Ligand ID: NOV


Drugbank ID:
DB01051
(Novobiocin)


Indication:
For the treatment of infections due to staphylococci and other susceptible organisms

Get human targets for NOV in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'NOV'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 9
ASN A 238
GLU A 240
ILE A 200
ALA A 129
THR A 201
1.77A20.25
None
MPD  A 307 (-3.9A)
MPD  A 307 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 288
ASP B 289
ILE B 286
ILE A 286
SER A 284
1.43A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 288
ASP B 289
ILE B 286
ILE A 286
SER A 284
1.38A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 288
ASP B 289
ILE B 286
ILE A 286
SER A 284
1.40A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU D 918
ILE D 916
GLN F 915
ILE F 916
SER E 919
1.54A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
PHE B 909
ALA A 912
GLN A 915
GLN C 902
1.22A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1x7q HLA, A-11
(Homo
sapiens)		4 / 7
PHE A  36
ARG A  35
GLN A  72
GLN A  32
1.17A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		3 / 3
ASP A 119
PHE B  62
VAL A  12
1.19A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.29A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.31A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASN B1238
GLU B1240
ILE B1200
ALA B1129
THR B1201
1.49A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 203
GLU A 290
ARG B1004
ALA A 206
THR A 111
1.76A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE E  16
GLN C  15
ALA C  12
ILE C  16
SER A  19
1.52A13.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
PHE A   9
ALA E  12
GLN E  15
GLN C   2
1.16A9.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		1zva E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A  54
ILE A  30
ASP A  36
ILE A  48
ALA A  50
1.77A13.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN B  21
SER B  25
ASP B  22
ASP B  28
ALA A  15
1.72A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A  17
ILE A  23
ASP B  28
ILE B  23
ARG A  26
1.60A7.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A  17
ILE A  23
ASP B  28
ILE B  23
ARG A  26
1.60A7.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
HIS B 164
ALA B 173
GLU B  47
VAL B 186
ARG B 188
1.71A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.42A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ASN D 219
ILE D 217
GLN D 210
ALA D 209
ILE D 205
1.74A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
PHE B 314
LEU B 309
ALA B 220
GLN B 320
1.41A21.97
GOL  B1004 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
ASN F 105
ILE F 112
ASP F 117
ILE F 111
ARG F 116
1.75A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
ASN F 105
ILE F 112
ASP F 117
ILE F 111
ARG F 116
1.77A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
ASN H 105
ILE H 112
ASP H 117
ILE H 111
ARG H 116
1.68A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 9
ASN E 105
ASP E 104
ILE E 112
ALA E 115
ILE E 111
1.60A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
ASP H 104
ILE H 112
ASP H 117
ILE H 111
ARG H 116
1.54A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
ASN H 105
ASP H 104
ILE H 112
ASP H 117
ILE H 111
1.61A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
ASN F 105
ASP F 106
ALA F 115
ILE F 111
ARG F 116
1.72A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		2ajf SPIKE PROTEIN
(SARSr-CoV)		5 / 12
SER F 386
ASP F 385
ASP F 351
ALA F 350
ILE F 345
1.53A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		2ajf ACE2
(Homo
sapiens)		5 / 12
ASN A 437
GLU A 435
ASP A 431
PRO A 415
ALA A 413
1.77A14.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		2ajf SPIKE PROTEIN
(SARSr-CoV)		3 / 3
ASN F 375
PHE F 325
VAL F 382
1.34A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2ajf SPIKE PROTEIN
(SARSr-CoV)		4 / 7
ARG F 449
LEU F 448
ALA F 406
GLN F 396
1.44A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.52A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.33A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
HIS A 164
ALA A 173
GLU A  47
VAL A 186
ARG A 188
1.70A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.37A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU F1177
ILE A 916
ASP F1181
ILE C 916
SER C 919
1.78A13.46
None
None
ACE  B 913 ( 3.7A)
ACE  C 913 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU F1177
ILE A 916
ASP F1181
ILE C 916
SER C 919
1.66A13.46
None
None
ACE  B 913 ( 3.7A)
ACE  C 913 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
SER E 313
PRO F 259
ASP E 341
ILE E 338
SER E 319
1.58A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 6
PHE C 275
ARG C 277
ALA C 265
GLN B 273
1.53A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 295
GLU A 290
ASP A 289
ARG B   4
ILE A 106
1.64A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 213
ASP A 216
SER A 301
ARG A 217
THR A 257
1.74A23.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
ASN H  58
ASP L  95
ASP H  95
ILE H  56
THR H  33
1.69A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN S 381
PHE S 325
VAL S 510
1.45A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER S 386
ASP S 385
ASP S 351
ALA S 350
ILE S 345
1.52A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
ASN H  58
ASP L  95
ASP H  95
ILE H  56
THR H  33
1.73A17.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		5 / 11
SER H  74
GLU H  73
ASP H  72
ILE H  53
THR H  71
1.39A24.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP S 385
PHE S 416
VAL S 420
1.34A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ASN B  38
ILE B  36
GLN B  29
ALA B  28
ILE B  24
1.62A20.33
None
None
None
None
APR  B 477 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 6
PHE C 133
LEU C 128
ALA C  39
GLN C 139
1.31A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
GLU D 213
PRO D 191
ASP D 192
ILE D 207
TYR D 218
1.42A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP A 385
PHE A 416
VAL A 420
1.38A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		2gri NSP3
(SARSr)		5 / 12
ASN A  37
GLU A  27
ASP A  29
ILE A  24
SER A  41
1.46A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE A  99
PRO A 111
ALA A  81
ILE A  79
SER A  97
1.68A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 6
PHE A 213
LEU A 214
ALA A 255
GLN A 208
1.49A23.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 10
ALA A  81
PRO A  67
GLU A  68
VAL A 127
ARG A 126
1.56A23.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
GLU A 113
ILE A  99
PRO A 111
ILE A  79
SER A  97
1.76A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
GLU A 113
ILE A  99
PRO A 111
ILE A  79
SER A  97
1.75A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
ASN A 350
ASP A 344
PRO A 310
ALA B 312
ILE A 305
1.67A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ASP A 552
PRO A 588
ALA A 590
ILE A 592
THR A 612
1.50A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		2kqv NSP3
(SARSr-CoV)		5 / 12
ARG A  32
ILE A  38
ILE A  45
TYR A  42
THR A  37
1.74A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2kqv NSP3
(SARSr-CoV)		5 / 9
ASP A  30
PRO A  66
ALA A  68
ILE A  70
THR A  90
1.38A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 9
ASN A 238
GLU A 240
ILE A 200
ALA A 129
THR A 201
1.80A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.50A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
ALA C  81
PRO C  67
GLU C  68
VAL C 127
ARG C 126
1.59A23.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
GLU D 113
ILE D  99
PRO D 111
ALA D  81
ILE D  79
1.75A22.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLU A 113
ILE A  99
PRO A 111
ILE A  79
SER A  97
1.67A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
PHE B 213
LEU B 214
ALA B 255
GLN B 208
1.47A23.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE C  99
