Ligand ID: RFX


Drugbank ID:
DB00472
(Fluoxetine)


Indication:
Labeled indication include: major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and combination treatment with olanzapine for treatment-resistant or bipolar I depression. Unlabeled indications include: selective mutism, mild dementia-associated agitation in nonpsychotic patients, post-traumatic stress disorder (PTSD), social anxiety disorder, chronic neuropathic pain, fibromyalgia, and Raynaud's phenomenon.

Get human targets for RFX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RFX'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
ASP A 122
TYR A  89
TYR A  90
SER A  56
GLY A  57
1.47A14.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA S 406
TYR S 410
PHE S 416
GLY S 400
ASP S 385
1.32A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR L  96
ALA H  57
GLY H  99
GLY H  49
THR S 487
1.20A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
TYR C  84
ALA C  69
TYR C  72
PHE C  57
THR C  11
1.54A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		2fyg REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY A  35
LEU A  31
ILE A  38
ALA A  26
LEU A  14
1.34A11.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY H  35
LEU H  31
ILE H  38
ALA H  26
LEU H  14
1.25A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA E 406
TYR E 410
PHE E 416
GLY E 400
ASP E 385
1.37A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASP B  99
TYR B  59
GLY A 488
GLY B  55
THR A 485
1.33A18.65
None
None
CL  A  88 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 12
LEU A  25
ARG A  48
ALA A  46
ASP A 115
ASP A  21
0.75A11.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A   7
PHE A 140
SER A  10
GLY A 124
ASP A 295
1.47A22.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		2w2g NSP3
(SARSr-CoV)		5 / 12
VAL B 445
GLY A 609
SER B 461
GLY B 466
ASP B 447
1.50A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		6 / 12
LEU A 161
GLY A 165
TYR A 211
ILE A 157
ALA A 168
LEU A 180
1.75A20.08
None
NA  A1295 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
LEU A 161
GLN A 159
ILE A 167
LEU A 180
ASP A 179
1.22A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 12
TYR L  71
GLY L  31
SER L  67
GLY L  68
THR A 468
1.41A15.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
VAL A 293
ALA A 296
SER A 425
GLY A 422
ASP A 292
1.48A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		3e9s NSP3
(SARSr-CoV)		5 / 12
TYR A  84
ALA A  69
TYR A  72
PHE A  57
THR A  11
1.54A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
ALA B 116
GLY B 174
SER B 144
GLY B 143
1.26A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		3i6l HLA, A-24
NUCLEOPROTEIN
PEPTIDE
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR D 159
TYR D 116
PHE F   2
GLY D 100
ASP D  74
1.53A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
TYR A  84
ALA A  69
TYR A  72
PHE A  57
THR A  11
1.49A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		6 / 12
LEU A 161
GLY A 165
TYR A 211
ILE A 157
ALA A 168
LEU A 180
1.74A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
TYR A  84
ALA A  69
TYR A  72
PHE A  57
THR A  11
1.55A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
VAL D 188
ALA D 231
GLY E  47
SER D 222
THR D 198
1.40A22.30
None
None
5MW  E  48 ( 2.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 171
GLY A 174
SER A 139
ASP A 197
THR A 135
1.76A16.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
TYR D  84
ALA D  69
TYR D  72
PHE D  57
THR D  11
1.45A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL B1043
ALA B1037
GLY B 928
GLY B1041
THR B 706
1.45A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
LEU C 803
LEU C 804
ARG C 797
ILE C 800
ALA C1037
1.28A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
VAL C 374
ALA C 597
GLY C 615
PHE C 617
GLY C 372
1.57A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY B 825
LEU B 821
GLN A  72
ILE B1071
ASP B1064
1.23A16.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C1043
ALA C1037
GLY C 928
GLY C1041
THR C 706
1.50A18.37
VAL  C1043 ( 0.6A)
ALA  C1037 ( 0.0A)
GLY  C 928 ( 0.0A)
GLY  C1041 ( 0.0A)
THR  C 706 ( 0.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
TYR A  84
ALA A  69
TYR A  72
PHE A  57
THR A  11
1.53A22.41
None
None
NA  A 405 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 953
LEU C 978
ARG C 977
ILE C 962
LEU C 966
1.33A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR A 660
VAL A 642
ALA A 676
TYR A 677
ASP A 643
1.33A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 552
GLN A 550
ILE A 573
PHE A 545
LEU A 538
1.15A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 552
GLN C 550
ILE C 573
PHE C 545
LEU C 538
1.09A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP A 191
ALA C 406
TYR C 410
GLY C 400
ASP C 385
1.41A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
TYR A 118
GLY A 138
SER A 123
GLY A 124
1.79A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 12
ALA E 419
TYR E 423
PHE E 429
GLY E 413
ASP E 398
1.37A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		8 / 12
