Ligand ID: PM6


Drugbank ID:
DB01033
(Mercaptopurine)


Indication:
For remission induction and maintenance therapy of acute lymphatic leukemia.

Get human targets for PM6 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'PM6'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
PHE B  56
THR B  67
ALA B  28
ALA B  16
1.47A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
GLY A 104
ALA A 107
LEU A  88
PRO B   6
1.32A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		1ysy REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 7
HIS A  38
LEU A  57
LEU A  15
LEU A  58
1.13A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE B1291
VAL B1297
LEU B1253
PRO B1293
1.41A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.32A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2ajf ACE2
(Homo
sapiens)		4 / 6
PHE A 438
ALA A 413
LEU A 424
PRO A 415
1.33A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2ajf ACE2
(Homo
sapiens)		4 / 8
PHE A 452
GLY A 448
VAL A 447
PRO A 451
1.40A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.47A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.42A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE B 291
VAL B 297
LEU B 253
PRO B 293
1.49A22.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE B 230
LEU B 242
LEU B 250
LEU B 205
1.31A22.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
GLU B 270
PHE B 223
ALA B 267
ALA B 266
1.50A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.46A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 6
PHE H 315
GLY H 317
ALA H 314
LEU G 292
1.42A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 8
ARG E  60
THR F  85
LEU F  13
ALA E  58
1.11A8.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 8
ARG C  60
THR D  85
LEU D  13
ALA C  58
1.14A7.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 8
ARG A  60
THR B  85
LEU B  13
ALA A  58
1.15A8.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.39A22.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A 291
ALA A 210
LEU A 250
PRO A 293
1.54A22.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		4 / 8
THR H 165
LEU L 136
ALA L 176
ALA L 175
1.25A15.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
GLY C 131
ALA C 130
LEU C 161
PRO C 137
1.37A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
HIS C 176
THR C  75
LEU C 133
LEU C 151
1.17A21.08
SO4  C 320 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
PHE U  16
THR X  12
LEU X  14
ALA U  18
1.22A13.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
GLU A  76
THR A  68
ALA A  65
ALA A  65
1.44A10.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 8
GLY D  26
VAL D   2
LEU D   4
ARG D  72
1.39A19.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 6
PHE A 315
GLY A 317
ALA A 314
LEU B 292
1.53A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.29A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
GLU A 270
PHE A 223
ALA A 267
ALA A 266
1.50A10.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 8
ARG A  69
LEU A 114
ALA A 139
ALA A 135
1.23A10.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.31A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
HIS B 246
PHE B 230
LEU B 202
LEU B 205
1.47A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
PHE C 123
THR C 120
ALA C  81
ALA C  80
1.52A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.48A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
PHE B 291
VAL B 297
LEU B 253
PRO B 293
1.47A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 7
PHE B 219
LEU B 208
LEU B 287
LEU B 271
1.32A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.47A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
GLU B 270
PHE B 223
ALA B 267
ALA B 266
1.47A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 6
HIS B 246
PHE B 230
LEU B 202
LEU B 205
1.40A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 8
PHE B 291
VAL B 297
LEU B 253
PRO B 293
1.42A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.46A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
GLY F 253
VAL F 236
LEU F 299
ARG F 198
1.36A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.46A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 7
PHE B 230
LEU B 242
LEU B 250
LEU B 205
1.30A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		2w2g NSP3
(SARSr-CoV)		4 / 8
PHE B 615
GLY A 465
PRO A 460
ARG A 473
1.32A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.44A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE B 230
LEU B 242
LEU B 250
LEU B 205
1.27A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE B 291
VAL B 297
LEU B 253
PRO B 293
1.45A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
THR H  93
PHE H  91
LEU L  36
LEU H  45
1.30A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		3bgf F26G19 FAB
(Mus
musculus)		5 / 8
SER L 174
PHE L 139
THR L 172
ALA L 112
ALA L 111
1.57A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
THR H  93
PHE H  91
LEU L  36
LEU H  45
1.38A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
THR B  31
PHE B  32
GLN B  76
LEU B 100
1.18A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
PHE A 438
ALA A 413
LEU A 424
PRO A 415
1.43A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
PHE A 452
GLY A 448
VAL A 447
PRO A 451
1.36A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLY F 418
LEU F 412
PRO F 413
ARG F 342
1.47A18.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
HIS A 540
THR A 414
GLN A 526
LEU A 539
1.38A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.44A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.44A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.42A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
HIS C 246
PHE C 230
LEU A 202
LEU A 205
1.46A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
PHE B  56
THR B  67
LEU B  69
ALA B  16
1.16A9.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
PHE B  56
THR B  67
ALA B  28
ALA B  16
1.44A9.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.46A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.45A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS B 246
PHE B 230
LEU B 202
LEU B 205
1.48A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3i6g HLA, A-2
(Homo
sapiens)		4 / 8
GLY A 252
VAL A 249
LEU A 201
ARG A 273
1.45A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		3i6k HLA, A-2
(Homo
sapiens)		4 / 8
SER A  11
THR A  94
LEU A  81
ALA A 117
1.23A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS D 246
PHE D 230
LEU B 202
LEU B 205
1.35A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
THR D 201
LEU B 287
LEU B 268
LEU B 272
1.24A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.32A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS B 246
PHE B 230
LEU B 202
LEU B 205
1.41A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
GLU A 270
PHE A 223
ALA A 267
ALA A 266
1.47A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS B 246
PHE B 230
LEU B 202
LEU B 205
1.40A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
HIS B 540
THR B 414
GLN B 526
LEU B 539
