkq NSP16
(SARS-CoV-2)		5 / 11
ALA C6966
LEU C6852
LEU C6924
LEU C6887
ALA C6858
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6wkq NSP16
(SARS-CoV-2)		5 / 9
TYR A6845
LEU A6893
HIS A6867
LEU A6887
ALA A6881
1.65A
SFG  A7103 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6wkq NSP16
(SARS-CoV-2)		5 / 9
TYR C6845
LEU C6893
HIS C6867
LEU C6887
ALA C6881
1.66A
SFG  C7103 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
PHE B  44
ALA B  55
LEU B  50
LEU B  58
ALA B  95
1.73A
TRS  B 402 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
PHE A  44
ALA A  55
LEU A  50
LEU A  58
ALA A  95
1.74A
TRS  A 402 (-4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE D 116
ALA D 124
LEU D 153
LEU D 140
ALA D 129
1.76A
None
None
None
None
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE B 116
ALA B 124
LEU B 153
LEU B 140
ALA B 129
1.74A
None
None
None
None
APR  B 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE C 156
LEU C 160
LEU C 164
SER C 139
ALA C 129
1.61A
APR  C 201 (-4.7A)
None
None
None
APR  C 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE A 156
LEU A 160
LEU A 164
SER A 139
ALA A 129
1.61A
APR  A 201 (-4.7A)
None
None
None
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE D 156
LEU D 160
LEU D 164
SER D 139
ALA D 129
1.60A
APR  D 201 (-4.5A)
None
None
None
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE A 116
ALA A 124
LEU A 153
LEU A 140
ALA A 129
1.75A
None
None
None
None
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE C 116
ALA C 124
LEU C 153
LEU C 140
ALA C 129
1.73A
None
None
None
None
APR  C 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE B 156
LEU B 160
LEU B 164
SER B 139
ALA B 129
1.59A
APR  B 201 (-4.6A)
None
None
None
APR  B 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ALA A6966
LEU A6852
LEU A6924
LEU A6887
ALA A6858
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
TYR A6845
LEU A6893
HIS A6867
LEU A6887
ALA A6881
1.66A
SAH  A7101 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 11
ALA A 116
LEU A 120
LEU A 172
LEU A 132
ALA A 176
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
ALA B 110
LEU A  71
LEU A  60
LEU A  56
ALA A  65
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE D 116
ALA D 124
LEU D 153
LEU D 140
ALA D 129
1.74A
None
None
None
None
EDO  D 205 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE E 116
ALA E 124
LEU E 153
LEU E 140
ALA E 129
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE C 116
ALA C 124
LEU C 153
LEU C 140
ALA C 129
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE A 116
ALA A 124
LEU A 153
LEU A 140
ALA A 129
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE B 116
ALA B 124
LEU B 153
LEU B 140
ALA B 129
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE D 116
ALA D 124
LEU D 153
LEU D 140
ALA D 129
1.77A
None
None
None
None
APR  D 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE E 116
ALA E 124
LEU E 153
LEU E 140
ALA E 129
1.76A
None
None
None
None
APR  E 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE C 116
ALA C 124
LEU C 153
LEU C 140
ALA C 129
1.79A
None
None
None
None
APR  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE B 116
ALA B 124
LEU B 153
LEU B 140
ALA B 129
1.79A
None
None
None
None
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE A 116
ALA A 124
LEU A 153
LEU A 140
ALA A 129
1.78A
None
None
None
None
APR  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE A 116
ALA A 124
LEU A 153
LEU A 140
ALA A 129
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE C 116
ALA C 124
LEU C 153
LEU C 140
ALA C 129
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE B 116
ALA B 124
LEU B 153
LEU B 140
ALA B 129
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 11
PHE B 147
TRP B 154
ALA B 188
SER A 672
ALA A 400
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7btf NSP12
(SARS-CoV-2)		5 / 11
PHE A 157
TRP A 162
LEU A 142
LEU A 146
LEU A 178
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7btf NSP12
(SARS-CoV-2)		5 / 11
PHE A 571
ALA A 639
LEU A 636
LEU A 655
LEU A 351
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
PHE A 571
ALA A 639
LEU A 636
LEU A 655
LEU A 351
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
ALA A 130
LEU A 142
LEU A 127
ARG A 181
LEU A 178
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
PHE A 157
TRP A 162
LEU A 142
LEU A 146
LEU A 178
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
TYR A 787
PHE A 157
LEU A 146
LEU A 178
ALA A 130
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 469
LEU A 630
ARG A 631
SER A 635
ALA A 634
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
PHE A 571
ALA A 639
LEU A 636
LEU A 655
LEU A 351
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
PHE A 157
TRP A 162
LEU A 142
LEU A 146
LEU A 178
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 11
PHE B 147
TRP B 154
ALA B 188
SER A 672
ALA A 400
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ALA A 130
LEU A 142
LEU A 127
ARG A 181
LEU A 178
1.76A
None