Ligand ID: HU5


Drugbank ID:
DB08873
(Boceprevir)


Indication:
Boceprevir, when used in combination with [DB00811], [DB00008], and [DB00022] is indicated for use in the treatment of chronic HCV genotype 1 infection in adults [FDA Label].

Get human targets for HU5 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HU5'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLN A  11
SER A 105
ALA B 108
ALA B 107
VAL B 110
1.38A17.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ILE D 205
LEU D 235
GLY D 233
ALA D 220
VAL D 218
1.40A24.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 281
GLY A   2
ALA A 210
ALA A 211
VAL A 212
1.31A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
HIS H 164
SER L 138
PHE L 140
ALA L 175
ALA L 176
1.51A24.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ILE B  24
LEU B  54
GLY B  52
ALA B  39
VAL B  37
1.33A22.17
APR  B 477 (-4.0A)
None
None
APR  B 477 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr)		5 / 12
ILE B 107
LEU B 101
GLY B  98
ALA B 130
ALA B 135
1.50A22.17
None
None
None
APR  B 477 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
LEU A  66
GLY A  71
ARG A  62
ALA A  65
ALA A  65
1.01A23.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE B 314
LEU D 122
GLY D 140
ALA D  80
VAL D  84
1.40A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A 207
LEU A  50
GLY A   8
ALA A 204
VAL A 169
1.50A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ILE A 207
LEU A  50
GLY A   8
ALA A 204
VAL A 169
1.50A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 12
GLN C  11
SER C 105
ALA D 108
ALA D 107
VAL D 110
1.48A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 281
GLY A   2
ALA A 210
ALA A 211
VAL A 212
1.46A22.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ILE A 281
GLY A   2
ALA A 210
ALA A 211
VAL A 212
1.21A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.46A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ARG A 232
LEU A 206
SER A 175
ALA A 204
VAL A 194
1.39A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 12
HIS A 278
ILE A 117
LEU A 104
GLY A 295
SER A 294
1.51A19.75
None
None
None
OCS  A  98 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ILE B 166
LEU B 117
GLY B 110
ALA B 119
VAL B 161
1.46A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ILE A 510
PHE A 326
ARG B  98
ALA A 323
ALA A 320
1.42A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.69A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.67A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLN A 630
ILE A 656
GLY A 634
ALA A 676
VAL A 675
1.41A9.77
NAG  A1301 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
LEU B 506
GLY B 552
SER B 508
ALA C 431
ALA C 432
1.31A9.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 201
GLY A 199
PHE A 185
ALA A  91
VAL A  98
1.31A10.06
GLN  A 201 ( 0.6A)
GLY  A 199 ( 0.0A)
PHE  A 185 ( 1.3A)
ALA  A  91 ( 0.0A)
VAL  A  98 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN C 599
ARG B 758
ILE C 650
GLY C 653
ALA B 754
1.33A10.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN B 632
LEU B 636
GLY B 634
ALA B 676
VAL B 675
1.26A9.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6cs2 ACE2
(Homo
sapiens)		6 / 12
ARG D 482
ILE D 256
LEU D 262
GLY D 268
ALA D 264
VAL D 488
1.79A14.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.66A22.30
ELL  D   3 (-4.6A)
ELL  D   3 (-3.6A)
ELL  D   3 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.67A22.30
ELL  D   3 (-3.9A)
ELL  D   3 (-3.6A)
ELL  D   3 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.68A23.23
ELL  D   3 (-3.9A)
ELL  D   3 (-3.6A)
ELL  D   3 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.65A23.23
ELL  D   3 (-4.5A)
ELL  D   3 (-3.6A)
ELL  D   3 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.70A23.23
None
3WL  A 401 (-3.3A)
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 163
GLY D 143
SER D 144
ALA D 116
VAL D 125
1.67A23.23
None
3WL  D 401 (-3.4A)
3WL  D 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 172
GLY D 143
SER D 144
ALA D 116
VAL D 125
1.60A23.23
None
3WL  D 401 (-3.4A)