1.44A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
PHE A 452
GLY A 448
VAL A 447
PRO A 451
1.30A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
THR B  31
PHE B  32
GLN B  76
LEU B 100
1.10A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
GLU A 270
PHE A 223
ALA A 267
ALA A 266
1.47A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.27A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS A 246
PHE A 230
LEU A 202
LEU A 205
1.43A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		3to2 BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLY A 237
ALA A 236
LEU B  65
PRO A 235
1.45A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.31A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
GLU A 270
PHE A 223
ALA A 267
ALA A 266
1.47A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE B 230
LEU B 242
LEU B 250
LEU B 205
1.32A23.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
HIS B 246
PHE B 230
LEU B 202
LEU B 205
1.48A23.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
PHE B 111
THR B 113
ALA B 270
ALA B 274
1.51A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 8
SER B 507
ARG B 400
PHE B 431
LEU B 439
ALA B 435
1.77A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
PHE D 111
THR D 113
ALA D 270
ALA D 274
1.47A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 8
PHE B   8
GLY B   6
VAL B   4
LEU B  27
ARG N  78
1.57A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 8
SER A 507
ARG A 400
PHE A 431
LEU A 439
ALA A 435
1.67A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		5r81 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 202
PRO A 293
ARG A 298
1.33A21.67
None
None
None
DMS  A1003 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.53A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 230
THR A 201
LEU A 208
ALA A 266
1.80A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.52A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.37A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A 246
GLN A 244
LEU A 242
LEU A 227
1.69A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.40A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.60A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.50A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 268
1.65A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
GLN A 244
LEU A 242
LEU A 262
LEU A 227
1.60A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.36A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
HIS A 246
GLN A 244
LEU A 242
LEU A 227
1.69A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 268
LEU A 272
LEU A 287
1.62A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 202
PRO A 293
ARG A 298
1.40A19.40
None
None
None
DMS  A 402 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 225
LEU A 268
LEU A 242
LEU A 205
1.78A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		4 / 7
GLN C 102
LEU C 100
LEU C 142
LEU C 137
1.08A16.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		4 / 7
GLN C 100
LEU C  98
LEU C 140
LEU C 135
1.22A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
THR A 706
LEU A 927
LEU A 920
LEU A 804
1.09A12.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		4 / 8
SER D  60
LEU E  31
ALA E  43
ALA E  40
1.28A9.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5x4r S PROTEIN
(MERS-CoV)		4 / 6
ARG A 335
THR A  68
ALA A  53
ALA A 336
1.40A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
THR A 247
LEU A 235
ALA A 251
ALA A 250
1.17A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
GLU A 801
THR A 773
ALA A 853
ALA A 854
1.35A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
PHE C  62
GLY C  39
LEU C 257
ARG C 620
1.28A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
GLU B 755
LEU B 994
ALA B 997
ALA B 998
1.25A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
GLY B 653
ALA B 654
LEU C 843
PRO C 844
1.42A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
GLU A 801
THR A 773
ALA A 853
ALA A 854
1.53A20.89
GLU  A 801 ( 0.5A)
THR  A 773 ( 0.8A)
ALA  A 853 ( 0.0A)
ALA  A 854 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PHE A 451
GLY C 192
LEU C 224
PRO C 223
1.47A12.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ARG C 183
PHE C  89
LEU C 235
ALA C 233
1.16A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6acg ACE2
(Homo
sapiens)		4 / 7
HIS D 540
THR D 414
GLN D 526
LEU D 539
1.18A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
THR C 743
PHE C 741
GLN A 947
LEU C 736
1.26A12.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6acg ACE2
(Homo
sapiens)		4 / 6
HIS D 540
THR D 414
GLN D 526
LEU D 539
1.14A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
THR C 743
PHE C 741
GLN A 947
LEU C 736
1.38A12.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
PHE A 870
THR A 865
ALA A 874
ALA A 875
1.22A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
PHE C  69
GLY C  77
ALA C  27
PRO C  28
1.31A12.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
THR B 247
LEU B 235
ALA B 251
ALA B 250
1.20A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
GLY C 653
ALA C 654
LEU A 843
PRO A 844
1.54A12.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
GLU B  93
PHE B 238
ALA B 250
ALA B 249
1.29A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
THR B 706
LEU B 927
LEU B 920
LEU B 804
1.02A12.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
SER B 173
PHE B 238
ALA B 250
ALA B 249
1.03A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
PHE C 451
ARG C 453
GLY A 225
PRO A 223
1.16A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
THR C 706
LEU C 927
LEU C 920
LEU C 804
1.03A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
THR C 706
GLN C1036
LEU C 927
LEU C 804
1.32A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
PHE C 451
ARG C 453
GLY A 225
PRO A 223
1.16A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6cs2 ACE2
(Homo
sapiens)		4 / 6
PHE D 438
ALA D 413
LEU D 424
PRO D 415
1.16A16.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6cs2 ACE2
(Homo
sapiens)		4 / 8
PHE D 452
GLY D 448
VAL D 447
PRO D 451
1.40A16.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
GLU C1054
THR A 865
ALA A 874
ALA A 875
1.21A21.56
NAG  C1320 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6cs2 ACE2
(Homo
sapiens)		4 / 6
HIS D 540
THR D 414
GLN D 526
LEU D 539
1.47A16.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLY A 237
ALA A 236
LEU B  65
PRO A 235
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLN A 155
LEU A 156
LEU C   8
LEU C   5
1.12A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6jyt HELICASE
(SARSr-CoV)		4 / 8
SER B 424
THR B 239
ALA B 134
ALA B 135
0.98A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6jyt HELICASE
(SARSr-CoV)		4 / 6
GLU A 375
ARG A 178
ALA A 313
ALA A 312
1.19A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.53A17.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.66A17.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.41A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.46A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.39A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 181