LEU A  52
GLY A  53
ARG A  57
TYR A 129
ILE A 132
PHE A 277
LEU A 482
ASP A 486
1.12A26.91
None
LEU  A 707 ( 4.6A)
None
LEU  A 707 ( 3.9A)
None
LEU  A 707 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ASP A 152
VAL A 163
ALA A 167
TYR A 174
GLY A 161
1.55A27.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR B 126
TYR B 118
GLY B 138
SER B 123
GLY B 124
1.77A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
TYR A 118
GLY A 138
SER A 123
GLY A 124
1.77A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 207
LEU A 241
ALA A 185
LEU A 212
ASP A 211
1.71A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.47A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL A 424
ALA A 423
TYR A 420
GLY A 432
ASP C   5
1.56A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m71 NSP7
(SARS-CoV-2)		5 / 12
LEU C  56
LEU C  59
ALA C  65
LEU C  71
ASP C  67
1.60A10.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 308
LEU A 636
ILE A 307
ALA A 639
LEU A 648
1.77A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.70A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
ILE A 589
PHE A 480
LEU A 758
ASP A 760
1.74A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 638
ARG A 640
ALA A 639
LEU A 655
ASP A 304
1.75A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 552
GLN B 550
ILE B 573
PHE B 545
LEU B 538
1.20A17.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP A 376
VAL A 314
GLY A 512
PHE A 316
GLY A 531
1.51A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6nur NSP12
(SARSr-CoV)		5 / 12
TYR A 619
VAL A 785
ALA A 784
TYR A 788
THR A 701
1.34A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 566
GLN A 564
ILE A 587
PHE A 559
LEU A 552
1.04A17.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP B  53
VAL B  36
ALA B 222
TYR B  37
PHE B 275
1.44A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
TYR B  41
ASP B  38
ALA B  46
SER B  43
THR F 446
1.51A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA F 419
TYR F 423
PHE F 429
GLY F 413
ASP F 398
1.34A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  47
SER B 128
GLY B 130
ASP A  67
THR A  71
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 566
GLN B 564
ILE B 587
PHE B 559
LEU B 552
1.13A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 419
TYR A 423
PHE A 429
GLY A 413
ASP A 398
1.36A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 419
TYR A 423
PHE A 429
GLY A 413
ASP A 398
1.37A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 566
GLN B 564
ILE B 587
PHE B 559
LEU B 552
1.13A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
ARG L  61
ILE L 106
ALA L  19
ASP L  82
1.80A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
GLY L  16
ILE L 106
ALA L  19
ASP L  82
1.57A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ALA C 419
TYR C 423
PHE C 429
GLY C 413
ASP C 398
1.34A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w4h NSP16
(SARS-CoV-2)		6 / 12
LEU A7073
GLY A7076
LEU A7078
ILE A7080
ALA A7056
ASP A6923
1.74A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6848
GLN A6804
ILE A7005
ALA A6808
LEU A6855
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A7073
GLY A7076
LEU A7078
ILE A7080
ALA A7056
ASP A6923
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7004
LEU A6978
GLN A6956
ILE A6967
PHE A6985
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A6916
ALA A6914
TYR A6950
GLY A6911
THR A6918
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A6959
GLY A6963
TYR A7009
ILE A6955
ALA A6966
LEU A6978
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		6 / 12
LEU C6959
GLY C6963
TYR C7009
ILE C6955
ALA C6966
LEU C6978
1.77A15.14
None
None
NA  C7103 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7004
LEU A6978
GLN A6956
ILE A6967
PHE A6985
1.79A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		6 / 12
LEU A6959
GLY A6963
TYR A7009
ILE A6955
ALA A6966
LEU A6978
1.76A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7073
GLY A6962
ILE A7069
ALA A7056
LEU A7060
1.70A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6848
GLN C6804
ILE C7005
ALA C6808
LEU C6855
1.62A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6900
ALA A6877
GLY A6911
SER A6872
GLY A6871
1.74A14.34
None
None
None
SAM  A7102 ( 4.6A)
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6848
GLN A6804
ILE A7005
ALA A6808
LEU A6855
1.62A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		6 / 12
LEU C7073
GLY C7076
LEU C7078
ILE C7080
ALA C7056
ASP C6923
1.75A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		6 / 12
LEU A7073
GLY A7076
LEU A7078
ILE A7080
ALA A7056
ASP A6923
1.76A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6900
ALA A6877
GLY A6911
SER A6872
GLY A6869
1.70A14.34
None
None
None
SAM  A7102 ( 4.6A)
SAM  A7102 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 150
GLN A 133
ILE A 151
PHE A 127
LEU A 117
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 172
LEU A 132
ILE A 151
ALA A 135
LEU A 117
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 153
TYR C 154
