Ligand ID: RO7


Drugbank ID:
DB08915
(Aleglitazar)


Indication:
Investigated for use in patients with type II diabetes to reduce their risks of cardiovascular mortality and morbidity.

Get human targets for RO7 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RO7'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
GLY B 124
SER B 144
HIS B 163
TYR B 161
VAL B  13
1.49A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.35A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B1114
CYH B1128
ILE B1106
ILE B1200
VAL B1204
1.78A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 7
LEU D  19
GLN E  93
LEU A  60
VAL A  16
1.08A18.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
HIS A 163
LEU A  27
VAL A  20
HIS A 164
1.41A22.29
None
9IN  A1001 (-3.8A)
9IN  A1001 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU E1168
GLN C 915
LEU D1179
LEU B 920
LYS A 914
1.71A12.35
None
None
ACE  B 913 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
VAL S 496
TYR S 436
ILE S 405
ILE H  56
TYR S 484
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
CYH T  74
CYH T  73
SER T  72
ILE T  55
ILE T  99
1.74A20.38
 ZN  T 998 (-2.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.29A22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.52A22.51
None
WR1  A 601 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
VAL D 291
SER B 241
MET D 271
ILE D 269
ILE B 235
1.52A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
LEU A 248
VAL A 320
LEU A 297
LEU A  75
0.97A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 7
LEU A  86
GLN A  19
VAL A 148
LEU A  32
LYS A  97
1.72A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.47A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
GLY B 124
SER B 144
HIS B 163
TYR B 161
VAL B  13
1.40A22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 7
LEU A  86
GLN A  19
VAL A 148
LEU A  32
LYS A  97
1.61A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.51A22.65
None
CYV  A 302 ( 4.2A)
CYV  A 302 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
VAL B  20
CYH B 145
SER B 144
HIS B 172
TYR B 126
1.69A23.71
None
XP1  B1304 (-1.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.46A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
LEU A 161
VAL A  67
LEU A  59
LEU A 180
1.10A20.79
None
None
NA  A1295 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
LEU A 161
VAL A  67
LEU A  59
LEU A 180
1.06A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.44A22.57
None
HSV  C   5 (-3.6A)
HSV  C   5 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LEU B 236
GLN B 526
VAL B 581
LEU B 450
1.02A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER B 170
TYR B 497
ILE B 151
HIS B 493
VAL B 491
1.72A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 124
SER B 144
HIS B 163
TYR B 161
VAL B  13
1.47A22.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.52A22.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 124
SER B 144
HIS B 163
TYR B 161
VAL B  13
1.51A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 7
LEU A  86
GLN A  19
VAL A 148
LEU A  32
LYS A  97
1.63A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.45A22.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
LEU A 161
VAL A  67
LEU A  59
LEU A 180
1.08A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3scj ACE2
(Homo
sapiens)		4 / 7
LEU B 236
GLN B 526
VAL B 581
LEU B 450
1.04A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 170
TYR A 497
ILE A 151
HIS A 493
VAL A 491
1.64A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LEU B 236
GLN B 526
VAL B 581
LEU B 450
1.01A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 124
SER B 144
HIS B 163
TYR B 161
VAL B  13
1.46A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
CYH A 128
ILE A 106
ILE A 200
VAL A 204
1.79A24.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 124
SER B 144
HIS B 163
TYR B 161
VAL B  13
1.50A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 7
LEU B 133
GLN A  36
LEU A  18
VAL A  58
LEU A  65
1.67A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.53A17.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.55A17.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 286
LEU A 242
VAL A 204
LEU A 272
1.51A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 250
LEU A 272
VAL A 204
LEU A 242
1.79A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
GLN A 110
LEU A 253
VAL A 204
LEU A 242
1.69A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
VAL C 115
TYR D 265
MET D 209
VAL D 166
TYR D 274
1.76A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY B 572
LEU B 415
VAL B 420
LEU B 441
TYR B 438
1.32A11.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU C 959