3WL  D 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B 172
GLY B 143
SER B 144
ALA B 116
VAL B 125
1.65A23.23
None
3WL  B 401 (-3.4A)
3WL  B 401 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 172
GLY C 143
SER C 144
ALA C 116
VAL C 125
1.62A23.23
None
3WL  C 401 (-3.4A)
3WL  C 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.67A23.23
None
3WL  A 401 (-3.3A)
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 163
GLY C 143
SER C 144
ALA C 116
VAL C 125
1.68A23.23
None
3WL  C 401 (-3.4A)
3WL  C 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.66A23.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.69A23.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLY A 503
SER A 561
PHE A 506
ALA A 376
ALA A 375
1.57A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 579
LEU A 575
GLY A 485
ARG A 640
VAL A 693
1.70A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 888
LEU A 885
PHE A 881
ALA A 866
ALA A 863
1.37A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 355
ILE B 119
LEU B 117
GLY A 327
ARG A 331
1.67A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ARG A 654
LEU A 351
GLY A 352
PHE A 652
ALA A 656
1.61A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 757
GLY A 616
PHE A 782
ALA A 699
VAL A 700
1.60A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLN A 541
ILE A 562
GLY A 559
ALA A 376
VAL A 373
1.63A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN C 632
LEU C 636
GLY C 634
ALA C 676
VAL C 675
1.43A9.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6nur NSP12
(SARSr)		5 / 12
ILE A 266
LEU A 265
ARG A 183
ALA A 253
VAL A 320
1.45A12.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6nur NSP12
(SARSr-CoV)		5 / 12
ILE A 888
LEU A 885
PHE A 881
ALA A 866
ALA A 863
1.37A12.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 727
GLY A1059
ARG A1019
ALA A1022
ALA A1025
1.49A9.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  47
ALA B  38
VAL B  36
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  51
ALA A  38
VAL A  36
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  51
ALA B  38
VAL B  36
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  47
ALA A  38
VAL A  36
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
HIS C 207
ILE C 128
SER C 205
ARG C 190
VAL C 120
1.47A9.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN A 197
ILE A  72
SER A 198
ALA A 161
VAL A  67
1.45A18.36
EDO  A 413 (-2.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w02 NSP3
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  51
ALA B  38
VAL B  36
1.37A23.04
APR  B 201 (-4.0A)
None
None
APR  B 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.64A
X77  A 401 ( 4.6A)
X77  A 401 (-3.6A)
X77  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A  46
PHE A 132
ALA A  38
ALA A  39
VAL A  95
1.51A
None
AMP  A 201 ( 4.3A)
AMP  A 201 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  47
ALA B  38
VAL B  36
1.57A
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  47
ALA A  38
VAL A  36
1.65A
AMP  A 201 ( 4.0A)
None
None
AMP  A 201 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
PHE A 132
ALA A  38
ALA A  39
VAL A  96
1.80A23.16
None
AMP  A 201 ( 4.3A)
AMP  A 201 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
PHE A 132
ALA A  38
ALA A  39
VAL A  95
1.54A
None
AMP  A 201 ( 4.3A)
AMP  A 201 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
GLY B  78
ALA B  39
ALA B  38
VAL B  49
1.76A23.16
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  43
GLY A  46
ALA A  38
ALA A  39
VAL A  95
1.78A23.16
None
None
AMP  A 201 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ARG C7053
LEU C6855
GLY C7006
SER C6964
ALA C6858
1.67A23.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ILE B4334
LEU B4328
PHE D4272
ALA B4279
ALA B4276
1.80A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLN C6801
ILE C7005
LEU C6848
GLY C6806
ALA C7002
1.61A23.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLN B 122
ARG B 138
ILE B 104
ALA B 139
ALA B 144
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLN A 133
ILE A 151
LEU A 117