VAL A  86
LEU A 177
ARG A 105
1.75A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.55A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.66A17.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.38A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.52A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0j ACE2
(Homo
sapiens)		4 / 6
PHE A 438
ALA A 413
LEU A 424
PRO A 415
1.32A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0j ACE2
(Homo
sapiens)		4 / 8
PHE A 452
GLY A 448
VAL A 447
PRO A 451
1.38A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.68A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.51A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.40A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.39A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.47A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.54A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.38A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.54A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		4 / 8
GLY E 431
VAL E 382
LEU E 387
PRO E 384
1.32A18.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
SER C 314
PHE C  58
LEU C  78
ALA C 271
1.27A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m18 ACE2
(Homo
sapiens)		4 / 8
PHE D 452
GLY D 448
VAL D 447
PRO D 451
1.46A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m18 ACE2
(Homo
sapiens)		4 / 6
PHE B 438
ALA B 413
LEU B 424
PRO B 415
1.39A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
PHE C 327
GLY C 246
ALA C 247
LEU C 389
1.37A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
PHE C 283
GLY C 285
VAL C 441
PRO C 442
1.40A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.30A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.37A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE C 291
THR C 292
ALA C 210
ALA C 206
1.66A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR D 199
LEU D 272
LEU D 287
LEU D 268
1.43A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR B 201
LEU B 287
LEU B 268
LEU B 272
1.46A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.53A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER C 284
LEU C 208
ALA C 210
ALA C 211
1.56A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.43A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE D 230
LEU D 242
LEU D 250
LEU D 205
1.37A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE B 219
LEU B 208
LEU B 287
LEU B 271
1.37A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE D 291
THR D 292
ALA D 210
ALA D 206
1.67A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE D 291
THR D 292
ALA D 210
ALA D 206
1.67A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
PHE C 305
GLY A 124
VAL A 125
LEU A 115
PRO C   9
1.78A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR D 201
LEU D 287
LEU D 268
LEU D 272
1.52A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE B 291
VAL B 297
LEU B 253
PRO B 293
1.50A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE D 305
GLY B 124
ALA D   7
LEU B 115
1.61A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
PHE D 305
GLY B 124
VAL B 125
LEU B 115
PRO D   9
1.74A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
HIS C 246
GLN C 244
LEU C 242
LEU C 227
1.76A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE C 291
VAL C 297
LEU C 253
PRO C 293
1.53A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE D 219
LEU D 208
LEU D 287
LEU D 271
1.40A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.44A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE C 230
LEU C 242
LEU C 250
LEU C 205
1.32A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE B 230
LEU B 242
LEU B 250
LEU B 205
1.32A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR B 199
LEU B 272
LEU B 287
LEU B 268
1.40A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR C 201
LEU C 287
LEU C 268
LEU C 272
1.45A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR C 199
LEU C 272
LEU C 287
LEU C 268
1.44A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE C 219
LEU C 208
LEU C 287
LEU C 271
1.39A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE C 291
THR C 292
ALA C 210
ALA C 206
1.65A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE D 291
VAL D 297
LEU D 253
PRO D 293
1.58A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.53A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 181
VAL A  86
LEU A 177
ARG A 105
1.79A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.58A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.39A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.64A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.40A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.45A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.38A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
GLY A 215
VAL A 212
LEU A 220
ARG A 279
1.66A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.64A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.54A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
PHE A 442
VAL A 410
LEU A 544
ARG A 553
1.50A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 8
PHE A 442
VAL C  11
LEU C  14
PRO A 412
1.70A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG A 331
GLY B 113
ALA B 110
LEU A 329
1.45A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLY A 590
VAL A 588
LEU A 758
TRP A 598
1.76A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP7
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  55
LEU C  14
LEU C  17
1.38A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 701
GLN A 698
LEU A 469
LEU A 630
1.46A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 8
THR A 141
LEU A 127
ALA A 125
ALA A  34
1.49A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 8
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.40A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.76A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
GLY A 385
ALA A 383
LEU A 387
PRO B 121
1.49A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 189
GLN A 210
LEU A 207
LEU A 241
1.48A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 8
THR A 206
LEU A 240
ALA A  34
ALA A 125
1.43A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 248
LEU A 142
LEU A 127
LEU A 131
1.43A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
THR A 701
GLN A 698
LEU A 469
LEU A 630
1.41A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 6
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.40A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.74A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 692
ARG A 631
LEU A 576
ALA A 685
1.69A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP7
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  13
LEU C  14
LEU C  17
1.48A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 701
LEU A 708
LEU A 731
LEU A 727
1.21A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE C  49
LEU D  98
LEU D  95
LEU D 103
1.43A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6m71 NSP12