GLN C 984
LEU C 745
LEU C 735
1.01A12.68
LEU  C 959 ( 0.6A)
GLN  C 984 ( 0.6A)
LEU  C 745 ( 0.5A)
LEU  C 735 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU B 959
GLN B 984
LEU B 745
LEU B 735
1.08A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
CYH A  19
CYH A 133
ILE A 152
MET A 151
VAL A 102
1.56A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
LEU C 615
GLN C 630
VAL C 596
LEU A 831
1.12A12.92
None
NAG  C1311 (-3.1A)
None
NAG  C1311 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6cs2 ACE2
(Homo
sapiens)		5 / 12
SER D 170
TYR D 497
ILE D 151
HIS D 493
VAL D 491
1.79A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 7
LEU E 984
LEU F1166
VAL F 976
LEU F 981
LEU D1166
1.51A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.60A22.12
None
None
ELL  D   3 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 242
GLN A 110
VAL A 204
LEU A 250
1.44A21.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.54A22.12
None
ELL  D   3 (-3.8A)
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  29
HIS A 164
TYR A 161
VAL A  13
HIS A 163
1.77A22.12
None
None
None
None
ELL  D   3 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m03 MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.49A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.52A22.12
None
ELL  D   3 (-3.7A)
ELL  D   3 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  29
HIS A 164
TYR A 161
VAL A  13
HIS A 163
1.76A22.12
None
None
None
None
ELL  D   3 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.59A22.12
None
None
ELL  D   3 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m17 ACE2
(Homo
sapiens)		5 / 12
SER D 170
TYR D 497
ILE D 151
HIS D 493
VAL D 491
1.56A16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m17 ACE2
(Homo
sapiens)		4 / 7
LEU B 236
GLN B 526
VAL B 581
LEU B 450
1.11A16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
LEU A 424
LEU A 244
LYS A 409
LEU A 389
1.09A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL C 505
SER C 291
TYR C 292
ILE C  15
VAL C 441
1.64A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C  29
HIS C 164
TYR C 161
VAL C  13
HIS C 163
1.76A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  15
CYH A  16
TYR A  37
VAL A 157
LEU A  75
1.76A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 124
SER C 144
HIS C 163
TYR C 161
VAL C  13
1.52A22.74
None
3WL  C 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 120
CYH B 117
SER B 144
TYR B 126
VAL B  13
1.59A22.74
None
None
3WL  B 401 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  29
HIS A 164
TYR A 161
VAL A  13
HIS A 163
1.75A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.56A22.74
None
3WL  A 401 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D  29
HIS D 164
TYR D 161
VAL D  13
HIS D 163
1.77A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
GLN B 110
LEU B 253
VAL B 204
LEU B 242
1.36A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 124
SER B 144
HIS B 163
TYR B 161
VAL B  13
1.56A22.74
None
3WL  B 401 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 120
CYH C 117
SER C 144
TYR C 126
VAL C  13
1.60A22.74
None
None
3WL  C 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D 124
SER D 144
HIS D 163
TYR D 161
VAL D  13
1.52A22.74
None
3WL  D 401 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
GLN A 110
LEU A 253
VAL A 204
LEU A 242
1.41A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU B 242
GLN B 110
VAL B 204
LEU B 250
1.44A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
GLN D 110
LEU D 253
VAL D 204
LEU D 242
1.41A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 242
GLN A 110
VAL A 204
LEU A 250
1.41A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D  23
LEU D  89
VAL D  68
LEU D  57
TYR D  54
1.65A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B  29
HIS B 164
TYR B 161
VAL B  13
HIS B 163
1.77A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D 120
CYH D 117
SER D 144
TYR D 126
VAL D  13
1.58A22.74
None
None
3WL  D 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.60A22.74
None
None
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU D 242
GLN D 110
VAL D 204
LEU D 250
1.35A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 242
GLN A 110
VAL A 204
LEU A 250
1.39A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.53A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.59A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP7
(SARS-CoV-2)		4 / 7
GLN C  31
LEU C  13
VAL C  53
LEU C  60
1.24A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 146
LEU A 241
LEU A 131
LEU A 251
1.39A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 7
LEU A 437
LEU C  55
VAL C   6
LEU C  40