ALA A 116
VAL A 165
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  47
ALA A  38
VAL A  36
1.57A
None
None
MES  A 202 (-3.4A)
MES  A 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  48
ALA A  38
VAL A  36
1.54A
None
None
None
MES  A 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
PHE A 132
ALA A  38
ALA A  39
VAL A  95
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wey NSP3
(SARS-CoV-2)		5 / 12
ILE A 227
LEU A 257
GLY A 255
ALA A 242
VAL A 240
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wey NSP3
(SARS-CoV-2)		5 / 12
ILE A 227
LEU A 257
GLY A 251
ALA A 242
VAL A 240
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wey NSP3
(SARS-CoV-2)		5 / 12
GLY A 251
PHE A 336
ALA A 242
ALA A 243
VAL A 299
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN D 303
ARG B 262
ALA B 273
ALA B 264
VAL B 270
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLN A6801
ILE A7005
LEU A6848
GLY A6806
ALA A7002
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ARG C7053
LEU C6855
GLY C7006
SER C6964
ALA C6858
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLN C6801
ILE C7005
LEU C6848
GLY C6806
ALA C7002
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLN A6801
ILE A7005
LEU A6848
GLY A6806
ALA A7002
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLN C6801
ILE C7005
LEU C6848
GLY C6806
ALA C7002
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ARG C7053
LEU C6855
GLY C7006
SER C6964
ALA C6858
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN B 197
ILE B  72
SER B 198
ALA B 161
VAL B  67
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN A 197
ILE A  72
SER A 198
ALA A 161
VAL A  67
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.63A
None
U5G  A 401 (-3.0A)
U5G  A 401 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.66A
None
U5G  A 401 (-3.0A)
U5G  A 401 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  51
ALA B  38
VAL B  36
1.38A
APR  B 201 (-3.8A)
None
None
APR  B 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  47
ALA B  38
VAL B  36
1.54A
APR  B 201 (-3.8A)
None
APR  B 201 (-4.0A)
APR  B 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY C  46
PHE C 132
ALA C  38
ALA C  39
VAL C  95
1.70A
APR  C 201 (-3.9A)
APR  C 201 (-3.5A)
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE D  23
LEU D  53
GLY D  51
ALA D  38
VAL D  36
1.37A
APR  D 201 (-3.8A)
None
None
APR  D 201 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE C  23
LEU C  53
GLY C  51
ALA C  38
VAL C  36
1.36A
APR  C 201 (-3.9A)
None
None
APR  C 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  46
PHE A 132
ALA A  38
ALA A  39
VAL A  95
1.67A
APR  A 201 (-3.9A)
APR  A 201 (-3.1A)
APR  A 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ARG A7030
LEU A7004
SER A6973
ALA A7002
VAL A6992
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.67A19.15
DMS  A 405 ( 4.8A)
None
DMS  A 405 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.66A19.15
DMS  A 405 (-3.9A)
None
DMS  A 405 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.70A
None
P6N  A 502 ( 4.4A)
P6N  A 502 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.71A
P6N  A 502 (-3.8A)
P6N  A 502 ( 4.4A)
P6N  A 502 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.71A
DMS  A 403 (-4.1A)
PK8  A 401 ( 4.0A)
DMS  A 403 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.67A
None
PK8  A 401 ( 4.0A)
DMS  A 403 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  47
PHE C 132
ALA C  38
ALA C  39
VAL C  95
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  51
ALA B  38
VAL B  36
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  47
ALA B  38
VAL B  36
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  47
PHE B 132
ALA B  38
ALA B  39
VAL B  95
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ARG A 141
ILE A 106
LEU A 109
GLY A  78
SER A 111
1.47A
None
None
None
None
EDO  D 202 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D  23
LEU D  53
GLY D  47
ALA D  38
VAL D  36
1.65A
EDO  D 208 (-4.0A)
None
EDO  D 206 (-4.5A)
EDO  D 205 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