PRO C 111
ALA C  81
ILE C  79
SER C  97
1.61A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLU A 113
ILE A  99
PRO A 111
ILE A  79
SER A  97
1.69A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.43A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 9
ASN B  84
ASP B 176
PRO B  39
ALA B  41
THR B 175
1.63A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
HIS A 164
ALA A 173
GLU A  47
VAL A 186
ARG A 188
1.67A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 7
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.20A22.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 6
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.17A22.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 295
GLU A 290
ASP A 289
ILE A 136
LYS A   5
1.70A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.54A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLU C 113
ILE C  99
PRO C 111
ILE C  79
SER C  97
1.68A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
ALA B  81
PRO B  67
GLU B  68
VAL B 127
ARG B 126
1.56A22.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ARG E  90
ILE F  42
PRO E 270
ASP E 267
ALA F  22
1.54A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASP F  36
ARG E  90
ILE E 269
PRO E 270
THR F  33
1.58A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLU D 113
ILE D  99
PRO D 111
ILE D  79
SER D  97
1.69A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE D  99
PRO D 111
ALA D  81
ILE D  79
SER D  97
1.60A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
PHE B 213
LEU B 214
ALA B 255
GLN B 208
1.55A22.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		3 / 3
ASN D  52
PHE B  55
VAL B  24
0.77A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		2w2g NSP3
(SARSr-CoV)		3 / 3
ASP A 481
PHE A 511
VAL A 478
1.30A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
ASP A 114
PHE A  70
VAL A 118
1.14A21.50
SAH  A1293 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
ASP A 114
PHE A  70
VAL A 118
1.11A21.30
SAH  A1300 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2z9k 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASN B 238
GLU B 240
ILE B 200
ALA B 129
THR B 201
1.78A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2z9k 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 295
GLU A 290
ASP A 289
ARG B   4
ILE A 106
1.61A19.29
DMS  A 813 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3aw0 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.50A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 12
ASN A 424
ASP B  56
ASP B 101
ILE A 489
THR B  31
1.69A23.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		3 / 3
ASP S 385
PHE S 416
VAL S 420
1.32A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3bgf F26G19 FAB
(Mus
musculus)		5 / 10
LEU B  69
ALA B  67
GLU B   5
SER B   7
VAL B  18
1.53A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG E 449
LEU E 448
ALA E 406
GLN E 396
1.32A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN E 375
PHE E 325
VAL E 382
0.93A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER F 386
ASP F 385
ASP F 351
ALA F 350
ILE F 345
1.55A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 437
GLU A 435
ASP A 431
PRO A 415
ILE A 291
1.54A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 437
GLU A 435
ASP A 431
ILE A 291
PRO A 415
1.75A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN F 375
PHE F 325
VAL F 382
0.96A21.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
PHE A  32
LEU A  29
ALA A  80
GLN A  81
1.42A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
ASP B 367
PHE B 369
VAL B 293
1.29A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER F 386
ASP F 385
ASP F 351
ALA F 350
ILE F 345
1.43A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG F 449
LEU F 448
ALA F 406
GLN F 396
1.44A18.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN F 375
PHE F 325
VAL F 382
0.90A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 437
GLU A 435
ASP A 431
ILE A 291
ALA A 413
1.65A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 437
GLU A 435
ASP A 431
PRO A 415
ALA A 413
1.75A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
ASN A 437
GLU A 435
ASP A 431
ILE A 291
ALA A 413
1.68A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 437
GLU A 435
ASP A 431
ILE A 291
PRO A 415
1.56A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER F 386
ASP F 385
ASP F 351
ALA F 350
ILE F 345
1.42A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG F 449
LEU F 448
ALA F 406
GLN F 396
1.41A18.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.48A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 133
ASP A 245
ASP B 176
ILE B 136
ARG B 105
1.66A23.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP B 248
PRO A 132
ASP A 289
ILE A 136
ALA A 173
1.80A23.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
PHE B 219
ARG D 222
LEU B 208
ALA B 211
1.52A17.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 288
ASP B 289
ILE B 286
ILE A 286
SER A 284
1.57A23.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.49A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 288
ASP B 289
ILE B 286
ILE A 286
SER A 284
1.58A23.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.26A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.30A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 288
ASP B 289
ILE B 286
ILE A 286
SER A 284
1.60A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 288
ASP B 289
ILE B 286
ILE A 286
SER A 284
1.57A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.53A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		5 / 10
HIS A  74
ALA A  69
TYR C   6
GLU A 148
VAL A  76
1.67A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3i6k HLA, A-2
(Homo
sapiens)		4 / 7
PHE A  36
ARG A  35
GLN A  72
GLN A  32
1.19A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3i6k HLA, A-2
(Homo
sapiens)		5 / 12
ASP E 106
PRO A 210
ASP A  30
ALA A 211
ILE A 213
1.77A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3i6l HLA, A-24
(Homo
sapiens)		4 / 7
PHE D  36
ARG D  35
GLN D  72
GLN D  32
1.15A23.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		3 / 3
ASP D 119
PHE E  62
VAL D  12
1.16A22.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
HIS A 164
ALA A 173
GLU A  47
VAL A 186
ARG A 188
1.70A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.50A22.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP B 295
GLU B 290
ASP B 289
ARG A   4
ILE B 106
1.75A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
ASP A 114
PHE A  70
VAL A 118
1.03A22.78
SAM  A 302 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG F 449
LEU F 448
ALA F 406
GLN F 396
1.37A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ARG F 449
LEU F 448
ALA F 406
GLN F 396
1.44A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER F 386
ASP F 385
ASP F 351
ALA F 350
ILE F 345
1.43A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN F 375
PHE F 325
VAL F 382
1.16A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER E 386
ASP E 385
ASP E 351
ALA E 350
ILE E 345
1.41A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
ASP B 367
PHE B 369
VAL B 293
1.36A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER E 386
ASP E 385
ASP E 351
ALA E 350
ILE E 345
1.47A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN E 375
PHE E 325
VAL E 382
1.02A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3to2 BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 119
PHE B  62
VAL A  12
1.13A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3to2 MD3-C9 PEPTIDE
DERIVED FROM
MEMBRANE
GLYCOPROTEIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARS-COV
TJF)		4 / 6
PHE C   4
LEU C   6
ALA A  69
GLN A 155
1.49A5.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 203
GLU A 290
ARG B   4
ALA A 206