1.34A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  71
GLN C  19
LEU C  55
LEU D  95
1.30A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP7
(SARS-CoV-2)		4 / 7
LEU C  20
VAL C  58
LEU C  14
LEU C  71
1.39A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU D  95
GLN C  19
LEU C  28
LEU C  55
1.31A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP7
(SARS-CoV-2)		4 / 7
GLN C  31
LEU C  60
VAL C  53
LEU C  28
1.37A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 575
LEU A 469
VAL A 693
LEU A 351
1.33A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  55
VAL C  12
LEU D  98
LEU C  41
1.24A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 316
LEU A 207
LEU A 186
LEU A 142
1.30A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 142
VAL A 128
LEU A 212
LEU A 172
1.18A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
LEU A 142
VAL A 128
LEU A 172
1.38A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6vw1 ACE2
(Homo
sapiens)		4 / 7
LEU A 236
GLN A 526
VAL A 581
LEU A 450
1.01A18.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
GLY L  64
TYR L  36
ILE L  75
LEU L  33
TYR L  91
1.65A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
GLN L  38
LEU L  46
VAL L  58
LEU L  73
1.73A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY C 381
SER C 383
LEU C 390
ILE L  28
TYR C 369
1.69A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
GLN L 147
LEU L 181
VAL L 133
LEU L 154
1.46A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H  82
GLN H   6
VAL H  67
LEU H   4
1.71A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY C 431
SER C 383
LEU C 390
ILE L  28
TYR C 369
1.69A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
GLN L  38
LEU L  73
VAL L  58
LEU H  45
1.68A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
GLN L  38
LEU L  73
LEU L  11
LEU H  45
1.71A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
GLN L 147
LEU L 175
VAL L 115
LEU L 201
1.51A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
LEU L  78
GLN L  38
LEU L  11
LEU H  45
1.49A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
LEU L 175
GLN L 147
LEU L 181
VAL L 133
1.57A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
GLN L  38
LEU L  47
LEU L  78
LEU H  45
1.79A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
LEU L  73
GLN L  42
VAL L 104
LEU L  78
1.59A18.77
None
SO4  L 302 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6902
CYH B4330
CYH B4332
ILE B4291
VAL B4274
1.57A21.43
None
ZN  B4401 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w4h NSP16
(SARS-CoV-2)		4 / 7
LEU A6959
VAL A6865
LEU A6857
LEU A6978
1.07A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6902
CYH B4330
CYH B4332
ILE B4291
VAL B4274
1.63A
None
ZN  B4403 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6848
VAL A6865
LEU A7050
LEU A7010
1.74A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A7050
LEU A6959
VAL A6865
LEU A7004
1.49A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6981
LEU A6857
LEU A6959
LEU A6848
1.58A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6978
LEU A6857
LEU A6959
LEU A6883
1.71A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A7042
LEU A6887
VAL A6882
LEU A6855
1.79A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A7072
LEU A6959
LEU A7010
LEU A6852
1.75A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6855
GLN A6801
LEU A7042
LEU A6848
1.51A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6959
VAL A6865
LEU A6857
LEU A6978
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6855
GLN A6847
LEU A7050
LEU A7042
1.77A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6848
VAL A6865
LEU A6857
LEU A6981
1.51A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.54A22.74
None
X77  A 401 (-3.4A)
X77  A 401 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.57A22.74
None
None
X77  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 123
VAL A  49
LEU A  88
LEU A  75
1.80A20.23
None
AMP  A 201 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 126
VAL A 151
LYS A  29
LEU B  10
1.78A20.23
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B  83
GLN B 118
LEU B 127
LEU B  75
1.74A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 153
VAL B  49
LEU B 123
LEU B  75
1.69A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 127
VAL B 147
LEU B 122
LEU B  75
1.79A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 127
VAL B 147
LEU B 140
LEU B  53
1.66A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 140
VAL B 147
LEU B 109
LEU B  53
1.73A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 169
LEU B  12
LEU A  10
LEU B 160
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 123
VAL B 151