(SARS-CoV-2)		4 / 8
THR A 680
LEU A 663
ALA A 634
ALA A 690
1.31A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
PHE A  45
GLY A  44
LEU A 731
ARG A 132
1.60A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
THR B 706
GLN B1036
LEU B 927
LEU B 804
1.47A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
GLU A1054
THR C 865
ALA C 874
ALA C 875
1.31A21.09
NAG  A1336 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
THR A 631
LEU A 597
ALA A 658
ALA A 676
1.29A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
THR B 706
LEU B 927
LEU B 920
LEU B 804
1.12A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 8
SER L 179
PHE L 144
THR L 177
ALA L 117
ALA L 116
1.64A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6nur NSP12
(SARSr-CoV)		4 / 7
THR A 701
LEU A 708
LEU A 731
LEU A 727
1.20A13.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6nur NSP7
NSP8
(SARSr-CoV)		4 / 7
GLN D  88
LEU C  13
LEU C  56
LEU C  59
1.21A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6nur NSP12
NSP8
(SARSr-CoV)		4 / 6
ARG A 331
GLY B 113
ALA B 110
LEU A 329
1.48A13.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6nus NSP12
(SARSr-CoV)		4 / 6
GLU A 180
THR A 248
ALA A 253
ALA A 252
1.25A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6nus NSP12
(SARSr-CoV)		4 / 8
GLU A 180
THR A 248
ALA A 253
ALA A 252
1.25A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLU A 773
LEU A1012
ALA A1015
ALA A1016
1.26A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY B 431
VAL B 382
LEU B 387
PRO B 384
1.26A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
THR C 724
LEU C 945
LEU C 938
LEU C 822
1.20A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE C1109
ALA C1070
LEU A 894
PRO C1069
1.40A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
HIS A1088
THR A1120
PHE A1121
GLN B 913
1.39A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vw1 ACE2
(Homo
sapiens)		4 / 6
HIS A 540
THR A 414
GLN A 526
LEU A 539
1.37A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vxs NSP3
(SARS-CoV-2)		4 / 6
GLY A 130
ALA A 134
LEU A 160
PRO A 136
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE B 132
THR A  71
ALA B  38
ALA B  39
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vxs NSP3
(SARS-CoV-2)		4 / 6
PHE A 156
ALA A 154
LEU A 126
PRO A 125
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vxs NSP3
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 160
PRO B 136
1.67A
None
None
SO4  B 204 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE C1109
ALA C1070
LEU A 894
PRO C1069
1.32A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
THR C 724
LEU C 945
LEU C 938
LEU C 822
1.15A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLU C 773
LEU C1012
ALA C1015
ALA C1016
1.16A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY B 431
VAL B 382
LEU B 387
PRO B 384
1.40A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
THR A 883
PHE A 898
GLN A 901
LEU A 878
1.42A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE B1109
ALA B1070
LEU C 894
PRO B1069
1.31A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLU A1072
THR B 883
ALA B 892
ALA B 893
1.25A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
THR C 724
LEU C 945
LEU C 938
LEU C 822
1.14A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
GLU A1072
THR B 883
ALA B 892
ALA B 893
1.22A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
PHE C 135
GLN C 239
LEU C 141
LEU C 241
1.25A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
THR C 430
PHE C 515
LEU C 390
LEU C 387
1.69A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ARG L 108
THR L 172
ALA L 112
ALA L 111
1.77A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
GLY C 431
VAL C 382
LEU C 387
PRO C 384
1.26A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 8
SER L 174
PHE L 139
THR L 172
ALA L 112
ALA L 111
1.64A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
ARG L 108
THR L 172
ALA L 112
ALA L 111
1.77A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
GLU C 516
SER C 359
THR C 523
ALA C 520
1.62A11.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
SER H  96
THR H 100
LEU L  46
ALA H  93
1.59A13.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
GLY C 381
VAL C 382
LEU C 387
PRO C 384
1.56A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
PHE L 139
THR L 172
ALA L 112
ALA L 111
1.77A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
SER L  25
THR L  69
LEU L  27
ALA L  51
1.65A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 6
THR C 430
PHE C 515
LEU C 390
LEU C 387
1.76A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
GLY C 431
LEU C 425
PRO C 426
ARG C 355
1.69A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w4b NSP9
(SARS-CoV-2)		4 / 7
THR A  35
PHE A  41
LEU A  43
LEU A  10
1.24A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w4b NSP9
(SARS-CoV-2)		4 / 6
PHE A  57
THR A  68
ALA A  29
ALA A  17
1.34A10.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6989
PHE A6991
LEU A6848
LEU A6852
1.69A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
THR A6908
LEU A6893
ALA A6881
ALA A6877
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w61 NSP10
(SARS-CoV-2)		4 / 8
PHE B4321
GLY B4322
LEU B4345
TRP B4376
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6964
PHE A6985
LEU A6855
ALA A6986
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6903
PHE A6901
THR A6908
LEU A6893
1.78A12.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.45A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.38A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.43A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 181
VAL A  86
LEU A 177
ARG A 105
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.33A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 7
PHE A 168
LEU A  12
LEU A 164
LEU A 140
1.59A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
GLY A 130
ALA A 134
LEU A 160
PRO A 136
1.60A
AMP  A 201 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w6y NSP3
(SARS-CoV-2)		4 / 8
PHE B 116
THR B 146
LEU B 109
ALA B 112
1.71A12.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 7
HIS A  94
GLN A  62
LEU A  43
LEU A  83
1.77A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 160
PRO B 136
1.71A
MES  B 201 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w6y NSP3
(SARS-CoV-2)		4 / 8
PHE A 116
THR A 146
LEU A 109
ALA A 112
1.73A12.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 7
THR B 146
PHE B 116
LEU B 127
LEU B 109
1.69A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B 104
SER B 128
PHE B 132
LEU B 108
1.79A12.57
None
MES  B 201 ( 4.5A)
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w6y NSP3
(SARS-CoV-2)		4 / 8
PHE B 132
LEU B  43
ALA B  50
ALA B  38
1.72A12.57
MES  B 201 ( 3.4A)
None
MES  B 201 ( 3.7A)
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 7
THR A 146
PHE A 116
LEU A 127
LEU A 109
1.68A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w6y NSP3
(SARS-CoV-2)		4 / 8
PHE A 132
LEU A  43
ALA A  50
ALA A  38
1.76A12.57
AMP  A 201 ( 4.3A)
None
None