TYR C  83
GLY C  81
THR C  74
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 172
LEU C 132
ILE C 151
ALA C 135
LEU C 117
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 172
GLN A 133
ILE A 151
ALA A 135
LEU A 117
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 150
GLN C 133
ILE C 151
PHE C 127
LEU C 117
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA B 153
TYR B 154
TYR B  83
GLY B  81
THR B  74
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 113
LEU B 117
ILE B 151
ALA B 139
LEU B 132
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 172
GLN C 133
ILE C 151
ALA C 135
LEU C 117
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 150
GLN B 133
ILE B 151
ALA B 135
LEU B 117
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 150
GLN A 133
ILE A 151
ALA A 135
LEU A 117
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  94
LEU A  42
ILE A  91
ALA A  30
LEU A  69
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7004
LEU A6978
GLN A6956
ILE A6967
PHE A6985
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU C7073
GLY C7076
LEU C7078
ILE C7080
ALA C7056
ASP C6923
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6848
GLN C6804
ILE C7005
ALA C6808
LEU C6855
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6848
GLN A6804
ILE A7005
ALA A6808
LEU A6855
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6900
ALA A6877
GLY A6911
SER A6872
GLY A6871
1.72A
None
None
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6900
ALA A6877
GLY A6911
SER A6872
GLY A6869
1.69A
None
None
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A7073
GLY A7076
LEU A7078
ILE A7080
ALA A7056
ASP A6923
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU C6959
GLY C6963
TYR C7009
ILE C6955
ALA C6966
LEU C6978
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A6959
GLY A6963
TYR A7009
ILE A6955
ALA A6966
LEU A6978
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A7076
LEU A7073
ARG A7077
ILE A7069
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASP D  81
ALA C 173
TYR C 172
GLY C  60
SER D  78
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP A6900
ALA A6877
GLY A6911
SER A6872
GLY A6871
1.71A
None
None
NA  A7102 ( 4.2A)
SFG  A7103 ( 4.5A)
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP A6900
ALA A6877
GLY A6911
SER A6872
GLY A6869
1.69A
None
None
NA  A7102 ( 4.2A)
SFG  A7103 ( 4.5A)
SFG  A7103 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL A6916
ALA A6914
TYR A6950
GLY A6911
THR A6918
1.78A
None
None
None
NA  A7102 ( 4.2A)
FMT  A7108 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A7073
GLY A6962
ILE A7069
ALA A7056
LEU A7060
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU C6959
GLY C6963
TYR C7009
ILE C6955
ALA C6966
LEU C6978
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU A7073
GLY A7076
LEU A7078
ILE A7080
ALA A7056
ASP A6923
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6848
GLN C6804
ILE C7005
ALA C6808
LEU C6855
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6848
GLN A6804
ILE A7005
ALA A6808
LEU A6855
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU A6959
GLY A6963
TYR A7009
ILE A6955
ALA A6966
LEU A6978
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU C7073
GLY C7076
LEU C7078
ILE C7080
ALA C7056
ASP C6923
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY B 165
ILE B  86
ALA B 161
LEU B  73
ASP B 273
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 157
TYR A 325
ILE A  72
ALA A 161
LEU A  73
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 215
GLN A 209
ILE A 253
PHE A 222
ASP A 301
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 165
ILE A  86
ALA A 161
LEU A  73
ASP A 273
1.67A
None
None
None
None
EDO  A 408 (-3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY B 157
TYR B 325
ILE B  72
ALA B 161
LEU B  73
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 215
GLN B 209
ILE B 253
PHE B 222
ASP B 301
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
TYR A 118
GLY A 138
SER A 123
GLY A 124
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A7073
GLY A7076
LEU A7078
ILE A7080
ALA A7056
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
GLY A6963
PHE A6985
ALA A6966
LEU A6978
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6848
GLN A6804
ILE A7005
ALA A6808
LEU A6855
1.66A
None
None
None
None
8NK  A7103 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A6959
GLY A6963
TYR A7009
ILE A6955
ALA A6966
LEU A6978
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A7076
LEU A7073
ARG A7077
ILE A7069
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 126
TYR A 118
GLY A 138
SER A 123
GLY A 124
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 125
LEU A 120
GLN A 122
PHE A 241
ASP A 302
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
TYR A 118
GLY A 138
SER A 123
GLY A 124
1.77A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 171
GLY A 174
SER A 139
ASP A 197
THR A 135
1.75A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
GLY L  16
ILE L 112
ALA L  19
ASP L  88