LEU B 126
LEU A 169
1.48A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 140
LEU B  93
VAL B 147
LEU B 127
1.65A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU B 123
VAL B  49
LEU B  88
LEU B  75
1.79A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 169
VAL A  16
LEU A 164
LEU B 169
1.78A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A  93
LEU A 140
VAL A 151
LEU A 127
1.79A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C7050
LEU C6959
VAL C6865
LEU C7004
1.48A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6959
VAL A6865
LEU A6857
LEU A6978
1.04A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6981
LEU A6857
LEU A6959
LEU A6848
1.58A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6855
GLN A6847
LEU A7050
LEU A7042
1.76A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C7072
LEU C6959
LEU C7010
LEU C6852
1.76A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6959
VAL C6865
LEU C6857
LEU C6978
1.04A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6855
GLN A6801
LEU A7042
LEU A6848
1.49A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A7042
LEU A6887
VAL A6882
LEU A6855
1.80A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6902
CYH D4330
CYH D4332
ILE D4291
VAL D4274
1.60A22.14
None
ZN  D4401 ( 2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6893
VAL C7094
LEU A6909
LEU A6959
1.80A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A7050
LEU A6959
VAL A6865
LEU A7004
1.48A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6892
VAL C7087
LEU C6909
LEU C6959
1.57A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6848
VAL C6865
LEU C7050
LEU C7010
1.74A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6848
VAL A6865
LEU A7050
LEU A7010
1.75A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6848
VAL A6865
LEU A6857
LEU A6981
1.54A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A7037
VAL A6992
LEU A6825
LYS A6822
1.75A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6978
LEU A6857
LEU A6959
LEU A6883
1.68A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6902
CYH B4330
CYH B4332
ILE B4291
VAL B4274
1.60A22.14
None
ZN  B4401 ( 2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6978
LEU C6857
LEU C6959
LEU C6883
1.66A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
CYH B 260
SER B 278
LEU B 101
ILE B 123
LEU B 282
1.78A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU C 178
GLN C 122
LEU C 172
LEU C 101
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU B 178
GLN B 122
LEU B 172
LEU B 101
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
CYH C 260
LEU C 118
ILE C 123
LEU C 282
TYR C 296
1.79A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 178
GLN A 122
LEU A 172
LEU A 101
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
CYH C 260
LEU C 101
ILE C 123
LEU C 253
TYR C 296
1.78A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
LEU A  42
LEU A   4
VAL A  -6
LEU A  97
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU A  55
VAL A  12
LEU B  98
LEU A  41
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wiq NSP7
(SARS-CoV-2)		4 / 7
GLN A  19
LEU A  55
VAL A  33
LEU A  28
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU B 128
LEU B  95
VAL A  53
LEU A  20
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 7
LEU B 128
GLN A  31
LEU A  13
VAL A  53
LEU A  60
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6959
VAL A6865
LEU A6857
LEU A6978
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6902
CYH B4330
CYH B4332
ILE B4291
VAL B4274
1.64A
None
ZN  B4401 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU C6959
VAL C6865
LEU C6857
LEU C6978
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL C6902
CYH D4330
CYH D4332
ILE D4291
VAL D4274
1.59A
None
ZN  D4401 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6902
CYH D4330
CYH D4332
ILE D4291
VAL D4274
1.59A
None
ZN  D4401 ( 2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU A6959
VAL A6865
LEU A6857
LEU A6978
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU C6959
VAL C6865
LEU C6857
LEU C6978
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU C6848
VAL C6865
LEU C7050
LEU C7073
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6902
CYH B4330
CYH B4332
ILE B4291
VAL B4274
1.61A
None
ZN  B4401 ( 2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  29
HIS A 164
TYR A 161
VAL A  13
HIS A 163
1.78A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  15
CYH A  16
LEU A  32
VAL A 157
LEU A  75
1.78A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.54A22.74
None
U5G  A 401 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.62A22.74
None
None