AMP  A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 7
HIS B  94
GLN B  62
LEU B  43
LEU B  83
1.77A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE B 156
ALA B 154
LEU B 126
PRO B 125
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C6903
PHE C6901
THR C6908
LEU C6893
1.77A12.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w75 NSP16
(SARS-CoV-2)		4 / 8
THR C6908
LEU C6893
ALA C6881
ALA C6877
1.56A12.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
GLY B4288
ALA D4271
LEU B4284
PRO B4290
1.80A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR C6989
PHE C6991
LEU C6848
LEU C6852
1.70A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w75 NSP16
(SARS-CoV-2)		4 / 8
THR A6908
LEU A6893
ALA A6881
ALA A6877
1.56A12.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6903
PHE A6901
THR A6908
LEU A6893
1.79A12.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C6964
PHE C6985
LEU C6855
ALA C6986
1.64A12.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR A6989
PHE A6991
LEU A6848
LEU A6852
1.69A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w75 NSP10
(SARS-CoV-2)		4 / 8
PHE D4321
GLY D4322
LEU D4345
TRP D4376
1.66A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
GLN C6847
LEU C6834
LEU D4298
LEU C7042
1.79A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6964
PHE A6985
LEU A6855
ALA A6986
1.68A12.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w75 NSP10
(SARS-CoV-2)		4 / 8
PHE B4321
GLY B4322
LEU B4345
TRP B4376
1.66A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR C6949
GLN C6956
LEU C6978
LEU C6981
1.76A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
THR A 102
LEU A 120
ALA A 135
ALA A 139
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
THR A 158
LEU A 113
ALA A 149
ALA A  86
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
HIS B 275
THR B 277
LEU B 118
LEU B 101
1.76A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
HIS B 175
THR B  74
LEU B 132
LEU B 150
1.32A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
HIS A 275
THR A 277
LEU A 118
LEU A 101
1.71A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
THR B 158
LEU B 113
ALA B 149
ALA B  86
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
PHE C  79
VAL C  57
LEU C  64
PRO C  59
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 6
PHE A  56
THR A  67
ALA A  28
ALA A  16
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
PHE A  56
THR A  67
LEU A  69
ALA A  16
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
GLN A  11
LEU A   9
LEU A 106
LEU A  -8
1.50A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 6
ARG A  55
THR A  24
ALA A  28
ALA A  15
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wen NSP3
(SARS-CoV-2)		4 / 7
PHE A 168
LEU A  12
LEU A 164
LEU A 140
1.49A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wey NSP3
(SARS-CoV-2)		4 / 8
PHE A 320
THR A 350
LEU A 313
ALA A 316
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wey NSP3
(SARS-CoV-2)		4 / 6
PHE A 360
ALA A 358
LEU A 330
PRO A 329
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE A  49
LEU B  98
LEU B  95
LEU B 103
1.43A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE C 346
GLN C 349
LEU D 331
LEU C 353
1.67A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE D 314
GLY D 316
VAL C 270
LEU C 291
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE A 314
GLY A 316
ALA A 313
LEU B 291
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE F 314
GLY F 316
ALA F 313
LEU E 291
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE E 314
GLY E 316
VAL F 270
LEU F 291
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE E 314
GLY E 316
ALA E 313
LEU F 291
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE F 314
GLY F 316
VAL E 270
LEU E 291
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE B 314
GLY B 316
ALA B 313
LEU A 291
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE C 314
GLY C 316
ALA C 313
LEU D 291
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE D 346
GLN D 349
LEU C 331
LEU D 353
1.71A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE F 346
GLN F 349
LEU E 331
LEU F 353
1.77A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE B 314
GLY B 316
VAL A 270
LEU A 291
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE C 314
GLY C 316
VAL D 270
LEU D 291
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
PHE A 314
GLY A 316
VAL B 270
LEU B 291
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE D 314
GLY D 316
ALA D 313
LEU C 291
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wjt NSP10
(SARS-CoV-2)		4 / 8
PHE D4272
LEU B4365
ALA B4276
ALA B4279
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
THR C6908
LEU C6893
ALA C6881
ALA C6877
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wjt NSP10
(SARS-CoV-2)		4 / 8
PHE B4321
GLY B4322
LEU B4345
TRP B4376
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER C6964
PHE C6985
LEU C6855
ALA C6986
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wjt NSP10
(SARS-CoV-2)		4 / 8
PHE D4321
GLY D4322
LEU D4345
TRP D4376
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6964
PHE A6985
LEU A6855
ALA A6986
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
THR A6908
LEU A6893
ALA A6881
ALA A6877
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A6964
PHE A6985
LEU A6855
ALA A6986
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wkq NSP10
(SARS-CoV-2)		4 / 8
PHE D4321
GLY D4322
LEU D4345
TRP D4376
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wkq NSP10
(SARS-CoV-2)		4 / 8
PHE B4321
GLY B4322
LEU B4345
TRP B4376
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wkq NSP16
(SARS-CoV-2)		4 / 8
THR A6908
LEU A6893
ALA A6881
ALA A6877
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER C6964
PHE C6985
LEU C6855
ALA C6986
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wkq NSP16
(SARS-CoV-2)		4 / 8
THR C6908
LEU C6893
ALA C6881
ALA C6877
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
GLY A 254
VAL A 237
LEU A 300
ARG A 199
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
PHE B 124
THR B 121
ALA B  82
ALA B  81
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
GLY B 254
VAL B 237
LEU B 300
ARG B 199
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
GLY B 170
VAL B 173
LEU B 163
PRO B  66
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
GLY A 170
VAL A 173
LEU A 163
PRO A  66
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PHE B 124
THR B 121
ALA B  82
ALA B  81
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PHE A 124
THR A 121
ALA A  82
ALA A  81
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.48A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.32A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.53A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.34A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
HIS A 246
GLN A 244
LEU A 242
LEU A 227
1.75A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.40A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
GLY D 130
ALA D 134
LEU D 160
PRO D 136
1.62A