THR A 111
1.75A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		4m0w UBIQUITIN
(Bos
taurus)		5 / 12
ILE B  30
PRO B  38
ASP B  39
GLN B  40
ILE B  36
1.69A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
ARG B  74
ASP B  52
ALA A 154
ARG B  42
THR A 169
1.54A11.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		4m0w UBIQUITIN
(Bos
taurus)		5 / 12
ILE B  30
PRO B  38
ASP B  39
GLN B  40
ILE B  36
1.61A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  51
ASP A  52
ASP B 303
SER B 156
ARG B 167
1.80A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
SER B 156
GLU B 168
ARG A  42
ARG B 167
THR B 169
1.80A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
SER B 156
GLU B 168
ARG A  42
ARG B 167
THR B 169
1.74A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		3 / 3
ASN B 178
PHE B 242
VAL B 126
1.36A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 11
SER A  79
GLU A  78
ASP A  77
ARG A  66
THR A  75
1.76A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 10
HIS A 281
ALA A 282
TYR A 279
SER A 167
VAL A 310
1.80A20.12
None
None
None
None
PO4  A 404 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 203
GLU B 290
ARG A   4
ALA B 206
THR B 111
1.73A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.48A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 10
ALA B 353
TYR B 351
GLU B 347
SER D 307
ARG D 310
1.72A20.98
SAH  B 605 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ASN D  71
GLU D 204
ARG D 213
ALA D  79
ILE D  74
1.59A16.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ASN D  71
GLU D 204
ARG D 213
ALA D  79
ILE D  74
1.66A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ASN D  71
GLU D 204
ARG D 213
ALA D  79
ILE D  74
1.54A16.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ASN B 408
SER B 407
ILE B 298
PRO B 297
ILE B 299
1.72A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		5 / 9
GLU F  51
ASP F  52
ARG F  54
ALA F  46
ILE F  44
1.74A15.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
ARG E  72
ASP E  52
ALA D 154
ARG E  42
THR D 169
1.61A11.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		5e6j POLYUBIQUITIN-B
REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV;
synthetic
construct)		5 / 12
GLU F  51
ASP F  52
ASP D  63
ALA F  46
ILE F  44
1.66A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
SER D  79
GLU D  78
ASP D  77
ARG D  66
THR D  75
1.59A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5f22 NSP8
(SARSr-CoV)		5 / 9
ASN B 105
ASP B 104
ILE B 112
ALA B 115
ILE B 111
1.64A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		5f22 NSP8
(SARSr-CoV)		5 / 12
ASN B 105
ARG B 101
ILE B 112
ALA B 107
ARG B 116
1.77A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		5f22 NSP8
(SARSr-CoV)		5 / 12
ASN B 105
ASP B 104
ILE B 112
ALA B 115
ILE B 111
1.69A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5f22 NSP8
(SARSr-CoV)		5 / 12
ASN B 105
ASP B 104
ILE B 112
ASP B 117
ILE B 111
1.65A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5f22 NSP8
(SARSr-CoV)		5 / 12
ASN B 105
ASP B 104
ILE B 112
ASP B 117
ILE B 111
1.69A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
LEU C 209
HIS C 229
ALA A 225
SER C 221
VAL C 231
1.79A20.98
PEG  C 604 (-4.5A)
ZN  C 601 (-2.9A)
None
PEG  A 604 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ASN D 386
ARG D 289
PRO D 429
ASP D 415
ALA D 430
1.67A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 9
ASN A  71
GLU A 204
ARG A 213
ALA A  79
ILE A  74
1.47A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.72A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.72A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
ASN D 178
PHE D 242
VAL D 126
1.36A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		4 / 7
PHE A 120
ARG A 151
ARG A 153
GLN A 111
1.40A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		3 / 3
ASP C 103
PHE C 120
VAL C 109
1.23A13.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ARG C 977
ILE A 979
GLN A 974
ILE A 975
SER A 728
1.78A10.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP B 572
PHE B 527
VAL B 562
1.39A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
PHE C 764
ARG C 761
ALA C1037
GLN C1036
1.42A11.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5x4r S PROTEIN
(MERS-CoV)		3 / 3
ASP A  83
PHE A 147
VAL A 118
1.07A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 120
ILE A 152
PRO A 136
ILE A 115
THR A 150
1.44A19.16
NAG  A 602 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
PHE B 629
LEU B 636
ALA B 676
GLN B 599
1.52A11.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASN C 530
ASP C 376
ARG A 965
ASP C 557
THR C 533
1.61A9.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
ASP C 166
PHE C 220
VAL C 123
1.18A15.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
ARG B 982
LEU B 983
GLN A 947
GLN B 947
1.42A11.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
SER A 113
ARG A 126
ILE A 152
GLN A 147
ILE A 234
1.76A10.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
SER B 386
ASP B 385
ASP B 351
ALA B 350
ILE B 345
1.46A9.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
ASN C1080
ILE C 696
PRO C 697
ALA C 695
THR C1087
1.71A10.83
None
None
None
NAG  C1305 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ASN B 719
ASP C 910
ALA B 678
ILE B 682
SER B 684
1.65A10.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ASN C 226
ASP C 174
PRO C 210
ASP C 306
ALA C 211
1.64A8.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ASN B 719
SER B 720
ASP C 910
ILE B 682
SER B 684
1.61A10.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5x59 S PROTEIN
(MERS-CoV)		3 / 3
ASP A  83
PHE A 147
VAL A 118
1.07A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ASN B 719
SER B 720
ASP C 910
ILE B 682
SER B 684
1.65A10.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASP C 296
ILE C 650
PRO C 651
ILE C 584
ALA C 595
1.32A15.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE B 696
GLN C 877
ALA B 695
ILE B 694
ARG B1055
1.44A10.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
ASN A 119
PHE A 153
VAL A 124
1.43A15.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
SER A1093
ARG A1089
ILE A1086
PRO A1072
ILE A1097
1.80A10.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
ARG C1057
LEU C1058
ALA C1065
GLN C1056
1.45A11.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
PHE A 473
ALA A 520
GLN A 522
GLN A 427
1.20A11.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
ASN A 839
PHE A1081
VAL A 802
1.03A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN B 214
PHE B 262
VAL B  40
1.26A15.94
ASN  B 214 ( 0.6A)
PHE  B 262 ( 1.3A)
VAL  B  40 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
ASN A 178
PHE A 242
VAL A 126
1.46A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
PHE B 764
ARG B 761
ALA B1037
GLN B1036
1.37A11.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 452
ASP B 454
ARG B 449
PRO B 450
ASP B 414
1.59A9.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 452
ASP B 454
ARG B 449
PRO B 450
ASP B 414
1.59A15.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 452
ASP B 454
ARG B 449
PRO B 450
ASP B 414
1.68A16.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN A 119
PHE A 153
VAL A 124
0.79A15.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A 810
ALA A 938
PRO A1039
GLU A 801
VAL A 842
1.61A11.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		6acg ACE2
(Homo
sapiens)		5 / 12
ASP D 471
GLU D 495
ASP D 494
PRO D 178
THR D 496
1.75A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP A 385
PHE A 325
VAL A 382
1.06A15.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 652
PRO A 651
ILE A 584
ALA A 595
THR A 631
1.57A15.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6acg ACE2
(Homo
sapiens)		5 / 12
GLU D 312
ILE D 379
ILE D 358
SER D 331