U5G  A 401 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6848
VAL A6865
LEU A7050
LEU A7073
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6902
CYH B4330
CYH B4332
ILE B4291
VAL B4274
1.63A
None
ZN  B4401 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6959
VAL A6865
LEU A6857
LEU A6978
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU D 128
LEU D  95
VAL C  53
LEU C  20
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU A  71
LEU B 128
VAL B 115
LEU A  35
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU B 128
LEU B  95
VAL A  53
LEU A  20
1.23A
None
None
EDO  B 302 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
(SARS-CoV-2)		4 / 7
LEU C  59
VAL C  22
LEU C  55
LEU A  14
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
(SARS-CoV-2)		4 / 7
LEU A  59
VAL A  22
LEU A  55
LEU C  14
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU A  55
VAL A  12
LEU B  98
LEU A  41
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU D  91
GLN A  18
LEU A  55
LEU A  40
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU B  91
GLN C  18
LEU C  55
LEU C  40
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 7
LEU C  40
LEU D  95
VAL C   6
LEU C  55
LEU A  40
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 7
LEU B 128
GLN A  31
LEU A  13
VAL A  53
LEU A  60
1.72A
None
None
None
EDO  B 302 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  55
VAL C  12
LEU D  98
LEU C  41
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU B  95
VAL A  16
LEU A  55
LEU D  91
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  14
GLN B  88
LEU A  55
VAL A  11
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU D  95
VAL C  16
LEU C  55
LEU B  91
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU A  14
GLN D  88
LEU C  55
VAL C  11
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 7
LEU D 128
GLN C  31
LEU C  13
VAL C  53
LEU C  60
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 7
GLN A  31
LEU A  60
VAL A  53
LEU B 128
LEU A  28
1.77A
None
None
EDO  B 302 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 7
LEU A  40
LEU B  95
VAL A   6
LEU A  55
LEU C  40
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  71
LEU D 128
VAL D 115
LEU C  35
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.60A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 242
GLN A 110
VAL A 204
LEU A 250
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.53A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 250
LEU A 272
VAL A 204
LEU A 242
1.78A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  29
HIS A 164
TYR A 161
VAL A  13
HIS A 163
1.79A17.88
None
None
None
None
DMS  A 405 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 286
LEU A 242
VAL A 204
LEU A 272
1.53A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.64A17.88
None
None
DMS  A 405 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.53A17.88
None
DMS  A 405 ( 3.7A)
DMS  A 405 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLN A 110
LEU A 253
VAL A 204
LEU A 242
1.71A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU A  55
VAL A  12
LEU B  98
LEU A  41
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 7
LEU C  40
LEU D  95
VAL C   6
LEU C  55
LEU A  40
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU B 128
LEU B  95
VAL A  53
LEU A  20
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU A  40
GLN A  19
LEU C  55
VAL C  16
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU C  55
VAL C  12
LEU D  98
LEU C  41
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU C  71
LEU D 128
VAL D 115
LEU C  35
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU B  91
GLN C  18
LEU C  55
LEU C  40
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU C  14
GLN B  88
LEU A  55
VAL A  11
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 7
LEU A  40
LEU B  95
VAL A   6
LEU A  55
LEU C  40
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU D  91
GLN A  18
LEU A  55
LEU A  40
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU D  95
VAL C  16
LEU C  55
LEU B  91
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU A  14
GLN D  88
LEU C  55
VAL C  11
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU B  95
VAL A  16
LEU A  55
LEU D  91
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU A  17
GLN A  63
LEU A  71
LEU A  56
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU D 128
LEU D  95
VAL C  53
LEU C  20
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU A  71
LEU B 128
VAL B 115
LEU A  35
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY C  70
TYR C  42
ILE C  81
LEU C  39
TYR C  97
1.74A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY L  70