LEU C  53
GLY C  47
ALA C  38
VAL C  36
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
LEU C  53
GLY C  51
ALA C  38
VAL C  36
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D  23
LEU D  53
GLY D  51
ALA D  38
VAL D  36
1.42A
EDO  D 208 (-4.0A)
None
None
EDO  D 205 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  47
ALA A  38
VAL A  36
1.58A
None
None
None
EDO  A 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  51
ALA A  38
VAL A  36
1.37A
None
None
None
EDO  A 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E  23
LEU E  53
GLY E  47
ALA E  38
VAL E  36
1.61A
EDO  E 205 (-4.2A)
None
EPE  E 202 (-4.3A)
EPE  E 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  47
ALA B  38
VAL B  36
1.60A
APR  B 201 (-4.1A)
None
APR  B 201 (-3.6A)
APR  B 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
LEU C  53
GLY C  51
ALA C  38
VAL C  36
1.35A
APR  C 201 (-3.9A)
None
None
APR  C 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  51
ALA A  38
VAL A  36
1.36A
APR  A 201 (-3.9A)
None
None
APR  A 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D  23
LEU D  53
GLY D  51
ALA D  38
VAL D  36
1.38A
APR  D 201 (-3.9A)
None
None
APR  D 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  51
ALA B  38
VAL B  36
1.37A
APR  B 201 (-4.1A)
None
None
APR  B 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  47
ALA A  38
VAL A  36
1.58A
APR  A 201 (-3.9A)
None
APR  A 201 (-4.1A)
APR  A 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E  23
LEU E  53
GLY E  51
ALA E  38
VAL E  36
1.37A
APR  E 201 (-4.1A)
None
None
APR  E 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  23
LEU A  53
GLY A  47
ALA A  38
VAL A  36
1.59A
None
None
MES  A 201 ( 4.8A)
MES  A 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  23
LEU B  53
GLY B  47
ALA B  38
VAL B  36
1.62A
EDO  B 202 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ARG C 141
ILE C  18
LEU C 164
SER C 166
VAL C 144
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
LEU C  53
GLY C  51
ALA C  38
VAL C  36
1.41A
EDO  C 206 (-4.1A)
None
None
MES  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
LEU C  53
GLY C  47
ALA C  38
VAL C  36
1.62A
EDO  C 206 (-4.1A)
None
MES  C 201 ( 4.9A)
MES  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.70A
PJE  C   5 (-4.4A)
PJE  C   5 (-3.1A)
PJE  C   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.67A
PJE  C   5 (-3.8A)
PJE  C   5 (-3.1A)
PJE  C   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7btf NSP12
(SARS-CoV-2)		5 / 12
ILE A 888
LEU A 885
PHE A 881
ALA A 866
ALA A 863
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7btf NSP12
(SARS-CoV-2)		5 / 12
ILE A 757
GLY A 616
PHE A 782
ALA A 699
VAL A 700
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7btf NSP12
(SARS-CoV-2)		5 / 12
ARG A 654
LEU A 351
GLY A 352
PHE A 652
ALA A 656
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLN A 541
ILE A 562
GLY A 559
ALA A 376
VAL A 373
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 355
ILE B 119
LEU B 117
GLY A 327
ARG A 331
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 172
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.65A
DMS  A 402 (-4.4A)
JRY  A 401 (-3.3A)
DMS  A 402 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 163
GLY A 143
SER A 144
ALA A 116
VAL A 125
1.68A
DMS  A 402 (-3.9A)
JRY  A 401 (-3.3A)
DMS  A 402 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 541
ILE A 562
GLY A 559
ALA A 376
VAL A 373
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ARG A 654
LEU A 351
GLY A 352
PHE A 652
ALA A 656
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ILE A 888
LEU A 885
PHE A 881
ALA A 866
ALA A 863
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ILE A 888
LEU A 885
PHE A 881
ALA A 866
ALA A 863
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ARG A 654
ILE A 632
GLY A 352
PHE A 652
ALA A 656
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ARG A 654
LEU A 351
GLY A 352
PHE A 652
ALA A 656
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 355
ILE B 119
LEU B 117
GLY A 327
ARG A 331
1.63A
None