THR D 324
1.79A17.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A 189
ARG B 342
ILE A 226
ALA A 127
ARG B 453
1.52A10.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6acj ACE2
(Homo
sapiens)		4 / 7
PHE D  32
LEU D  29
ALA D  80
GLN D 101
1.35A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6ack ACE2
(Homo
sapiens)		5 / 12
ASP D 471
GLU D 495
ASP D 494
PRO D 500
ALA D 501
1.74A14.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 949
ASP B 557
ASP A 727
ILE A 724
SER A 985
1.58A10.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 452
ASP B 454
ARG B 449
PRO B 450
ASP B 414
1.67A10.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ARG B1073
ILE B1063
PRO B1072
ALA B1062
ILE B1115
1.53A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6ack ACE2
(Homo
sapiens)		5 / 12
ASP D 206
GLU D 398
ARG D 514
ILE D 513
THR D 517
1.64A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ack ACE2
(Homo
sapiens)		3 / 3
ASP D 509
PHE D 464
VAL D 506
1.28A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 452
ASP B 454
ARG B 449
PRO B 450
ASP B 414
1.70A9.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN C1056
GLU C1054
ILE C 696
ILE C 694
THR C 698
1.68A15.59
NAG  C1310 (-1.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASN C1056
GLU C1054
ILE C 696
ILE C 694
THR C 698
1.75A10.76
NAG  C1310 (-1.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
PHE A 137
ARG A 232
LEU A 235
ALA A 237
1.53A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
ASN B1107
PHE B1071
VAL B1110
0.54A15.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP B 849
PRO B 844
ASP A 600
GLN A 599
ALA A 633
1.50A10.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 386
ASP C 385
ASP C 351
ALA C 350
ILE C 345
1.46A9.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
ASP B 385
PHE B 329
VAL B 382
1.07A15.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASN A 119
ILE A 152
PRO A 136
ILE A 115
THR A 150
1.52A10.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN A 119
ILE A 152
PRO A 136
ILE A 115
THR A 150
1.51A10.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN A1117
ILE A1097
ASP A1100
ILE A1096
SER A1083
1.47A10.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLU A 999
ILE A 995
ILE B 995
ALA C 998
ARG A 996
1.51A15.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ARG B 982
LEU B 986
GLN B 744
GLN B 947
1.36A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A  75
LEU A  78
GLN A  87
GLN A  72
1.44A23.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6jyt HELICASE
(SARSr-CoV)		5 / 9
ARG A 443
ILE A 448
PRO A 445
ALA A 469
ILE A 572
1.46A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6jyt HELICASE
(SARSr-CoV)		4 / 6
PHE B 200
ARG B 178
LEU B 176
ALA B 152
1.39A18.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ASN A 349
SER A 350
ILE A 333
ASP A 315
ILE A 334
1.60A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ASN A 349
SER A 350
ILE A 333
ASP A 315
ILE A 334
1.69A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ILE A 448
PRO A 445
GLN A 470
ALA A 469
ILE A 572
1.59A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6jyt HELICASE
(SARSr-CoV)		3 / 3
ASP A 435
PHE A 291
VAL A 272
1.08A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6jyt HELICASE
(SARSr-CoV)		5 / 12
SER A 453
ASP A 458
ASP A 450
ALA A 568
ILE A 565
1.73A16.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
SER E 974
ILE E 980
ASP D 985
ILE D 980
ARG E 983
1.37A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
SER E 974
ILE E 980
ASP D 985
ILE D 980
ARG E 983
1.34A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 10
LEU A1186
ALA A1190
GLU B1188
SER C 937
VAL C1189
1.66A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
ASN E 978
SER E 982
ASP E 979
ASP E 985
ALA F 972
1.77A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.71A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.69A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER B 399
ASP B 398
ASP B 364
ALA B 363
ILE B 358
1.45A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		3 / 3
ASP E 398
PHE E 429
VAL E 433
1.34A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.70A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.68A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
SER E 399
ASP E 398
ASP E 364
ALA E 363
ILE E 358
1.56A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m17 ACE2
SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
PHE C 348
ARG D 678
ALA C 374
GLN C 377
1.30A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6m17 ACE2
(Homo
sapiens)		5 / 12
ASN B 437
GLU B 435
ASP B 431
ILE B 291
PRO B 415
1.69A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
ASN A 435
PHE A 277
VAL A 125
0.93A20.86
LEU  A 707 (-4.0A)
LEU  A 707 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6m17 ACE2
(Homo
sapiens)		5 / 12
ASN B 437
GLU B 435
ASP B 431
ILE B 291
PRO B 415
1.64A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER C 151
GLU C 405
ARG C 328
ILE C 407
THR C 408
1.66A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ASN A 293
SER A 294
GLU A  28
ARG A  32
PRO A  33
1.67A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
ALA C 247
TYR C 322
PRO C  59
GLU C 394
PHE C 420
1.77A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6m1d ACE2
(Homo
sapiens)		5 / 12
GLU D 208
ASP D 201
ASP D 225
ILE D 513
SER D 511
1.46A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m1d ACE2
(Homo
sapiens)		4 / 7
PHE D  28
LEU D  29
ALA D  80
GLN D  81
1.42A15.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		6m1d ACE2
SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ASN D 636
ASP D 637
PRO D 677
ASP C 349
ILE D 679
1.71A11.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLU C 179
ILE C 183
PRO C 565
ASP C 564
SER C 192
1.79A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6m1d ACE2
(Homo
sapiens)		5 / 12
ASP D 471
GLU D 495
ASP D 494
PRO D 500
ALA D 501
1.58A11.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ASP A 189
ILE A 562
ILE A 576
TYR A 560
THR A 185
1.69A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6m1d ACE2
(Homo
sapiens)		5 / 12
GLU D 208
ASP D 201
ASP D 225
ILE D 513
SER D 511
1.56A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE D   3
ARG D   4
LEU D 282
ALA D 210
1.55A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.63A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE C   3
ARG C   4
LEU C 282
ALA C 210
1.55A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE B   3
ARG B   4
LEU B 282
ALA B 210
1.59A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.61A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE D   3
ARG D   4
LEU D 282
ALA D 210
1.56A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.64A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE C   3
ARG C   4
LEU C 282
ALA C 210
1.57A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.61A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.63A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 691
ASP A 684
ALA A 580
ILE A 589
SER A 759
1.80A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A 208
PHE A  45
VAL A 128
1.78A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
(SARS-CoV-2)		4 / 6
PHE A 881
ARG A 889
ALA A 866
GLN A 886
1.77A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 209
ASP A 218
ASP A 211
ASP A  92
ALA A 195
1.55A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 777
1.56A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
(SARS-CoV-2)		4 / 6
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.58A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.61A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 652
VAL A 354
1.10A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 348
VAL A 535