TYR L  42
ILE L  81
LEU L  39
TYR L  97
1.73A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
GLN C 153
LEU C 181
VAL C 121
LEU C 207
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
GLN L 153
LEU L 187
VAL L 139
LEU L 160
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY L  70
TYR L  42
ILE L  81
LEU L  39
TYR L  97
1.75A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.53A22.74
None
None
P6N  A 502 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.53A22.74
None
P6N  A 502 (-3.3A)
P6N  A 502 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 242
GLN A 110
VAL A 204
LEU A 250
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY L  70
TYR L  42
ILE L  81
LEU L  39
TYR L  97
1.72A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY C  70
TYR C  42
ILE C  81
LEU C  39
TYR C  97
1.73A20.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.52A22.74
None
DMS  A 403 ( 2.9A)
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.54A22.74
None
None
DMS  A 403 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.53A22.74
None
PJE  C   5 ( 4.1A)
PJE  C   5 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  15
CYH A  16
TYR A  37
VAL A 157
LEU A  75
1.79A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
LEU A  89
VAL A  68
LEU A  57
TYR A  54
1.65A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  29
HIS A 164
TYR A 161
VAL A  13
HIS A 163
1.79A22.74
None
None
None
None
PJE  C   5 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.60A22.74
None
None
PJE  C   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  55
VAL C  12
LEU D  98
LEU C  41
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU D 128
LEU D  95
VAL C  53
LEU C  20
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 7
GLN A 444
LEU C  55
VAL C  11
LYS C  51
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP7
(SARS-CoV-2)		4 / 7
GLN C  31
LEU C  60
VAL C  53
LEU C  28
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 316
LEU A 207
LEU A 186
LEU A 142
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 397
TYR B 149
LEU B 128
VAL B 186
ILE B 185
1.77A15.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLY A 214
HIS A  99
TYR A  87
LEU A  90
LEU A 119
1.67A15.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 146
LEU A 241
LEU A 131
LEU A 251
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
LEU A 142
VAL A 128
LEU A 172
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 7
LEU C  55
GLN A 444
VAL C  22
LEU A 544
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
VAL A 234
LEU A 207
LEU A 470
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 142
VAL A 128
LEU A 212
LEU A 172
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU D  95
GLN C  19
LEU C  28
LEU C  55
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  29
HIS A 164
TYR A 161
VAL A  13
HIS A 163
1.77A22.74
None
None
None
None
DMS  A 402 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 120
CYH A 117
SER A 144
TYR A 126
VAL A  13
1.59A22.74
None
None
DMS  A 402 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 242
GLN A 110
VAL A 204
LEU A 250
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 124
SER A 144
HIS A 163
TYR A 161
VAL A  13
1.50A22.74
None
DMS  A 402 ( 3.6A)
DMS  A 402 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  15
CYH A  16
LEU A  32
VAL A 157
LEU A  75
1.79A22.74
DMS  A 403 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
LEU A 142
VAL A 128
LEU A 172
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 146
LEU A 241
LEU A 131
LEU A 251
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 142
VAL A 128
LEU A 212
LEU A 172
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
GLY D 144
CYH D 142
TYR D 135
VAL D 186
ILE D 156
1.67A19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  55
VAL C  12
LEU D  98
LEU C  41
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU B 117
VAL A 342
LEU B 103
LEU A 401
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv1 NSP7
(SARS-CoV-2)		4 / 7
GLN C  19
LEU C  55
VAL C  33
LEU C  28
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 146
LEU A 241
LEU A 131
LEU A 251
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
VAL A 234
LEU A 207
LEU A 470
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 207
LEU A 146
LEU A 212
LEU A 172
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 337
SER A 363
LEU A 361
LEU A 366
TYR A 374
1.55A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 361
GLN A 357
VAL A 342
LYS A 369
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 142
VAL A 128
LEU A 212
LEU A 172
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 316
LEU A 207
LEU A 186
LEU A 142
1.28A
None