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 419
TYR A 423
PHE A 429
GLY A 413
ASP A 398
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
ARG L  67
ILE L 112
ALA L  19
ASP L  88
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU C  15
GLY C  16
ILE C 112
ALA C  19
ASP C  88
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLY H 112
GLN H  39
ILE H  20
ALA H  92
LEU H  81
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
ARG L  67
ILE L 112
ALA L  19
ASP L  88
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
GLY L  16
ILE L 112
ALA L  19
ASP L  88
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU C  15
GLY C  16
ILE C 112
ALA C  19
ASP C  88
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
GLY L  16
ILE L 112
ALA L  19
ASP L  88
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU L  15
ARG L  67
ILE L 112
ALA L  19
ASP L  88
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU C  15
ARG C  67
ILE C 112
ALA C  19
ASP C  88
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 126
TYR A 118
GLY A 138
SER A 123
GLY A 124
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP C 145
VAL C  16
PHE C 168
ASP C  14
THR C  13
1.45A
None
None
None
EDO  C 205 (-3.5A)
EDO  C 205 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 164
ILE B 137
PHE B 168
ALA A  52
ASP A  22
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 126
TYR A 118
GLY A 138
SER A 123
GLY A 124
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 437
GLY A 839
LEU A 838
PHE A 843
ASP A 418
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASP A 833
VAL A 880
TYR A 877
GLY A 839
SER A 434
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLY A 179
LEU A 178
GLN A 184
ILE A 244
LEU A 241
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 887
ASP A 418
VAL A 844
GLY A 841
ASP A 846
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL A 424
ALA A 423
TYR A 420
GLY A 432
ASP C   5
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 437
GLY A 839
LEU A 838
PHE A 843
ASP A 421
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLY A 179
GLN A 184
ILE A 244
ALA A 185
LEU A 241
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP8
(SARS-CoV-2)		5 / 12
LEU B 169
GLN B 158
ILE B 172
LEU B 180
ASP B 161
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 207
LEU A 241
ALA A 185
LEU A 212
ASP A 211
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 663
GLN A 661
ILE A 632
ALA A 656
LEU A 636
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 437
GLY A 839
LEU A 838
PHE A 843
ALA A 423
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 437
GLY A 839
LEU A 838
PHE A 843
ALA A 423
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLY A 841
LEU A 862
ILE A 837
PHE A 419
ALA A 863
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ASP A 833
VAL A 880
TYR A 877
GLY A 839
SER A 434
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLY A 841
LEU A 862
ILE A 837
ALA A 863
LEU A 869
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 547
TYR A 546
GLY A 841
SER A 549
ASP A 846
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLY A 179
LEU A 178
GLN A 184
ILE A 244
LEU A 241
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL A 424
ALA A 423
TYR A 420
GLY A 432
ASP C   5
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 405
GLY A 446
PHE A 407
SER A 672
GLY A 670
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 178
GLN A 184
ILE A 244
ALA A 185
LEU A 245
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 437
GLY A 839
LEU A 838
PHE A 843
ASP A 421
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 437
GLY A 839
LEU A 838
PHE A 843
ASP A 418
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 663
GLN A 661
ILE A 632
ALA A 656
LEU A 636
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 841
LEU A 862
PHE A 419
ALA A 863
LEU A 869
1.69A
None
U  P  17 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 862
ILE A 837
PHE A 419
ALA A 863
LEU A 869
1.63A
 U  P  17 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 838
GLY A 839
ARG A 836
TYR A 884
ASP A 865
1.49A
None
None
U  P  18 ( 2.9A)
None
U  P  18 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 838
GLY A 839
ARG A 836
TYR A 884
LEU A 869
1.52A
None
None
U  P  18 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 179
LEU A 178
GLN A 184
ILE A 244
LEU A 241
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL A 424
ALA A 423
TYR A 420
GLY A 432
ASP C   5
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 638
ARG A 640
ALA A 639
LEU A 655
ASP A 304
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 663
GLN A 661
ILE A 632
ALA A 656
LEU A 636
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 178
GLN A 184
ILE A 244
ALA A 185
LEU A 245
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 203
GLN A 224
PHE A 222
ALA A 199
ASP A  92
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
LEU A 131
ILE A 145
LEU A 212
ASP A 126
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 841
LEU A 838
TYR A 887
PHE A 859
ALA A 866
1.67A
None