1.07A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.55A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ARG A 569
LEU A 576
ALA A 580
GLN A 570
1.74A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
PHE A  45
VAL A 128
1.52A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASN A  39
PHE A  48
VAL A  42
1.08A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 6
PHE A 442
LEU C  41
ALA A 550
GLN C  34
1.67A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6m71 NSP12
(SARS-CoV-2)		4 / 6
PHE A 506
LEU A 372
ALA A 375
GLN A 524
1.70A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A1056
GLU A1054
ILE A 696
ILE A 694
THR A 698
1.73A10.13
NAG  A1336 (-1.8A)
NAG  A1336 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP A 376
PHE A 379
VAL A 369
1.27A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASN B 942
PHE C 558
VAL B 945
1.30A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASP A1100
ARG A1073
ILE A1086
PRO A1072
THR A1098
1.77A10.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A1093
ARG A1055
ILE A 696
GLN C 877
ILE A 694
1.72A10.13
None
NAG  A1341 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A1056
GLU A1054
ILE A 696
ILE A 694
THR A 698
1.60A15.26
NAG  A1336 (-1.8A)
NAG  A1336 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
ARG B 996
LEU A 994
ALA A 997
GLN A 756
GLN B 993
1.76A11.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU L  78
ALA L  19
PRO L  64
VAL L  88
ARG L  44
1.76A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		3 / 3
ASN L 142
PHE L 123
VAL H 195
1.13A18.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6nur NSP8
(SARSr-CoV)		5 / 12
ASP D  99
ILE D 107
ASP D 112
ILE D 106
ARG D 111
1.77A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6nur NSP8
(SARSr-CoV)		5 / 12
ILE B 106
ASP B  99
ILE B 107
ALA B 110
THR B 123
1.59A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6nur NSP12
(SARSr-CoV)		5 / 12
ASP A 303
ARG A 640
ILE A 632
ALA A 311
ARG A 651
1.73A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6nur NSP12
(SARSr-CoV)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.28A14.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6nur NSP8
(SARSr-CoV)		5 / 9
ASN D 100
ASP D  99
ILE D 107
ALA D 110
ILE D 106
1.63A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6nus NSP12
(SARSr-CoV)		5 / 10
LEU A 576
HIS A 572
ALA A 685
VAL A 662
ARG A 631
1.77A14.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6nus NSP12
(SARSr-CoV)		5 / 12
ASN A 691
ASP A 684
ALA A 580
ILE A 589
SER A 759
1.71A13.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6nus NSP12
(SARSr-CoV)		4 / 6
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.21A14.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
SER A 343
ASP A 377
ILE B 120
PRO B 121
ILE B 106
1.73A13.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
ASP B  99
ASP B 112
ALA B 110
ILE B 106
ARG A 331
1.63A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6nus NSP12
(SARSr-CoV)		3 / 3
ASN A 356
PHE A 348
VAL A 535
0.98A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
SER A 343
ASP A 377
ILE B 120
PRO B 121
ILE B 106
1.72A13.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A1074
GLU A1072
ILE A 714
ILE A 712
THR A 716
1.73A10.56
NAG  A1309 (-1.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP B1041
PHE C 888
VAL C1033
1.32A15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 7
ARG B1014
LEU C1012
ALA C1015
GLN C 774
GLN B1011
1.79A11.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 709
SER B 708
ASP C 796
MET C 900
ALA C 903
1.70A9.94
NAG  B1305 (-1.8A)
None
NAG  B1305 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ASN A1074
GLU A1072
ILE A 714
ILE A 712
THR A 716
1.72A10.74
NAG  A1309 (-1.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A1074
GLU A1072
ILE A 714
ILE A 712
THR A 716
1.62A15.44
NAG  A1309 (-1.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B1023
PRO B 728
ASP B 950
GLN B 954
ILE B1018
1.75A10.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6vw1 ACE2
(Homo
sapiens)		4 / 7
LEU B 418
ALA B 296
GLN B 300
GLN B 442
1.41A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP F 398
PHE F 429
VAL F 433
1.36A23.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 399
ASP E 398
ASP E 364
ALA E 363
ILE E 358
1.56A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU A 114
ILE A 100
PRO A 112
ILE A  80
SER A  98
1.71A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU A 114
ILE A 100
PRO A 112
ILE A  80
SER A  98
1.71A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 100
PRO A 112
ALA A  82
ILE A  80
SER A  98
1.64A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6vxs NSP3
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 116
VAL B 151
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6vxs NSP3
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 168
VAL B 144
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP B1041
PHE C 888
VAL C1033
1.21A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ASN C1074
GLU C1072
ILE C 714
ILE C 712
THR C 716
1.75A11.06
NAG  C1316 (-1.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 399
ASP A 398
ASP A 364
ALA A 363
ILE A 358
1.48A9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C 807
ASP C 808
ILE C 805
LYS C 795
THR C 874
1.45A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 205
GLU A 191
ARG A  34
ALA A 288
ILE A 285
1.43A9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO A 807
ASP A 808
ILE A 805
LYS A 795
THR A 874
1.38A15.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP C1041
PHE A 888
VAL A1033
1.21A15.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 234
ARG C 355
ILE A 231
PRO A 230
ASP A 228
1.73A10.54
NAG  A1303 (-1.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PHE B 214
LEU B 215
ALA B 256
GLN B 209
1.46A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP A  79
ILE B 116
ASP B  79
ILE B 108
THR B 115
1.77A22.13
EDO  A 407 (-4.0A)
None
EDO  B 404 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA B  82
PRO B  68
GLU B  69
VAL B 128
ARG B 127
1.62A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6w02 NSP3
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 168
VAL A 144
1.00A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w37 PROTEIN 7A
(SARS-CoV-2)		4 / 6
PHE A  44
ARG A  10
ARG A  63
LEU A  62
1.71A14.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w37 PROTEIN 7A
(SARS-CoV-2)		4 / 7
PHE A  44
ARG A  10
ARG A  63
LEU A  62
1.67A14.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLU H  56
ASP H  54
ARG H  58
ILE H  51
ILE H  34
1.47A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLU H  56
ASP H  54
ARG H  58
ILE H  69
ALA H  78
1.60A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 9
GLU H  56
ASP H  54
ARG H  58
ILE H  51
ILE H  34
1.47A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
SER C 399
ASP C 398
ASP C 364
ALA C 363
ILE C 358
1.36A24.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLU H  56
ASP H  54
ARG H  58
ILE H  51
ILE H  34
1.38A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLU H  56
ASP H  54
ARG H  58
ILE H  51
ILE H  34
1.42A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLU H  56
ASP H  54
ARG H  58
ILE H  51
ILE H  34
1.51A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
SER H  55
ASP H  54
ARG H  58
ALA H  93
ILE H  34
1.78A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
ASN L 137
PHE L 118
VAL H 181
1.17A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLU H  56
ASP H  54
ARG H  58
ILE H  51
ILE H  34
1.42A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6w4h NSP16
(SARS-CoV-2)		3 / 3
ASP A6912
PHE A6868
VAL A6916
1.06A24.21
SAM  A7102 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP A6912
PHE A6868
VAL A6916
1.06A