APR  D 201 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
GLY D 130
ALA D 134
LEU D 126
PRO D 136
1.79A
APR  D 201 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE C 132
LEU C  43
ALA C  50
ALA C  38
1.70A
APR  C 201 (-3.5A)
None
APR  C 201 (-3.5A)
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
GLY C 130
ALA C 134
LEU C 126
PRO C 136
1.73A
APR  C 201 (-3.0A)
None
APR  C 201 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE B 132
LEU B  43
ALA B  50
ALA B  38
1.70A
APR  B 201 (-3.6A)
None
APR  B 201 (-3.3A)
APR  B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
GLY C 130
ALA C 134
LEU C 160
PRO C 136
1.67A
APR  C 201 (-3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 132
LEU A  43
ALA A  50
ALA A  38
1.69A
APR  A 201 (-3.1A)
None
APR  A 201 (-3.4A)
APR  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 116
THR A 146
LEU A 109
ALA A 112
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 126
PRO B 136
1.75A
APR  B 201 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 160
PRO B 136
1.62A
APR  B 201 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
GLY A 130
ALA A 134
LEU A 160
PRO A 136
1.65A
APR  A 201 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wq3 NSP10
(SARS-CoV-2)		4 / 8
PHE B4321
GLY B4322
LEU B4345
TRP B4376
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6964
PHE A6985
LEU A6855
ALA A6986
1.65A
None
None
8NK  A7103 (-3.6A)
8NK  A7103 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
THR A6908
LEU A6893
ALA A6881
ALA A6877
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
SER C  57
LEU D 122
ALA D 150
ALA D 102
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE C  49
LEU D  98
LEU D  95
LEU D 103
1.42A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqd NSP7
(SARS-CoV-2)		4 / 7
HIS A  36
LEU A  55
LEU A  14
LEU A  17
1.47A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
SER A  57
LEU B 122
ALA B 150
ALA B 102
1.68A
None
None
EDO  B 302 (-3.7A)
EDO  B 302 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE A  49
LEU B  98
LEU B  95
LEU B 103
1.46A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqd NSP7
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  55
LEU C  14
LEU C  17
1.51A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wqd NSP7
(SARS-CoV-2)		4 / 8
SER A   4
LEU A  40
ALA A  48
ALA A  42
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.53A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.38A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.50A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.48A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.45A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
HIS A 275
THR A 277
LEU A 118
LEU A 101
1.76A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
PHE A  79
VAL A  57
LEU A  64
PRO A  59
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6xez NSP12
NSP8
(SARS-CoV-2)		4 / 6
GLY A 385
ALA A 383
LEU A 387
PRO B 121
1.39A14.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.32A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.37A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 202
PRO A 293
ARG A 298
1.41A18.80
None
None
None
DMS  A 403 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 230
THR A 201
LEU A 208
ALA A 266
1.76A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLN A 244
LEU A 242
LEU A 262
LEU A 227
1.60A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 268
1.65A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.40A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.50A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.38A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 225
LEU A 268
LEU A 242
LEU A 205
1.79A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 268
LEU A 272
LEU A 287
1.60A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
HIS A 246
GLN A 244
LEU A 242
LEU A 227
1.66A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A 246
GLN A 244
LEU A 242
LEU A 227
1.66A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.50A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.61A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
GLN B  88
LEU A  13
LEU A  56
LEU A  59
1.42A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  55
LEU C  14
LEU C  17
1.47A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
GLU A  50
SER A  57
LEU B 103
ALA B 150
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE A  49
LEU B  98
LEU B  95
LEU B 103
1.50A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE C  49
LEU D  98
LEU D  95
LEU D 103
1.49A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
SER C  57
LEU D 122
ALA D 150
ALA D 102
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
HIS A  36
LEU A  55
LEU A  14
LEU A  17
1.49A17.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY A 431
LEU A 425
PRO A 426
ARG A 355
1.76A
None
None
None
PG0  A 902 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
PHE L 145
THR L 178
ALA L 118
ALA L 117
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
PHE C 145
THR C 178
ALA C 118
ALA C 117
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
ARG C 114
THR C 178
ALA C 118
ALA C 117
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 8
SER L 180
PHE L 145
THR L 178
ALA L 118
ALA L 117
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY E 431
VAL E 382
LEU E 387
PRO E 384
1.16A
None
DMS  L1601 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLU E 516
SER E 359
THR E 523
ALA E 520
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
GLY H  99
VAL H 108
LEU H   4
TRP H  36
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY A 431
VAL A 382
LEU A 387
PRO A 384
1.21A
None
DMS  A 905 (-4.3A)
DMS  A 905 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER A 383
THR B 104
LEU C  52
ALA B  97
1.68A
DMS  A 905 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 8
SER C 180
PHE C 145
THR C 178
ALA C 118
ALA C 117
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
ARG L 114
THR L 178
ALA L 118
ALA L 117
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ym0 HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER E 383
THR H 104
LEU L  52
ALA H  97
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 8
SER L 180
PHE L 145
THR L 178
ALA L 118
ALA L 117
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
ARG L 114
THR L 178
ALA L 118
ALA L 117
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
PHE L 145
THR L 178
ALA L 118
ALA L 117
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
ARG L 114
THR L 178
ALA L 118
ALA L 117
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 8
GLY H  99
VAL H 108
LEU H   4
TRP H  36
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
HIS A 246
GLN A 244
LEU A 242
LEU A 227
1.70A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.51A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.46A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.43A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.37A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.41A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLU E 516