SAM  A7104 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.63A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.66A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 116
VAL A 151
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 168
VAL A 144
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASP A 145
PHE A 168
VAL A  16
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w6y NSP3
(SARS-CoV-2)		4 / 6
PHE B 116
LEU B  93
ALA B 124
GLN B 118
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 168
VAL B 144
0.87A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP A6912
PHE A6868
VAL A6916
1.04A18.44
SAM  A7102 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP C6912
PHE C6868
VAL C6916
1.04A18.44
SAM  C7105 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP A  37
PHE A  55
VAL A  41
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 173
LEU A 178
ALA A 176
GLN A 237
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ARG B 166
LEU B 211
ALA B 249
GLN B 250
1.59A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE C 173
LEU C 178
ALA C 176
GLN C 237
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ARG A 166
LEU A 211
ALA A 249
GLN A 250
1.76A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ARG C 166
LEU C 211
ALA C 249
GLN C 250
1.53A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE B 173
LEU B 178
ALA B 176
GLN B 237
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
PHE B 173
LEU B 125
ALA B 176
GLN B 122
1.79A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6wcf NSP3
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 116
VAL A 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6wen NSP3
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 168
VAL A 144
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6wen NSP3
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 116
VAL A 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6wey NSP3
(SARS-CoV-2)		3 / 3
ASN A 219
PHE A 320
VAL A 355
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6wey NSP3
(SARS-CoV-2)		3 / 3
ASN A 219
PHE A 372
VAL A 348
1.08A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6wiq NSP8
(SARS-CoV-2)		5 / 9
ASN B 100
ASP B  99
ILE B 107
ALA B 110
ILE B 106
1.65A24.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.70A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.72A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ALA B 110
ILE B 106
1.70A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.66A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ILE B 107
ASP B 112
ILE B 106
ARG B 111
1.79A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.66A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ARG B  96
ALA B 110
ILE B 106
1.56A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ARG A 293
LEU A 291
GLN A 303
GLN A 289
1.78A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
ARG E 293
LEU E 291
GLN E 303
GLN E 289
1.76A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP C6912
PHE C6868
VAL C6916
1.03A
SAH  C7102 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP A6912
PHE A6868
VAL A6916
1.04A
SAH  A7102 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN B  77
SER B  78
ASP B  82
PRO A 106
ALA A  90
1.20A21.18
None
None
ZN  B 202 (-2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN D  77
SER D  78
ASP D  82
PRO C 106
ALA C  90
1.46A21.18
None
None
ZN  D 202 (-2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6wkq NSP16
(SARS-CoV-2)		3 / 3
ASP A6912
PHE A6868
VAL A6916
1.05A
SFG  A7103 ( 3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6wkq NSP16
(SARS-CoV-2)		3 / 3
ASP C6912
PHE C6868
VAL C6916
1.05A
SFG  C7103 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PHE B 124
ARG B 136
LEU B 134
ALA B  82
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU A 114
ILE A 100
PRO A 112
ILE A  80
SER A  98
1.71A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU A 114
ILE A 100
PRO A 112
ILE A  80
SER A  98
1.71A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA B  82
PRO B  68
GLU B  69
VAL B 128
ARG B 127
1.67A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PHE A 124
ARG A 136
LEU A 134
ALA A  82
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 100
PRO A 112
ALA A  82
ILE A  80
SER A  98
1.66A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 124
ARG B 136
LEU B 134
ALA B  82
1.79A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU B 114
ILE B 100
PRO B 112
ILE B  80
SER B  98
1.75A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA B  82
PRO B  68
GLU B  69
VAL B 128
ARG B 127
1.61A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PHE B 214
LEU B 215
ALA B 256
GLN B 209
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 100
PRO B 112
ALA B  82
ILE B  80
SER B  98
1.72A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU B 114
ILE B 100
PRO B 112
ILE B  80
SER B  98
1.76A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU A 114
ILE A 100
PRO A 112
ILE A  80
SER A  98
1.77A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA A  82
PRO A  68
GLU A  69
VAL A 128
ARG A 127
1.63A22.69
None
None
EDO  A 408 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
PHE A 214
LEU A 215
ALA A 256
GLN A 209
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 124
ARG A 136
LEU A 134
ALA A  82
1.77A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA A  82
PRO A  68
GLU A  69
VAL A 128
ARG A 127
1.68A22.69
None
None
EDO  A 408 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.67A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 168
VAL A 144
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASN D  15
PHE D 168
VAL D 144
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP A 145
PHE A 168
VAL A  16
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASN C  15
PHE C 168
VAL C 144
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 168
VAL B 144
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP A6912
PHE A6868
VAL A6916
1.07A
SAH  A7101 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.69A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6wqd NSP8
(SARS-CoV-2)		5 / 9
ASN D 100
ASP D  99
ILE D 107
ALA D 110
ILE D 106
1.72A24.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ASN D 100
ASP D  99
ILE D 107
ASP D 112
ILE D 106
1.71A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.66A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.71A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ALA B 110
ILE B 106
1.71A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.66A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6wqd NSP8
(SARS-CoV-2)		5 / 9
ASN B 100
ASP B  99
ILE B 107
ALA B 110
ILE B 106
1.65A24.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.65A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
PHE A 173
LEU A 178
ALA A 176
GLN A 237
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 10
LEU A 118
HIS A 275
ALA A 114
GLU A 124
VAL A 165
1.75A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6xez NSP12
(SARS-CoV-2)		3 / 3
ASN A  39
PHE A  48
VAL A  42
1.02A18.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6xez NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 348
VAL A 535
1.02A18.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.34A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.28A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.73A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.72A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.71A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.65A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ILE B 107
ALA B 110
ILE B 106
ARG B 111
1.55A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ASP B 112
ILE B 106
1.65A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ILE B 107
ASP B 112
ILE B 106
ARG B 111
1.56A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B 101
ALA B 110
ILE B 106
ARG B 111
1.68A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ASP B  99
ILE B 107
ALA B 110
ILE B 106
1.71A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ILE B 107
ASP B 112
ILE B 106
ARG B 111
1.67A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN B 100
ILE B 107
ASP B 112
ILE B 106
ARG B 111
1.61A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASN D 100
ASP D 101
ALA D 110
ILE D 106
ARG D 111
1.79A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.47A20.46
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.53A19.29
MLI  B 302 (-4.4A)
MLI  B 302 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.56A19.29
MLI  B 302 (-4.4A)
MLI  B 302 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.60A19.29
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.56A20.46
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.52A20.46
MLI  B 302 (-4.4A)
MLI  B 302 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 398
PHE A 347
VAL A 341
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.52A20.46
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN E 388
ARG C  60
PRO C  65
ASP C  88
GLN C  85
1.80A21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN E 388
ASP E 364
PRO C  65
ASP C  88
ARG C  67
1.80A22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN A 388
ARG L  60
PRO L  65
ASP L  88
GLN L  85
1.77A21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.52A20.46
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  70
ALA H  79
1.76A19.29
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 9
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.57A24.19
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 399
ASP A 398
ASP A 364
ALA A 363
ILE A 358
1.53A22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN E 388
ARG C  60
PRO C  65
ASP C  88
GLN C  85
1.78A21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 9
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.52A24.19
MLI  B 302 (-4.4A)
MLI  B 302 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.44A20.46
MLI  B 302 (-4.4A)
MLI  B 302 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
ASN C 143
PHE C 124
VAL B 185
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLU C  87
PRO C  65
ASP C  66
ILE C  81
TYR C  92
1.63A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.49A20.46
MLI  B 302 (-4.4A)
MLI  B 302 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 399
ASP E 398
ASP E 364
ALA E 363
ILE E 358
1.51A22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP E 398
PHE E 429
VAL E 433
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.49A20.46
MLI  B 302 (-4.4A)
MLI  B 302 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
ASN L 143
PHE L 124
VAL H 185
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLU L  87
PRO L  65
ASP L  66
ILE L  81
TYR L  92
1.66A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 398
PHE A 429
VAL A 433
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.59A19.29
MLI  E 908 ( 4.4A)
MLI  E 908 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP E 398
PHE E 347
VAL E 341
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.42A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.43A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.38A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 9
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.46A24.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.47A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.45A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP E 398
PHE E 429
VAL E 433
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.44A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
ASN L 143
PHE L 124
VAL H 185
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP E 398
PHE E 347
VAL E 341
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 399
ASP E 398
ASP E 364
ALA E 363
ILE E 358
1.55A22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.29A19.30
None
CL  A 503 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.30A
None
CL  A 503 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.53A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 9
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.57A24.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.54A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 398
PHE A 347
VAL A 341
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP E 398
PHE E 347
VAL E 341
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.57A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLU C  87
PRO C  65
ASP C  66
ILE C  81
TYR C  92
1.65A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.53A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  70
ALA H  79
1.76A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLU L  87
PRO L  65
ASP L  66
ILE L  81
TYR L  92
1.66A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 399
ASP E 398
ASP E 364
ALA E 363
ILE E 358
1.51A23.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 399
ASP A 398
ASP A 364
ALA A 363
ILE A 358
1.51A23.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
ASN L 143
PHE L 124
VAL H 185
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.48A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 9
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.58A24.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.60A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.61A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.48A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
ASN C 143
PHE C 124
VAL B 185
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.61A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  70
ALA B  79
1.77A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 398
PHE A 429
VAL A 433
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP E 398
PHE E 429
VAL E 433
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.53A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU H  57
ASP H  55
ARG H  59
ILE H  51
ILE H  34
1.59A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
GLU B  57
ASP B  55
ARG B  59
ILE B  51
ILE B  34
1.58A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.70A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN D  15
PHE D 116
VAL D 151
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 116
VAL A 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 116
VAL B 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE D 116
LEU D  93
ALA D 124
GLN D 118
1.78A
None
None
None
EDO  D 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP E 145
PHE E 168
VAL E  16
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 145
PHE B 168
VAL B  16
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN E  15
PHE E 168
VAL E 144
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 145
PHE A 168
VAL A  16
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 168
VAL B 144
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 116
LEU C  93
ALA C 124
GLN C 118
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN E  15
PHE E 116
VAL E 151
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 168
VAL A 144
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN C  15
PHE C 168
VAL C 144
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 116
LEU A  93
ALA A 124
GLN A 118
1.77A
None
None
None
EDO  D 201 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN D  15
PHE D 168
VAL D 144
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN C  15
PHE C 116
VAL C 151
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN C  15
PHE C 116
VAL C 151
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 168
VAL B 144
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 116
VAL B 151