SER E 359
THR E 523
ALA E 520
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 8
SER C 180
PHE C 145
THR C 178
ALA C 118
ALA C 117
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
PHE L 145
THR L 178
ALA L 118
ALA L 117
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY E 431
VAL E 382
LEU E 387
PRO E 384
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
ARG L 114
THR L 178
ALA L 118
ALA L 117
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
ARG C 114
THR C 178
ALA C 118
ALA C 117
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
GLY B  99
VAL B 108
LEU B   4
TRP B  36
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
PHE C 145
THR C 178
ALA C 118
ALA C 117
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
GLY H  99
VAL H 108
LEU H   4
TRP H  36
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY A 431
VAL A 382
LEU A 387
PRO A 384
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 8
SER L 180
PHE L 145
THR L 178
ALA L 118
ALA L 117
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.40A21.67
PEG  A 404 (-3.0A)
PEG  A 404 (-3.4A)
PEG  A 404 (-2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ARG A 217
GLY A 215
VAL A 212
LEU A 220
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.62A
 CL  A 406 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.53A
 CL  A 406 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.48A21.67
None
PEG  A 404 (-2.9A)
None
PEG  A 404 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.39A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.36A21.67
None
None
PEG  A 404 (-2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
HIS A 246
GLN A 244
LEU A 242
LEU A 227
1.67A21.67
PEG  A 405 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.62A
 CL  A 406 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE D 132
LEU D  43
ALA D  50
ALA D  38
1.68A
EDO  D 205 ( 3.6A)
None
EDO  D 206 (-3.6A)
EDO  D 205 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 156
ALA E 154
LEU E 126
PRO E 125
1.77A
None
EDO  E 205 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 160
PRO B 136
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE C 132
LEU C 109
ALA C 129
ALA C 134
1.64A
None
None
None
EDO  C 208 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY D 130
ALA D 134
LEU D 160
PRO D 136
1.66A
EDO  D 205 ( 4.9A)
EDO  D 211 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY A 130
ALA A 134
LEU A 160
PRO A 136
1.71A
EDO  A 202 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 156
ALA A 154
LEU A 126
PRO A 125
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE B 132
LEU B 109
ALA B 129
ALA B 134
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 156
ALA C 154
LEU C 126
PRO C 125
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY E 130
ALA E 134
LEU E 160
PRO E 136
1.67A
EPE  E 202 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE E 132
LEU E  43
ALA E  50
ALA E  38
1.71A
EPE  E 202 (-3.2A)
None
EPE  E 202 (-3.1A)
EPE  E 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 156
ALA B 154
LEU B 126
PRO B 125
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY C 130
ALA C 134
LEU C 160
PRO C 136
1.67A
None
EDO  C 208 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE A 116
THR A 146
LEU A 109
ALA A 112
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 156
ALA D 154
LEU D 126
PRO D 125
1.72A
EDO  D 209 ( 3.6A)
EDO  D 208 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY C 130
ALA C 134
LEU C 126
PRO C 136
1.76A
APR  C 201 (-3.2A)
None
APR  C 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY C 130
ALA C 134
LEU C 160
PRO C 136
1.62A
APR  C 201 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 156
ALA C 154
LEU C 126
PRO C 125
1.74A
APR  C 201 (-4.9A)
APR  C 201 (-4.5A)
APR  C 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE E 156
ALA E 154
LEU E 126
PRO E 125
1.79A
None
APR  E 201 (-4.5A)
APR  E 201 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY E 130
ALA E 134
LEU E 160
PRO E 136
1.70A
APR  E 201 (-3.2A)
None
None
EDO  B 202 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PHE B 168
LEU B  12
LEU B 164
LEU B 140
1.53A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY D 130
ALA D 134
LEU D 126
PRO D 136
1.73A
APR  D 201 (-3.2A)
None
APR  D 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY D 130
ALA D 134
LEU D 160
PRO D 136
1.64A
APR  D 201 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY A 130
ALA A 134
LEU A 126
PRO A 136
1.77A
APR  A 201 ( 3.2A)
EDO  A 204 ( 3.9A)
APR  A 201 (-4.8A)
EDO  A 205 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 156
ALA A 154
LEU A 126
PRO A 125
1.78A
None
APR  A 201 (-4.4A)
APR  A 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE B 132
LEU B  43
ALA B  50
ALA B  38
1.68A
APR  B 201 (-3.5A)
None
APR  B 201 (-3.5A)
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY E 130
ALA E 134
LEU E 126
PRO E 136
1.76A
APR  E 201 (-3.2A)
None
APR  E 201 (-4.7A)
EDO  B 202 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 156
ALA B 154
LEU B 126
PRO B 125
1.77A
None
APR  B 201 (-4.5A)
APR  B 201 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE D 132
LEU D  43
ALA D  50
ALA D  38
1.70A
APR  D 201 (-3.3A)
None
APR  D 201 (-3.6A)
APR  D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY A 130
ALA A 134
LEU A 160
PRO A 136
1.64A
APR  A 201 ( 3.2A)
EDO  A 204 ( 3.9A)
None
EDO  A 205 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 160
PRO B 136
1.63A
APR  B 201 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 126
PRO B 136
1.74A
APR  B 201 (-3.2A)
None
APR  B 201 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 156
ALA D 154
LEU D 126
PRO D 125
1.77A
EDO  D 204 (-3.9A)
APR  D 201 (-4.5A)
APR  D 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY C 130
ALA C 134
LEU C 160
PRO C 136
1.72A
MES  C 201 (-3.3A)
None
EDO  C 203 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 156
ALA A 154
LEU A 126
PRO A 125
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY B 130
ALA B 134
LEU B 160
PRO B 136
1.66A
None
EDO  B 204 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
GLY A 130
ALA A 134
LEU A 160
PRO A 136
1.74A
MES  A 201 (-3.1A)
EDO  A 205 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PHE C 168
LEU C  12
LEU C 164
LEU C 140
1.53A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE A 116
THR A 146
LEU A 109
ALA A 112
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PHE B 116
THR B 146
LEU B 109
ALA B 112
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE B 156
ALA B 154
LEU B 126
PRO B 125
1.76A
None
EDO  B 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.37A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.34A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.34A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.47A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLY A  13
VAL A  11
LEU A   8
ARG A  18
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLY A 203
VAL A 233
LEU A 205
PRO A 232
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
THR A 701
GLN A 698
LEU A 469
LEU A 630
1.41A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP7
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  55
LEU C  14
LEU C  17
1.41A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
PHE A  45
GLY A  44
LEU A 731
ARG A 132
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 8
GLU C  50
SER C  54
LEU D 103
ALA D 150
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLY A 616
VAL A 763
LEU A 614
PRO A 809
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 8
ARG A  33
THR A 123
LEU A 127
ALA A 130
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 8
THR A 141
LEU A 127
ALA A 125
ALA A  34
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 8
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG A 331
GLY B 113
ALA B 110
LEU A 329
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
ARG A 331
GLY B 113
VAL B 115
LEU A 329
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
THR B 124
LEU B  98
ALA A 379
ALA A 382
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLY A 590
VAL A 588
LEU A 758
TRP A 598
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 518
ARG A 513
ALA A 502
ALA A 512
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE C  49
LEU D  98
LEU D  95
LEU D 103
1.43A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
THR A 701
LEU A 708
LEU A 731
LEU A 727
1.28A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 8
THR A 206
LEU A 240
ALA A  34
ALA A 125
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7btf NSP12
(SARS-CoV-2)		4 / 8
THR A 680
LEU A 663
ALA A 634
ALA A 690
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 8
PHE A 442
VAL C  11
LEU C  14
PRO A 412
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLY A 203
VAL A 204
LEU A 205
PRO A 232
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
THR A 248
LEU A 142
LEU A 127
LEU A 131
1.49A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
GLY A 385
ALA A 383
LEU A 387
PRO B 121
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
PHE A 442
VAL A 410
LEU A 544
ARG A 553
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A 199
LEU A 272
LEU A 287
LEU A 268
1.41A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 219
LEU A 208
LEU A 287
LEU A 271
1.40A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A 201
LEU A 287
LEU A 268
LEU A 272
1.47A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
PHE A 291
VAL A 297
LEU A 253
PRO A 293
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
SER A 284
LEU A 208
ALA A 210
ALA A 211
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PHE A 291
THR A 292
ALA A 210
ALA A 206
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
HIS A 246
LEU A 250
LEU A 242
LEU A 205
1.52A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 242
LEU A 250
LEU A 205
1.36A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG A 331
GLY B 113
ALA B 110
LEU A 329
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
PHE A  45
GLY A  44
LEU A 731
ARG A 132
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
HIS A 752
THR A 769
GLN A 773
LEU A 775
1.72A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
GLY A 203
VAL A 233
LEU A 205
PRO A 232
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
THR A 701
LEU A 708
LEU A 731
LEU A 727
1.26A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP7
(SARS-CoV-2)		4 / 8
SER C   4
LEU C  40
ALA C  48
ALA C  42
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE C  49
LEU D  98
LEU D  95
LEU D 103
1.42A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP7
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  13
LEU C  14
LEU C  17
1.41A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP7
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  55
LEU C  14
LEU C  17
1.31A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 8
SER C  54
LEU D 128
ALA D 125
ALA D 126
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
THR A 680
LEU A 663
ALA A 634
ALA A 690
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
THR A 701
GLN A 698
LEU A 469
LEU A 630
1.45A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
GLY A 385
ALA A 383
LEU A 387
PRO B 121
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
GLY A 590
VAL A 588
LEU A 758
TRP A 598
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
GLY A 203
VAL A 204
LEU A 205
PRO A 232
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ARG B 190
THR B 123
LEU A 270
ALA B 150
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
THR B 187
LEU B 128
ALA B 125
ALA B 126
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
THR A 141
LEU A 127
ALA A 125
ALA A  34
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ARG A 331
GLY B 113
VAL B 115
LEU A 329
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
THR A 206
LEU A 240
ALA A  34
ALA A 125
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.38A
None
F86  P 102 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG A 331
GLY B 113
ALA B 110
LEU A 329
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
THR A 680
LEU A 663
ALA A 634
ALA A 690
1.26A
F86  P 102 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP7
(SARS-CoV-2)		4 / 7
GLN C  63
LEU C  59
LEU C  56
LEU C  60
1.45A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
THR A 206
LEU A 240
ALA A  46
ALA A  34
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
GLY A 385
ALA A 383
LEU A 387
PRO B 121
1.45A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
SER A 564
THR A 538
ALA A 660
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
THR A 141
LEU A 127
ALA A 125
ALA A  34
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
PHE A  45
GLY A  44
LEU A 731
ARG A 132
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLY A 590
VAL A 588
LEU A 758
TRP A 598
1.64A
 A  T  13 ( 3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
THR A 701
GLN A 698
LEU A 469
LEU A 630
1.38A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP8
(SARS-CoV-2)		4 / 8
THR B 187
LEU B 128
ALA B 125
ALA B 126
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
THR A 701
GLN A 698
LEU A 469
LEU A 630
1.40A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 694
THR A 680
ALA A 634
ALA A 690
1.38A
None
F86  P 102 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
THR A 701
LEU A 708
LEU A 731
LEU A 727
1.23A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ARG A 331
GLY B 113
VAL B 115
LEU A 329
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
THR A 189
GLN A 210
LEU A 207
LEU A 241
1.46A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
THR B 124
LEU B  98
ALA A 379
ALA A 382
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP7
(SARS-CoV-2)		4 / 7
HIS C  36
LEU C  55
LEU C  14
LEU C  17
1.45A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ARG A 858
PHE A 859
LEU A 838
ALA A 840
1.66A
 U  P  17 ( 3.2A)
None
None
U  P  18 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
THR A 206
LEU A 240
ALA A  34
ALA A 125
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
PHE A 326
GLY A 327
LEU B 117
PRO B 116
1.71A
None