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN E  15
PHE E 116
VAL E 151
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 116
VAL A 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN E  15
PHE E 168
VAL E 144
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP E 145
PHE E 168
VAL E  16
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN D  15
PHE D 116
VAL D 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 145
PHE C 168
VAL C  16
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PHE D 116
LEU D  93
ALA D 124
GLN D 118
1.67A22.83
None
None
None
EDO  A 207 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 168
VAL A 144
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 145
PHE A 168
VAL A  16
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN C  15
PHE C 168
VAL C 144
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN D  15
PHE D 168
VAL D 144
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE A 116
LEU A  93
ALA A 124
GLN A 118
1.76A
None
None
None
EDO  A 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN C  15
PHE C 116
VAL C 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 116
VAL B 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN C  15
PHE C 168
VAL C 144
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
PHE C 116
LEU C  93
ALA C 124
GLN C 118
1.79A
None
None
None
EDO  A 204 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 145
PHE A 168
VAL A  16
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN B  15
PHE B 168
VAL B 144
0.93A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 168
VAL A 144
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 145
PHE B 168
VAL B  16
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASN A  15
PHE A 116
VAL A 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.69A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A  68
ASP A  67
ARG A  55
ASP A 218
ARG A 116
1.78A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 348
VAL A 535
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 753
ARG A 750
LEU A 749
ALA A 777
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 287
ARG A 285
ARG A 183
LEU A 186
1.80A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.65A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		5 / 12
ILE A  86
ASP A 221
ILE A 201
ALA A 199
THR A  85
1.59A17.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 777
1.42A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASN A 691
ASP A 684
ALA A 580
ILE A 589
SER A 759
1.71A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 881
LEU A 869
ALA A 866
GLN A 875
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		5 / 10
LEU A 708
ALA A  46
TYR A 728
SER A 239
VAL A 128
1.80A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A  68
ASP A  67
ARG A  55
ASP A 218
ARG A 116
1.76A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 287
ARG A 285
ARG A 183
LEU A 186
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.33A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
ARG B  80
LEU A 372
ALA A 375
GLN B  73
1.76A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 153
PHE A 157
VAL A 174
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 100
PHE A   7
VAL A  72
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 652
VAL A 354
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		7btf NSP8
(SARS-CoV-2)		5 / 9
ASN D 100
ASP D  99
ILE D 107
ALA D 110
ILE D 106
1.50A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 517
PHE A 368
VAL B  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASN A  39
PHE A  48
VAL A  42
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 528
ARG A 569
ALA A 529
GLN A 573
1.75A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
PHE A  45
VAL A 128
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 208
PHE A  45
VAL A 128
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.66A
None
None
DMS  A 404 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A   3
ARG A   4
LEU A 282
ALA A 210
1.68A19.30
None
None
DMS  A 404 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ASN A 691
ASP A 684
ALA A 580
ILE A 589
SER A 759
1.77A11.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
ILE B 106
ASP B  99
ILE B 107
ALA B 110
THR B 123
1.73A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
ASN D 100
ILE D 107
ASP D 112
ALA D 110
ILE D 106
1.48A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 753
ARG A 750
LEU A 749
ALA A 777
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 287
ARG A 285
ARG A 183
LEU A 186
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 348
ARG A 279
LEU A 351
ALA A 656
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 287
ARG A 285
ARG A 183
LEU A 186
1.79A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 506
LEU A 372
ALA A 375
GLN A 524
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ILE A  86
ASP A 221
ILE A 201
ALA A 199
THR A  85
1.46A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.74A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.44A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
ASN D 100
ASP D 101
ASP D 112
ALA D 110
ILE D 106
1.60A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 777
1.50A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 652
VAL A 354
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
PHE A  45
VAL A 128
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASN A 874
PHE A 428
VAL A 435
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv1 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 517
PHE A 368
VAL B  83
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 368
LEU A 372
GLN A 524
GLN B  88
1.68A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 348
VAL A 535
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASN A 691
ASP A 684
ALA A 580
ILE A 589
SER A 759
1.70A11.45
F86  P 102 (-4.2A)
None
A  T  13 ( 3.7A)
None
U  P  20 ( 2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A 153
PHE A 157
VAL A 174
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASN A 691
ASP A 760
ASP A 623
MET A 626
PRO A 627
1.77A11.62
F86  P 102 (-4.2A)
F86  P 102 ( 3.0A)
POP  A1003 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 506
LEU A 372
ALA A 375
GLN A 524
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 348
VAL A 535
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 777
1.47A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASP A  92
ILE A  86
ASP A 221
ILE A 201
THR A  85
1.78A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASN A 874
PHE A 428
VAL A 435
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 368
LEU A 372
GLN A 524
GLN B  88
1.75A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.39A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 348
ARG A 279
LEU A 351
ALA A 656
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASN A 356
PHE A 652
VAL A 354
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
ARG A 279
LEU A 351
ALA A 656
1.75A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 753
ARG A 750
LEU A 749
ALA A 777
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 517
PHE A 368
VAL B  83
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
PHE A  45
VAL A 128
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A 208
PHE A  45
VAL A 128
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
ARG A 349
LEU A 351
ALA A 656
1.65A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A 753
ARG A 750
LEU A 749
ALA A 702
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASN A 691
ASP A 760
ASP A 623
MET A 626
PRO A 627
1.76A11.62
F86  P 102 (-4.2A)
F86  P 102 ( 3.0A)
POP  A1003 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
PHE A  48
VAL A  42
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A 418
PHE A 859
VAL A 848
1.47A
None